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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Ribotypes and viru- lence gene polymorphisms suggest three distinct Listeria mono- cytogenes lineages with differences in pathogenic potential显示文摘 | Wiedmann M Bruce JL Keating C | 1997 | Infect Immun1997，65，7： | 1 |
| 3 | Ribotypes and virulence gene polymorphisms suggest three distinct L/s- teria monoeytogenes lineages with differences in pathogenic potential显示文摘 | Wiedmann M Bruce JL Keating C et at | 1997 | Infection and Immunity1997，65，： | 1 |
| 4 | Ribotypes and virulence gene polymorphisms suggestthree distinct Listeria monocytogenes lineages with differences in pathogenic potential显示文摘 | Wiedman M Bruce JL Keating C | 1997 | Infect Immun1997，65，7： | 1 |
| 5 | Oxidative injury rapidly activates the heat shock transcription factor but fails to increase levels of heat shock proteins 显示文摘 | Bruce JL Price BD Coleman CN | 1993 | Cancer Res1993，53，1： | 1 |
| 6 | EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease显示文摘 | Zamorano JL Badano LP Bruce C | 2011 | Eur Heart J2011，32，17： | 1 |
| 7 | EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease显示文摘 | Zamorano JL Badano LP Bruce C | 2011 | Eur Heart J2011，32，17： | 1 |
| 8 | Comparative genetic characterization of Listeria monocytogenes isolates from human and animal listeriosis cases显示文摘 | Jeffers GT Bruce JL McDonough PL | | 0，，5： | 1 |
| 9 | Oxidative injury rapidly activates the heat shock transcription factor but fails to increase levels of heat shock proteins 显示文摘 | Bruce JL Price BD Coleman CN | 1993 | Cancer Res1993，53，1： | 1 |
| 10 | Ribotypes and virulence gene polymorphisms suggest three distinct Listeria monocytogenes lineages with differences in pathogenic potential显示文摘 | Wiedmann M Bruce JL Keating C | | 0，，07： | 1 |
| 11 | Interaction between glutamine availability and metabolism of glycogen,tricarboxylic acid cycle inter-mediates and glutathione显示文摘 | Rennie MJ Bowtell JL Bruce M | 2001 | J Nutr2001，131，9： | 1 |
| 12 | Frozen shoulder-a stiff problem that requires a flexible approach显示文摘 | Guyver PM Bruce DJ Rees JL | 2014 | Maturitas2014，78，1： | 1 |
| 13 | Monocytes are recruited from venules during arteriogenesis in the murine spinotrapezius ligation model 显示文摘 | Bruce AC Kelty-Goss MR Heuslein JL | 2014 | Arterioscler Thromb Vasc Biol2014，34，9： | 1 |
| 14 | Comparative evaluation of an automated ribotyping instrument versus pulsed -iield gel electrophoresis for epidemiological investigation of clinical isolates of bacteria 显示文摘 | Hollis R J Bruce JL Fritschel S J | 1999 | Diagn Microbiol infect Dis1999，34，4： | 1 |
| 15 | Association of human papillomavirus type 16 and 18 E6 proteins with p53 显示文摘 | Arnold JL Peter MH | 1990 | Science1990，248，4951： | 1 |
| 16 | Responses of female orange wheat blossom midge,Sitodiplosis mosellana,to wheat panicle volatiles显示文摘 | Birkett MA Bruce TJA Martin JL Smart LE Oakley J Wadhams LJ | | 0，，07： | 1 |
| 17 | Development of a pheromone trap monitoring system for orange wheat blossom midge,Sitodiplosis mosellana,in the UK显示文摘 | Bruce TJA Hooper AM Ireland L Jones OT Martin JL Smart LE Oakley J Wadhams L J | | 0，，01： | 1 |
| 18 | Ribotypes and virulence gene polymorphisms suggest three distinct Listeria monocytogenes lineages with differences in pathogenic potential显示文摘 | Wiedmann M Bruce JL Keating C | 1997 | Infect Immun1997，65，： | 1 |
| 19 | Ribotypes and virulence gene polymorphisms suggest three distinct Listeria monocytogenes lineages with differences in pathogenic potential显示文摘 | WIEDMANN M BRUCE JL KEATING C | 1997 | Infect Immun1997，65，7： | 1 |
| 20 | EAE/ASE recommendations for the use of echoeardiography in new transeatheter interventions for valvular heart disease显示文摘 | Zamoranol JL Badano LP Bruce C | 2011 | J Am Soc Eehocardiogr2011，249，： | 1 |
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