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| 1 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 2 | Dopamine Agonists Exert Nurrl-inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease显示文摘 | Li-Min Zhang Cong-Cong Sun Ming-Shu Mo Luan Cen Lei Wei Fei-Fei Luo Yi Li Guo-Fei Li Si-Yun Zhang Li Yi Wei Huang Zhuo-Lin Liu Wei-Dong Leg Ping-Yi Xu | 2015 | Chinese Medical Journal2015，，13： | 3 |
| 3 | The biomarkers of immune dysregulation and inflammation response in Parkinson disease显示文摘Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction. | Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu | 2016 | Translational Neurodegeneration2016，5，1： | 3 |
| 4 | Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease显示文摘 | Ming-Shu Mo Wei Huang Cong-Cong Sun Li-Min Zhang Luan Cen You-Sheng Xiao Guo-Fei Li Xin-Ling Yang Shao-Gang Qu Ping-Yi Xu | 2016 | Chinese Medical Journal2016，，9： | 3 |
| 5 | Few-mode fibre-optic microwave photonic links显示文摘The fibre-optic microwave photonic link has become one of the basic building blocks for microwave photonics.Increasing the optical power at the receiver is the best way to improve all link performance metrics including gain,noise figure and dynamic range.Even though lasers can produce and photodetectors can receive optical powers on the order of a Watt or more,the power-handling capability of optical fibres is orders-of-magnitude lower.In this paper,we propose and demonstrate the use of few-mode fibres to bridge this power-handling gap,exploiting their unique features of small acousto-optic effective area,large effective areas of optical modes,as well as orthogonality and walk-off among spatial modes.Using specially designed few-mode fibres,we demonstrate order-of-magnitude improvements in link performances for single-channel and multiplexed transmission.This work represents the first step in few-mode microwave photonics.The spatial degrees of freedom can also offer other functionalities such as large,tunable delays based on modal dispersion and wavelength-independent lossless signal combining,which are indispensable in microwave photonics. | He Wen Hongjun Zheng Qi Mo Amado Manuel Velázquez-Benítez Cen Xia Bin Huang Huiyuan Liu Huang Yu Pierre Sillard Jose Enrique Antonio Lopez Rodrigo Amezcua Correa Guifang Li | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 6 | Synthesis and insecticidal activities of N-(5-dehydroabietyl-1,3,4-thiadiazol-2-yl)-benzenesulfonamides显示文摘 | Fangyao Li Qijin Mo Wengui Duan Guishan Lin Bo Cen Naiyuan Chen Zhangqi Yang | 2014 | Medicinal Chemistry Research2014，，10： | 1 |
| 7 | Numerical Simulation of the NOx Emissions in a 1000 MW Tangentially Fired Pulverized-Coal Boiler: Influence of the Multi-group Arrangement of the Separated over Fire Air显示文摘 | H Zhou G Y Mo D B Si K F Cen | 2011 | ENERGY & FUELS2011，25，5： | 1 |
| 8 | Prospective study of light dark matter search with a newly proposed DarkSHINE experiment显示文摘Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass range.We have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV energy.This analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the detector.This experiment takes advantage of using missing momentum to enhance signal versus background separation power.In this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with GEANT4.For better background estimates,major rare background processes have also been simulated.This paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment sensitivity.With 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models. | Jing Chen Ji-Yuan Chen Jun-Feng Chen Xiang Chen Chang-Bo Fu Jun Guo Le He Zheng-Ting He Kim Siang Khaw Jia-Lin Li Liang Li Shu Li Meng Lv Dan-Ning Liu Han-Qing Liu Kun Liu Qi-Bin Liu Yang Liu Ze-Jia Lu Cen Mo Si-Yuan Song Xiao-Long Wang Yu-Feng Wang Zhen Wang Zi-Rui Wang Wei-Hao Wu Dao Xiang Hai-Jun Yang Jun-Hua Zhang Yu-Lei Zhang Zhi-Yu Zhao Xu-Liang Zhu Chun-Xiang Zhu Yi-Fan Zhu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，1： | 0 |
| 9 | HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China显示文摘Objective The mode of human immunodeficiency virus(HIV) transmission via injection drug use(IDU)still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in Guangxi.Methods We performed a molecular epidemiological investigation of infections across Guangxi from2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.Results Among the 535 subjects, CRF08_BC(57.4%), CRF01_AE(28.4%), and CRF07_BC(10.7%) were the top 3 HIV strains;72.6% of infections were linked to other provinces in the transmission network;93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces,predominantly Guangdong and Yunnan;92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive IDUs.Conclusion HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other provinces.Coverage of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened. | CEN Ping LIANG Hua Yue YANG Yuan ZHANG Fei YANG Shi Xiong MO Ju Cong FENG Yi HUANG Jie Gang NING Chuan Yi HUANG Chun Yuan YANG Yao LIANG Na LIANG Bing Yu YE Li LIANG Hao | 2023 | Biomedical and Environmental Sciences2023，36，5： | 0 |
| 10 | Sensitivity study of coastal plumes显示文摘A three-dimensional numerical model of the coastal plume in an ideal basin for the western Gulf of Maine of USA, based on the observations, was configured to examine the dynamical properties under the spring riverine, tidal, and wind forcing. The purpose of this paper is to reveal possible effects of different factors on the coastal plume. The control run with a sloping bottom mimicking the western Gulf of Maine reproduced a southward advection speed of 14 km/d, consistent with the observed speed of 13.3 km/d. The plume evolutions due to the two typical wind forcing, upwelling favourable (wind from north) and downwelling favourable (wind from south). were simulated to explain the observations during the spring of 1993. A systematic sensitivity study was also conducted on the following themes: model parameters. dynamic processes, and topography effect. | Wang Jia Mo Ruxi Gao Zhenhui Yin Zhongbin and Chen Mingjian 1. International Arctic Research Center-Frontier, University of Alaska Fairbanks, Fairbanki, Alaska 99775, USA. Email: jwang @ chukchi. iare. uaf. edu 2. Guangxi Marine Monitoring Forecast Cen | 1999 | Acta Oceanologica Sinica1999，18，2： | 0 |
| 11 | Experimental measurements of gas-solid flow and splitting mechanisms of a coal pipe splitter with a perpendicularly arranged upstream elbow显示文摘 | Hao Zhou Yan Huang Yu Yang Guiyuan Mo Jianzhong Li Kefa Cen | 2016 | Particuology2016，14，2： | 0 |
| 12 | Only Sunda and Chinese pangolin(Pholidota)are naturally distributed in China显示文摘INTRODUCTION Pangolin is the common name for animals in the Family Pholidota,Mammalia,which consists of eight extant species.All pangolin species have been listed as critically endangered(CR),endangered(EN),or vulnerable(VU)species in the International Union for Conservation of Nature(IUCN)Red List of Threatened Species(Challender et al.2020).In June 2020,the Chinese government upgraded the Chinese pangolin(Manis pentadactyla Linnaeus,1758)from a national second-class protected animal to a national first-class protected animal.In February 2021,the Sunda pangolin(Manis javanica Desmarest,1822)and the Indian pangolin(Manis crassicaudata Geoffroy,1803)were added to the list of national first-class protected animals.However,the number of species of pangolins naturally distributed in China varies in the literature:Some sources have recorded only one species,namely the Chinese pangolin(Nowak&Paradiso 1983;Sheng 1999),while most have recorded two species,namely the Chinese pangolin and Indian pangolin(Allen 1938;Zhang 1997;Wang 2003;Wu et al.2005a;Hu&Hu 2017). | Peng CEN Jiankun SUN Qiaoyan WANG Fuhua ZHANG Lianxian MO Amna MAHMOOD Jiaqi LI Yifu WANG Shibao WU | 2023 | Integrative Zoology2023，18，4： | 0 |
| 13 | A Compact Difference Scheme on Graded Meshes for the Nonlinear Fractional Integro-differential Equation with Non-smooth Solutions显示文摘In this paper,a compact finite difference scheme for the nonlinear fractional integro-differential equation with weak singularity at the initial time is developed,with O(N^(-(2-α))+M^(-4))accuracy order,where N;M denote the numbers of grids in temporal and spatial direction,α ∈(0,1)is the fractional order.To recover the full accuracy based on the regularity requirement of the solution,we adopt the L1 method and the trapezoidal product integration(PI)rule with graded meshes to discretize the Caputo derivative and the Riemann-Liouville integral,respectively,further handle the nonlinear term carefully by the Newton linearized method.Based on the discrete fractional Gr¨onwall inequality and preserved discrete coefficients of Riemann-Liouville fractional integral,the stability and convergence of the proposed scheme are analyzed by the energy method.Theoretical results are also confirmed by a numerical example. | Da-kang CEN Zhi-bo WANG Yan MO | 2022 | Acta Mathematicae Applicatae Sinica2022，38，3： | 0 |
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