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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 3 | Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury显示文摘Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ- | Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao | 2017 | Science Bulletin2017，62，11： | 29 |
| 4 | Association of COVID-19 Vaccination and Clinical Severity of Patients Infected with Delta or Omicron Variants——China,May 21,2021-February 28,2022显示文摘Summary What is already known about this topic?Compared with the international mRNA and adenovirus-vectored coronavirus disease 2019(COVID-19)vaccines,there is less real-world research data about breakthrough cases in people vaccinated with China-made COVID-19 vaccines.Analyses of clinical outcomes of breakthrough cases will be an important supplement to the clinical trial efficacy and observational effectiveness data of China-made COVID-19 vaccines. | Mingshuang Li Qianqian Liu Dan Wu Lin Tang Xiaoqi Wang Tingting Yan Zhijie An Zundong Yin Geroge F.Gao Fuzhen Wang Hui Zheng | 2022 | China CDC weekly2022，4，14： | 10 |
| 5 | Effect of heat treatment on structure and gasification reactivity of petroleum coke显示文摘 | Chao Li Xin Liu Zhijie Zhou Zhenghua Dai Ji Yan Fuchen Wang | 2016 | International Journal of Coal Science & Technology2016，3，1： | 9 |
| 6 | Uncertainty analyses on the calculation of water environmental capacity by an innovative holistic method and its application to the Dongjiang River显示文摘The estimation and allocation of water environmental capacity(WEC) are essential to water quality management and social–economic interests. However, there is inevitable uncertainty in the capacity estimation due to model conceptualization, data collection and parameter calibration. An innovative holistic approach was developed, which took both independence and relevance between parameters into account to analyze the uncertainties in WEC calculation and estimate the margin of safety. The Dongjiang River was taken as the case to demonstrate the method, focusing on the chemical oxygen demand and NH4+–N that were the two major water quality problems in the river. The results showed that the proposed holistic approach is very promising and applicable compared to traditional methods of uncertainty analysis. | Qiuwen Chen Qibin Wang Zhijie Li Ruonan Li | 2014 | Journal of Environmental Sciences2014，26，9： | 9 |
| 7 | Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province,Peoples’Republic of China using a geographical detector method显示文摘Background:Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma,which is prevalent most of the developing world.Transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role.Few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission.Methods:We used a series of different detectors(i.e.,specific detector,risk detector,ecological detector and interaction detector)to evaluate separate and interactive effects of the environmental factors on schistosomiasis prevalence.Specifically,(i)specific detector quantifies the impact of a risk factor on an observed spatial disease pattern,which were ranked statistically by a value of Power of Determinate(PD)calculation;(ii)risk detector detects high risk areas of a disease on the condition that the study area is stratified by a potential risk factor;(iii)ecological detector explores whether a risk factor is more significant than another in controlling the spatial pattern of a disease;(iv)interaction detector probes whether two risk factors when taken together weaken or enhance one another,or whether they are independent in developing a disease.Infection data of schistosomiasis based on conventional surveys were obtained at the county level from the health authorities in Anhui Province,China and used in combination with information from Chinese weather stations and internationally available environmental data.Results:The specific detector identified various factors of potential importance as follows:Proximity to Yangtze River(0.322)>Land cover(0.285)>sunshine hours(0.256)>population density(0.109)>altitude(0.090)>the normalized different vegetation index(NDVI)(0.077)>land surface temperature at daytime(LST_(day))(0.007).The risk detector indicated that areas of schistosomiasis high risk were located within a buffer distance of 50 km from Yangtze River.The ecological detector disclosed that the factors investigated have significantly different effects.The interaction detector revealed that interaction between the factors enhanced their main effects in most cases.Conclusion:Proximity to Yangtze River had the strongest effect on schistosomiasis prevalence followed by land cover and sunshine hours,while the remaining factors had only weak influence.Interaction between factors played an even more important role in influencing schistosomiasis prevalence than each factor on its own.High risk regions influenced by strong interactions need to be targeted for disease control intervention. | Yi Hu Congcong Xia Shizhu Li Michael PWard Can Luo Fenghua Gao Qizhi Wang Shiqing Zhang Zhijie Zhang | 2017 | Infectious Diseases of Poverty2017，6，1： | 9 |
| 8 | Critical velocity in phosphorus exchange processes across the sediment-water interface显示文摘Sediments are ultimate sinks of nutrients in lakes that record the pollution history evolutionary processes, and anthropogenic activities of a lake. However, sediments are considered as inner sources of environmental factor changes such as the variation in hydrodynamic conditions because of the nutrients they release. How does this process happen? This study investigates a typical nutrient phosphorus(P) exchange among sediment, suspended particle matter(SPM), and water. Compared with numerical and experimental studies, this study confirms that the critical velocity that occurs at a lower flow rate state exists in the range of 7 to 15 cm/sec. Critical velocity below the critical flow rate promotes the migration of particulate phosphorus(PP) to the SPM. On the other hand, critical velocity above the critical flow rate promotes the release of PP in water. | Jun Wan Ze Wang Zhijie Li Huiling Duan HezhongYuan | 2013 | Journal of Environmental Sciences2013，25，10： | 9 |
| 9 | Underwater explosion in centrifuge Part Ⅱ:Dynamic responses of defensive steel plate显示文摘Part II of this paper is focused on the dynamic response of a steel plate of the centrifuge model which is fixed on the container. This plate is 5 cm thick, allowing for non-destructive elastic response to all the 19 blasts. Three accelerators and 10 sets of strain gauges are installed on the plate to monitor the acceleration and deformation histories induced by shock waves and bubble oscillations.This article presents the characteristic values measured for shock waves and bubble oscillations response. The detailed information can be found in a database available on the web. In order to obtain the correct acceleration time history, the cut-off frequency of low-pass filtering by Fourier transformation was applied. The results indicated that the acceleration and strain induced by shock wave was nearly unaffected by the increasing gravity, while the effect of gravity has remarkable influence on those induced by bubble oscillation. A preliminary study of comparing the measured dynamic response with numerical simulations has been carried out using ANSYS LS-DYNA. The results captured the dynamic response in terms of characteristics and trends, but deviated in magnitude due the theoretical and technological limitations involved in both the physical and numerical models. It certainly deserves further studies. | LONG Yuan ZHOU HongYuan LIANG XiangQian SONG Ge CHEN ZuYu HU Jing WANG QiuSheng ZHANG XueDong LIANG JianHui HUANG ZhiJie | 2017 | Science China(Technological Sciences)2017，60，12： | 8 |
| 10 | Directly patterned substrate-free plasmonic “nanograter” structures with unusual Fano resonances显示文摘The application of three-dimensional(3D)plasmonic nanostructures as metamaterials(MMs),nano-antennas,and other devices faces challenges in producing metallic nanostructures with easily definable orientations,sophisticated shapes,and smooth surfaces that are operational in the optical regime and beyond.Here,we demonstrate that complex 3D nanostructures can be readily achieved with focused-ion-beam irradiation-induced folding and examine the optical characteristics of plasmonic“nanograter”structures that are composed of free-standing Au films.These 3D nanostructures exhibit interesting 3D hybridization in current flows and exhibit unusual and well-scalable Fano resonances at wavelengths ranging from 1.6 to 6.4 mm.Upon the introduction of liquids of various refractive indices to the structures,a strong dependence of the Fano resonance is observed,with spectral sensitivities of 1400 nm and 2040 nm per refractive index unit under figures of merit of 35.0 and 12.5,respectively,for low-order and high-order resonance in the near-infrared region.This work indicates the exciting,increasing relevance of similarly constructed 3D free-standing nanostructures in the research and development of photonics and MMs. | Ajuan Cui Zhe Liu Jiafang Li Tiehan H Shen Xiaoxiang Xia Zhiyuan Li Zhijie Gong Hongqiang Li Benli Wang Junjie Li Haifang Yang Wuxia Li Changzhi Gu | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 11 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 12 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 13 | Changes in sediment discharge in a sediment-rich region of the Yellow River from 1955 to 2010: implications for further soil erosion control显示文摘The well-documented decrease in the discharge of sediment into the Yellow River has attracted considerable attention in recent years. The present study analyzed the spatial and temporal variation of sediment yield based on data from 46 hydrological stations in the sediment-rich region of the Yellow River from 1955 to 2010. The results showed that since 1970 sediment yield in the region has clearly decreased at different rates in the 45 sub-areas controlled by hydrological stations. The decrease in sediment yield was closely related to the intensity and extent of soil erosion control measures and rainstorms that occurred in different periods and sub-areas. The average sediment delivery modulus(SDM) in the study area decreased from 7,767.4 t/(km2?a) in 1951–1969 to 980.5 t/(km2?a) in 2000–2010. Our study suggested that 65.5% of the study area with the SDM below 1,000 t/(km2?a) is still necessary to control soil deterioration caused by erosion, and soil erosion control measures should be further strengthened in the areas with the SDM above 1,000 t/(km2?a). | JuYing JIAO ZhiJie WANG GuangJu ZHAO WanZhong WANG XingMin MU | 2014 | Journal of Arid Land2014，6，5： | 7 |
| 14 | Soil erosion and sediment interception by check dams in a watershed for an extreme rainstorm on the Loess Plateau,China显示文摘The magnitude of soil erosion and sediment load reduction efficiency of check dams under extreme rainstorms is a long-standing concern.The current paper aims to use check dams to deduce the amount of soil erosion under extreme rainstorms in a watershed and to identify the difference in sediment interception efficiency of different types of check dams.Based on the sediment deposition at 12 check dams with 100% sediment interception efficiency and sub-catchment clustering by taking 12 damcontrolled catchments as clustering criteria,the amount of soil erosion resulting from an extreme rainstorm event on July 26,2017(named '7·26' extreme rainstorm) was estimated in the Chabagou watershed in the hill and gully region of the Loess Plateau.The differences in the sediment interception efficiency among the check dams in the watershed were analyzed according to field observations at 17 check dams.The results show that the average erosion intensity under the '7-26' extreme rainstorm was approximately 2.03×10~4 t/km^2,which was 5 times that in the second largest erosive rainfall in 2017(4.15×10~3 t/km^2) and 11-384 times that for storms in 2018(0.53×10~2 t/km^2-1.81×10~3 t/km^2).Under the '7-26' extreme rainstorm,the amount of soil erosion in the Chabagou watershed above the Caoping hydrological station was 4.20 × 106 t.The sediment interception efficiency of the check dams with drainage canals(including the destroyed check dams) and with drainage culverts was 6.48 and 39.49%,respectively.The total actual sediment amount trapped by the check dams was 1.11 × 106 t,accounting for 26.36% of the total amount of soil erosion.In contrast,3.09×106 t of sediment were input to the downstream channel,and the sediment deposition in the channel was 2.23×10~6 t,accounting for 53.15%of the total amount of soil erosion.The amount of sediment transport at the hydrological station was8.60×10~5 t.The Sediment Delivery Ratio(SDR) under the '7·26' extreme rainstorm was 0.21.The results indicated that the amount of soil erosion was huge,and the sediment interception efficiency of the check dams was greatly reduced under extreme rainstorms.It is necessary to strengthen the management and construction technology standards of check dams to improve the sediment interception efficiency and flood safety in the watershed. | Leichao Bai Nan Wang Juying Jiao Yixian Chen Bingzhe Tang Haolin Wang Yulan Chen Xiqin Yan Zhijie Wang | 2020 | International Journal of Sediment Research2020，35，4： | 7 |
| 15 | IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling显示文摘Interleukin-17 (IL-17 或 IL-17A ) 生产是 TH17 房间的一个特点,贡献多重自体免疫、煽动性的疾病的致病的 CD4+ T 淋巴细胞的一个新唯一的系。IL-17 受体(IL-17R 或 IL-17RA ) 为 IL-17 生物活动是必要的。新兴的数据建议 heteromeric 或 homomeric 受体建筑群的形成为 IL-17 发信号被要求。这里,我们证明孤儿受体 IL-17RD (Sef,类似的表示到 FGF 基因或 IL-17RLM ) 被联系并且有 IL-17R 的 colocalized。重要地, IL-17RD 调停 IL-17 发信号,用一个酶记者评估了由 24p3 的本国的倡导者开车, IL-17 目标基因。另外,主导否定地缺乏细胞内部的领域的 IL-17RD 异种压制 IL-17R-mediated IL-17 发信号。而且,象 IL-17R 一样的 IL-17RD 与 TRAF6 被联系,一个 IL-17R 下游的分子。这些结果显示 IL-17RD 是表明建筑群的 IL-17 受体的部分,因此为通过 heteromeric 或 homomeric 受体建筑群发信号的 IL-17 提供新奇证据。 | Zhili Rong Anan Wang Zhiyong Li Yongming Ren Long Cheng Yinghua Li Yinyin Wang Fangli Ren Xiaoning Zhang Jim Hu Zhijie Chang | 2009 | Cell Research2009，19，2： | 6 |
| 16 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 17 | The application of perovskite materials in solar water splitting显示文摘Solar water splitting is a promising strategy for sustainable production of renewable hydrogen,and solving the crisis of energy and environment in the world.However,large-scale application of this method is hampered by the efficiency and the expense of the solar water splitting systems.Searching for non-toxic,low-cost,efficient and stable photocatalysts is an important way for solar water splitting.Due to the simplicity of structure and the flexibility of composition,perovskite based photocatalysts have recently attracted widespread attention for application in solar water splitting.In this review,the recent developments of perovskite based photocatalysts for water splitting are summarized.An introduction including the structures and properties of perovskite materials,and the fundamentals of solar water splitting is first provided.Then,it specifically focuses on the strategies for designing and modulating perovskite materials to improve their photocatalytic performance for solar water splitting.The current challenges and perspectives of perovskite materials in solar water splitting are also reviewed.The aim of this review is to summarize recent findings and developments of perovskite based photocatalysts and provide some useful guidance for the future research on the design and development of highly efficient perovskite based photocatalysts and the relevant systems for water splitting. | Yanbin Huang Jun Liu Yanchun Deng Yuanyuan Qian Xiaohao Jia Mengmeng Ma Cheng Yang Kong Liu Zhijie Wang Shengchun Qu Zhanguo Wang | 2020 | Journal of Semiconductors2020，41，1： | 6 |
| 18 | A Covert Communication Method Using Special Bitcoin Addresses Generated by Vanitygen显示文摘As an extension of the traditional encryption technology,information hiding has been increasingly used in the fields of communication and network media,and the covert communication technology has gradually developed.The blockchain technology that has emerged in recent years has the characteristics of decentralization and tamper resistance,which can effectively alleviate the disadvantages and problems of traditional covert communication.However,its combination with covert communication thus far has been mostly at the theoretical level.The BLOCCE method,as an early result of the combination of blockchain and covert communication technology,has the problems of low information embedding efficiency,the use of too many Bitcoin addresses,low communication efficiency,and high costs.The present research improved on this method,designed the V-BLOCCE which uses base58 to encrypt the plaintext and reuses the addresses generated by Vanitygen multiple times to embed information.This greatly improves the efficiency of information embedding and decreases the number of Bitcoin addresses used.Under the premise of ensuring the order,the Bitcoin transaction OP_RETURN field is used to store the information required to restore the plaintext and the transactions are issued at the same time to improve the information transmission efficiency.Thus,a more efficient and feasible method for the application of covert communication on the blockchain is proposed.In addition,this paper also provides a more feasible scheme and theoretical support for covert communication in blockchain. | Lejun Zhang Zhijie Zhang Weizheng Wang Rasheed Waqas Chunhui Zhao Seokhoon Kim Huiling Chen | 2020 | Computers, Materials & Continua2020，，10： | 6 |
| 19 | Effectiveness of Catch-Up Vaccinations after COVID-19 Containment--China,2020显示文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs. | Jing Wu Wenzhou Yu Lei Cao Lingsheng Cao Lance Rodewald Jiakai Ye Yifan Song Li Li Xiaoxue Liu Ning Wen Fuzhen Wang Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Yanmin Liu Guomin Zhang Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，50： | 6 |
| 20 | 2001-2005年中国4省份精神疾病的患病率、治疗情况和相关残疾:一项流行病学调查显示文摘背景在中国和其他中等收入国家,神经精神状况是影响男性和女性健康的最重要的原因,但由于缺乏有关各种精神疾病患病率、治疗情况和相关残疾的高质量的和具有国家特异性的资料,这些国家提高精神卫生服务的工作受到了限制。因此,我们在中国4个省份开展了一系列流行病学研究,以此来估算相关数据。方法采用多阶段分层随机抽样的方法在中国的4个省抽取了96个城市和267个农村作为初级抽样点;1.13亿个年龄≥18岁的成年人的抽样框架涵盖了中国12%的成年人。在抽样点使用简单随机抽样法选取63004例受试者,采用一般健康问卷(GHQ)的扩展版对这些个体进行筛查,并由精神科医生使用中文版的诊断与统计手册(DSM).Iv轴I障碍定式临床检查(SCID)问卷对其中的16577例受试者进行调查。结果所有精神疾病近1个月的校正患病率为17.5%(95%CI16.6%~18.5%)。其中,心境障碍患病率为6.1%(95%CI5.7%~6.6%),焦虑障碍为5.6%(95%cI5.0%~6.3%),物质滥用障碍为5.9%(95%CI5-3%~6.5%),精神病性障碍为1.0%(95%C10.8%~1.1%)。女性的心境障碍和焦虑障碍的患病率比男性高,年龄〉140岁个体的患病率高于年龄〈40岁的个体。男性酒精使用障碍的患病率是女性的48倍。农村居民比城市居民更可能患有抑郁障碍和酒精依赖。在被诊断患有某种精神疾病的人群中,24%存在由所患精神疾病引起的中度或重度残疾,8%曾向专业人员寻求过帮助,5%曾就诊于精神科。结论本研究结果与全球疾病负担分析中使用的中国精神疾病的患病率、残疾和治疗率估计值有相当大的差距,这需要引起中、低收入国家注意,在提高精神卫生服务前需针对国家具体情况进行详细的现状分析。 | Jingxuan Zhang Qichang Shi Zhiqiang Song Zhijie Ding Shutao Pang Xianyun Li Yali Zhang Zhiqing Wang 张亚利(译) 安静(审校) 费立鹏(审校) | 2009 | 世界临床医学2009，，11： | 5 |
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