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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Nutrients removal and biomass production from anaerobic digested effluent by microalgae: A review显示文摘This article summarizes the recent progress of nutrient removal from wastewater via microalgae.Removal of nitrogen and phosphorous compounds from wastewater are of great importance,while those compounds are suitable for growth of some microalgae species.Such a combination provides more opportunities for anaerobic digestion facilities,which are producing large amount of wastewater with high nitrogen and phosphorous contents.However,in order to optimize and maximize the performance and durability of the nutrient removal process,it is suggested that the basic principles about nitrogen and phosphorous migration should be investigated thoroughly,especially from the fundamentals of substance transfer mechanism between water environment and algal cells. | Gang Li Xue Bai Huan Li Zhitao Lu Yuguang Zhou Yingkuan Wang Jinxin Cao Zhigang Huang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，5： | 5 |
| 4 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 5 | HY5-HDA9 orchestrates the transcription of HsfA2 to modulate salt stress response in Arabidopsis显示文摘Integration of light signaling and diverse abiotic stress responses contribute to plant survival in a changing environment.Some reports have indicated that light signals contribute a plant’s ability to deal with heat,cold,and stress.However,the molecular link between light signaling and the saltresponse pathways remains unclear.We demonstrate here that increasing light intensity elevates the salt stress tolerance of plants.Depletion of HY5,a key component of light signaling,causes Arabidopsis thaliana to become salinity sensitive.Interestingly,the small heat shock protein(sHsp)family genes are upregulated in hy5-215 mutant plants,and HsfA 2 is commonly involved in the regulation of these sH sps.We found that HY5directly binds to the G-box motifs in the HsfA2promoter,with the cooperation of HISTONE DEACETYLASE 9(HDA9),to repress its expression.Furthermore,the accumulation of HDA9 and the interaction between HY5 and HDA9 are significantly enhanced by salt stress.On the contrary,high temperature triggers HY5 and HDA9 degradation,which leads to dissociation of HY5-HDA9from the HsfA2 promoter,thereby reducing salt tolerance.Under salt and heat stress conditions,fine tuning of protein accumulation and an interaction between HY5 and HDA9 regulate HsfA2 expression.This implies that HY5,HDA9,and HsfA2play important roles in the integration of light signaling with salt stress and heat shock response. | Jiaheng Yang Xiao Qu Tao Li Yixiang Gao Haonan Du Lanjie Zheng Manchun Ji Paifeng Zhang Yan Zhang Jinxin Hu Liangyu Liu Zefu Lu Zijian Yang Huiyong Zhang Jianping Yang Yongqing Jiao Xu Zheng | 2023 | Journal of Integrative Plant Biology2023，65，1： | 1 |
| 6 | Aqueous synthesis of 79%efficient AgInGaS/ZnS quantum dots for extremely high color rendering white light-emitting diodes显示文摘Over the past few decades,I-III-VI quantum dots(QDs)have attracted considerable attention due to their large Stokes shifts,good eco-friendliness,and wide tunable emissions.In this work,a facile microwave-assisted aqueous route using glutathione(GSH)and citric acid(CA)as dual stabilizers is introduced to synthesize AgInGaS/ZnS(AIGS/ZnS)core/shell QDs.An exceptional photoluminescence quantum yield(PL QY)as high as 79%is successfully achieved,boosting the best performance of water-dispersible AIGS QDs.By varying the Ag/Ga ratio,the PL peak wavelength can be tuned from 547 to 616 nm,and luminescent hydrogel films with different colors are obtained by embedding AIGS/ZnS QDs in polyacrylamide/poly-vinyl alcohol(PAAm/PVA)hydrogels.The white light-emitting diode(WLED)with a high color rendering index(CRI)of 92.1(R_(9)=92.0)and a correlated color temperature(CCT)of 3022 K is fabricated using QDs-PAAm/PVA hydrogel films in combination with a blue InGaN LED chip,indicating that the as-prepared QDs are competitive color-conversion materials for WLEDs. | Zhe Hu Hanxu Lu Wenjie Zhou Jinxin Wei Hanqing Dai b Hong Liu Zhiyong Xiong Fengxian Xie Wanlu Zhang Ruiqian Guo | 2023 | Journal of Materials Science & Technology2023，，3： | 1 |
| 7 | Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering显示文摘Lanthanum(La)has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic disorders.However,controlling its distribution and keeping the release of La^(3+)ions sustained and steady in the body is still a big challenge.In this study,we prepared La-OCP powders via co-precipitation method,and further prepared La-OCP/PLA porous scaffolds by 3 D printing.La^(3+)was successfully introduced into the OCP crystal structure and substituted Ca^(2+)at the Ca-5 and Ca-8 sites.In particular,some La^(3+)ions were deposited on the crystal surface in the form of nanoparticles.Both octacalcium phosphate(OCP,Ca_(8)H_(2)(PO_(4))_6·5 H_(2)O)crystals and nanoparticles played as the carriers for La^(3+)ions.The La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La^(3+).The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere,grow and proliferation.At a certain La^(3+)concentration,the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes,thus promoting the osteogenic differentiation of BMSCs.Moreover,the extracts regulated the immune responses.The experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in vivo.These findings suggest that 3 D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering. | Zeya Xu Bin Lin Chaoqian Zhao Yanjin Lu Tingting Huang Yan Chen Jungang Li Rongcan Wu Wenge Liu Jinxin Lin | 2022 | Journal of Materials Science & Technology2022，，23： | 1 |
| 8 | Evaluating Water Withdrawals for Regional Water Management Under a Data-driven Framework显示文摘With an increase in population and economic development,water withdrawals are close to or even exceed the amount of water available in many regions of the world.Modelling water withdrawals could help water planners improve the efficiency of water use,water resources allocation,and management in order to alleviate water crises.However,minimal information has been obtained on how water withdrawals have changed over space and time,especially on a regional or local scale.This research proposes a data-driven framework to help estimate county-level distribution of water withdrawals.Using this framework,spatial statistical methods are used to estimate water withdrawals for agricultural,industrial,and domestic purposes in the Huaihe River watershed in China for the period 1978–2018.Total water withdrawals were found to have more than doubled,from 292.55×10^(8)m^(3) in 1978 to 642.93×10^(8)m^(3) in 2009,and decreased to 602.63×10^(8)m^(3) in 2018.Agricultural water increased from 208.17×10^(8)m^(3) in 1978 to 435.80×10^(8)m^(3) in 2009 and decreased to 360.84×10^(8)m^(3) in 2018.Industrial and domestic water usage constantly increased throughout the 1978–2018 period.In 1978,industrial and domestic demands were 20.35×10^(8)m^(3) and 60.04×10^(8)m^(3),respectively,and up until 2018,the figures were 105.58×10^(8)m^(3) and 136.20×10^(8)m^(3).From a spatial distribution perspective,Moran’s I statistical results show that the total water withdrawal has significant spatial autocorrelation during 1978–2018.The overall trend was a gradual increase in 1978–2010 with withdrawal beginning to decline in 2010–2018.The results of Getis-Ord G_(i)^(*)statistical calculations showed spatially contiguous clusters of total water withdrawal in the Huaihe River watershed during1978–2010,and the spatial agglomeration weakened from 2010 to 2018.This study provides a data-driven framework for assessing water withdrawals to enable a deeper understanding of competing water use among economic sectors as well as water withdrawal modelled with proper data resource and method. | LU Yan WANG Jinxin LIU Jianzhong QIN Fen WANG Jiayao | 2022 | Chinese Geographical Science2022，32，3： | 0 |
| 9 | 3,4-Dinitrobenzamide Functionalized CdTe/ZnTe Quantum Dots as a Nanoprobe for Imaging Glutathione S-Transferase in Living Cells显示文摘一篇小说荧光灯为谷胱甘肽 S-transferase (GST ) 的 nanoprobe 被合并 3,4-dinitrobenzamide (GST 的特定的底层) 到 CdTe/ZnTe 量点上开发了。探查本身在量点上由于 3,4-dinitrobenzamide 的撤退电子的单位的强壮的熄灭效果显示一个低背景信号。然而, GST 能高效地在 nanoprobe 的 p-nitro 组上催化减少的谷胱甘肽的亲核的替换,导致大荧光改进。最尤其是,这改进向 GST 显示出高选择和敏感而不是另外的生物物质。与这 nanoprobe,为细胞内部的 GST 的一个简单荧光成像方法被建立了,并且它的适用性成功地在不同生活房间为成像 GST 被表明了,它表明 A549 房间表示大约 3 比 NIH-3T3 和 Hela 房间高预定的 GST。 | Jinxin Lu Yanchao Song Wen Shi Xiaohua Li Huimin Ma | 2013 | Chinese Journal of Chemistry2013，31，4： | 0 |
| 10 | Revealing an initiation inhibition of RCA and its application in nucleic acid detection显示文摘Rolling circle amplification is a widely used biosensing technique.Although various secondary structures have been employed in RCA,their effects on RCA efficiency have seldom been reported.Here,we find that stems in circular templates can strongly inhibit RCA,and the primer-stem distance is responsible for the inhibition.Based on the results,we propose an initiation inhibition mechanism and present a design principle for a general RCA assay.Inspired by this mechanism,we further propose a new nucleic acid detection method.The results verify that this method can increase RCA detection sensitivity according to the target recycling principle.Besides DNA detection,it can also achieve single mismatch discrimination of miRNA detection after optimization.This method also shows convenient visualization detection.The initiation inhibition of RCA could be helpful for RCA applications as promising detection techniques. | Qian Zhuang Meiqiong Ge Xiaodong Yu Jing Chai Lu Zhang Suming Tang Hua Wei Jinxin Zhang Guojie Zhao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 0 |
| 11 | Variation in Leaf Shapes of Nitraria Species and Effect on Leaf δ^(13)C显示文摘Leaf shapes are not only the useful indicators in plant taxonomy,but also the important factors affecting energy and material exchange in leaves.In this paper,we collected and scanned the leaves of Nitraria tangutorum in Dengkou of Inner Mongolia Autonomous Region(the mean annual precipitation 145 mm) and Minqin of Gansu Province (the mean annual precipitation 115 mm) and N. sphaerocarpa in Dunhuang,and then analyzed leaf shape parameters with Image - Pro Plus6.0 image processing software and leafδ13C values in the isotope laboratory of the Chinese Academy of Forestry.The result showed that:1) as leaf area increased with increasing water availability the increases in the leaf length and width were asynchronously;2) with the same leaf width,the 1 eaves of N.tangutorum and N.sphaerocarpa were significantly longer in high water available conditions;and 3) although there were significantly differences in water availability between Dengkou and Minqin,as well as between the bottom and middle of the alluvial fan near the East Lake in Dunhuang,the leafδ13C values of N.tangutorum or N.sphaerocarpa were similar in different water conditions(P>0.05).Our results suggested that the ratio of leaf perimeter to area would be an important factor which linked leaf shape to plant water physiology.During growing procedure of leaf area,leaf length increase was prior to its width to alleviate the reduction in ratio of perimeter to area and maintain water use efficiency of the plant. | Li Yonghua Wu Bo Lu Qi Jin Zhanhu Liu Dianjun Zhang Jinxin | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 12 | Synergistic Effects of Rotavirus and Co-Infecting Viral Enteric Pathogens on Diarrheal Disease-Guangzhou City,Guangdong Province,China,2019显示文摘What is already known about this topic?Diarrhea represents a substantial public health issue,contributing globally to a high number of pediatric medical consultations,hospital admissions,and mortality rates.What is added by this report?An increase in diarrheal frequency serves as a critical benchmark for evaluating severity.The predominant pathogens associated with pediatric diarrhea are rotavirus and norovirus,with co-infections exerting a notable compounding effect that leads to more severe diarrhea.What are the implications for public health practice?Implementing sensitive diagnostic techniques and comprehensive monitoring is paramount in identifying co-infections.Such strategies can provide physicians with critical insights into disease progression,thus considerably reducing the burden of diarrhea. | Shunxian Zhang Liguang Tian Yan Lu Lei Wang Wenwen Lyu Jinxin Zheng Shan Lyu Lili Pang Guobing Yang Hongli Wang Ruitao Liu Guanhua Chen Jichun Wang | 2023 | China CDC weekly2023，5，33： | 0 |
| 13 | 二维晶格形变恢复规律的研究显示文摘文章简介晶格直接决定电子结构,它能够通过使二维(2D)材料的晶格变形来可控地裁剪属性。由于位错原子之间存在静电平衡不平衡,因此变形后的晶格在热力学上极不稳定,会恢复到初始态。在本研究中,课题组证明了通过掺杂金属给体来重建静电平衡,可以直接调节变形的2D晶格的恢复。 | Jinxin Liu Lu Zhou Ke Huang Xianyin Song Yunxu Chen Xiaoyang Liang Jin Gao Xiangheng Xiao Mark HRümmeli 付磊 | 2020 | 科学新闻2020，，2： | 0 |
| 14 | Oestrogen ameliorates blood-brain barrier damage after experimental subarachnoid haemorrhage via the SHH pathway in male rats显示文摘Background Sex differences affect the occurrence,progression and regression of subarachnoid haemorrhage(SAH).Oestrogen plays a protective role in alleviating the vasospasm and neuronal apoptosis induced by SAH.However,whether oestrogen affects blood‒brain barrier(BBB)integrity has not been fully studied.Oestrogen has been found to regulate the sonic hedgehog(SHH)signalling pathway through the oestrogen receptor in gastric cancer and adrenal glands,and the SHH signalling pathway has an important role in maintaining the BBB by upregulating the expression of tight junction proteins.In this study,we investigated the relationship between oestrogen and the SHH signalling pathway using clinical data and established an experimental SAH model to explore whether oestrogen could ameliorate BBB damage after SAH through the SHH pathway.Methods Correlations between oestrogen and the SHH pathway were analysed by patients’cerebrospinal fluid(CSF)samples and the Genotype-Tissue Expression database(GTEx).Then,an experimental rat SAH model was established using the endovascular perforation method and treated with oestrogen,oestrogen inhibitors and SHH signalling pathway inhibitors.Then,the effects of oestrogen on BBB damage were analysed by western blot,immunofluorescence and neurobehavioural experiments.Results ESLIA detection and correlation analysis showed that oestrogen levels in patients’CSF were positively correlated with the SHH pathway,which was further verified by GTEx gene-correlation analysis.SHH was found to be mainly expressed in neurons and astrocytes in rats under physiological conditions and was upregulated by oestrogen pretreatment.In the SAH model,oestrogen pretreatment was found to reverse SAH-induced decreases in the SHH pathway,which were counteracted by oestrogen receptor inhibitors.Furthermore,oestrogen pretreatment reduced SAH-induced BBB damage,brain oedema and neurological dysfunction,which were eliminated by SHH pathway inhibitors.Conclusion In conclusion,we demonstrate here that oestrogen pretreatment ameliorates brain injury after SAH,at least in part through SHH pathway-mediated BBB protection. | Jie Zhang Haiying Li Zhongmou Xu Jinxin Lu Chang Cao Haitao Shen Xiang Li Wanchun You Gang Chen | 2023 | Stroke & Vascular Neurology2023，8，3： | 0 |
| 15 | Tuning osteoporotic macrophage responses to favour regeneration by Cu-bearing titanium alloy in Porphyromonas gingivalis lipopolysaccharide-induced microenvironments显示文摘Guided bone regeneration in inflammatory microenvironments of osteoporotic patients with large alve-olar bone defects remains a great challenge.Macrophages are necessary for alveolar bone regeneration via their polarization and paracrine actions.Our previous studies showed that Cu-bearing Ti6AI4V alloys are capable of regulating macrophage responses.When considering the complexity of oral microenvir-onments,the influences of Cu-bearing Ti6AI4V alloys on osteoporotic macrophages in infectious microenvironments are worthy of further investigations.In this study,we fabricated Ti6AI4V-Cu alloy by selective laser melting technology and used Porphyromonas gingivalis lipopolysaccharide(P.g-LPS)to imitate oral pathogenic bacterial infections.Then,we evaluated the impacts of T6AI4V-Cu on osteoporotic macrophages in infectious microenvironments.Our results indicated that Ti6AI4V-Cu not only inhibited the P.g-LPS-induced M1 polarization and pro-inflammatory cytokine production of osteoporotic macrophages but also shifted polarization towards the pro-regenerative M2 phenotype and remarkably promoted antinflammatory cytokine release.In addition,T6AI4V-Cu effectively promoted the actity of COMMD1 to potentially repress NF-κB-mediated transcription.It is concluded that the Cubearing Ti6AI4V alloy results in ameliorated osteoporotic macrophage responses to create a favourable microenvironment under infectious conditions,which holds promise to develop a GBR-barrier membrane for alveolar bone regeneration of osteoporosis patients. | Xiongcheng Xu Yanjin Lu Ling Zhou Mengjiao He Jin Zhuo Quan Zhong Kai Luo Jinxin Lin | 2021 | Regenerative Biomaterials2021，8，1： | 0 |
| 16 | Security-Critical Components Recognition Algorithm for Complex Heterogeneous Information Systems显示文摘With the skyrocketing development of technologies,there are many issues in information security quantitative evaluation(ISQE)of complex heterogeneous information systems(CHISs).The development of CHIS calls for an ISQE model based on security-critical components to improve the efficiency of system security evaluation urgently.In this paper,we summarize the implication of critical components in different filed and propose a recognition algorithm of security-critical components based on threat attack tree to support the ISQE process.The evaluation model establishes a framework for ISQE of CHISs that are updated iteratively.Firstly,with the support of asset identification and topology data,we sort the security importance of each asset based on the threat attack tree and obtain the security-critical components(set)of the CHIS.Then,we build the evaluation indicator tree of the evaluation target and propose an ISQE algorithm based on the coefficient of variation to calculate the security quality value of the CHIS.Moreover,we present a novel indicator measurement uncertainty aiming to better supervise the performance of the proposed model.Simulation results show the advantages of the proposed algorithm in the evaluation of CHISs. | Jinxin Zuo Yueming Lu Hui Gao Tong Peng Ziyv Guo Tong An Enjie Liu | 2021 | Computers, Materials & Continua2021，，8： | 0 |
| 17 | Tuning the Corrosion Resistance,Antibacterial Activity,and Cytocompatibility by Constructing Grooves on the Surface of Ti6Al4V3Cu Alloy显示文摘Ti6Al4V3Cu alloy is a promising biomaterial for combating implant-related infection.However,the antibacterial property of Ti6Al4V3Cu is expected to be enhanced due to the low content of Cu element in titanium.To address this issue,the antibacterial property of Ti6Al4V3Cu was tailored by the grooves with different groove widths(30μm,60μm,and 90μm)that were constructed on the surface of the Ti6Al4V3Cu by selective laser melting.The effect of grooves on corrosion resistance,antibacterial property,and cytocompatibility was investigated.The electrochemical tests showed that the corrosion resistance decreased with increasing groove width.The antibacterial tests indicated that the groove with a width of 30μm and 90μm groups showed better antibacterial activity against S.aureus(>90%)compared with the groove with a width of 60μm.The in vitro study suggested that all samples with different grooves were found to exhibit good cytocompatibility with osteoblast cells.It is considered that creating grooves on Ti6Al4V3Cu by selective laser melting is a promising strategy to enhance the antibacterial activity without sacrificing cytocompatibility. | Minghui Zhou Hui Sun Yanming Gan Cheng Ji Yan Chen Yanjin Lu Jinxin Lin Qiang Wang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，12： | 0 |
| 18 | Retrospective Analysis of the Duration of Hospitalization of Imported Patients Infected with SARS-CoV-2 in Guangzhou, 2021显示文摘The pandemic of coronavirus disease 2019 is“not over,”in fact,the“dynamic clearing”policy for SARS-CoV-2 control and prevention in China has been firmly enforced.This study aimed to analyze the clinical symptoms and dynamic viral RNA changes in 2021 at Guangzhou Eighth People’s Hospital.This study showed that 31.4%of the patients(695/2212)tested negative for viral RNA from admission to the final release from quarantine.Of all negative cases,86.5%(601/695)remained in the hospital for no more than 5 days and were asymptomatic or mild.Among the remaining 402 patients who stayed for no more than 5 days,76.4%(307/402)were viral RNA retest positive during the isolation stage.However,96.4%of the peak viral RNA(296/307)was over Ct=33 cycles during the isolation stage. | Zhiwei Xie Guofang Tang Lu Li Jingrong Shi Qingxin Gan Xiaowen Zheng Jingyan Tang Huimin Zeng Chuyu Zhang Sisi Cheni Jianping Cui Zishi Lin Lihua Lin Youxia Li Jinxin Liu Feng Li Fengyu Hui Xiaoping Tang Xilong Deng | 2023 | Infectious Diseases & Immunity2023，3，1： | 0 |
| 19 | Comprehensive Information Security Evaluation Model Based on Multi-Level Decomposition Feedback for IoT显示文摘The development of the Internet of Things(IoT)calls for a comprehensive in-formation security evaluation framework to quantitatively measure the safety score and risk(S&R)value of the network urgently.In this paper,we summarize the architecture and vulnerability in IoT and propose a comprehensive information security evaluation model based on multi-level decomposition feedback.The evaluation model provides an idea for information security evaluation of IoT and guides the security decision maker for dynamic protection.Firstly,we establish an overall evaluation indicator system that includes four primary indicators of threat information,asset,vulnerability,and management,respectively.It also includes eleven secondary indicators of system protection rate,attack detection rate,confidentiality,availability,controllability,identifiability,number of vulnerabilities,vulnerability hazard level,staff organization,enterprise grading and service continuity,respectively.Then,we build the core algorithm to enable the evaluation model,wherein a novel weighting technique is developed and a quantitative method is proposed to measure the S&R value.Moreover,in order to better supervise the performance of the proposed evaluation model,we present four novel indicators includes residual risk,continuous conformity of residual risk,head-to-tail consistency and decrease ratio,respectively.Simulation results show the advantages of the proposed model in the evaluation of information security for IoT. | Jinxin Zuo Yueming Lu Hui Gao Ruohan Cao Ziyv Guo Jim Feng | 2020 | Computers, Materials & Continua2020，，10： | 0 |
| 20 | Doping Gd^(3+)Ion in PDA-PHBV Coating on Ti6Al4V Alloy for Enhancing Corrosion Resistance and Proliferation of Human Gingival Fibroblasts and Human Umbilical Vein Endothelial Cells显示文摘In this study,we fabricated poly(3-hydroxybutyrate-3-hydroxyvalerate)(PHBV)coatings doped with Gd^(3+)(1,5,and 10×10^(−4) mol/L)on Ti6Al4V alloy for the first time to promote soft tissue sealing around dental implants.The corrosion resistance of Gd^(3+)-modified PHBV-coated Ti6Al4V was studied by electrochemical and immersion tests,respectively,whereas CCK-8 and RT-PCR evaluated the biocompatibility to human gingival fibroblasts(HGFs)and human umbilical vein endothelial cells(HUVECs).It was found that the Gd^(3+)-modified PHBV coating could enhance the corrosion resistance of Ti6Al4V.In vitro cell tests showed that PHBV coatings with and without Gd^(3+) addition could promote adhesion and proliferation of HGFs and HUVECs,showing a Gd^(3+) content-dependent manner.Moreover,it was found that the PDA-PHBV@1Gd showed the best proliferation to HGFs by up-regulating gene expressions of VINCULIN,ITGB1,and ITGA3,whereas the best response to HUVECs with the highest gene expression of eNOS and HIF-1αgenes was found in the PDA-PHBV@5Gd-coated group. | Sijie Qin Xiongcheng Xu Yanjin Lu Liu Li Tingting Huang Jinxin Lin | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，5： | 0 |
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