|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 3 | Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance显示文摘 | Yaqing Zhang Wei Yan Meredith A. Collins Filip Bednar Sabita Rakshit Bruce R. Zetter Ben Z. Stanger Ivy Chung Andrew D. Rhim Marina Pasca di Magliano | 2013 | Cancer Research2013，，20： | 2 |
| 4 | Collateral Flow Predicts Response to Endovascular Therapy for Acute Ischemic Stroke显示文摘 | Oh Young Bang Jeffrey L. Saver Suk Jae Kim Gyeong-Moon Kim Chin-Sang Chung Bruce Ovbiagele Kwang Ho Lee David S. Liebeskind | 2011 | Stroke2011，，3： | 2 |
| 5 | Inflammation as a Risk Factor for Atrial Fibrillation显示文摘 | Ronnier J. Aviles David O. Martin Carolyn Apperson-Hansen Penny L. Houghtaling Pentti Rautaharju Richard A. Kronmal Russell P. Tracy David R. Van Wagoner Bruce M. Psaty Michael S. Lauer Mina K. Chung | 2003 | Circulation: Journal of the American Heart Association2003，，24： | 2 |
| 6 | Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation显示文摘 | Ayman A. Hussein Walid I. Saliba David O. Martin Mazyar Shadman Mohamed Kanj Mandeep Bhargava Thomas Dresing Mina Chung Thomas Callahan Bryan Baranowski Patrick Tchou Bruce D. Lindsay Andrea Natale Oussama M. Wazni | 2011 | Circulation2011，，19： | 2 |
| 7 | Inflammation as a Risk Factor for Atrial Fibrillation显示文摘 | Ronnier J. Aviles David O. Martin Carolyn Apperson-Hansen Penny L. Houghtaling Pentti Rautaharju Richard A. Kronmal Russell P. Tracy David R. Van Wagoner Bruce M. Psaty Michael S. Lauer Mina K. Chung | 2003 | Circulation: Journal of the American Heart Association2003，，24： | 1 |
| 8 | Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘 | Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M | 2011 | Gastroenterology2011，，2： | 1 |
| 9 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 10 | Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘 | Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M | 2011 | Gastroenterology2011，，2： | 1 |
| 11 | Soluble Epoxide Hydrolase Gene Deficiency or Inhibition Attenuates Chronic Active Inflammatory Bowel Disease in IL-10(?/?) Mice显示文摘 | Wanying Zhang Allison L. Yang Jie Liao Haonan Li Hua Dong Yeon Tae Chung Han Bai Kristina A. Matkowskyj Bruce D. Hammock Guang-Yu Yang | 2012 | Digestive Diseases and Sciences2012，，10： | 1 |
| 12 | Genetic analysis of opaque2 modifier loci in quality protein maize显示文摘 | David R. Holding Brenda G. Hunter Taijoon Chung Bryan C. Gibbon Clark F. Ford Arvind K. Bharti Joachim Messing Bruce R. Hamaker Brian A. Larkins | 2008 | Theoretical and Applied Genetics2008，，2： | 1 |
| 13 | Collateral Flow Averts Hemorrhagic Transformation After Endovascular Therapy for Acute Ischemic Stroke显示文摘 | Oh Young Bang Jeffrey L. Saver Suk Jae Kim Gyeong-Moon Kim Chin-Sang Chung Bruce Ovbiagele Kwang Ho Lee David S. Liebeskind | 2011 | Stroke2011，，8： | 1 |
| 14 | Disruption of endothelial barrier function by lipolytic remnants of triglyceride-rich lipoproteins显示文摘 | Chung B H Bruce A | 1992 | Atherosclerosis1992，95，8： | 1 |
| 15 | Impact of Baseline Tissue Status (Diffusion-Weighted Imaging Lesion) Versus Perfusion Status (Severity of Hypoperfusion) on Hemorrhagic Transformation显示文摘 | Jong Hun Kim Oh Young Bang David S. Liebeskind Bruce Ovbiagele Gyeong-Moon Kim Chin Sang Chung Kwang Ho Lee Jeffrey L. Saver | 2010 | Stroke2010，，3： | 1 |
| 16 | High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection显示文摘 | Georg M. Lauer Eleanor Barnes Michaela Lucas Joerg Timm Kei Ouchi Arthur Y. Kim Cheryl L. Day Gregory K. Robbins Deborah R. Casson Markus Reiser Geoffrey Dusheiko Todd M. Allen Raymond T. Chung Bruce D. Walker Paul Klenerman | 2004 | Gastroenterology2004，，3： | 1 |
| 17 | Inflammation as a Risk Factor for Atrial Fibrillation显示文摘 | Ronnier J. Aviles David O. Martin Carolyn Apperson-Hansen Penny L. Houghtaling Pentti Rautaharju Richard A. Kronmal Russell P. Tracy David R. Van Wagoner Bruce M. Psaty Michael S. Lauer Mina K. Chung | 2003 | Circulation: Journal of the American Heart Association2003，，24： | 1 |
| 18 | Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘 | Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M | 2011 | Gastroenterology2011，，2： | 1 |
| 19 | Protocoled thrombolytic therapy for frostbite improves phalangeal salvage rates显示文摘Background:Frostbite is a cold injury that has the potential to cause considerable morbidity and long-term disability.Despite the complexity of these patients,diagnostic and treatment practices lack standardization.Thrombolytic therapy has emerged as a promising treatment modality,demonstrating impressive digit salvage rates.We review our experience with thrombolytic therapy for severe upper extremity frostbite.Methods:Retrospective data on all frostbite patients evaluated at our institution from December 2017 to March 2018 was collected.A subgroup of patients with severe frostbite treated with intraarterial thrombolytic therapy(IATT)were analysed.Results:Of the 17 frostbite patients treated at our institution,14(82%)were male and the median age was 31(range:19–73).Substance misuse was involved in a majority of the cases(58.8%).Five(29.4%)patients with severe frostbite met inclusion criteria for IATT and the remaining patients were treated conservatively.Angiography demonstrated a 74.5%improvement in perfusion after tissue plasminogen activator thrombolysis.When comparing phalanges at risk on initial angiography to phalanges undergoing amputation,the phalangeal salvage rate was 83.3%and the digit salvage rate was 80%.Complications associated with IATT included groin hematoma,pseudoaneurysm and retroperitoneal hematoma.Conclusions:Thrombolytic therapy has the potential to greatly improve limb salvage and functional recovery after severe frostbite when treated at an institution that can offer comprehensive,protocoled thrombolytic therapy.A multi-center prospective study is warranted to elucidate the optimal treatment strategy in severe frostbite. | Rosemary Elizabeth Paine Elizabeth Noel Turner Daniel Kloda Carolyne Falank Bruce Chung Damien Wilson Carter | 2020 | Burns & Trauma2020，8，1： | 0 |
| 20 | NON-INVASIVE MEASUREMENT OF DEEP TISSUE TEMPERATURE CHANGES CAUSED BY APOPTOSIS DURING BREAST CANCER NEOADJUVANT CHEMOTHERAPY:A CASE STUDY显示文摘Treatment-induced apoptosis of cancer cells is one goal of cancer therapy.Interestingly,more heat is generated by mitochondria during apoptosis,especially the uncoupled apoptotic state,^(1,2) compared to the resting state.In this case study,we explore these thermal effects by longitudinally measuring temperature variations in a breast lesion of a pathological complete responder during neoadjuvant chemotherapy(NAC).Diffuse Optical Spectroscopic Imaging(DOSI)was employed to derive absolute deep tissue temperature using subtle spectral features of the water peak at 975 nm.^(3)A significant temperature increase was observed in time windows during the anthracycline and cyclophosphamide(AC)regimen but not in the paclitaxel and bevacizumab regimen.Hemoglobin concentration changes generally did not follow temperature,suggesting the measured temperature increases were likely due to mitochondrial uncoupling rather than a direct vascular effect.A simultaneous increase of tissue oxygen saturation with temperature was observed,suggesting that oxidative stress also contributes to apoptosis.Although preliminary,this study indicates longitudinal DOSI tissue temperature monitoring provides information that can improve our understanding of the mechanisms of tissue response during NAC. | SO HYUN CHUNG RITA MEHTA BRUCE J.TROMBERG A.G.YODH | 2011 | Journal of Innovative Optical Health Sciences2011，4，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员