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| 1 | A mammalian fossil from the Dingqing Formation in the Lunpola Basin,northern Tibet,and its relevance to age and paleo-altimetry显示文摘The distal extremity of a rhinocerotid humerus from the upper part of the Dingqing Formation at the Lunbori locality in Baingoin County,northern Tibet,is the first mammalian fossil found in Cenozoic deposits of the Lunpola Basin.The medial condyle of the distal trochlea of the humerus specimen from Lunbori gradually contracts from medially to laterally.The margin of the medial surface of the medial condyle is not prominent,the well-developed medial epicondyle strongly extends posteriorly,and is divided from the articular facet of the medial condyle by a groove;all of which are characteristic for the Rhinocerotidae.The medial condyle is wide at the bottom and narrow at the top.The medial collateral ligament fossa is relatively shallow,and the medial collateral ligament tubercle is very weak.The medial part of the upper margin of the medial condyle smoothly connects to the bony surface above,but there is no clear boundary between them.All of these characteristics are identical with those of Plesiaceratherium.These comparisons imply that the Lunbori specimen is closest to Plesiaceratherium gracile in the Shanwang Fauna from Linqu,Shandong Province,in size and morphology.Thus,its age is suggested to be the late Early Miocene(Shanwangian Age),about 18-16 Ma.Discovery of the rhinocerotid fossil suggests that the upper part of the Dingqing Formation deposited in the Neogene.While adjusting to paleo-temperatures of the Early Miocene,a paleo-ecosystem reconstruction indicates that the paleo-elevation was close to 3000 m in the Lunpola Basin during this time. | DENG Tao WANG ShiQi XIE GuangPu LI Qiang HOU SuKuan SUN BoYang | 2012 | Chinese Science Bulletin2012，57，2： | 30 |
| 2 | Prognostic value of programmed death.1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1.4N+M0 gastric adenocarcinoma显示文摘Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies. | Yuan Gao Su Li Dazhi Xu Shangxiang Chen Yuchen Cai Wenqi Jiang Xinke Zhang Jin Sun Kefeng Wang Boyang Chang Fenghua Wang Minghuang Hong | 2017 | Chinese Journal of Cancer2017，36，11： | 8 |
| 3 | Current taxane formulations and emerging cabazitaxel delivery systems显示文摘 | Boyang Sun Robert M. Straubinger Jonathan F. Lovell | 2018 | Nano Research2018，11，10： | 5 |
| 4 | Highly conductive polymer nanocomposites for emerging high voltage power cable shields:experiment,simulation and applications显示文摘High voltage power cables play a critical role in global electricity transmission and distribution.The currently used power cables cannot fulfil the green and sustainable requirement of modern society because of the thermoset nature of cable insulation and shields.This study is aimed at developing thermoplastic shields for high voltage power cable,which is one bottleneck restricting the development of environmental-friendly cables.Using carbon black(CB)as the main conductive component and a small amount of carbon nanotubes(CNTs)or graphene as the second filler,highly conductive polypropylene based composite materials were prepared for potential shield applications.It was found that,at a fixed conductive filler loading,the replacement of a small amount CB by CNTs can significantly enhance the electrical conductivity and suppress its temperature dependence.However,when CB was replaced by graphene,only limited enhancement of electrical conductivity could be achieved and the electrical conductivity is still highly dependent on temperature.Dissipative particle dynamics simulations demonstrated that the enhanced conduction property in the CNTs-containing composites could be understood by the shorter average distance between CB and CNTs.Finally,the coordination between the newly developed conductive composites and the environmental-friendly thermoplastic polypropylene insulation was evaluated via high voltage direct current measurements,and the results revealed that the CNTs-containing composites showed excellent suppression effect on the space charge injection and accumulation in the insulation.This research paved a new way for developing environmental-friendly high voltage power cable shields. | Xingyi Huang Boyang Sun Chunyang Yu Jiandong Wu Jun Zhang Pingkai Jiang | 2020 | High Voltage2020，5，4： | 2 |
| 5 | New fossils of the Early Pleistocene Equus huanghoensis(Equidae,Perissodactyla)from Nihewan in Hebei Province of China显示文摘This paper describes new fossils of Equus huanghoensis from an Early Pleistocene bed in Nihewan, Hebei Province, which confirms the classification of E. huanghoensis by Chinese researchers. The new fossils include a relatively complete male skull and mandible with all upper and lower dentition, a broken female skull with fragment of mandible and a broken Mc III of Equus sp. The fossils were collected from the Yangshuizhan site of Nihewan. The age of the formation is about 1.6 Ma. The new materials verify some classification characteristics based on teeth published in previous descriptions. These characteristics include large teeth size, short protocone, and tilted protoloph and metaloph. We have added to these characteristics of large skull size, a developed protuberantia supramagna, pentagonal nuchal side, weak Pli cabaline, simple enamel plications; a series of new characteristics strikingly different from the other Equus horses. The broken Mc III is similar to Equus qingyangensis from Qingyang, Gansu. | LI YongXiang ZHANG YunXiang SUN BoYang AO Hong XUE XiangXu | 2016 | Science China Earth Sciences2016，59，1： | 2 |
| 6 | An Asian origin for Sinomastodon(Proboscidea, Gomphotheriidae) inferred from a new Upper Miocene specimen from Gansu of China显示文摘We report a fossil specimen referable to Sinomastodontinae gen. et sp. indet. from the Neogene strata at Yanghecun locality, Xihe County, Gansu Province, China. The specimen is characterized by a brevirostrine mandible, complete pretrite trefoils, and relatively simple posttrite half lophids, showing typical features of Sinomastodon. It differs from the other known species of Sinomastodon by the following features: relatively short and wide m3 due to fewer lophid numbers, less inflated pretrite accessory central conules, poorly developed secondary trefoils and cementum, and relatively strong cingulid. All of these features indicate a bias towards pleisiomorphies of Sinomastodon, implying that this specimen is more ancestral than any known species of Sinomastodon. The symphysis of the new specimen is relatively long, which differs from the typical brevirostrine Sinomastodon, and thus we consider it a gen. et sp. indet. in the Subfamily Sinomastodontinae. In addition, the horizon in which the present specimen was found probably represents the Upper Miocene because it is lower than Pliocene strata yielding Hipparion(Proboscidipparon) pater. Generally, Sinomastodon is considered to have migrated from North America at about the time of the Miocene/Pliocene boundary, and to have been derived from a certain clade of American gomphotheres. However, the discovery of the Yanghecun specimen verifies that Sinomastodon lived in East Asia during the Late Miocene, and probably derived from Old World gomphotheres(e.g., G. wimani). The similarity between the members of the Subfamilies Sinomastodontinae and those of Cuvieroniinae is suggested to have been the result of parallel evolution. | WANG ShiQi ZHAO DeSi XIE GuangPu SUN BoYang | 2014 | Science China Earth Sciences2014，57，10： | 2 |
| 7 | Infrared LSS-Target Detection Via Adaptive TCAIE-LGM Smoothing and Pixel-Based Background Subtraction显示文摘Infrared small target detection is a significant and challenging topic for daily security. This paper proposes a novel model to detect LSS-target (low altitude, slow speed, and small target) under the complicated background. Firstly, the fundamental constituents of an infrared image including the complexity and entropy are calculated, which are invoked as adaptive control parameters of smoothness. Secondly, the adaptive L0 gradient minimization smoothing based on texture complexity and information entropy (TCAIE-LGM) is proposed in order to remove noises and suppress low-amplitude details in infrared image abstraction. Finally, difference of Gaussian (DoG) map is incorporated into the pixel-based adaptive segmentation (PBAS) background modeling algorithm, which can differ LSS-target from the sophisticated background. Experimental results demonstrate that the proposed novel model has a high detection rate and produces fewer false alarms, which outperforms most state-of-the-art methods. | Yanfeng WU Yanjie WANG Huiyuan LUO Boyang CHENG Haijiang SUN | 2019 | Photonic Sensors2019，9，2： | 1 |
| 8 | Coping with extremes:lowered myocardial phosphofructokinase activities and glucose content but increased fatty acids content in highland Eurasian Tree Sparrows显示文摘Background:Efficient and selective utilization of metabolic substrates is one of the key strategies in high-altitude animals to cope with hypoxia and hypothermia.Previous findings have shown that the energy substrate utilization of highland animals varies with evolutionary history and phylogeny.The heart is a proxy for the cardiopulmonary system,and the metabolic substrate utilization in the myocardium is also under the strong selective pressure of chronically hypoxic and hypothermic environments.However,little information is available on the physiological adjustments in relation to metabolic substrate utilization in the myocardium for coping with high-altitude environments.Methods:We compared the metabolic enzyme activities,including hexokinase(HK),phosphofructokinase(PFK),pyruvate kinase(PK),citrate synthase(CS),carnitine palmitoyl transferase 1(CPT-1),lactic dehydrogenase(LDH),and creatine kinase(CK),and metabolic substrate contents including glucose(Glu),triglyceride(TG),and free fatty acid(FFA)in the myocardium of a typical human commensal species,Eurasian Tree Sparrows(Passer montanus)between the Qinghai-Tibet Plateau(the QTP,3230 m)and low altitude population(Shijiazhuang,80 m),and between sexes.Results:Among the seven metabolic enzymes and three substrates investigated,we identified no significant differences in PK,CPT-1,HK,CS,LDH,and CK activities and TG content of the myocardium between high and low altitude populations.However,the QTP sparrows had significantly lower Glu content and PFK activities but higher FFA content relative to their lowland counterparts.In addition,male sparrows had higher myocardial HK and CS activities relative to females,independent of altitude.Conclusions:Our results showed that the QTP sparrows elevated fatty acid utilization rather than glucose preference in the myocardium relative to lowland counterpart,which contributes to uncovering both the physiological adjustments for adapting to the extreme conditions of the QTP,intraspecifically. | Boyang Ding Yuliang Zhao Yanfeng Sun Qian Zhang Mo Li Ghulam Nabi Yuefeng Wu Chuan Jiang Dongming Li | 2021 | Avian Research2021，12，4： | 1 |
| 9 | Cross-linking enhanced room-temperature phosphorescence of carbon dots显示文摘Currently,there is a strong drive to discover alternative materials that exhibit room-temperature phosphorescence(RTP)for displays,bioimaging,and data security.Ideally,these materials should be nontoxic,cheap,and possess controllable photoluminescent properties.Carbon dots(CDs)possess each of these characteristics,but to date,less attention has been paid to their RTP mechanism.Herein,we synthesized a series of CDs by self-crosslinking and carbonization of precursor.The resultant CDs were luminescent and exhibited a bright,micro-second afterglow lifetime.To increase the RTP,a second microwave processing step was used to coat the CDs with polyvinyl alcohol(PVA),polyacrylamide(PAM),or tetraethyl orthosilicate(TEOS),producing CDs@PVA,CDs@PAM,and CDs@TEOS composites.The core-shell structure acted to enhance crosslinking at the surface of the CDs to boost the RTP,creating abundant energy levels for intersystem crossover.In situ X-ray photoelectron spectroscopy verified electron transfer during luminescence.Finally,we present a design rule that can be used to tune the quantum yields and RTP lifetime of CDs,based on the effective stabilization of triplet excited states through the extent and strength of cross-linking.This simple strategy provides a flexible route for guiding the further development of CDs with tailored RTP properties for various applications. | Boyang Wang Zhen Sun Jingkun Yu Geoffrey I.N.Waterhouse Siyu Lu Bai Yang | 2022 | SmartMat2022，3，2： | 1 |
| 10 | Rambutan-like hierarchically porous carbon microsphere as electrodematerial for high-performance supercapacitors显示文摘Used as high-performance electrodes,both structural and compositional alterations of carbon materials play very important roles in energy conversion/storage devices.Especially in supercapacitors,hierarchical pores and heteroatom doping in carbon materials are indispensable.Here the rambutan-like hierarchically porous carbon microspheres(PCMs)have been constructed via a hydrothermal treatment,followed by carbonization/activation.The hierarchically porous microstructure is composed of three-dimensional porous carbon networks,which give rise to a large surface area.Moreover,N and O functional groups are introduced in the as-prepared samples,which could generate the extra pseudocapacitance.Benefitting from the interconnected hierarchical and open structure,PCM exhibits outstanding capacitive performance,for example,superior specific capacitance and rate capability(397 and 288 F g^(−1) at 0.5 and 20A g^(−1),respectively),as well as long cycling stability(about 95%capacitance retention after 10,000 cycles).These encouraging results may pave an efficient way to fabricate advanced supercapacitors in the future. | Chunfeng Shao Shujun Qiu Guiming Wu Boyang Cui Hailiang Chu Yongjin Zou Cuili Xiang Fen Xu Lixian Sun | 2021 | Carbon Energy2021，3，2： | 1 |
| 11 | Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration显示文摘Diabetes mellitus(DM)aggravates periodontitis,resulting in accelerated periodontal bone resorption.Disordered glucose metabolism in DM causes reactive oxygen species(ROS)overproduction resulting in compromised bone healing,which makes diabetic periodontal bone regeneration a major challenge.Inspired by the natural bone healing cascade,a mesoporous silica nanoparticle(MSN)-incorporated PDLLA(poly(DL-lactide))-PEG-PDLLA(PPP)thermosensitive hydrogel with stepwise cargo release is designed to emulate the mesenchymal stem cell“recruitment-osteogenesis”cascade for diabetic periodontal bone regeneration.During therapy,SDF-1 quickly escapes from the hydrogel due to diffusion for early rat bone marrow stem cell(rBMSC)recruitment.Simulta-neously,slow degradation of the hydrogel starts to gradually expose the MSNs for sustained release of metformin,which can scavenge the overproduced ROS under high glucose conditions to reverse the inhibited osteogenesis of rBMSCs by reactivating the AMPK/β-catenin pathway,resulting in regulation of the diabetic microenvironment and facilitation of osteogenesis.In vitro experiments indicate that the hydrogel markedly restores the inhibited migration and osteogenic capacities of rBMSCs under high glucose conditions.In vivo results suggest that it can effectively recruit rBMSCs to the periodontal defect and significantly promote periodontal bone regeneration under type 2 DM.In conclusion,our work provides a novel therapeutic strategy of a bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration. | He Wang Xiaowei Chang Qian Ma Boyang Sun Han Li Jinmin Zhou Yiyao Hu Xiaoyu Yang Jie Li Xin Chen Jinlin Song | 2023 | Bioactive Materials2023，，3： | 1 |
| 12 | Rapid divergent coevolution of Sinopotamon freshwater crab genitalia facilitates a burst of species diversification显示文摘One of the most striking radiations in brachyuran evolution is the considerable morphological diversification of the external reproductive structures of primary freshwater crabs:the male first gonopod(G1)and the female vulva(FV).However,the lack of quantitative studies,especially the lack of data on female genitalia,has seriously limited our understanding of genital evolution in these lineages.Here we examined 69 species of the large Chinese potamid freshwater crab genus Sinopotamon Bott,1967(more than 80%of the described species).We used a landmark-based geometric morphometric approach to analyze variation in the shape of the G1 and FV,and to compare the relative degree of variability of the genitalia with non-reproductive structures(the third maxillipeds).We found rapid divergent evolution of the genitalia among species of Sinopotamon when compared to non-reproductive traits.In addition,the reconstruction of ancestral groundplans,together with plotting analyses,indicated that the FV show the most rapid divergence,and that changes in FV traits correlate with changes in G1 traits.Here we provide new evidence for coevolution between the male and female external genitalia of Sinopotamon that has likely contributed to rapid divergent evolution and an associated burst of speciation in this lineage. | Fengxin YAO Boyang SHI Xiaoqi WANG Da PAN Ming BAI Jie YAN Neil CUMBERLIDGE Hongying SUN | 2020 | Integrative Zoology2020，15，3： | 0 |
| 13 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 14 | A Method Based on Knowledge Distillation for Fish School Stress State Recognition in Intensive Aquaculture显示文摘Fish behavior analysis for recognizing stress is very important for fish welfare and production management in aquaculture.Recent advances have been made in fish behavior analysis based on deep learning.However,most existing methods with top performance rely on considerable memory and computational resources,which is impractical in the real-world scenario.In order to overcome the limitations of these methods,a new method based on knowledge distillation is proposed to identify the stress states of fish schools.The knowledge distillation architecture transfers additional inter-class information via a mixed relative loss function,and it forces a lightweight network(GhostNet)to mimic the soft probabilities output of a well-trained fish stress state recognition network(ResNeXt101).The fish school stress state recognition model’s accuracy is improved from 94.17%to 98.12%benefiting from the method.The proposed model has about 5.18 M parameters and requires 0.15 G FLOPs(floating-point operations)to process an image of size 224×224.Furthermore,fish behavior images are collected in a land-based factory,and a dataset is constructed and extended through flip,rotation,and color jitter augmentation techniques.The proposed method is also compared with other state-of-the-art methods.The experimental results show that the proposed model is more suitable for deployment on resource-constrained devices or real-time applications,and it is conducive for real-time monitoring of fish behavior. | Siyuan Mei Yingyi Chen Hanxiang Qin Huihui Yu Daoliang Li Boyang Sun Ling Yang Yeqi Liu | 2022 | Computer Modeling in Engineering & Sciences2022，，6： | 0 |
| 15 | Performance analysis on reconfigurable intelligent surface and network-controlled repeater in 3GPP release-18显示文摘As a candidate technique to achieve sixth-generation wireless communication(6G),reconfigurable intelligent surface(RIS)has become popular in both academia and industry.For better exploration of the advantages of RIS,we compare the performances of RIS and network-controlled repeater(NCR)in 3GPP release-18.We first theoretically analyze the received signal power and signal-to-noise ratio performances for both RIS and NCR.Then,we simulate the reference signal received power and signal-to-interference-and-noise ratio performances at the system level for both RIS and NCR in the frequency range 1 and frequency range 2 bands.Finally,several insights on engineering applications are given based on the comparison between RIS and NCR. | Yiwei SUN Boyang DUAN Xin SU Hanning WANG Qi GU Jing JIN Yifei YUAN | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，12： | 0 |
| 16 | Current status and progress in immunotherapy for malignant pleural mesothelioma显示文摘Malignant pleural mesothelioma(MPM)is a rare and aggressive malignant disease.Currently,the platinum doublet of pemetrexed and cisplatin is the standard first-line treatment for unresectable MPM.However,recent promising results of immunotherapy have markedly changed the landscape of MPM treatment.Further,the ongoing innovative therapeutic strategies are expected to expand the range of treatment options;however,several questions remain unanswered.First,establishing predictive biomarkers with high potency is urgently needed to optimize the patient selection process.Second,further exploration of the combination algorithm is expected to unveil more effective and safe regimens.Moreover,other dilemmas,such as the resistance mechanism of immunotherapy and the role of immunotherapy in perioperative settings,still warrant further exploration. | Boyang Sun Yiting Dong Jiachen Xu Zhijie Wang | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 0 |
| 17 | METTL14 is a chromatin regulator independent of its RNA N^(6)-methyladenosine methyltransferase activity显示文摘METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m^(6)A methyltransferase complex(MTC)that installs m^(6)A.Surprisingly,depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of mouse embryonic stem cell(mESC).While comparable global hypo-methylation in RNA m^(6)A was observed in Mettl3 or Mettl14 knockout mESCs,respectively.Mettl14 knockout led to a globally decreased nascent RNA synthesis,whereas Mettl3 depletion resulted in transcription upregulation,suggesting that METTL14 might possess an mA-independent role in gene regulation.We found that METTL14 colocalizes with the repressive H3K27me3 modification.Mechanistically,METTL14,but not METTL3,binds H3K27me3 and recruits KDM6B to induce H3K27me3 demethylation independent of METTL3.Depletion of METTL14 thus led to a global increase in H3K27me3 level along with a global gene suppression.The effects of METTL14 on regulation of H3K27me3 is essential for the transition from self-renewal to differentiation of mESCs.This work reveals a regulatory mechanism on heterochromatin by METTL14 in a manner distinct from METTL3 and independently of m^(6)A,and critically impacts transcriptional regulation,stemness maintenance,and differentiation ofmESCs. | Xiaoyang Dou Lulu Huang Yu Xiao Chang Liu Yini Li Xinning Zhang Lishan Yu Ran Zhao Lei Yang Chuan Chen Xianbin Yu Boyang Gao Meijie Qi Yawei Gao Bin Shen Shuying Sun Chuan He Jun Liu | 2023 | Protein & Cell2023，14，9： | 0 |
| 18 | Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis显示文摘Periodontitis is an oral chronic inflammatory disease.Inhibiting tissue destruction and promoting tissue regeneration are important means for the treatment of periodontitis.Metformin not only has hypoglycemic effect but also has anti-inflammatory effect.Metformin has been shown to inhibit oxidative stress and activate autophagy through AMPK/mTOR pathway.High mobility group box 1(HMGB1)has been implicated in the pathogenesis of many inflammatory diseases including periodontitis,it can participate in the induction of oxidative stress.HMGB1 is an autophagy regulator under oxidative stress,which can activate mTOR pathway.However,it is not clear whether metformin is related to HMGB1 and its mechanism in the process of periodontitis.Cell viability and expression of inflammatory cytokines were clarified by Cell Counting Kit-8,real-time PCR and enzyme-linked immunosorbent assay.Western blot and immunofluorescence were conducted to determine HMGB1 intracellular localization and expression of autophagy-associated proteins in vitro.Experimental periodontitis mice model was induced by administering a ligature.Immunohistochemistry was performed to detect the expression and localization of HMGB1 in vivo.The results of CCK-8,real-time PCR,enzyme-linked immunosorbent assay,Western blot and immunofluorescence showed lipopolysaccharide(LPS)treatment inhibited cell viability,and increased HMGB1 expression at a dose-independent manner.Metformin can reduce the effect of LPS.It also improves autophagy pathway inhibited by LPS and down-regulates mTOR expression.In addition,metformin attenuated alveolar bone resorption induced by ligation.This study provides new evidence for that metformin is a potential drug for the treatment of periodontitis and HMGB1 may be a potential target for periodontal intervention. | Boyang Sun Siqi Ying Qian Ma Han Li Jie Li Jinlin Song | 2023 | Genes & Diseases2023，10，2： | 0 |
| 19 | Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel显示文摘Photodynamic therapy(PDT)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent chemotherapy.Previously,we demonstrated that liposomes containing a bilayer-anchored photosensitizer(porphyrin-phospholipid;PoP)can be loaded with drugs in their aqueous core to improve drug delivery and tumor ablation upon target tissue irradiation with red-light.In the present work,we demonstrate that this concept can be extended to drugs loaded within the hydrophobic bilayer of liposomes.Cabazitaxel(CTX)is a potent second generation taxane anti-cancer drug that was loaded in the bilayer of liposomes also containing 0.1 molar%PoP,generating CTX-loaded PoP liposomes(CTX-PoP-Lip).CTX-PoP-Lip showed unilamellar vesicle morphology,and exhibited integrity in storage and serum,while maintaining drug stability under laser irradiation.In vitro cell killing evaluation showed that red-light laser irradiation induced cytotoxicity in cells incubated with CTX-PoP-Lip,compared to control treatments.In vivo pharmacokinetic analysis revealed that following intravenous administration to mice,CTX and PoP exhibited somewhat altered circulation profiles,suggesting that the CTX may have exchanged with serum factors in blood.Nevertheless,when a single treatment of CTX-PoP-Lip with laser irradiation was administered to mice bearing human MIA Paca-2 tumors,tumors were effectively ablated whereas the equivalent chemotherapy and PDT monotherapies were ineffective.These results demonstrate the versatility of liposome delivery systems for achieving tumor ablation with chemophototherapy. | Boyang Sun Sanjana Ghosh Xuedan He Wei-Chiao Huang Breandan Quinn Meiling Tian Dushyant Jahagirdar Moustafa T.Mabrouk Joaquin Ortega Yumiao Zhang Shuai Shao Jonathan F.Lovell | 2022 | Nano Research2022，15，5： | 0 |
| 20 | Neogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas显示文摘The remarkable uplift of the Tibetan Plateau in the Neogene had great impacts on the climate and environment of East Asia and even the world.Therefore,establishment of the Neogene stratigraphic framework of the Tibetan Plateau is of great significance to research in various fields of geosciences.Based on marine sediments,the international chronostratigraphic system of the Neogene is divided into six stages in the Miocene and two stages in the Pliocene.Since the beginning of the Cenozoic,the share of terrestrial strata on continents has increased rapidly.By the Neogene,it had far exceeded that of marine strata,and almost all deposits on the Tibetan Plateau and its surrounding areas were terrestrial strata.In China,the Miocene includes five stages and the Pliocene includes two stages.Except for the Tunggurian of the Miocene,which has a lower boundary at 15 Ma,the other stages have the same paleomagnetic definitions and time intervals as the corresponding international marine stages.Mammalian fossils play a very important role in the division and correlation of Cenozoic terrestrial strata,and rodent,carnivore,proboscidean,perissodactyl and artiodactyl fossils are especially important in Neogene terrestrial biostratigraphy.There are many basins with well-exposed strata and abundant mammalian fossils in the Tibetan Plateau.The lower boundary stratotype sections of the Neogene Xiejian and Bahean stages are located respectively in the Xining and Linxia basins,and there are precise paleomagnetic dates in coordination with mammalian fossils.The lower boundary stratotypes of other stages can also be effectively determined in the Tibetan Plateau.Many first appearing mammalian genera in East Asia also appeared in the Tibetan Plateau and its surrounding areas,especially in the Linxia Basin on the northeast margin and in the Siwaliks on the southwest margin.Among them,Prodeinotherium first appeared at the bottom of the Miocene in the Siwaliks,and the earliest Hipparion of the Old World first appeared at the bottom of the Bahean Stage in the Linxia Basin.Carbon and oxygen isotope analysis of enamel and paleosols of Cenozoic sediments and mammal fossils in the Tibetan Plateau and its surrounding areas have been used to reconstruct the climate,environment and vegetation development characteristics,and revealed that these changes were not only related to global change,but also had regional features.Evidence of the Late Miocene C4plant expansion event based on carbon isotope changes comes from the southern margin of the Tibetan Plateau,but in sharp contrast,δ13C indicates that there was still no clear or significant C4plant signal on the northern margin of the Tibetan Plateau until the end of the Neogene.Theδ18O analysis shows that there were several major climate change events in the Cenozoic,especially in the Late Miocene at about 7 Ma,when positive drift ofδ18O indicates that the northern and southern sides of the Tibetan Plateau were changing to drier environments.The strong uplift of the Tibetan Plateau in the Late Miocene strengthened the thermal contrast between sea and land,which strengthened monsoon circulation and led to the expansion of C4vegetation in South Asia.However,the East Asian summer monsoon,which can bring atmospheric precipitation and a climate suitable for C4plants to northern China,was not enough to affect the northern Tibetan Plateau.The Tibetan Plateau on the whole rose to an altitude of about 3000 m in the Miocene,becoming a barrier to mammalian migration;it reached its modern altitude of more than 4000 m in the Pliocene,thus forming a cryosphere environment,which led to the emergence of ancestral types of the Ice Age fauna. | Tao DENG Xiaomin FANG Qiang LI Shiqi WANG Feixiang WU Sukuan HOU Jiao MA Qigao JIANGZUO Danhui SUN Yan ZHENG Qinqin SHI Boyang SUN Lu LI | 2024 | Science China Earth Sciences2024，67，4： | 0 |
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