|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultra-high pressure zone of Dabie Mountains,China显示文摘The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dabie Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that ( i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2 -bearing fluids were presentin the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite. | LIU Jingbo YE Kai CONG Bolin Maruyama Shegnori FAN Hongrui | 2001 | Chinese Science Bulletin2001，46，22： | 22 |
| 2 | Characteristics and dynamic settings of the Central-east Asia multi-energy minerals metallogenetic domain显示文摘That more than 82 percent of proved sandstone-type uranium deposits coexist with proved oil-gas or coalfields in the world reflects the fact of coexistence and accumulation of multi-energy minerals including oil, gas, coal and uranium in the same basin. Especially, this phenomenon is most typical in the Central-east Asia energy basins. Across China, Mongolia and some central Asian countries, the giant Central-east Asia metallogenetic domain (CEAMD) stretches more than 6,000 km from Songliao Basin of China in the east to the Caspian Sea in the west. The multi-energy minerals distribution characteristics of the domain include: their spatial distribution is complicated and ordered; the ore-bearing horizon relates closely to the geographical region; the accumulation/mineralization and localization time is the same or close; the occurrence setting and accumulation/mineralization have close correlation; and they have rich provenance for all the minerals. All of these imply that they have close relations between each other under a unified geodynamic background. The exogenetic uranium mineralization process in CEAMD can be divided into five phases using time limits of 100 Ma, (50±2) Ma, 20±(2―4) Ma, 8―5 Ma. The major mineralization periods and their differences in each primary uranium-bearing basin are identical to the oil-gas accumulation and localization periods and phases in the same basin, and are also in response to regional tectonics and controlled in general by the regional geodynamic environment. For industrial application and commercial exploitation, it is suggested that an important period for coexistence, accumulation and localization of oil, gas, coal and uranium and their interaction mainly occur in the late/last and post basin evolution. Through generalized analysis and comparison of accumulation/mineralization environment of the energy basins in CEAMD, the authors propose that the relatively stable regional tectonic background and moderate (weaker) structural deformation probably are necessary for formation, coexistence and preservation of large and medium-scaled sandstone-type uranium ore deposits, oil-gas fields and coalfields, while basins in favor of coexistence and accumulation are those intracratonal, intermediary massif basins and corresponding reformed basins. | LIU ChiYang QIU XinWei WU BoLin ZHAO HongGe | 2007 | Science China Earth Sciences2007，50，z2： | 13 |
| 3 | Epigenetic mechanism of Survivin dysregulation in human cancer显示文摘Survivin(coding gene BIRC5) is a dual functional protein acting as a critical inhibitor of apoptosis(IAP) and key regulator of cell cycle progression. It is usually produced in embryonic tissues during development and undetectable in most adult tissues.Overexpression of Survivin frequently occurs in various human cancers and increased Survivin correlates with poor clinic outcome, tumor recurrence, and therapeutic resistance. Because of its selective expression in tumor, but not normal tissues,Survivin has been recognized as an attractive target for cancer treatment. Although several therapeutic approaches targeting Survivin are actively under clinical trials in human cancers, to date no Survivin-targeted therapy has been approved for cancer treatment. Numerous studies have devoted to uncovering the underlying mechanism resulting in Survivin dysregulation at multiple levels, such as transcriptional and post-transcriptional regulation. The current article provides a literature review on the transcriptional and epigenetic regulation of Survivin expression in human cancers. We focus on the impact of DNA methylation and histone modifications, including specific lysine methylation, demethylation, and acetylation on the expression of Survivin.The latest development of epigenetic approaches targeting Survivin for cancer treatment are also discussed. | Hui Lyu Jingcao Huang Zhimin He Bolin Liu | 2018 | Science China(Life Sciences)2018，61，7： | 11 |
| 4 | Basical characteristics of fluid geologic process of interlayer oxidation zone sandstone-typeuranium deposit显示文摘This paper reveals the physicochemical properties such as component, formulation, genesis, tem- perature, pH, Eh, salinity and pressure of all main alteration fluid of interlayer oxidation zone sand- stone-type uranium deposits after studying the geologic process and geochemistry of internal typical sandstone-type uranium deposits such as Shihongtan deposit in the Turpan-Hami basin, 512 deposit in the Yili basin, Dongsheng deposit in the Ordos basin. The composition of fluid can be divided into two parts based on the analysis of inclusion: one can be affirmed as atmospheric water with ordinary temperature epigenesist according to the character of hydrogen and oxygen isotope of inclusion, the other is natural gas containing gaseous hydrocarbon like CH4, and CO2 as well as a little H2S, CO, H2, N2 and so on, it always contains a small quantity of hydrocarbon liquid in petroliferous basins. The fluid property of oxidation alteration zone is always oxidation alkaline, and neutrality or weak acid-weak alkaline and reducibility during the metallizing process, but at secondary reduction or deoxidization zone it becomes strong reduction alkaline. Oxygenic groundwater in the fluid is the activate and mig- ratory medium of uranium element, but the gaseous hydrocarbon like CH4 as well as H2, H2S, CO from natural gas is the important sedimentary reducer of uranium mineral; the transformation of pH,Eh in fluid environment is the main reason for the formation of uranium metallization. | WU BoLin LIU ChiYang WANG JianQiang | 2007 | Science China Earth Sciences2007，50，z2： | 9 |
| 5 | Seismic tomography showing subduction and slab breakoff of the Yangtze block beneath the Dabie-Sulu orogenic belt显示文摘Seismic tomography reveals that a subducted ancient block has been preserved beneath the Moho of the Dabie-Sulu orogenic belt. Taking into account of geological and geochronological data, we inferred from the tomographic images that the Yangtze block was subducted northward beneath the Sino-Korean block and broken off at the depth <200 km during 200-190 Ma. The slab breakoff of the Yangtze block is the most important dynamic mechanism to control the exhumation of UHP rocks. | Peifen Xu Ruomei Sun Futian Liu Qingchen Wang Bolin Cong | 2000 | Chinese Science Bulletin2000，45，1： | 7 |
| 6 | Understanding the biology of HER3 receptor as a therapeutic target in human cancer显示文摘HER3 belongs to the human epidermal growth factor receptor(HER) family which also includes HER1/EGFR/erb B1,HER2/erb B2,and HER4/erb B4. As a unique member of the HER family,HER3 lacks or has little intrinsic tyrosine kinase activity. It frequently co-expresses and forms heterodimers with other receptor tyrosine kinases(RTKs) in cancer cells to activate oncogenic signaling,especially the PI-3 K/Akt pathway and Src kinase. Elevated expression of HER3 has been observed in a wide variety of human cancers and associates with a worse survival in cancer patients with solid tumors.Studies on the underlying mechanism implicate HER3 expression as a major cause of treatment failure in cancer therapy. Activation of HER3 signaling has also been shown to promote cancer metastasis. These data strongly support the notion that therapeutic inactivation of HER3 and/or its downstream signaling is required to overcome treatment resistance and improve the outcomes of cancer patients. | Hui Lyu Amy Han Erik Polsdofer Shuang Liu Bolin Liu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
| 7 | Role of erbB3 receptors in cancer therapeutic resistance显示文摘ErbB3 受体是 erbB 受体酷氨酸 kinases (RTK ) 的独特成员,它经常是在人的癌症的异常地表示的 and/oractivated。不同于在家庭的另外的成员, erbB3 缺乏或损害了 kinase 活动。到 transducecell 发信号, erbB3 不得不与另外的 RTK 交往并且是由它的交互搭挡的 phosphorylated,那些, erbB2is 最重要的。 ErbB3 经常在癌症房间与另外的 RTK 被共同表示激活 oncogenic 发信号,例如 phosphoinositide-3-kinase/protein kinase B ( Akt )小径, 激活mitogen 的蛋白质 kinase kinase ( MEK ) /mitogen-activatedprotein kinase ( MAPK )小径, Janus kinase ( Jak ) /signal 变换器和抄写( Stat )的使活跃之物小径,等等 andthereby 支持 tumorigenesis 。众多的研究证明了 erbB3 发信号的激活玩许多肿瘤的前进打的重要 rolein,例如 erbB2-overexpressing 乳癌,阉割抵抗的 prostatecancer,铂倔强 / 抵抗的卵巢的癌症,表皮的生长因素受体 TKI 抵抗的 non-small-cell 肺癌症,和其它。关于内在的机制的基本研究含有是的 erbB3 的功能治疗 failurein 癌症的一个主要原因治疗。因此, erbB3 的伴随物抑制被认为被要求克服抵抗并且 effectivelytreat 人癌症。这评论在我们到癌症治疗的在 developmentof 抵抗的开始 erbB3 的发信号的理解集中于最近的进展。 | Youngseok Lee JianMa Hui Lyu Jingcao Huang Aeree Kim Bolin Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，3： | 5 |
| 8 | Biogenic carbonate formation and sedimentation in the Xisha Islands: evidences from living Halimeda显示文摘A recent island survey reveals that the Xuande Atoll and the Yongle Atoll in the Xisha Islands can be classified into one of two systems: the depleted atoll system and growth atoll system; the survey also indicates that the decreased area of several shoals is an unbearable burden for the Xisha Islands, of which the largest island area is 2.13 km2 and the minimum elevation is 1.4 m. According to a survey on the ecological characteristics of Halimeda in the Laolongtou breaker zone of Shidao Island in the Xisha Islands, the green and white living Halimeda are collected,the isotopic ages of 14 C contained in the Halimeda are shown to be 27 years and 55 years, respectively, and carbonate mainly occurs in five types, i.e., luster, segment, sand, sand grain, and marl in the formation. The Halimeda segments mainly provide the carbonate sediments of long-term biogenic deposits in the reef environment and the annual productivity per area is 60–100 g/m2; the characteristics of the microstructure of the Halimeda are analyzed, the aragonite raphide carbonate is deposited and enriched in the cortexes, medullas and cysts, and the Halimeda generally contain major elements such as C, O, Ca, Cl, Mg, K, Na, S and Al, and are rich in trace elements such as tellurium(Te), rhodium(Rh) and strontium. It is believed that the Halimeda grow slowly,including the biotic community of reef corals in the reef areas, thus they possess an environmental remediation capacity, but it takes much time to remedy the environment, and it is necessary to make the law to protect the diversity and vulnerability of the Xisha marine ecology, the ecology of the reef community and the island environment in a scientific way. As indicated in the survey, under the background of global warming and sea-level rise, the discovery of large amounts of Halimeda in the Laolongtou sea area is significant for the natural increase of the depleted atoll system of the Xuande Atoll, while the Halimeda segments represent the primary form of the fossil Halimeda, of which the species can be identified and preserved in great numbers under geological conditions. The Miocene was discovered in large amounts in the Xichen-1 well, therefore the study on the characteristics and mechanism of Halimeda carbonate sediments plays a pivotal role in the formation and construction of organic reefs in the South China Sea as well as oil and gas exploration. | XU Hong ZHAO Xinwei EBERLI G.P. LIU Xinyu ZHU Yurui CAI Ying LUO Wei YAN Guijing ZHANG Bolin WEI Kai SHI Jian | 2015 | Acta Oceanologica Sinica2015，34，4： | 4 |
| 9 | A possible relict mantle wedge: Geochemical evidence from Paleogene volcanics in North China显示文摘The major and trace element and isotopic composition were analyzed for the Paleogene volcanics in North China dated by the K-Ar method. The geochemical data show that most volcanics are in calc-alkaline series and the minor is in alkaline series. They differ obviously from Neogene and Quaternary volcanics in geochemistry. In particular, the Paleogene volcanics from the southern part of North China were derived from enriched lithospheric mantle (EMU), which were likely to be a relict mantle wedge formed during the subduction of the Yangtze plate into the North China plate in late Triassic (Indo- Sinian). | Bolin Cong Jinghui Guo Wenjun Liu | 2001 | Chinese Science Bulletin2001，46，22： | 3 |
| 10 | Fluid inclusions in whiteschist in the ultrahigh-pressure metamorphic belt of Dabie Shan,China显示文摘Hualiangting whiteschist in the Dabie Shan ultrahigh-pressure eclogite complex is a specific Mg-Al-rich metamorphic rock. Its protolith was a felsic dyke, which suffered replacement by high-pressure fluids during ec-logite-facies metamorphism. Based on fluid inclusion results in whiteschist, primary high-pressure fluids are CO2-bearing aqueous solutions. Those prove that there exists CO2-H2O fluid during the ultrahigh-pressure metamorphism. Pseu-dosecondary H2O inclusions were trapped during ultra-high-pressure exhumation, whereas secondary H2O inclusions were related to the latest evolutionary stage of the ultrahigh-pressure exhumation. | Hongrui Fan Jingbo Liu Jinghui Guo Kai Ye Bolin Cong | 2002 | Chinese Science Bulletin2002，47，12： | 3 |
| 11 | Targeted lapatinib anti-HER2/ErbB2 therapy resistance in breast cancer:opportunities to overcome a difficult problem显示文摘Approximately 20%of invasive breast cancers have upregulation/gene amplification of the oncogene human epidermal growth factor receptor-2(HER2/ErbB2).Of these,some also express steroid receptors(the so-called Luminal B subtype),whereas others do not(the HER2 subtype).HER2 abnormal breast cancers are associated with a worse prognosis,chemotherapy resistance,and sensitivity to selected anti-HER2 targeted therapeutics.Transcriptional data from over 3000 invasive breast cancers suggest that this approach is overly simplistic;rather,the upregulation of HER2 expression resulting from gene amplification is a driver event that causes major transcriptional changes involving numerous genes and pathways in breast cancer cells.Most notably,this includes a shift from estrogenic dependence to regulatory controls driven by other nuclear receptors,particularly the androgen receptor.We discuss members of the HER receptor tyrosine kinase family,heterodimer formation,and downstream signaling,with a focus on HER2 associated pathology in breast carcinogenesis.The development and application of anti-HER2 drugs,including selected clinical trials,are discussed.In light of the many excellent reviews in the clinical literature,our emphasis is on recently developed and successful strategies to overcome targeted therapy resistance.These include combining anti-HER2 agents with programmed cell death-1 ligand or cyclin-dependent kinase 4/6 inhibitors,targeting crosstalk between HER2 and other nuclear receptors,lipid/cholesterol synthesis to inhibit receptor tyrosine kinase activation,and metformin,a broadly inhibitory drug.We seek to facilitate a better understanding of new approaches to overcome anti-HER2 drug resistance and encourage exploration of two other therapeutic interventions that may be clinically useful for HER+invasive breast cancer patients. | Reema Wahdan-Alaswad Bolin Liu Ann D.Thor | 2020 | Cancer Drug Resistance2020，3，2： | 3 |
| 12 | Genome sequencing and phylogenetic analysis of allotetraploid Salix matsudana Koidz显示文摘Polyploidy is a common phenomenon among willow species.In this study,genome sequencing was conducted for Salix matsudana Koidz(also named Chinese willow),an important greening and arbor tree species,and the genome of this species was compared with those of four other tree species in Salicaceae.The total genome sequence of S.matsudana was 655.72 Mb in size,with repeated sequences accounting for 45.97%of the total length.In total,531.43 Mb of the genome sequence could be mapped onto 38 chromosomes using the published genetic map as a reference.The genome of S.matsudana could be divided into two groups,the A and B genomes,through homology analysis with the genome of Populus trichocarpa,and the A and B genomes contained 23,985 and 25,107 genes,respectively.4DTv combined transposon analysis predicted that allotetraploidy in S.matsudana appeared~4 million years ago.The results from this study will help reveal the evolutionary history of S.matsudana and lay a genetic basis for its breeding. | Jian Zhang Huwei Yuan Yujuan Li Yanhong Chen Guoyuan Liu Meixia Ye Chunmei Yu Bolin Lian Fei Zhong Yuna Jiang Jichen Xu | 2020 | Horticulture Research2020，7，1： | 3 |
| 13 | Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells显示文摘Akt 在反肿瘤代理人的发展正在成为一个吸引人的目标。在现在的学习,我们试图对恶意的 glioma 发现新奇否定 Akt 管理者。屏蔽站台在一根 Akt-GFP overexpression 房间线执行了的一个 Akt 管理者被开发,并且自然产品图书馆被屏蔽并且评估了使用这个平台。另外,管理者的细胞毒素的效果被 MTT 试金检测。房间 apoptosis 是由 Hoechst 33342 染色和流动 cytometry 分析的 assayed。以后,表明小径的 apoptotic 被西方的污点分析调查。Glaucocalyxin A,从 Rabdosia 孤立装饰用的梨树,作为一个有势力被识别 Akt 的否定管理者。在导出人的恶意的 glioma U87MG 房间, glaucocalyxin A 禁止了 Akt phosphorylation,压制了增长,并且支持了以一种剂量依赖者方式,然而并非在正常 glial 房间的 apoptosis。而且, glaucocalyxin A 激活 caspase-3,减少的坏 phosphorylation,并且减少了 apoptosis 的 X 连接禁止者的表示蛋白质。一起拿,这些结果显示 glaucocalyxin A 可以在恶意的 glioma 的处理成为一个有希望的候选人。 | Xian Xiao Weidong Cao Xiaofan Jiang Wei Zhang Yongqiang Zhang Bolin Liu Jinxiang Cheng Huiyong Huang Junli Huo Xiang Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 2 |
| 14 | The Study of a Micro Channel Integrated Gas Flow Sensor显示文摘 | YU Bolin GAN Zhiyin XU Jingping LIU Sheng | 2009 | Chinese Journal of Electronics2009，18，3： | 2 |
| 15 | Research about the Effect of Ultrasonic Impact on the Fatigue Properties of Cruciform Joints of 16MnR Steel显示文摘Surface impact treatment was carried out on the cruciform joint weldment of 16MnR steel by using the HJ-II-type ultrasonic impact machine.The ultrasonic impact current is 1.2 A,the impact amplitude is 30?m and ultrasonic impacting time is 30 and 60 min,respectively.Fatigue experiments were carried out for both treated specimen and un-treated specimen by using EHF-EM200K2-070-1A fatigue testing machine.The fatigue fractures were observed with the scanning electron microscope of 6360LA type and the microstructure of ultrasonic impact treating surface layer was analyzed by using high resolution transmission electron microscope of JEM-2100 type.The experimental results show that the microstructure of ultrasonic impact surface layer has been successfully nanocrystallized.The fatigue life of welded cruciform joints of 16MnR steel can be significantly improved through the ultrasonic impact treatment.The main reasons are that the ultrasonic impact treating can reduces the stress concentration in the weld toe,decrease the tensile stress,and even change to compressive stress in the weldment,the grain size in the welded joint can be refined.The longer the impact time,the greater increasing range of fatigue life will be.Compared to the sample without treatment,its fatigue life was increased 210.37%,362.48%,respectively,when the impact time was 30,60 min,respectively. | He Bolin Yu Yingxia Liu Jing Zhang Xiaodong Shi Jianping | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 16 | Could tectonic overpressure cause ultrahigh-pressure metamorphism?显示文摘Could ultrahigh-pressure metamorphic rocks be caused, at depth of 32 km, by tectonic overpressure resulting from differential stress? The differential stress is limited by rock strength, which depends on strain rate and temperature. Therefore, tectonic overpressure could not go beyond 1 GPa, and could not cause the uitrahigh-pressure metamorphism. | Qingchen Wang Jingbo Liu Bolin Cong | 1999 | Chinese Science Bulletin1999，44，24： | 2 |
| 17 | Recent advances on interface engineering of perovskite solar cells显示文摘Lead halide perovskite solar cells(PSCs)have been rapidly developed in the past decade.Owing to its excellent power conversion efficiency with robust and low-cost fabrication,perovskite quickly becomes one of the most promising candidates for the next-generation photovoltaic technology.With the development of PSCs,the interface engineering has witnessed its increasingly critical role in maximizing the device performance as well as the long-term stability,because the interfaces in PSCs are closely correlated with the defect management,carrier dynamics and surface passivation.This review focuses on interfacial modification between the perovskite active layer and the charge transport layer,as well as the recent advances on high-efficiency and stable PSCs driven by interface engineering strategies.The contributing roles of interface engineering in terms of defect passivation,inhibiting ion migration,optimization of energy band alignment and morphological control are discussed.Finally,based on the latest progress and advances,strategies and opportunities for the future research on interface engineering for PSCs are proposed to promote the development of perovskite photovoltaic technology. | Wenjing Yu Xiaoran Sun Mu Xiao Tian Hou Xu Liu Bolin Zheng Hua Yu Meng Zhang Yuelong Huang Xiaojing Hao | 2022 | Nano Research2022，15，1： | 2 |
| 18 | A HIGH VELOCITY FEED UNIT DRIVEN BY LINEAR MOTOR显示文摘In order to realize high speed machining, the special requirements for feed transmission system of the CNC machine tool have to be satisfied. A high velocity feed unit driven by a induction linear motor is developed. The compositions of the high velocity CNC feed unit and main problems in the unit design are discussed. | Zhang Bolin Chen Yanji Li Zhiying Liu Yurong Luo Yong (Department of Mechanical and Electronical Engineering, Guangdong University of Technology) | 2000 | Chinese Journal of Mechanical Engineering2000，13，4： | 2 |
| 19 | Utilization of Bayer Red Mud Derived from Bauxite for Belite-Ferroaluminate Cement Production显示文摘Bayer red mud(BRM)is a kind of industrial solid waste characterized by huge volume and high alkalinity.Its disposal generates serious environmental pollution and occupies a large number of farmland.The utilization and recycling of BRM is currently a crucial issue and needs to be addressed as soon as possible.The chemical composition of BRM is similar to cement clinker.In this study,the feasibility of preparing Belite-ferroaluminate clinker(BFAC)with different BRM was explored.The physical properties,mechanics performance,radioactivity levels and trace harmful metals leaching were measured.XRD,BEI and EDS were used to characterize the mineral formation,and SEM is used to reveal the solidified mechanism of trace harmful metal.The results show that the preparation of BFAC using a certain amount of BRM was feasible.The formed phases in clinkers mainly included C_(4)A_(3)Š,C_(2)S and C_(4)AF.The flexural strength and compressive strength of BFAC at 3 days increased whereas 28 and 90 days decreased with the increase of BRM due to the formation of higher C_(4)AF and lower C_(2)S.The formation of large amounts of Al_(2)O_(3)·3H_(2)O gel and Fe_(2)O_(3)·3H_(2)O gel in hydration products enhanced the adsorption capability to heavy metals and other ions.The trace harmful metal concentration in the leaching solution was much less than the upper limits.The radioactivity level of leaching solution was close to natural radioactive background.BRM is safe as raw material of BFAC. | Yanrong Zhao Ping Chen Shifeng Wang Yaxiong Ji Yuanhao Wang Bolin Wu Rongjin Liu | 2020 | Journal of Renewable Materials2020，8，11： | 2 |
| 20 | Metformin induces unique biological and molecular responses in triple negative breast cancer cells显示文摘 | Bolin Liu Zeying Fan Susan M | 2009 | Cell Cycle2009，8，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员