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| 1 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 2 | Cervical cancer: Epidemiology, risk factors and screening显示文摘Cervical cancer is one of the leading causes of cancer death among females worldwide and its behavior epidemiologically likes a venereal disease of low infectiousness. Early age at first intercourse and multiple sexual partners have been shown to exert strong effects on risk. The wide differences in the incidence among different countries also influenced by the introduction of screening. Although the general picture remains one of decreasing incidence and mortality, there are signs of an increasing cervical cancer risk probably due to changes in sexual behavior. Smoking and human papillomavirus(HPV) 16/18 are currently important issues in a concept of multifactorial, stepwise carcinogenesis at the cervix uteri. Therefore, society-based preventive and control measures, screening activities and HPV vaccination are recommended. Cervical cancer screening methods have evolved from cell morphology observation to molecular testing. High-risk HPV genotyping and liquid-based cytology are common methods which have been widely recommended and used worldwide. In future, accurate,cheap, fast and easy-to-use methods would be more popular. Artificial intelligence also shows to be promising in cervical cancer screening by integrating image recognition with big data technology. Meanwhile, China has achieved numerous breakthroughs in cervical cancer prevention and control which could be a great demonstration for other developing and resource-limited areas. In conclusion, although cervical cancer threatens female health, it could be the first cancer that would be eliminated by human beings with comprehensive preventive and control strategy. | Shaokai Zhang Huifeng Xu Luyao Zhang Youlin Qiao | 2020 | Chinese Journal of Cancer Research2020，32，6： | 25 |
| 3 | Fluorination vs. chlorination: a case study on high performance organic photovoltaic materials显示文摘Halogenation is a very efficient chemical modification method to tune the molecular energy levels, absorption spectra and molecular packing of organic semiconductors. Recently, in the field of organic solar cells(OSCs), both fluorine-and chlorinesubstituted photovoltaic materials, including donors and acceptors, demonstrated their great potentials in achieving high power conversion efficiencies(PCEs), raising a question that how to make a decision between fluorination and chlorination when designing materials. Herein, we systemically studied the impact of fluorination and chlorination on the properties of resulting donors(PBDB-T-2 F and PBDB-T-2 Cl) and acceptors(IT-4 F and IT-4 Cl). The results suggest that all the OSCs based on different donor and acceptor combinations can deliver good PCEs around 13%–14%. Chlorination is more effective than fluorination in downshifting the molecular energy levels and broadening the absorption spectra. The influence of chlorination and fluorination on the crystallinity of the resulting materials is dependent on their introduction positions. As chlorination has the advantage of easy synthesis, it is more attractive in designing low-cost photovoltaic materials and therefore may have more potential in largescale applications. | Yun Zhang Huifeng Yao Shaoqing Zhang Yunpeng Qin Jianqi Zhang Liyan Yang Wanning Li Zhixiang Wei Feng Gao Jianhui Hou | 2018 | Science China Chemistry2018，61，10： | 11 |
| 4 | Temperature and substrate availability regulate soil respiration in the tropical mountain rainforests,Hainan Island,China显示文摘Aims Tropical forest plays a key role in global C cycle;however,there are few studies on the C budget in the tropical rainforests in Asia.This study aims to(i)reveal the seasonal patterns of total soil respiration(R_(T)),litter respiration(R_(L))and soil respiration without surface organic litter(R_(NL))in the primary and secondary Asian tropical mountain rainforests and(ii)quantify the effects of soil temperature,soil moisture and substrate availability on soil respiration.Methods The seasonal dynamics of soil CO_(2) efflux was measured by an automatic chamber system(Li-8100),within the primary and secondary tropical mountain rainforests located at the Jianfengling National Reserve in Hainan Island,China.The litter removal treatment was used to assess the contribution of litter to belowground CO_(2) production.Important Findings The annual R_(T) was higher in the primary forest(16.73±0.87 Mg C ha−1)than in the secondary forest(15.10±0.26 Mg C ha−1).The rates of R_(T),R_(NL) and R_(L) were all significantly higher in the hot and wet season(May–October)than those in the cool and dry season(November–April).Soil temperature at 5cm depth could explain 55–61%of the seasonal variation in R_(T),and the temperature sensitivity index(Q_(10))ranked by R_(L)(Q_(10)=3.39)>R_(T)(2.17)>R_(NL)(1.76)in the primary forest and by R_(L)(4.31)>R_(T)(1.86)>R_(NL)(1.58)in the secondary forest.The contribution of R_(L) to R_(T) was 22–23%,while litter input and R_(T) had 1 month time lag.In addition,the seasonal variation of R_(T) was mainly determined by soil temperature and substrate availability.Our findings suggested that global warming and increased substrate availability are likely to cause considerable losses of soil C in the tropical forests. | Zhang Zhou Lai Jiang Enzai Du Huifeng Hu Yide Li Dexiang Chen Jingyun Fang | 2013 | Journal of Plant Ecology2013，6，5： | 8 |
| 5 | Critical Role of Molecular Electrostatic Potential on Charge Generation in Organic Solar Cells显示文摘 | Huifeng Yao Deping Qian Hao Zhang Yunpeng Qin Bowei Xu Yong Cui Runnan Yu Feng Gao Jianhui Hou | 2018 | Chinese Journal of Chemistry2018，36，6： | 8 |
| 6 | Footprint Problem with Angle of Attack Optimization for High Lifting Reentry Vehicle显示文摘A formal analysis to footprint problem with effects of angle of attack (AOA) is presented. First a flexible and rapid standardized method for footprint generation is developed. Zero bank angle control strategy and the maximum crossrange method are used to obtain virtual target set; afterward, closed-loop bank angle guidance law is used to find footprint by solving closest approach problem for each element in virtual target set. Then based on quasi-equilibrium glide condition, the typical inequality reentry trajectory constraints are converted to angle of attack lower boundary constraint. Constrained by the lower boundary, an original and practical angle of attack parametric method is proposed. By using parametric angle of attack profile, optimization algorithm for angle of attack is designed and the impact of angle of attack to footprint is discussed. Simulations with different angle of attack profiles are presented to demonstrate the performance of the proposed footprint solution method and validity of optimal algorithm. | LI Huifeng ZHANG Ran LI Zhaoying ZHANG Rui | 2012 | Chinese Journal of Aeronautics2012，25，2： | 8 |
| 7 | Organic photovoltaic cell with 17% efficiency and superior processability显示文摘The development of organic photoactive materials,especially the newly emerging non-fullerene electron acceptors(NFAs),has enabled rapid progress in organic photovoltaic(OPV)cells in recent years.Although the power conversion efficiencies(PCEs)of the top-performance OPV cells have surpassed 16%,the devices are usually fabricated via a spin-coating method and are not suitable for large-area production.Here,we demonstrate that the fine-modification of the flexible side chains of NFAs can yield 17%PCE for OPV cells.More crucially,as the optimal NFA has a suitable solubility and thus a desirable morphology,the high efficiencies of spin-coated devices can be maintained when using scalable blade-coating processing technology.Our results suggest that optimization of the chemical structures of the OPV materials can improve device performance.This has great significance in larger-area production technologies that provide important scientific insights for the commercialization of OPV cells. | Yong Cui Huifeng Yao Ling Hong Tao Zhang Yabing Tang Baojun Lin Kaihu Xian Bowei Gao Cunbin An Pengqing Bi Wei Ma Jianhui Hou | 2020 | National Science Review2020，7，7： | 7 |
| 8 | Monocyte chemoattractant protein-1 induces endothelial cell apoptosis in vitro through a p53-dependent mitochondrial pathway显示文摘cystinecystine (CC ) chemokine 单核白血球 chemoattractant protein-1 (MCP-1 ) 被建立了由于它领先的单核白血球的趋化性的能力在动脉粥样硬化的发展起一个病原的作用定位到 subendothelia。最近的研究揭示了除趋化性以外的更多的 MCP-1 功能。这里,我们报导 MCP-1 的各种各样的集中(0.1100 ng/ml ) 导致了人的脐的静脉 endothelial 房间(HUVEC ) 紧张 CRL-1730 apoptosis, caspase-9 激活,和几 mitochondrial 改变。而且, HUVEC 的 MCP-1 upregulated p53 表示和 p53 特定的禁止者 pifithrin-(PFT ) 救了 HUVEC 的 MCP-1-induced apoptosis。而且,激活或抑制可能也影响的 PKC (蛋白质 kinase C ) HUVEC apoptosis 由 MCP-1 导致了。这些调查结果一起证明 MCP-1 经由一条 p53 依赖的 mitochondrial 小径在 vitro 在 HUVEC 上施加直接 proapoptotic 效果。 | Xuan Zhang, Xiping Liu Huifeng Shang Yan Xu Minzhang Qian | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 6 |
| 9 | Zanthoxylum-specific whole genome duplication and recent activity of transposable elements in the highly repetitive paleotetraploid Z.bungeanum genome显示文摘Zanthoxylum bungeanum is an important spice and medicinal plant that is unique for its accumulation of abundant secondary metabolites,which create a characteristic aroma and tingling sensation in the mouth.Owing to the high proportion of repetitive sequences,high heterozygosity,and increased chromosome number of Z.bungeanum,the assembly of its chromosomal pseudomolecules is extremely challenging.Here,we present a genome sequence for Z.bungeanum,with a dramatically expanded size of 4.23 Gb,assembled into 68 chromosomes.This genome is approximately tenfold larger than that of its close relative Citrus sinensis.After the divergence of Zanthoxylum and Citrus,the lineage-specific whole-genome duplication event q-WGD approximately 26.8 million years ago(MYA)and the recent transposable element(TE)burst~6.41 MYA account for the substantial genome expansion in Z.bungeanum.The independent Zanthoxylum-specific WGD event was followed by numerous fusion/fission events that shaped the genomic architecture.Integrative genomic and transcriptomic analyses suggested that prominent speciesspecific gene family expansions and changes in gene expression have shaped the biosynthesis of sanshools,terpenoids,and anthocyanins,which contribute to the special flavor and appearance of Z.bungeanum.In summary,the reference genome provides a valuable model for studying the impact of WGDs with recent TE activity on gene gain and loss and genome reconstruction and provides resources to accelerate Zanthoxylum improvement. | Shijing Feng Zhenshan Liu Jian Cheng Zihe Li Lu Tian Min Liu Tuxi Yang Yulin Liu Yonghong Liu He Dai Zujun Yang Qing Zhang Gang Wang Jisen Zhang Huifeng Jiang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 5 |
| 10 | A DFT Study on the Adsorption Behavior of Sulfur and Nitrogen Compounds on the NiMoS Phase显示文摘The density functional theory(DFT)with dispersion corrections was used to study the adsorption behavior of sulfur and nitrogen compounds on NiMoS phase.The calculations were performed based on a hexagonal cluster model including the Mo-edge,the S-edge,and the rarely mentioned corner site.It was found that the adsorption of quinoline is stronger than that of benzothiophene at all the active sites.It indicated the origin of the inhibition effect of nitrogen compounds on HDS.And Ni atoms located around Mo-edge and corner site exhibit higher adsorption selectivity to sulfur compounds than the nitrogen ones.It means that the increase in Ni-promoting effect may weaken the inhibition effect of nitrogen compounds on HDS. | Wang Wei Li Huifeng Han Wei Zhang Le Zhao Xiaoguang Li Mingfeng | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，1： | 5 |
| 11 | HMGB1 involved in stress-induced depression and its neuroinflammatory priming role:a systematic review显示文摘Background Evidence from clinical and preclinical studies has demonstrated that stress can cause depressive-like symptoms including anhedonia and psychomotor retardation, namely, the manifestation of motivational deficits in depression. The proximate mediator of linking social-environmental stress with internal motivational deficits remains elusive, although substantial studies proposed neural endocrine mechanisms. As an endogenous danger-associated molecule, high mobility group box-1 (HMGB1) is necessary and sufficient for stress-induced sensitization of innate immune cells and subsequent (neuro)inflammation. Aim This review aims to provide evidence to unveil the potential mechanism of the relationship between motivational deficits and stress in depression. M ethods We reviewed original case-control studies investigating the association between HMGB1-mediated inflammation and stress-induced depression. The literature search of Pubmed and Web of Science electronic database from Inception up to March 28th, 2019 were conducted by two independent authors. We performed a qualitative systematic review approach to explore the correlation between HMGB1 -mediated inflammation and anhedonia/psychomotor retardation in depression. Results A total of 69 studies based on search strategy were retrieved and seven eligible studies met the inclusion criteria. Studies showed that HMGB1 was implicated with depressive-like behaviors, which are similar with motivational deficits. Furthermore, HMGB1 -mediated inflammation in depressive-like behaviors may be involved in Nod-like receptor family pyrin domain containing three (NLRP3) inflammasome and proinflammatory cytokines, abnormal kynurenine pathway and imbalance between neuroprotective and neurotoxic factors. Conclusions We found that stress-induced inflammation mediated by HMGB1 may affect motivational deficits through regulating dopamine pathway in corticostriatal neurocircuitry. The systematic review may shed light on the novel neurobiological underpinning for treatment of motivation deficits in depression. | Huifeng Zhang Lei Ding Ting Shen Daihui Peng | 2019 | General Psychiatry2019，32，4： | 4 |
| 12 | Model-free adaptive optimal design for trajectory tracking control of rocket-powered vehicle显示文摘An adaptive optimal trajectory tracking controller is presented for the Solid-RocketPowered Vehicle(SRPV)with uncertain nonlinear non-affine dynamics in the framework of adaptive dynamic programming.First,considering that the ascent model of the SRPV is non-affine,a model-free Single Network Adaptive Critic(SNAC)method is developed based on the dynamic neural network and the traditional SNAC method.This developed model-free SNAC method overcomes the limitation of the traditional SNAC method that can only be applied to affine systems.Then,a closed-form adaptive optimal controller is designed for the non-affine dynamics of SRPVs.This controller can adjust its parameters under different flight conditions and converge to the approximate optimal controller through online self-learning.Finally,the convergence to the approximate optimal controller is proved.The theoretical analysis of the uniformly ultimate boundedness of the tracking error is also presented.Simulation results demonstrate the effectiveness of the proposed controller. | Wenming NIE Huifeng LI Ran ZHANG | 2020 | Chinese Journal of Aeronautics2020，33，6： | 4 |
| 13 | The protective effects of peptides from Chinese baijiu on AAPH-induced oxidative stress in HepG2 cells via Nrf2 signaling pathway显示文摘Antioxidant peptides have been widely reported.However,only a few reports have been published examining the antioxidant peptides derived from Chinese baijiu.In this study,6 novel peptides derived from Chinese baijiu were identified successfully using high-performance liquid chromatography-quadrupoletime-of-flight mass spectrometry(HPLC-QTOF-MS)with a concentration of 0.835–24.540μg/L.The underlying molecular mechanisms were investigated,and their cytoprotective effects were examined against 2,2’-azobis(2-methylpropanimidamidine)dihydrochloride(AAPH)-induced oxidative stress in Hep G2 cells.The results showed that these peptides exerted protective effects by suppressing reactive oxygen species(ROS)generation,preventing malondialdehyde(MDA)formation,and upregulating cellular antioxidant enzyme activities(SOD,CAT,and GSH-Px)in a dose-dependent manner.Further experiments proved that these peptides exerted antioxidant effects via Nrf2/ARE-mediated signaling pathway by promoting Nrf2 nuclear translocation,inhibiting ubiquitination,and enhancing transcription capacity of Nrf2 in Hep G2 cells.These findings provide the molecular basis for the effects of antioxidant peptides derived from Chinese baijiu,which is important for a deeper understanding of the relationship between human health and moderate drinking. | Jiaying Huo Yuezhang Ming Huifeng Li Anjun Li Jiwen Zhao Mingquan Huang Weizheng Sun Jihong Wu Jinglin Zhang | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 14 | Magnetic beads-based multicolor colorimetric immunoassay for ultrasensitive detection of aflatoxin B_(1)显示文摘Aflatoxin B_(1)(AFB_(1))is one of the most toxic,mutagenic and carcinogenic mycotoxin,widely exists in contaminated food,grains and feedstuff products.In this study,a novel magnetic beads multicolor colorimetric immunoassay(MBMCIA)based on Au@Ag nanorods(Au@Ag NRs)is proposed to visual detect ultralow concentration of AFB_(1)with high-resolution by the naked-eye.To design the MBMCIA system,AFB_(1)-BSA conjugates were first coated on the surface of magnetic beads(MBs),then alkaline phosphatase(ALP)as a bridge between immunoassay a nd color reaction was used for catalytic hydrolysis of ascorbic acid-phosphate to generate reductive ascorbic acid.Finally,the yielded ascorbic acid could reduce silver ions to grow a silver coating on the surface of gold nanorods to generate Au@Ag NRs,which leads to the bule-shifted longitudinal absorption peak of Au NRs,accompanying with a series of perceptible color change.Under the optimal conditions,the proposed MBMCIA exhibited go od sensitivity and specificity for the detection of AFB_(1)with the detection limit as low as 5.7 pg/mL Meanwhile,the MBMCIA was also applied for the analysis of AFB_(1)in spiked wheat samples,the obtained recoveries range from 99.1%to 104.3%with relative standard deviation(RSD)less than 7.05%were acceptable.The proposed MBMCIA integrates separated,enriched,anti-interfe rence and signal read-out into one,which opens up a new avenue for an on-site visual food safety inspection or environmental monitoring. | Shan He Qitong Huang Ying Zhang Huifang Zhang Huifeng Xu Xun Li Xiaoming Ma | 2021 | Chinese Chemical Letters2021，32，4： | 3 |
| 15 | Immunogenicity of recombinant F4 (K88) fimbrial adhesin FaeG expressed in tobacco chloroplast显示文摘到通常对腹泻在植物生产新奇疫苗的可能性在新生、最新断奶的小猪发现了的测试, faeG 基因,编码主要 F4ac fimbrial 子单元蛋白质,被介绍进烟草叶绿体染色体。在在 spectinomycin 下面的二轮选择以后,我们将近获得了转基因的植物 homoplasmic。RNA 胶化污点分析显示了那 faeG 和抗菌素选择基因 aminoglycoside 3 adenylyltransferase (aadA ) 高度作为 dicistron 被抄录,当在 transplastomic 烟草的 recombinant FaeG 的翻译水平是大约 0.15% 全部的可溶的蛋白质时。在烟草叶绿体生产的 recombinant FaeG 的 immunogenicity 被 FaeG 特定的抗体在与导出叶绿体的 recombinant FaeG 刺激的老鼠 sera 能抵销的转基因的植物,以及结果的全部的可溶的蛋白质使免疫的老鼠被得到的观察证实在 vivo 的 F4ac enterotoxigenic Escherichia coli (ETEC ) 。这研究为用叶绿体表达式系统生产 ETEC 疫苗提供一种新选择。 | Huifeng Shen Bingjun Qian Weiwei Chen Zhenhua Liu Litao Yang Dabing Zhang Wanqi Liang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 3 |
| 16 | Species richness and composition of shrub-encroached grasslands in relation to environmental factors in northern China显示文摘Aims Shrub encroachment has taken place in many of China’s northern grasslands.This study attempts to answer the following questions:which plant communities are present in these shrub-encroached grasslands(SEGs)?What are the species richness and composition of these communities?Which environmental factors determine the spatial distribution thereof?Methods We investigated the community characteristics of 255 SEG plots with a size of 20 m×20 m at 69 locations across grasslands in northern China.In each plot,paired 1-m^(2) quadrats were estab-lished within shrub patches and the neighbouring grassy matrix to record herb species composition.The quantitative character-istics(abundance,coverage and height)of herbs were meas-ured in 0.25-m2 subquadrats,and soil samples were collected in the quadrats.Two-way indicator species analysis(TWINSPAN),detrended canonical analysis(DCA)and canonical correspond-ence analysis(CCA)were used for community clustering and ordination.Important Findings The DCA and TWINSPAN results suggested that the SEGs in northern China can be divided into six community types:Potentilla fruticosa+Carex atrofusca,Spiraea hypericifolia+Festuca ovina,Caragana acanthophylla+Stipa sareptana,Caragana microphylla+Leymus chinensis,Caragana microphylla+Stipa klemenzii and Caragana tibetica+Cleistogenes songorica.At a regional scale,climate and soil nutrients controlled the spatial patterns of species richness and community composition of the SEGs in northern China.Temperature exerted a negative impact,whereas precipitation and nutrients had positive effects on species richness.Among the environmental factors used,climate was the major controller of the variations in commu-nity structure.These results provide new insights into the community composition of SEGs in China and enrich the global dataset of SEGs. | Luhong Zhou Haihua Shen Leiyi Chen He Li Pujin Zhang Xia Zhao Taoyu Liu Shangshi Liu Aijun Xing Huifeng Hu Jingyun Fang | 2019 | Journal of Plant Ecology2019，12，1： | 3 |
| 17 | The origin of Mosuo people as revealed by mtDNA and Y chromosome variation显示文摘The Mosuo, living in the Lugu Lake area in northwest Yunnan Province, China, is the only matriarchal population in China. The Mosuo was officially identified as Naxi nationality although its relationship with Naxi remains controversial. We studied the genetic relationship between the Mosuo and five other ethnic groups currently residing in northwest Yunnan, i.e. Naxi, Tibetan, Bai, Yi and Pumi, by typing the genetic variations in mtDNA HVS1 and 21 Y chromosome markers (13 SNPs & 8 STR markers). We showed that the maternal lineages of the Mosuo bear the strongest resemblance with those found in Naxi while its paternal lineages are more similar to those that are prevalent in Yunnan Tibetan. The marked difference between paternal and maternal lineages may be attributable to the genetic history, matriarchal structure, and visiting marriage. | WEN Bo, SHI Hong, REN Ling, XI Huifeng, LI Kaiyuan, ZHANG Wenyi, SU Bing, SI Shiheng, JIN Li & XIAO ChunjieJoined Laboratory of Human Population Genetics of Yunnan University and Fudan University, Kunming 650091, China Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University, Kunming 650091, China National Key Laboratory of Genetic Engineering & Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai 200433, China Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650031, China Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati 45267, USA The Central Hospital of Ninglang County, Ninglang 674300, China | 2004 | Science China(Life Sciences)2004，47，1： | 3 |
| 18 | The origin and evolution of the diosgenin biosynthetic pathway in yam显示文摘Diosgenin,mainly produced by Dioscorea species,is a traditional precursor of most hormonal drugs in the pharmaceutical industry.The mechanisms that underlie the origin and evolution of diosgenin biosynthesis in plants remain unclear.After sequencing the whole genome of Dioscorea zingiberensis,we revealed the evolutionary trajectory of the diosgenin biosynthetic pathway in Dioscorea and demonstrated the de novo biosynthesis of diosgenin in a yeast cell factory.First,we found that P450 gene duplication and neofunctionalization,driven by positive selection,played important roles in the origin of the diosgenin biosynthetic pathway.Subsequently,we found that the enrichment of diosgenin in the yam lineage was regulated by CpG islands,which evolved to regulate gene expression in the diosgenin pathway and balance the carbon flux between the biosynthesis of diosgenin and starch.Finally,by integrating genes fromplants,animals,and yeast,weheterologously synthesized diosgenin to 10mg/l in genetically-engineered yeast.Our study not only reveals the origin and evolutionary mechanisms of the diosgenin biosynthetic pathway in Dioscorea,but also introduces an alternative approach for the production of diosgenin through synthetic biology. | Jian Cheng Jing Chen Xiaonan Liu Xiangchen Li Weixiong Zhang Zhubo Dai Lina Lu Xiang Zhou Jing Cai Xueli Zhang Huifeng Jiang Yanhe Ma | 2021 | Plant Communications2021，2，1： | 2 |
| 19 | Stable wide-temperature and low volume expansion Al batteries:Integrating few-layer graphene with multifunctional cobalt boride nanocluster as positive electrode显示文摘To achieve stable positive electrode for promoting the overall electrochemical performance of Al batteries(ABs),here novel cobalt boride(CoB)nanoclusters are synthesized to construct composite electrodes with few-layer graphene(FLG).Due to the presence of amorphous channels in the employed CoB nanoclusters,the ABs with FLG/CoB composite positive electrodes exhibit high rate.capability and both mechanical and electrochemical stability in the ABs.With assistance of in situ scanning electron microscopy(SEM),the observation results suggest that the positive electrode of CoB nanoclusters holds almost ignorable volume variation upon electrochemical processes,which substantially alleviates the massive electrode expansion induced by the anion intercalation in the composite positive electrode.Interestingly,the composite positive electrodes provide stable reversible energy storage capability within a broadened temperature range(-30-60℃),promising a novel strategy to design advanced ABs positive electrodes with enhanced overall energy storage performance. | Li-Li Chen Na Li Huifeng Shi Yuefei Zhang Wei-Li Song Shuqiang Jiao Haosen Chen Daining Fang | 2020 | Nano Research2020，13，2： | 2 |
| 20 | NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy显示文摘Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of OSCC.Autophagy is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain unknown.In our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis. | Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
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