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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP29 activation 显示文摘 | Brand S Damb2acher J Bejgel F | 2005 | Exp Cell Res2005，310，1： | 1 |
| 3 | Reactive oxygen species mediate endothelial dependent relaxations in tetrahydrobiopterin-deficient mice 显示文摘 | Cosentino F Barker JE Brand MP | 2001 | Arterioscler Thromb VASc Biol2001，21，4： | 1 |
| 4 | Stress -restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus 显示文摘 | Harvey B H Oosthuizen F Brand L | 2004 | Psychopharmacology ( Berl )2004，175，4： | 1 |
| 5 | IL -28A and IL -29 mediateantiproliferative and antiviral signals in intestinal epithelial cellsand murine CMV infection increases colonic IL - 28A expression显示文摘 | Brand S Beigel F 0]szak T | 2005 | Am J Physiol Gastrointest Liver Physiol2005，289，5： | 1 |
| 6 | IL-22-mediated liver cell re- generation is abrogated by SOCS-1/3 overexpression in vitro显示文摘 | Brand S Dambacher J Beigel F | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，： | 1 |
| 7 | A prospective study on glioblastoma in the elderly 显示文摘 | Brandes AA Vastola F Basso U | 2003 | Cancer2003，97，3： | 1 |
| 8 | Methylene blue in the treatment and prevention of ifosfamideinduced encephalopathy:report of 12cases and a review of the literature显示文摘 | Pelgrims J De Vos F Van den Brande J | 2000 | Br J Cancer2000，82，： | 1 |
| 9 | Hematocrit and the risk of cardiovascular disease-The Framingham Study : a 34-year follow-up 显示文摘 | Gagnon D Zhang T Brand F | 1994 | Am Heart J1994，127，3： | 1 |
| 10 | Antigen-pressing cells and keratinocytes express interleukin-12 in allergic contact dermatitis显示文摘 | Yawalkar N Egli F Brand CU | 2000 | Contact Dermatitis2000，42，1： | 1 |
| 11 | Two Dimension Photoic- Bandgap Structure Operating at Near Infrared Wavelengths显示文摘 | Krauss T F Rue D L RM Brand S | 1996 | Nature1996，383，： | 1 |
| 12 | Genotype-phenotype relationships for the renin-angiotensin-aldosterone system in a normal population 显示文摘 | Paillard F Chansel D Brand E | 1999 | Hypertension1999，34，2： | 1 |
| 13 | IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression显示文摘 | Brand S Beigel F Olszak T | 2005 | Am J Physiol Gastrointest Liver Physiol2005，289，5： | 1 |
| 14 | Adaptive control of HVAC processes using predicitive neural networks显示文摘 | Cuetiss P S J F Kreider M J Brande Muchl | 1993 | ASHRAE Trans1993，，1： | 1 |
| 15 | Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue显示文摘 | Leandro Luongo de Matos Gabriel Manfro Ricardo Vieira dos Santos Elaine Stabenow Evandro Sobroza de Mello Venancio Avancini F. Alves Fábio Roberto Pinto Marco Aurélio Vamondes Kulcsar Lenine Garcia Brand?o Cláudio Roberto Cernea | 2014 | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology2014，，： | 1 |
| 16 | The synthesis of peptides related to gramicidin显示文摘 | Erlanger B F Sachs H Brand E J | 1954 | J Am Chem Soc1954，76，4： | 1 |
| 17 | A myogenic basis for the overactive bladder显示文摘 | Branding A F | 1997 | Urol1997，50，6： | 1 |
| 18 | Genotype-Phenotype Relationships for the Reuiu-Augioteusiu-Aldosteroue System in a Normal Population 显示文摘 | Paillard F Chansel Brand E | 1999 | Hypertension1999，34，3： | 1 |
| 19 | Thermal Conductivity of Single-walled Carbon Nanotube/PMMA Nanocomposites 显示文摘 | GUTHY C DU F BRAND S | 2007 | J Heat Transfer2007，129，： | 1 |
| 20 | Crosspresenting human gamma delta T cells induce robust CD8+alpha beta T cell responses显示文摘 | Brandes M Willimann K Bioley G Lévy N Eberl M Luo M TampéR Lévy F Romero P Moser B | 2009 | Proc Natl Acad Sci USA2009，106，7： | 1 |
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