|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 3 | Overexpression of potato miR482e enhanced plant sensitivity to Verticillium dahliae infection显示文摘Verticillium wilt of potato is caused by the fungus pathogen Verticillium dahliae. Present s RNA sequencing data revealed that miR482 was in response to V. dahliae infection but the function in potato is elusive. Here, we characterized potato miR482 family and its putative role resistance to Verticillium wilt. Members of the potato mi R482 superfamily are variable in sequence, but all variants target a class of disease-resistance proteins with nucleotide binding site(NBS)and leucine-rich repeat(LRR) motifs. When potato plantlets were infected with V. dahliae, the expression level of miR482e was downregulated, and that of several NBS-LRR targets of miR482e were upregulated. Transgenic potato plantlets overexpressing miR482e showed hypersensitivity to V. dahliae infection. Using s RNA and degradome datasets, we validated that miR482e targets m RNAs of NBS-LRR disease-resistance proteins and triggers the production of trans-acting(ta)si RNAs, most of which target m RNAs of defense-related proteins. Thus, the hypersensitivity of transgenic potato could be explained by enhanced miR482e and miR482e-derived tasi RNA-mediated silencing on NBS-LRR-disease-resistance proteins. It is speculated that a miR482-mediated silencing cascade mechanism is involved in regulating potato resistance against V. dahliae infection and could be a counter defense action of plant in response to pathogen infection. | Liu Yang Xiaoying Mu Chao Liu Jinghui Cai Ke Shi Wenjiao Zhu Qing Yang | 2015 | Journal of Integrative Plant Biology2015，57，12： | 14 |
| 4 | A continuous/discontinuous deformation analysis(CDDA)method based on deformable blocks for fracture modeling显示文摘In the framework of finite element meshes,a novel continuous/discontinuous deformation analysis(CDDA)method is proposed in this paper for modeling of crack problems.In the present CDDA,simple polynomial interpolations are defined at the deformable block elements,and a link element is employed to connect the adjacent block elements.The CDDA is particularly suitable for modeling the fracture propagation because the switch from continuous deformation analysis to discontinuous deformation analysis is natural and convenient without additional procedures.The SIFs(stress intensity factors)for various types of cracks,such as kinked cracks or curved cracks,can be easily computed in the CDDA by using the virtual crack extension technique(VCET).Both the formulation and implementation of the VCET in CDDA are simple and straightforward.Numerical examples indicate that the present CDDA can obtain high accuracy in SIF results with simple polynomial interpolations and insensitive to mesh sizes,and can automatically simulate the crack propagation without degrading accuracy. | Yongchang CAI Hehua ZHU Xiaoying ZHUANG | 2013 | Frontiers of Structural and Civil Engineering2013，7，4： | 10 |
| 5 | Plume aerodynamic effects of cushion engine in lunar landing显示文摘During the second period of China 'Tanyue' Project, the explorer will softland on the moon. The cushion engines are used to decelerate the explorer and reduce the impact on the lunar ground. It is necessary to study its plume effects on the explorer component. The self-developed PWS (Plume WorkStation) software based on direct simulation Monte Carlo (DSMC) method is used to simulate the plume effects of two 150 N engines. Due to the complex structure of the explorer, PWS uses a decoupling method to treat the boundary mesh, which mainly interacts with simulation particles, and has no relation with the computational grids. After the analytical expressions of plane surfaces and curved surfaces of each boundary block are given, the particle position within or without the boundary blocks can be easily determined. Finally the 3D plume field of two 150 N engines is simulated. The pressure, temperature and velocity distributions of plume field are clearly presented by three characteristic slices. The aerodynamic effects on the explorer bottom, the landfall legs and antenna are separately shown. The compression influence on the plume flow of four landfall legs can be observed. | He Bijiao He Xiaoying Zhang Mingxing Cai Guobiao | 2013 | Chinese Journal of Aeronautics2013，26，2： | 9 |
| 6 | On the seismic stability analysis of reinforced rock slope and optimization of prestressed cables显示文摘The evaluation of the seismic stability of high rock slopes is of vital importance to ensure the safe operation of the hydropower stations.In this paper,an equivalent pseudo-static force analysis based on the finite element method is developed to evaluate the seismic stability of reinforced rock slopes where the prestressed cables are modeled by the bar elements applied with nodal forces and bounded only at the anchored parts.The method is applied to analyze a high rock slope in south-west China and the optimization of cables.The stabilization effects of prestressed cables on the seismic stability of the slope are studied,the simulations of the concrete heading are discussed and the potential failure modes of the shear concrete plug are compared.Based on this,the optimization of cables is studied including the anchor spacing and inclined angles. | Wenbo ZHENG Xiaoying ZHUANG Yongchang CAI | 2012 | Frontiers of Structural and Civil Engineering2012，6，2： | 6 |
| 7 | Validity of distress thermometer for screening of anxiety and depression in family caregivers of Chinese breast cancer patients receiving postoperative chemotherapy显示文摘Objective:Family caregivers(FCs)of breast cancer patients play a vital role throughout the treatment process.Psychological distress of FCs is common and often ignored.A simple and effective instrument for screening psychological distress would help in selecting those FCs requiring special attention and intervention.Here,the validity of distress thermometer(DT)in FCs of Chinese breast cancer patients receiving postoperative chemotherapy was assessed,and the prevalence of anxiety and depression was evaluated.Methods:We recruited 200 FCs of hospitalized breast cancer patients in this cross-sectional descriptive study.Before the first cycle of adjuvant chemotherapy,the levels of anxiety and depression among FCs were assessed using DT and Hospital Anxiety and Depression Scale(HADS).In total,191 valid cases were analyzed.HADS was used as the diagnostic standard to assess the effectiveness of DT as a screening tool for anxiety and depression as well as to analyze the diagnostic efficiency of DT at various cutoff points.Results:The definitive prevalence of both anxiety and depression was 8.90%.The mean level of anxiety and depression among FCs was 5.64±3.69 and 5.09±3.85,respectively,both of which were significantly higher than corresponding Chinese norms(P<0.01).The areas under receiver operating characteristic curves of DT for the diagnoses of FCs'anxiety and depression were 0.904 and 0.885,respectively.A cutoff value of 5 produced the best diagnostic effects of DT for anxiety and depression.Conclusions:The levels of both anxiety and depression were higher in the FCs of Chinese breast cancer patients receiving postoperative chemotherapy than the national norm.DT might be an effective tool to initially screen psychological distress among FCs.This process could be integrated into the palliative care of breast cancer patients and warrant further research. | Min Yang Fei Ma Bo Lan Jianqiang Cai Xiaoying Sun Binghe Xu | 2020 | Chinese Journal of Cancer Research2020，32，4： | 5 |
| 8 | Extension of the low diffusion particle method for near-continuum two-phase flow simulations显示文摘The low diffusion (LD) particle method, proposed by Burt and Boyd, is modified for the near-continuum two-phase flow simulations. The LD method has the advantages of easily coupling with the direct simulation Monte Carlo (DSMC) method for multi-scale flow simulations and dramatically reducing the numerical diffusion error and statistical scatter of the equilibrium particle methods. Liquidor solid-phase particles are introduced in the LD method. Their velocity and temperature updating are respectively, calculated from the motion equation and the temperature equation according to the local gas properties. Coupling effects from condensed phase to gas phase are modeled as momentum and energy sources, which are respectively, equal to the negative values of the total momentum and energy increase in liquid or solid phase. The modified method is compared with theoretical results for unsteady flows, and good agreements are obtained to indicate the reliability of the one-way gas-to-particle coupling models. Hybrid LD-DSMC algorithm is implemented and performed for nozzle discharging gas-liquid flow to show the prospect of the LD-DSMC scheme for multi-scale two-phase flow simulations. | Su Wei He Xiaoying Cai Guobiao | 2013 | Chinese Journal of Aeronautics2013，26，1： | 3 |
| 9 | Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2显示文摘Dear Editor,Lassa virus(LASV)belongs to the Mammarenavirus genus,Arenaviridae family.Arenaviruses are classified into two main groups-Old World(OW)and New World(NW)-based on virus genetics,serology,antigenic properties and geographical relationships.The OW LASV and Lujo virus(LUJV),as well as NW Jurn'n virus(JUNV),Machupo virus(MACV),Guanarito virus(GTOV),Sabia virus(SABV)and Chapare virus(CHAPV),are known to cause severe hemorrhagic fever and are listed as biosafety level 4(BSL-4)agents.The arenavirus glycoprotein complex(GPC)contains three subunits-the retained stable-signal peptide(SSP),the receptor-binding subunit GP1,and the membrane fusion subunit GP2(Lenz et al.,2001).Notably,the proximate external membrane region and TM of GP2,together with the ectodomain loop and TMs of SSP,form an SSP-GP2 interface,playing essential roles in regulating membrane fusion,and providing targets for distinct fusion inhibitors(Larson et al.,2008;Lee et al.,2008;York et al.,2008;York and Nunberg,2009;Thomas et al.,2011;Burgeson et al.,2013a;Shankar et al.,2016;Wang et al.,2016;Wang et al.,2018).Among these inhibitors,ST-161 is LASV specific(Burgeson et al.,2013a).In this study,we conducted structure-activity relationship(SAR)optimization of ST-161.As a result,21 derivatives with IC50 values<1 pmol/L are presented in Table S1.Hit compounds 21,29 and 57 exhibiting robust inhibition of the LASV pseudotype virus(LASVpv,VSV backbone enveloped by LASV GPC with single cycle infection)entry with IC50 values lower than 0.2 nmol/L(Figs.1A and S1),as well as hit compound 72 with an ester bond instead of acylhydrazone,were further investigated.To test whether the four hit compounds inhibit LASV entry by blocking the GPC-mediated membrane fusion,the inhibition effects of these compounds against LASV GPC mediated fusion were quantitatively determined by dual-luciferase assay(Thomas et al.,2011;Wang et al.,2018). | Guangshun Zhang Junyuan Cao Yan Cai Yang Liu Yanli Li Peilin Wang Xiaoying Jia Mengmeng Zhang Gengfu Xiao Yu Guo Wei Wang | 2019 | Protein & Cell2019，10，2： | 3 |
| 10 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 11 | Effect of graph generation on slope stability analysis based on graph theory显示文摘Limit equilibrium method(LEM) and strength reduction method(SRM) are the most widely used methods for slope stability analysis. However, it can be noted that they both have some limitations in practical application. In the LEM, the constitutive model cannot be considered and many assumptions are needed between slices of soil/rock. The SRM requires iterative calculations and does not give the slip surface directly. A method for slope stability analysis based on the graph theory is recently developed to directly calculate the minimum safety factor and potential critical slip surface according to the stress results of numerical simulation. The method is based on current stress state and can overcome the disadvantages mentioned above in the two traditional methods. The influences of edge generation and mesh geometry on the position of slip surface and the safety factor of slope are studied, in which a new method for edge generation is proposed, and reasonable mesh size is suggested. The results of benchmark examples and a rock slope show good accuracy and efficiency of the presented method. | Enpu Li Xiaoying Zhuang Wenbo Zheng Yongchang Cai | 2014 | Journal of Rock Mechanics and Geotechnical Engineering2014，6，4： | 2 |
| 12 | The effect of weak interlayer on the failure pattern of rock mass around tunnel – Scaled model tests and numerical analysis显示文摘 | Feng Huang Hehua Zhu Qianwei Xu Yongchang Cai Xiaoying Zhuang | 2012 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2012，，： | 1 |
| 13 | Aqueous-Phase, Palladium-Catalyzed Heck Reaction: The Significant Role of CN-containing Counter Anion显示文摘水溶性的 diol-functionalized imidazolium 离子的液体 1,从 2,2 二度(1-methyl-methyl-imidazolium ) 准备了 propane-1,3-diol 溴化物,钾氢氧化物,和 malononitrile,在温和条件下面在水的阶段与 acrylates 为芳基卤化物的催化钯的 arylation 被用作有效没有磷化氢的 ligand。与包含 CN 阴离子协调 diol-functionalized imidazolium 阳离子的行动的 synergistic 在改进催化剂的活动和稳定性起了关键作用,这被发现。 | Cai Yueqin Song Gonghua Zhou Xiaoying | 2012 | Chinese Journal of Chemistry2012，30，12： | 1 |
| 14 | Simulation of rocket plume and lunar dust using DSMC method显示文摘 | Xiaoying He Bijiao He Guobiao Cai | 2011 | Acta Astronautica2011，，： | 1 |
| 15 | 基于上皮–间质转化标志物的循环肿瘤细胞表型检测对HER2阴性转移性乳腺癌一线化疗的预后意义显示文摘背景与目的上皮–间质转化(epithelia-mesenchymal,EMT)参与肿瘤细胞的转移,并且对基于上皮细胞黏附分子的循环肿瘤细胞(circulating tumor cells,CTCs)检测技术提出了挑战,CTCs已被证实是转移性乳腺癌的预后指标。虽然有证据表明基于EMT标志物的CTCs异质性与疾病进展相关,但在临床应用方面尚无统一的参考标准。本研究旨在评估基于EMT的动态CTCs检测对转移性乳腺癌患者的预后意义。方法我们从CAMELLIA III期前瞻性研究中招募了108例人表皮生长因子受体2阴性转移性乳腺癌患者,并应用CanPatrol CTC富集技术检测外周血中不同亚型的CTCs(包括上皮型CTCs、混合型上皮/间质CTCs和间质型CTCs)。应用1年无进展生存(progression-free survival,PFS)率作为界值分别寻找CTC总数和间质CTCs比例的受试者工作曲线来确定最佳阈值,并采用Kaplan-Meier分析和Cox比例风险回归分析验证综合考虑CTC总数和间质型CTCs比例制定的诊断标准的预后价值。结果CTC总数的最佳阈值为9.5[曲线下面积(area under the curve,AUC)=0.538,95%置信区间(confidence interval,CI=0.418–0.657)]及间质CTCs比例为10.7%(AUC=0.581,95%CI:0.463–0.699)作为预测1年PFS率的界值。我们采用CTC总数≥10/5 mL且间质CTCs比例>10.7%的联合标准预测PFS。符合联合标准的患者的中位PFS显著短于不符合标准的患者(6.2个月vs.9.9个月,P=0.010)。根据该标准和显著的临床病理学特征绘制列线图,C指数为0.613(P=0.010)。结论CTC总数和间质CTCs比例的联合标准可用于监测转移性乳腺癌患者的治疗耐药性和预测患者预后。 | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | 癌症2019，38，9： | 1 |
| 16 | Simulation of two-phase plume field of liquid thruster显示文摘When the liquid propellant thruster works,its plume field would contain many propellant liquid droplets,especially at pulse state.Liquid droplets may move along with the gas flow and deposit on the components of spacecraft as contamination.The simulation of the plume field involving the gas molecules and liquid droplets is an important part in contamination studies of thruster plume.Based on the PWS software developed by Beihang University(BUAA),axial-symmetric two-phase direct simulation Monte Carlo(DSMC) method is used with the liquid droplet taken as a kind of solid particle.The computation of gas-to-particle effect and gas reflection on the particle surface are decoupled.The inter-particle collision is also considered.The gas parameters at nozzle exit of 120N engine after 20 ms pulse work are taken as the entrance condition of the numerical simulation.Four test cases are conducted for comparison of different collision modules.Simulation results show that the effects of liquid propellant droplets mainly concentrate near the axis line of engine.The particle-to-gas collision would cause evident differences in the gas field and subtle differences in the particle phase.The liquid droplets in the plume field are generally accelerated and convected by the gas molecules.The DSMC method is proved to be a feasible solver to numerically simulate the two-phase flow involving solid phase and rarefied gas flow. | HE XiaoYing HE BiJiao CAI GuoBiao | 2012 | Science China(Technological Sciences)2012，55，6： | 1 |
| 17 | Motion speed modulates walking direction discrimination: The role of the feet in biological motion perception显示文摘The human visual system is tuned to the motions of biological entities, which provide potentially vital information for survival. The current study examines the interplay between motion speed and motion direction perception. Following a brief presentation of a point-light walker walking straight ahead or slightly leftward or rightward, observers were asked to quickly judge the walking direction (left or right). Participants showed better direction discrimination when the walker walked at a fast pace compared to a natural or slow pace, and this was not simply due to a difference in motion cycles. Moreover, walking direction sensitivity could be enhanced by increasing the feet motion speed alone, so long as the direction of feet movement was consistent with that of the other body parts. These findings demonstrate that our perception of walking direction is influenced by local motion speed, and highlight the role of the feet in biological motion perception. | CAI Peng YANG XiaoYing CHEN Lin JIANG Yi | 2011 | Chinese Science Bulletin2011，56，19： | 1 |
| 18 | Discovery and bioassay of disubstituted β-elemene-NO donor conjugates:synergistic enhancement in the treatment of leukemia显示文摘Natural products are essential sources of antitumor drugs.One such molecule,β-elemene,is a potent antitumor compound extracted from Curcuma wenyujin.In the present investigation,a series of novel 13,14-disubstituted nitric oxide(NO)-donorβelemene derivatives were designed,withβ-elemene as the foundational compound,and subsequently synthesized to evaluate their therapeutic potential against leukemia.Notably,the derivative labeled as compound 13d demonstrated a potent anti-proliferative activity against the K562 cell line,with a high NO release.In vivo studies indicated that compound 13d could effectively inhibit tumor growth,exhibiting no discernible toxic manifestations.Specifically,a significant tumor growth inhibition rate of 62.9%was observed in the K562 xenograft tumor mouse model.The accumulated data propound the potential therapeutic application of compound 13d in the management of leukemia. | ZHU Junlong JIANG Xiaoying LUO Xinyu GAO Yuan ZHAO Rui LI Junjie CAI Hong DANG Xiawen YE Xiangyang BAI Renren XIE Tian | 2023 | Chinese Journal of Natural Medicines2023，21，12： | 1 |
| 19 | Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle显示文摘 | Huanxing Su Lihui Wang Jinglei Cai Qiuju Yuan Xiaoying Yang Xiaoli Yao Wai-Man Wong Wenhao Huang Zhiyuan Li Jian-Bo Wan Yitao Wang Duanqing Pei Kwok-Fai So Dajiang Qin Wutian Wu | 2013 | Stem Cell Research2013，，1： | 1 |
| 20 | Antibiotics in global rivers显示文摘Antibiotics have received extensive attention due to their sophisticated effects on human health and ecosystems.However,there is an extreme scarcity of information on composition,content,geographic distribution,and risk of riverine antibiotics at a large spatial scale.Based on a systematic review of over 600 pieces of literature(1999-2021),we established a global dataset containing more than 90,000 records covering 169 antibiotics and their metabolites in surface water and sediment across 76 countries.The occurrence of prioritized antibiotics largely depended on socioeconomic developmental levels,and the current“hotspots”of polluted rivers were found mostly in less developed countries or emerging economies(e.g.,some in Africa,South America,and Asia).By developing the screening protocol for risk-based prioritization of antibiotics,we advanced a rank list of antibiotics for guiding formulation of region-specific strategies,which highlighted the importance of whole life cycle management of antibiotics in health maintenance of the world’s rivers. | Si Li Yi Liu Yang Wu Jingrun Hu Yiqing Zhang Qian Sun Weiling Sun Jiagen Geng Xiaoying Liu Dantong Jia Xiuqi You Dianqing Qi Moran Tang Yitao Lyu Fanguang Kong Leilei Cai Yufan Ai Yichu Wang Jinren Ni | 2022 | National Science Open2022，1，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员