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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | Transient simulation code development of prima- ry coolant system of Chinese Experimental Fast Reactor显示文摘 | CUI Manman GUO Yun ZHANG Zhijian | 2013 | Annals of Nuclear Energy2013，，53： | 1 |
| 3 | A comparative study on grid resource utilization rate between China Southern Power Grid and National Grid Plc of UK显示文摘Grid resource utilization rate plays a key role in power grid operation.Although the proportion of population and the area in China Southern Power Grid(CSG)and National Grid Plc of UK(NG)are nearly,grid resources utilization of CSG is lower than that of NG.In this paper,the utilization of human resources and equipment resources of CSG and NG have been reviewed.It is discovered that there is a large gap between these two companies.The results show that the utilization in CSG is about 20%to 50%of that in NG.And it is estimated that if the equipment resources utilization of CSG increases to the level of NG in 2012,the coal consumption and thus CO2 emissions would be reduced by 17 million tons and 21 million tons,respectively.As China is a developing country and Britain is a mature developed country,it is to some extent reasonable that grid resources utilization of CSG is lower than that of NG.The benefits of improving equipment resources utilization are illustrated in detail,which provided the reference for developing the grid resource utilization in China. | Long Zhou Di Zhang Weijie Wu Manman Zhu Hanyu Yang Canbing Li Ge Li Fei Li Mingjian Cui | 2018 | Protection and Control of Modern Power Systems2018，3，1： | 0 |
| 4 | Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives显示文摘Tissue engineering aims to offer large-scale replacement of damaged organs using implants with the com-bination of cells,growth factors and scaffolds.However,the intra/peri-implant region is exposed to se-vere hypoxic stress and oxidative stress during the early stage of implantation with bone graft materials,which endangers the survival,proliferation and differentiation of seed cells within the implants as well as the host cells surrounding the implants.If the bone graft material could spontaneously and intelligently regulate the hypoxic stress and oxidative stress to a moderate level,it will facilitate the vascularization of the implants and the rapid regeneration of the bone tissue.In this review,we will first introduce the signaling pathways of cellular response under hypoxic stress and oxidative stress,then present the clas-sical material designs and examples in response to hypoxic stress and oxidative stress.And finally,we will address the important role of epigenetic mechanisms in the regulation of hypoxic stress and oxida-tive stress and describe the potential applications and prospective smart bone graft materials based on novel epigenetic factors against hypoxic stress and oxidative stress in bone repair.The main content of this review is summarized in the following graphical abstract. | Hao Hu Xiao Liu Jun Chen Shangbin Cui Hualin Yi Gang Wang Renxian Wang Tiansheng Zheng Ben Wan Zhiyu Zhou Yong Wan Manman Gao Dafu Chen Xuenong Zou | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
| 5 | Data Watch on China's Foreign Trade and Investment in the First Five Months of 2011显示文摘According to the Statistics of China Customs, China's imports and exports registered US$1401.79 billion in the first fives months of the year, an increase of 27.4% year on year, 16.6 percentage points lower than the same period of last year, Specifically, exports reached US$712.38 billion, an increase of 25.5%, 7.7 percentage points lower than the same period of last year; imports reached US$689.41 billion, an increase of 29.4%, 28.1 percentage points lower than the same period of last year. The trade surplus stood at US$22.97 billion, a decline of 35.1%. | Yan Manman, Cui Xiaoling | 2011 | China's Foreign Trade2011，，7： | 0 |
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