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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | Amine-catalyzed polycyclotrimerization of arylene bipropiolate:A metal-free and regioselective route to hyperbranched polymer显示文摘This paper presents a new synthetic route to hyperbranched polymer. An arylene bipropiolate monomer,dimethylmethylenebis(1,4-phenylene) bipropiolate,was prepared by a one-step esterification reaction of bisphenol A with propiolic acid. Polycyclotrimrtization of the monomer was effected by reflux in dimethylformamide(DMF),producing a soluble hyperbranched poly(aroxycarbonylphenylene) in a good yield. The polymer was perfectly branched with a degree of branching of 100%. | JIM Cathy K W LAM Jacky W Y HAEUSSLER Matthias | 2008 | Science China Chemistry2008，51，8： | 3 |
| 3 | Integrating perceived playfulness into expectation-confirmation model for web portal context 显示文摘 | Cathy L Sheng W Ray T | 2005 | Information and Management2005，42，5： | 1 |
| 4 | Combretastatin A4 prodrug study of effect on the growth and the microvascttlature of colorectal liver metastases in a murine modell 显示文摘 | CATHY M W VIJAYARAGAVAN M STEWART S | 2001 | Clin Cancer Res2001，7，： | 1 |
| 5 | A model of senior tourism motivations-Anecdotes from Beijing and Shanghai显示文摘 | Cathy H Liping C Kevin W | 2007 | Tourism Management2007，，28： | 1 |
| 6 | Effect of ACE-inhibitor ramiprilat and AT1-receptor antagonist candesartan on norepinephrine release :comparision between ischemic and nonischemic conditions显示文摘 | DOREEN R SEBASTIAN W CATHY B | 2002 | Journal of Cardiovascular Pharmacology2002，40，： | 1 |
| 7 | Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database显示文摘 | Rohini K Hernandez Thy P Do Cathy W Critchlow Ricardo E Dent Susan S Jick | 2012 | Acta Orthopaedica2012，，6： | 1 |
| 8 | Given capsule endoscopy in celiac disease显示文摘 | Rima Petroniene Elena Dubcenco Jeffrey P Baker Ralph E Warren Cathy J Streutker Geoffrey W Gardiner Khursheed N Jeejeebhoy | 2004 | Gastrointestinal Endoscopy Clinics of North Americ2004，，1： | 1 |
| 9 | How to consolidate urban flows of goods without setting up an urban consolidation center 显示文摘 | SARA V CATHY M FRANK W | 2012 | Pro Soc Behav Sci2012，，39： | 1 |
| 10 | Mucopurulent cervicitis and Mycoplasma genitalium 显示文摘 | Lisa E Manhart Cathy W | 2003 | Infect Dis J2003，187，： | 1 |
| 11 | Vegetation and climate change in northwest America during the past 125 kyr显示文摘 | CATHY W PATRICK J B | 1997 | Nature1997，388，3： | 1 |
| 12 | The protein information resource 显示文摘 | Cathy H W Lai-Su L Yeh Hongzhan Huang | 2003 | Nucleic Acids Research2003，31，： | 1 |
| 13 | Asymmetrical reaction to US stock-return news: Evidence from major stock markets based on double-threshold model显示文摘 | Cathy W S Chen T C Chiang M | 2003 | Journal of Economics an Business2003，55，56： | 1 |
| 14 | Chronic fatigue syndrome: Oxidative stress and dietary modifications显示文摘 | Alan L Cathy W Cand ND | 2001 | Alternative Medicine Review2001，6，5： | 1 |
| 15 | A model of senior tourism motivations - Anecdotes from Beijing and Shanghai 显示文摘 | Cathy H Liping C Kevin W | 2007 | Tourism Management2007，，28： | 1 |
| 16 | The effect of epidermal growth factor on differentiation of isolated enterocytes after small bowel resection显示文摘 | Richard A Falcone Cathy E Shin Christopher R Erwin Brad W Warner | 1999 | Journal of Pediatric Surgery1999，，1： | 1 |
| 17 | Bayesian time-varying quantile forecasting for value at risk in financial markets显示文摘 | Richard H Cathy W S | 2012 | Journal of Business & Economic Statistics2012，43，29： | 1 |
| 18 | Bacteremia and bacterial translocation in the naturally occurring canine gastric dilatation-volvulus patient 显示文摘 | Kevin P W Cathy L G David J S | 2003 | Journal of the American Animal Hospital Association2003，39，4： | 1 |
| 19 | A model of senior tourism motivations:an ecdotes from Beijing and Shanghai显示文摘 | CATHY H C H LIPING A C KEVIN K F W | 2007 | Tourism management2007，28，5： | 1 |
| 20 | Desmosomal proteins,including desmoglein3, serve as novel negative markers for epidermal stem cellcontaining population of keratinocytes显示文摘 | HONG W MICHAELI G S CATHY S | 2003 | J Cell Sci2003，116，20： | 1 |
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