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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Assessment of humanpapilloma viral load of archival cervical intraepithelial neoplasia byreal-time polymerase chain reaction in a Turkish population 显示文摘 | Onan MA Taskiran C Bozdayi G | 2005 | EurJ Gynaecol Oncol2005，26，6： | 1 |
| 3 | Assessment of human papilloma viral load of archival cervical intraepithelial neoplasia by real-time polymerase chain reaction in a Turkish population显示文摘 | Taskiran C Bozdayi G | 2005 | Eur J Gynaecol Oncol2005，26，6： | 1 |
| 4 | Molecular detection of cytomega-lovirus,herpes simplex virus 2,human papillomavirus 16-18 inTurkish pregnants显示文摘 | Dinc B Bozdayi G Biri A | 2010 | Braz J Infect Dis2010，14，6： | 1 |
| 5 | Circulating IL-2, IL-10 and TNF-alpha in chronic hepatitis B: their relations to HBeAg status and the activity of liver disease 显示文摘 | Bozkaya H Bozdayi M Turkyilmaz R | 2000 | Hepatogastroentemlogy2000，47，36： | 1 |
| 6 | The detection of CMV in amnioticfluid and cervicovaginal smear samples by real-time PCR assay inprenatal diagnosis显示文摘 | Biri A Bozdayi G Cicfti B | 2006 | Arch Gynecol Obstet2006，273，5： | 1 |
| 7 | Circulating IL-2, IL-10and TNF-alpha in chronic hepatitis B: their relations to HBeAg status and the activity of liver disease 显示文摘 | Bozkaya H Bozdayi M Turkyilmaz R | 2000 | Hepatogastroenterology2000，47，36： | 1 |
| 8 | Community-based research:cost of the tests used for anti-HBc total serepositivity only and hepatitis B screening显示文摘 | Ozkan S Atak A Bozdayi G | | 0，，： | 1 |
| 9 | Circulating IL - 2, IL - 10 and TNF- alpha in chronic hepatitis B: their relations to HBeAg status and the activity of liver disease 显示文摘 | Bozkaya H Bozdayi M TurkyILmazR | 2000 | Hepatogastroenterology2000，47，： | 1 |
| 10 | Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis显示文摘 | Ozlem Erkan Abdurrahman M. Bozdayi Selcuk Disibeyaz Dilek Oguz Muhit Ozcan Kadir Bahar Selim Karayalcin Ali Ozden Hakan Bozkaya Cihan Yurdaydin Ozden Uzunalimoglu | 2005 | European Journal of Gastroenterology & Hepatology2005，，3： | 1 |
| 11 | The relationship between cervical human papillomavirus infection and apoptosis显示文摘 | Fidan I Bozdayi G Rota S Biri A Gurelik F C Yuksel S | 2008 | Clin Invest Med2008，31，： | 1 |
| 12 | YSDD:a novel mutation in HBV DNA polyrnerase confers clinical resistance to lamivudine显示文摘 | Bozdayi AM Uzunalimoglu O Turkyilmaz AR | | 0，，4： | 1 |
| 13 | YSDD : a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine 显示文摘 | Bozdayi AM Uzunalimogu O Turkyilmaz AR | 2003 | J Viral Hepat2003，10，4： | 1 |
| 14 | Diagnosis of Toxoplama gondii by polymerase chain reaction method in pregnant woman from Turkey 显示文摘 | Dinc B Bozdayi G Biri A | 2006 | Clin Microbiol In-feet2006，12，4： | 1 |
| 15 | Distribution of secreted aspartyl proteinases using a polymcrase chain reaction assay with SAP specific primers in Candida albicans isolates 显示文摘 | Kalkanci A Bozdayi G Biri A | 2005 | Folia Microbiol2005，50，5： | 1 |
| 16 | Circulating IL-2, IL-10 and TNF-ct in chronic hepatitis B: their relations to HBeAg status and the activity of liver disease 显示文摘 | Bozkaya H Bozdayi M TflRKYILMAZ R | 2000 | Hepatogastroenterology2000，47，36： | 1 |
| 17 | Community-based research: cost of the tests used for anti-HBc total seropositivity only and hepatitis B screening显示文摘 | Ozkan S Atak A Bozdayi G | 2010 | Trans R Soc Trop Med Hyg2010，104，12： | 1 |
| 18 | Oral ganciclovir for treatment of lamivudine-resistant hepatitis B Virus infection: a pilot study显示文摘 | Bozkaya H Yurdaydin C Bozdayi AM | 2002 | Clin Infect Dis2002，35，： | 1 |
| 19 | Community-based research: cost of the tests used for anti-HBc total seropositivity only and hepatitis B screening 显示文摘 | Secil Ozkan Aysegul Atak Gulendam Bozdayi | 2008 | Clinical Gastroenterology and Hepatology2008，6，12： | 1 |
| 20 | Circulating IL-2, IL-10 and TNF-alpha in chronic hepatitis B: their relations to HBeAg status and the activity of liver disease显示文摘 | Bozkaya H Bozdayi M Turkyilmaz R | 2000 | Hepatogastroenterology2000，47，36： | 1 |
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