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| 1 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 2 | Thiolactone copolymer donor gifts organic solar cells a 16.72% efficiency显示文摘Since 1995,bulk-heterojunction organic solar cells consisting of one or two organic donors and one or two organic acceptors have been fighting for high power conversion efficiencies(PCEs)and good stability[1].Until recent years,this next-generation photovoltaic technology starts to offer decent PCEs,shedding the light on commercialization,and attracting great attention again[2-14].Compared w让h the continuously emerging highperformance nonfullerene acceptors,high-performance donors are rare. | Ji Xiong Ke Jin Yufan Jiang Jianqiang Qin Tan Wang Jinfeng Liu Qishi Liu Haili Peng Xiongfeng Li Anxin Sun Xianyi Meng Lixiu Zhang Ling Liu Wenting Li Zhimin Fang Xue Jia Zuo Xiao Yaqing Feng Xiaotao Zhang Kuan Sun Shangfeng Yang Shengwei Shi Liming Ding | 2019 | Science Bulletin2019，64，21： | 17 |
| 3 | Effects of pyrite on the spontaneous combustion of coal显示文摘 | Jun Deng Xiaofeng Ma Yutao Zhang Yaqing Li Wenwen Zhu | 2015 | International Journal of Coal Science & Technology2015，2，4： | 14 |
| 4 | Nickel-free Stainless Steel for Medical Applications显示文摘BIOSS4 steel is essentially a nickel-free austenitic stainless steel developed by the Institute of Metal Research, Chinese Academy of Sciences, in response to nickel allergy problems associated with nickel-containing stainless steels that are widely used in medical applications. The high nitrogen content of this steel effectively maintains the austenitic stability and also contributes to the high levels of corrosion resistance and strength. BIOSS4 steel possesses a good combination of high strength and toughness, better corrosion resistance, and better blood compatibility, in comparison with the medical 316L stainless steel. Potential applications of BIOSS4 steel can include medical implantation material and orthodontic or orthopedic devices, as well as jewelries and other decorations. | Yibin REN, Ke YANG, Bingchun ZHANG, Yaqing WANG and Yong LIANGInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2004 | Journal of Materials Science & Technology2004，20，5： | 11 |
| 5 | Spatial and Temporal Changes of Arable Land Driven by Urbanization and Ecological Restoration in China显示文摘Since the industrial revolution, human activities have both expanded and intensified across the globe resulting in accelerated land use change. Land use change driven by China’s development has put pressure on the limited arable land resources, which has affected grain production. Competing land use interests are a potential threat to food security in China. Therefore, studying arable land use changes is critical for ensuring future food security and maintaining the sustainable development of arable land. Based on data from several major sources, we analyzed the spatio-temporal differences of arable land among different agricultural regions in China from 2000 to 2010 and identified the drivers of arable land expansion and loss. The results revealed that arable land decreased by 5.92 million ha or 3.31%. Arable land increased in the north and decreased in the south of China. Urbanization and ecological restoration programs were the main drivers of arable land loss, while the reclamation of other land cover types(e.g., forest, grassland, and wetland) was the primary source of the increased arable land. The majority of arable land expansion occurred in the Northwest, but the centroid for grain production moved to northeast, which indicated that new arable land was of poor quality and did not significantly contribute to the grain production capacity. When combined with the current ‘Red Line of Arable Land Policy’(RAL) and ‘Ecological Redline Policy’(EPR), this study can provide effective information for arable land policymaking and help guide the sustainable development of arable land. | WANG Liyan ANNA Herzberger ZHANG Liyun XIAO Yi WANG Yaqing XIAO Yang LIU Jianguo OUYANG Zhiyun | 2019 | Chinese Geographical Science2019，29，5： | 9 |
| 6 | Relationality and processual construction: bringing Chinese ideas into international relations theory显示文摘30年来兴起的的西方国际关系理论三大主流学派——结构现实主义、新自由制度主义和结构建构主义——有一个共同的缺失,这就是忽视对国际体系过程和国际社会中复杂关系的研究。本文针对这一重要缺失,借鉴主流建构主义,将“过程”和“关系”这两个中国文化中的重要理念植入国际关系理论,提出一个过程建构主义的理论模式。论文将过程定义为运动中的关系,论证了过程的自在性、过程动力和过程在国际关系中的作用。过程的核心是关系。如果说西方个体本位的社会性质的核心理念是“理性”,那么中国社会文化的一个根本理念则是“关系”。将这个理念挖掘出来并进行概念化处理,依此确立过程建构主义“关系本位”的基本假定。同时,过程建构主义还认为,国际社会中的关系网络确定国家身份并孕化国际权力。过程建构主义是体系层次的进化理论,将分析重点置于国家之间的互动实践,强调过程的自在性以及对国际规范、国家身份和认同的建构作用。 | Qin Yaqing | 2009 | Social Sciences in China2009，30，4： | 7 |
| 7 | Repair of abnormal perfusion foci in idiopathic epilepsy patients under long-term antiepileptic treatment显示文摘Epileptic seizure control and the disappearance of epileptiform discharge are not indicative of the absence of abnormal perfusion foci.Perfusion abnormalities are a major cause of epileptic discharge,and the existence of abnormal perfusion foci implies possible relapse.Very little is known about perfusion abnormality repair in epilepsy.The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months.Comparisons between interictal single-photon emission CT(SPECT)images and long-term electroencephalogram(EEG)pre-and post-treatment showed that cases of normal SPECT increased by 48%(12/25)following treatment,with a total number of 15 reduced foci(36%,15/41).Perfusion foci,i.e.,region of interest,were altered following treatment.These changes included:normal to abnormal in 3 cases(7%,3/43;2 hyperperfusion and 1 hypoperfusion);abnormal to normal in 14 cases(32%,14/43;10 pre-treatment hypoperfusion and 4 hyperperfusion);abnormal to abnormal in 7 cases(16%,7/43;hyperperfusion to hypoperfusion in 5 cases,hypoperfusion to hyperperfusion in 2 cases).Long-term EEG revealed in an increase in the number of normal cases by 20(40%,20/39),and there were 25 fewer cases with epileptiform discharges(66%,25/38).These findings demonstrate that long-term control of anti-epileptic drugs partially repaired cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy. | Weimin Wang Siyu Zhao Yaqing Liu | 2011 | Neural Regeneration Research2011，6，2： | 7 |
| 8 | Different quasispecies with great mutations hide in the same subgroup J field strain of avian leukosis virus显示文摘Blood samples were collected from a local strain of chickens associated with serious tumor cases in Shandong Province.The samples were inoculated into chicken embryo fibroblast and DF-1 cells for virus isolation and identification,respectively.The inoculated cells were screened for three common chicken tumor viruses.Nine strains of avian leukosis virus subgroup J(ALV-J) were identified,and were designated LY1201‐LY1209.The env gene from the LY1201 strain was amplified and cloned.All nine resultant env clones(clones 01-09) were sequenced,and the gp85 and gp37 amino acid regions were subjected to homology analysis.Clones 01 and 03 had 10 amino acid deletions in the gp85 region compared to the other seven clones,suggesting that at least two quasispecies with obvious mutations coexist in the same field strain.Among these nine clones,three had identical gp85 and gp37 sequences,and were recognized as the dominant LY1201 quasispecies.The amino acid sequence homology of gp37 and gp85 among the nine clones was 98.5%-100.0% and 96.6%-100.0% respectively,suggesting that the gp85 region of the env gene can better display the quasispecies diversity of ALV-J than gp37. | MAO YaQing LI WeiHua DONG Xuan LIU JinHua ZHAO Peng | 2013 | Science China(Life Sciences)2013，56，5： | 6 |
| 9 | Ultra-deep desulfurization by reactive adsorption desulfurization on copper-based catalysts显示文摘In this paper,a novel copper-based catalyst for FCC gasoline improving the ability of removal the sulfur and avoiding the loss of the octane number from olefin saturation by reactive adsorption desulfurization(RADS) was investigated.The series of Cu/Zn O-Al_2 O_3 catalysts were characterized by X-ray powder diffraction(XRD),N_2 adsorption analysis and temperature-programmed reduction(TPR) studies,X-ray photoelectron spectroscopy(XPS),scanning electron microscope(SEM) and transmission electron microscopy(TEM).The experiment results showed that the catalysts had an optimum desulfurization ability with copper loading 6 wt%,which the sulfur contents of product decreased less than 10 μg/g and olefin contents decreased from 16.19% to 14.14% for the long period operation.The appropriate Cu loading content could lead to the high active and low apparent activation energy(E_a).Therefore,the Cu-based catalyst may become a novel catalyst for second-generation for reactive adsorption desulfurization,which achieves the high desulfurization active and low olefins saturation to satisfy the upgrading the product. | Yaqing Liu Hongying Wang Jinchong Zhao Yunqi Liu Chenguang Liu | 2019 | Journal of Energy Chemistry2019，28，2： | 6 |
| 10 | Aptamer-quantum dots and teicoplanin-gold nanoparticles constructed FRET sensor for sensitive detection of Staphylococcus aureus显示文摘The detection of bacterial pathogen such as Staphylococcus aureus(S.aureus) is essential for the regulation of food hygiene and disease diagnosis.Herein,we developed a simple one-step fluorescence resonance energy transfer(FRET)-based sensor for specific and sensitive detection of S.aureus in food and serum samples,in which aptamer-modified quantum dots(aptamer-QDs) was employed as the energy donor and antibiotic of teicoplanin functionalized-gold nanoparticles(Teico-AuNPs) was chosen as the energy acceptor.Within 1 h,the FRET-based sensor showed a linear range of from 10 cfu/mL to 5 × 10^(8) cfu/mL,with the low limit of detection(LOD,2 cfu/mL) for S.aureus in buffer.When further applied to assay S.aureus in real samples,the FRET-based sensor showed good recoveries ranging from 84.5% to 110.0%,with relative standard derivations(RSDs) of 0.01%-0.44% and a LOD of 100 cfu/mL in milk,orange juice and human serum. | Xiaoqi Tao Ziyi Liao Yaqing Zhang Fei Fu Mengqi Hao Yang Song Erqun Song | 2021 | Chinese Chemical Letters2021，32，2： | 5 |
| 11 | Electrochemical Oxidative C-H Sulfenylation of Imidazopyridines with Hydrogen Evolution显示文摘Summary of main observation and conclusion Selective oxidative C-H sulfenylation of imidazopyridine heterocycles is achieved using an undivided electrolytic cell.The reaction avoids the use of stoichiometric amount of external chemical oxidant and produces hydrogen gas as the only byproduct. Both aryl and aliphatic thiols demonstrate good reactivity for C-S bond formation. | Yong Yuan Yangmin Cao Jin qiao Yueping Lin Xiaomei Jiang Yaqing Weng Shan Tang Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，1： | 5 |
| 12 | Development of source profiles and their application in source apportionment of PM2.5 in Xiamen, China显示文摘 | Ningning Zhang Mazhan Zhuang Jie Tian Pengshan Tian Jieru Zhang Qiyuan Wang Yaqing Zhou Rujin Huang Chongshu Zhu Xuemin Zhang Junji Cao | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 5 |
| 13 | Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke:the first multicentre,phase III trial in China显示文摘background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whether AIS patients would benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke symptoms in a prospective,multicentre,single-arm trial in China.Materials and methods Eligible AIS patients were given 0.9 mg/kg alteplase intravenously.The primary efficacy endpoint was a favourable outcome at 3 months,defined as a score of 0 or 1 on the modified Rankin Scale.Thresholds for the primary efficacy endpoint were determined to be 40%based on the literature review.The primary safety endpoint was symptomatic intracranial haemorrhage(sICH)according to the European Cooperative Acute Stroke Study III(ECASS III)trial definition.Post hoc analysis between this study and the ECASS III trial were compared using the propensity score matching(PSM)method.results A total of 120 eligible AIS patients from 11 sites in China received thrombolysis therapy in this study.The median time from onset of symptoms to needle was 3 hours 54 min.The percentage of patients with a favourable outcome was 63.3%(95%CI 54.4 to 71.4),significantly higher than the predefined threshold(p<0.0001).Three patients(2.5%,95%CI 0.5 to 7.1)had sICH,including two fatal sICH.Six patients died within 3 months after treatment.The post hoc PSM analysis showed a numerically higher rate of the primary efficacy endpoint in this study(63.3%)than the matched placebo arm(56.7%)in the ECASS III trial.Conclusions Intravenous alteplase with a standard dose administered between 3 and 4.5 hours after onset of symptoms is effective and safe for Chinese AIS patients. | Huaguang Zheng Yi Yang Huisheng Chen Chuanling Li Yangkun Chen Fu-Dong Shi Li Yang Xiaoping Cui Zuneng Lu Yanling Liang Songbiao Cui Anding Xu Yiqing Wu Yaqing Sun Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，3： | 4 |
| 14 | Mea6 controls VLDL transport through the coordinated regulation of COPil assembly显示文摘 | Yaqing Wang Liang Liu Hongsheng Zhang Junwan Fan FengZhang Mei Yu Lei Shi Lin Yang Sin Man Lam Huimin Wang Xiaowei Chen Yingchun Wang Fei Gao Guanghou Shui Zhiheng Xu | 2016 | Cell Research2016，26，7： | 4 |
| 15 | Carbon Segregation of Bearing Steel Concasting Billet显示文摘The formation mechanism of 'white band' and central carbon segregation of high-carbon Cr bearing steel concasting billets are discussed in this paper. The maximum oxygen content in the steel produced by concasting process was 13 ?10-6 with an average oxygen content of 9.3?10-6. Comparison of metallurgical quality and fatigue property between the concasting steel (CC) and ingot casting steel (IC) showed that the carbon segregation (C/C0) in former steel was 0.921.10 and its fatigue life was equal to that of the latter steel. | Deguang ZHOU, Jie FU and Ping WANG (University of Science and Technology Beijing, Beijing 100083, China) Junhao XU, Yaqing XIE and Zheng LI (Daye Special Steel Co. Ltd, Huangshi 435001, China) | 2000 | Journal of Materials Science & Technology2000，16，3： | 4 |
| 16 | Preparation of dye-sensitized solar cells with high photocurrent and photovoltage by using mesoporous titanium dioxide particles as photoanode material显示文摘几 mesoporous TiO 2(MT ) 材料在跟随 poly 使用的一个热水的过程(乙烯乙二醇) 的不同条件下面被综合 -block-poly(propylene-glycol)-block-poly(ethylene-glycol)(P123 ) 作为是的模板和钛 isopropoxide 钛来源。Ti/P123 的臼齿的比率,和在一个压热器的反应解决方案的 pH 值被调查。象 BrunauerEmmettTeller (赌注) 那样的各种各样的技术, X 光检查衍射(XRD ) , X 光检查光电子光谱学(XPS ) ,激光拉曼 spectrometry (LRS ) ,扫描电子显微镜学(SEM ) ,和高分辨率的传播电子显微镜学(HRTEM ) 被用来描绘产品。然后,这些材料被装配进敏化染料的太阳能电池(DSSC ) 。JV 曲线和电气化学的阻抗光谱学(EIS ) 的分析被使用描绘房间。结果显示特定的表面区域和这些材料的水晶的结构为房间提供高光电流的可能性,并且标本的结构的特征导致了,这增加了房间的电子转移抵抗,它为 DSSC 的 photovoltage 的改进是有益的。包含 MT 材料的房间的最高光电的变换效率到达了 8.33% ,与基于 P25 的太阳能电池(5.88%) 的相比,它增加了 41.7% 。 | Yi Zhang Bao Zhang Xiao Peng Lin Liu Shuo Dong Liping Lin Si Chen Shuxian Meng Yaqing Feng | 2015 | Nano Research2015，8，12： | 4 |
| 17 | Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice显示文摘OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action. METHODS: BALB/c mice were randomly divided into four groups of 10 (untreated model group, JZD group, CTX group, and JZD + CTX group) and subcutaneously injected with 4T1 mouse breast cancer cells. Tumors were allowed to establish for ~7 d before initiation of treatment with CTX (100 mg/kg every week by intraperitoneal injection) and/or JZD (0.015 mL of 1.65 g/mL crude drug, administered daily by gavage). The model group received equivalent volumes of vehicle on the same schedules. Tumor volumes were measured every 3 d. Mice were sacrificed after 3 weeks of treatment, and tumors were excised and subjected to RT-qPCR and western blot analysis to evaluate expression of the Wnt/β-catenin signaling pathway components β-catenin, c-Myc, and cyclin D1 at the mRNA and protein levels. RESULTS: The mean tumor volume was smaller and the growth rate was slower in the CTX and JZD + CTX groups compared with the model group (P < 0.05), and in the JZD + CTX group compared with the CTX and JZD groups (P < 0.05). Tumor growth was inhibited by 35.4% and 48.1% by CTX and JZD + CTX treatment, respectively (P < 0.001). The expression of β-catenin, c-Myc, and cyclin D1 mRNA and protein in tumors was significantly lower in mice treated with JZD or JZD + CTX compared with the untreated mice (P < 0.05), and was significantly lower in mice treated with JZD + CTX compared with either JZD or CTX alone (P < 0.05). CONCLUSION: JZD inhibited the growth of mouse breast cancer cells in vivo, possibly by reducing the expression of β-catenin, c-Myc, and cyclin D1. Combination therapy with JZD plus CTX had a more potent inhibitory effect on breast cancer growth compared with either agent alone. | Guan Huiting Xie Su Liu Shangyi Xie Qing Hou Shengkai Liu Huarong Zhang Yunjie Hu Yaqing Zhang Chenyu | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 4 |
| 18 | Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice显示文摘 | Collins Meredith A Bednar Filip Zhang Yaqing Brisset Jean-Christophe Galbán Stefanie Galbán Craig J Rakshit Sabita Flannagan Karen S Adsay N Volkan di Magliano Marina Pasca | 2012 | EN2012，，： | 3 |
| 19 | Preparation and Characterization of Exfoliated Poly(ethyleneterephthalate)/Montmorillonite Nanocomposites Using Modified MMTs with Variable Content of Antimony Acetate显示文摘(乙烯 terephthalate )( 宠物) Poly, /montmorillonite (MMT ) nanocomposite 被直接聚合准备, MMT 与锑醋酸盐的可变内容修改了(Sb (OAc ) 3 ) ,它也被用作催化剂聚合。修改 MMT (AS-Sb-MMT ) 被两个都设置准备 Sb (OAc ) 3 并且两性的表面活化剂(作为) 进 MMT 层。九种 Sb-MMTs [与 Sb (OAc ) 对待的 MMT 3 ] 与不同 Sb,内容被获得,但是六种仅仅 PET/MMT nanocomposites 能被准备。ICPAES 被用来描绘修改 MMT 的 Sb 内容, XRD 被用来描绘夹层间距,红外光谱学被用来在修改 MMT 描绘 Sb 催化剂的作文变化, TEM 被用来调查 PET/MMT nanocomposites 的 micromorphology。几结果被获得,即, Sb-MMT 的(a) Sb 内容被两个都弄干温度和洗弄干顺序影响,(b)与 Na-MMT (未修改的 MMT )相比,在 Sb-MMT 的夹层间距的变化被归因于溶剂乙烯乙二醇(例如)而非设置或吸收的 Sb ( OAc ) 3 ,(c)基于这,一个模型被开发描述 Na-MMT 胀大并且修改了 MMT 由例如并且在夹层间距上弄干温度的效果, MMT 的(d) | Wang, xiaoqun Wang, Yaqing Zhao, Zhenlu Zhu, Xiaoguang Nie, Cong Du, Shanyi | 2011 | Chinese Journal of Chemistry2011，29，6： | 3 |
| 20 | Higher Dietary Arachidonic Acid Levels Improved the Growth Performance, Gonad Development, Nutritional Value, and Antioxidant Enzyme Activities of Adult Sea Urchin(Strongylocentrotus intermedius)显示文摘The gonads of sea urchins(Strongylocentrotus intermedius) are characterized by high levels of arachidonic acid(ARA, 20:4 n-6) and eicosapentaenoic acid(EPA, 20:5 n-3). However, to our knowledge, little information is available regarding the physiological response of adult sea urchins to dietary ARA. In the present study, four dietary feeds were formulated with graded ARA(0, 0.5%, 1%, and 2% dry diet). Each diet was randomly allocated to three cages during a 56-day feeding experiment. The results showed that the sea urchin weight gain rate(WGR) and the gonadosomatic index(GI) significantly increased as ARA was equal to or above 1.0% of dry diet(P < 0.05). The activities of superoxide dismutase(SOD), catalase(CAT), and total anti-oxidative capacity(T-AOC) were the highest in the coelomic fluid of sea urchins that were fed diets with 1% ARA. The total essential amino acid(TEAA) and its ratio to total non-essential amino acid(TNEAA) showed a similar tendency to WGR and GI as dietary ARA increased, and the highest TEAA and TEAA/TNEAA were observed in the gonads of sea urchins that were fed diets with 1% ARA. Levels of ARA and ARA/EPA of the gonads increased while n-3/n-6 polyunsaturated fatty acid(PUFA) decreased with the increase of dietary ARA(P < 0.05). EPA in the gonads of experimental animals fed with formulated feeds showed no significant differences(P> 0.05), but was significantly lower than those fed with kelp(P < 0.05). These results suggested that relatively higher levels of ARA(1% dry diet) significantly promoted growth, gonad development, activities of antioxidant enzymes, as well as nutritional values(TEAA, TEAA/TNEAA, and PUFA) of adult S. intermedius. | ZUO Rantao LI Min DING Jun CHANG Yaqing | 2018 | Journal of Ocean University of China2018，17，4： | 3 |
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