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| 1 | 载脂蛋白E基因型影响老年人心输出量与认知功能的相关性显示文摘心输出量的轻微下降与低脑血流量相关,尤其是在阿尔茨海默病病理改变的首发区域。载脂蛋白E(apolipoprotein E,APOE)-ε4是阿尔茨海默病的一个遗传易感性危险因素,同时能减轻血管损伤。该研究旨在探讨携带APOE-ε4基因是否影响心输出量与认知功能的相关性。研究人员纳入范德比尔特记忆老化项目中无临床脑卒中和痴呆的参与者306例,平均年龄(73±7)岁,其中42%为女性。 | 陈嘉睿 刘莉 Bown CW Liu D Osborn KE Gupta DK Mendes LA Pechman KR Hohman TJ Wang TJ Gifford KA Jefferson AL | 2019 | 中华高血压杂志2019，27，10： | 2 |
| 2 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Barry J Shelp Alan W Bown Michael D McLean | 1999 | Trends in Plant Science1999，，11： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Pro- norm and anti-norm deviance within and between groups 显示文摘 | ABRAMS D MARQUES J M BOWN N | 2000 | Journal of Personality and Social Psychology2000，78，5： | 1 |
| 5 | Pro- norm and anti-norm deviance within and between groups显示文摘 | ABRAMS D MARQUES J M BOWN N | 2000 | Journal of personality and social psychology2000，78，5： | 1 |
| 6 | Ceramic coatings by anodic spark deposition显示文摘 | Writz G P Bown S D Kriven W M | 1991 | Materials and Manufacturing Processes1991，6，1： | 1 |
| 7 | Evaluating the effects of functional communication training in the presence and absence of establishing operations显示文摘 | BOWN K A WACKER D P DERBY K M | 2000 | J Appl Behavior Analysis2000，33，： | 1 |
| 8 | Midgut car- boxypeptidase from Helicoverpa armigera (Lepidoptera: Noctuidae)larvae:enzyme eharacterisation,cDNA cloning and expression 显示文摘 | Bown D P Wilkinson H S Gatehouse J A | 1998 | Insect Bioehem Mol Biol1998，28，10： | 1 |
| 9 | A capillary membrane bioreactor r using immobilized polyphenol oxidase for the removal of phenols from industrial effluents 显示文摘 | Edwards W Bownes R Leukes W D | 1999 | Enzyme and Microbial Technology1999，24，： | 1 |
| 10 | Papillary Phenotype Confers Improved Survival After Resection of Hilar Cholangiocarcinoma显示文摘 | William R. Jarnagin Wilbur Bowne David S. Klimstra Leah Ben-Porat Kevin Roggin Karina Cymes Yuman Fong Ronald P. DeMatteo Michael D?Angelica Jonathan Koea Leslie H. Blumgart | 2005 | Annals of Surgery2005，，5： | 1 |
| 11 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | SHELP B J BOWN A W MCLEAN M D | 1999 | Trends in Plant Science1999，4，11： | 1 |
| 12 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Shelp B J Bown A W McLean M D | | 0，，： | 1 |
| 13 | Metabolism and functions of gamma-aminobutyric acid 显示文摘 | Shelp B J Bown A W Mclean M D | 1999 | Trends Plant Sci1999，4，11： | 1 |
| 14 | Nature of the bleeding vessel in recurrently bleeding gastric ulcers显示文摘 | Swain CP Storey D Bowns | 1986 | Gastroenterology1986，90，6： | 1 |
| 15 | Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma显示文摘 | Jarnagin W R Bowne W Klimstra D S | 2005 | Ann Surg2005，241，5： | 1 |
| 16 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Shelp B J Bown A W Mclean M D | 1999 | Trends in Plant Sci1999，4，11： | 1 |
| 17 | Metabolism and functions of gamma-aminobutyrie acid显示文摘 | SHELP B J BOWN A W MCLEAN M D | 1999 | Trends in Plant Science1999，4，11： | 1 |
| 18 | Injection of DNA encoding granulocyte - macrophage colony - stimulating factor recruits dendritic cells for immune adjuvant effects显示文摘 | BOWNE W B WOLCHOK J D HAWYdNS W G | 1999 | Cytokines Cell Mol Ther1999，5，4： | 1 |
| 19 | Photodynamic therapy for cancer of the pancreas显示文摘 | Bown S G Rogowska A Z Whitelaw D E | 2002 | Gut2002，50，4： | 1 |
| 20 | A capillary membrane bioreactor using immobilized polyphenol oxidase for the removal of phenols from industrial efflu- ents 显示文摘 | Edwards W Bownes R Leukes W D | 1999 | Enzyme Microb Technol1999，24，4： | 1 |
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