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| 1 | Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography显示文摘BACKGROUND Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques(CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients. However, there are no studies correlating subclinical atherosclerosis and adverse events(AE) in obese subjects.AIM To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1, 2006 to December 31, 2010, 2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography. Exclusion criteria included previous vascular disease, left ventricular ejection fraction < 50%, positive EE, significant valvular heart disease and inferior to submaximal EE. An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident. Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography Consensus.RESULTS Of the 652 patients who fulfilled the inclusion criteria, 226(34.7%) had body mass indexes ≥ 30 kg/m2, and 76 of them(33.6%) had CP. During a mean follow-up time of 8.2(2.1) years, 27 AE were found(11.9%). Mean event-free survival at 1, 5 and 10 years was 99.1%(0.6), 95.1%(1.4) and 86.5%(2.7), respectively. In univariate analysis, CP predicted AE [hazard ratio(HR) 2.52, 95% confidence interval(CI) 1.17-5.46; P = 0.019]. In multivariable analysis, the presence of CP remained a predictor of AE(HR 2.26, 95%CI 1.04-4.95, P = 0.041). Other predictors identified were glomerular filtration rate(HR 0.98, 95%CI 0.96-0.99; P= 0.023), peak metabolic equivalents(HR 0.83, 95%CI 0.70–0.99, P = 0.034) and moderate mitral regurgitation(HR 5.02, 95%CI 1.42–17.75, P = 0.012).CONCLUSION Subclinical atherosclerosis defined by CP predicts AE in obese patients with negative EE. These patients could benefit from aggressive prevention measures. | Rafael Vidal-Perez Raúl Franco-Gutiérrez Alberto J Pérez-Pérez Virginia Franco-Gutiérrez Alberto Gascón-Vázquez Andrea López-López Ana María Testa-Fernández Carlos González-Juanatey | 2019 | World Journal of Cardiology2019，11，1： | 7 |
| 2 | Comparison of two clinical scales for causality assessment in hepatotoxicity显示文摘 | Ma Isabel Lucena Raquel Camargo Raúl J. Andrade Carlos J. Perez-Sanchez Felipe Sanchez De La Cuesta | 2001 | Hepatology2001，，1： | 2 |
| 3 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 4 | Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants显示文摘 | Stoll B J Hansen N Fanaroff AA Wright LL Carlo WA Ehrenkranz RA | 2002 | N Engl J Med2002，347，4： | 1 |
| 5 | Physiology and Pathology of Ovarian Hyperstimulation Syndrome显示文摘 | Raúl Gómez Sergio Soares Cristiano Busso Juan Garcia-Velasco Carlos Simón Antonio Pellicer | 2010 | Semin Reprod Med2010，，06： | 1 |
| 6 | Halophilic hydrolases as a new tool for the biotechnological industries显示文摘 | Mariana Delgado‐García Blanca Valdivia‐Urdiales Cristóbal Noe Aguilar‐González Juan Carlos Contreras‐Esquivel Raúl Rodríguez‐Herrera | 2012 | J. Sci. Food Agric2012，，13： | 1 |
| 7 | The effect of the vehicles on the pHof calcium ydroxide显示文摘 | Donald RA Terenc e MG Carlos ER | 1982 | Oral Surg1982，54，： | 1 |
| 8 | Syphilis: diagnosis, treatment and control显示文摘 | Joao Carlos RA Giuliana B | 2006 | An Bras Dermatol2006，81，2： | 1 |
| 9 | Separation of nickel ( Ⅱ), cobalt (Ⅱ) and lanthanides from spent Ni-MH batteries by hydro- chloric acid leaching, solvent extraction and precipitati- on显示文摘 | Aline Fernandes Julio Carlos Afonso Achilles Junquei- ra Bourdot Dutra | 2013 | Hydrometallurgy2013，133，： | 1 |
| 10 | Emotional responsivity to others: behavioral Correlates and socialization antecedents 显示文摘 | Eisenberg N Fabes RA Carlo G | 1992 | New Dir Child Dev1992，55，1： | 1 |
| 11 | Cryopreservation does not alter the ultrastructure of the meniscus显示文摘 | Pablo Eduardo Gelber Gemma Gonzalez Raúl Torres Natalia Garcia Giralt Enrique Caceres Juan Carlos Monllau | 2009 | Knee Surgery Sports Traumatology Arthroscopy2009，，6： | 1 |
| 12 | Late-onset sepsis in very low birth weight neo-nates:the experience of the NICHD Neonatal Research Network显示文摘 | Stoll BJ Hansen N Fanaroff AA Wright LL Carlo WA Ehren-kranz RA | 2002 | Pediatrics2002，110，21： | 1 |
| 13 | Surfactant replacement therapy for preterm and term neonates with respiratory distress 显示文摘 | Polin RA Carlo WA | 2014 | Pediatrics2014，133，1： | 1 |
| 14 | Treatment with 1-MCP and the role of ethylene in aroma development of mountain papaya fruit显示文摘 | Cristian Balbontín Carlos Gaete-Eastman Mireya Vergara Raúl Herrera María Alejandra Moya-León | 2006 | Postharvest Biology and Technology2006，，1： | 1 |
| 15 | Buccinator Myomucosal Flap as Soft Tissue Covering for Vascularized Free Fibular Flap in Anterior Maxillary Bony Defects显示文摘 | Raúl González-García Luis Ruiz-Laza Damián Manzano Leticia Román-Romero Carlos Moreno Florencio Monje | 2010 | Journal of Oral and Maxillofacial Surgery2010，，4： | 1 |
| 16 | PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways显示文摘 | Jordi Camps Anabel García-Heredia Anna Rull Carlos Alonso-Villaverde Gerard Aragonès Raúl Beltrán-Debón Esther Rodríguez-Gallego Jorge Joven J. Reddy | 2012 | PPAR Research2012，，： | 1 |
| 17 | Surfactant replacement therapy for preterm and term neonates with respiratory distress 显示文摘 | Polin RA Carlo WA | 2014 | Pediatrics2014，133，1： | 1 |
| 18 | Second-trimester pregnancy termination with 600-μg vs. 400-μg vaginal misoprostol and systematic curettage postexpulsion: a randomized trial显示文摘 | Josep L. Carbonell Miguel A. Torres Raúl Reyes Lourdes Ortega Francisca García-Gallego Carlos Sánchez | 2008 | Contraception2008，，1： | 1 |
| 19 | Kinematics and dynamics of 2(3-RPS) manipulators by means of screw theory and the principle of virtual work显示文摘 | JAIME G CARLOS RA LUIS C | 2008 | Mechanism and Machine Theory2008，43，10： | 1 |
| 20 | A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination显示文摘 | Juliana Cassataro Karina A. Pasquevich Silvia M. Estein Diego A. Laplagne Carlos A. Velikovsky Silvia de la Barrera Raúl Bowden Carlos A. Fossati Guillermo H. Giambartolomei Fernando A. Goldbaum | 2007 | Vaccine2007，，22： | 1 |
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