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| 1 | Cirrhotic cardiomyopathy:A cardiologist's perspective显示文摘Cardiac dysfunction is frequently observed in patients with cirrhosis, and has long been linked to the direct toxic effect of alcohol. Cirrhotic cardiomyopathy(CCM) has recently been identified as an entity regardless of the cirrhosis etiology. Increased cardiac output due to hyperdynamic circulation is a pathophysiological hallmark of the disease. The underlying mechanisms involved in pathogenesis of CCM are complex and involve various neurohumoral and cellular pathways, including the impaired β-receptor and calcium signaling, altered cardiomyocyte membrane physiology, elevated sympathetic nervous tone and increased activity of vasodilatory pathways predominantly through the actions of nitric oxide, carbon monoxide and endocannabinoids. The main clinical features of CCM include attenuated systolic contractility in response to physiologic or pharmacologic strain, diastolic dysfunction, electrical conductance abnormalities and chronotropic incompetence. Particularly the diastolic dysfunction with impaired ventricularrelaxation and ventricular filling is a prominent feature of CCM.The underlying mechanism of diastolic dysfunction in cirrhosis is likely due to the increased myocardial wall stiffness caused by myocardial hypertrophy,fibrosis and subendothelial edema,subsequently resulting in high filling pressures of the left ventricle and atrium.Currently,no specific treatment exists for CCM.The liver transplantation is the only established effective therapy for patients with end-stage liver disease and associated cardiac failure.Liver transplantation has been shown to reverse systolic and diastolic dysfunction and the prolonged QT interval after transplantation.Here,we review the pathophysiological basis and clinical features of cirrhotic cardiomyopathy,and discuss currently available limited therapeutic options. | Natig Gassanov Evren Caglayan Nasser Semmo Gero Massenkeil Fikret Er | 2014 | World Journal of Gastroenterology2014，20，42： | 18 |
| 2 | The impact of macroeconomic uncertainty on non-financial firms’ demand for liquidity显示文摘 | Christopher F. Baum Mustafa Caglayan Neslihan Ozkan Oleksandr Talavera | 2006 | Review of Financial Economics2006，，4： | 3 |
| 3 | The Second Moments Matter:The Impact of Macroeconomic Uncertainty on the Allocation of Loanable Funds 显示文摘 | Baum C F Caglayan M Ozkan N | 2009 | Economics Letters2009，102，2： | 1 |
| 4 | Effects of different anesthetic techniques on serum leptin,c reactive protein and cortisol concentration in anorectal surgery 显示文摘 | Buyukkocak U Daphan C Caglayan O | 2006 | Croat Med J2006，47，6： | 1 |
| 5 | Experimental and finite element investigations on the collapse of a Mero space truss roof structure: a case study 显示文摘 | Caglayan O Yuksel E | 2008 | Engineering Failure Analysis2008，15，5： | 1 |
| 6 | Are heteroehromatin polymorphisms associated with recurrent miscarriage?显示文摘 | Caglayan AO Ozyazgan I Demiryilmaz F | 2010 | J Obstet Gynaecol Res2010，36，4： | 1 |
| 7 | Fatigue life prediction of existing crane runway girders显示文摘 | Ozden Caglayan Kadir Ozakgul Ovunc Tezer | | 0，，66： | 1 |
| 8 | Monetary Instability, the Predictability of Prices, and the Allocation of Investment: An Empirical Investigation Using UK Panel Data显示文摘 | Beaudry P Caglayan M Schiantarelli F | 2001 | American Economic Review2001，91，3： | 1 |
| 9 | A formal role-based access control model for security policies in multi-domain mobile networks显示文摘 | Unal D and Caglayan M U | 2013 | Computer Networks2013，57，1： | 1 |
| 10 | Plasma and synovial fluid soluble CD23 concentrations in children with juvenile chronic arthritis显示文摘 | KUTUKCULER N CAGLAYANS S | 1998 | Autoimmunity1998，27，： | 1 |
| 11 | Obesity, per- oxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes 显示文摘 | Blaschke F Takata Y Caglayan E | 2006 | Arterioscler Thromb Vasc Biol2006，26，： | 1 |
| 12 | Design and Implementation of a Personal Computer Authorization System using Color Detection 显示文摘 | F Yucel O Oral N Caglayan | 2011 | Electronics and Electrical Engineering2011，115，9： | 1 |
| 13 | Phosphodiesterase type 5 inhibition is a novel therapeutic option in Raynand disease显示文摘 | CAGLAYAN E HUNTGEBURTH M KARASCH T et o1 | 2006 | Arch Intern Med2006，166，2： | 1 |
| 14 | The Impact of Macro- economic Uncertainty on Non - financial Firms' De- mand for Liquidity显示文摘 | Baum C Caglayan M Ozkan N | 2006 | Review of Financial Economics2006，15，4： | 1 |
| 15 | Are heterochromatin polymorphisms associated with recurrent miscarriage? 显示文摘 | Caglayan AO Ozyazgan I Demiryilmaz F | 2010 | J Obstet Gynaecol Res2010，36，4： | 1 |
| 16 | Are het erochromatin polymorphisms associated with recurrent miscarriage? 显示文摘 | Caglayan AO Ozyazgan I Demiryilmaz F | 2010 | J Obstet Gynaecol Res2010，36，4： | 1 |
| 17 | Analysis of the two microsatellite repeat polymorphisms of the factor Ⅷ gene in the Turkish population显示文摘 | Timur AA Caglayan SH | 1998 | Brit J Haematol1998，100，3： | 1 |
| 18 | Study of proinflammatory(TNF-alpha, IL-1 alpha, IL-6) and T-cell- derived (IL-2,IL-4)cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis:correlations with clinical and laboratory parameters 显示文摘 | Kutukculer N Caglayan S Aydogdu F | 1998 | Clin Rheumatol1998，17，4： | 1 |
| 19 | The effect of body mass index on functional parameters and quality of life in COPD patients显示文摘 | SALEPCI B EREN A CAGLAYAN B | 2007 | Tuberk Toraks2007，55，4： | 1 |
| 20 | Persistence in International Inflation Rates 显示文摘 | Baum C F Barkoulas J T Caglayan M | 1999 | Southern Economic Journal1999，65，4： | 1 |
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