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| 1 | Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors显示文摘Normal cells become cancer cells after a malignant transformation,but whether cancer cells can be reversed to normal status remains elusive.Here,we report that the combination of hepatocyte nuclear factor IA (HNFIA),HNF4A and forkhead box protein A3 (FOXA3)synergistically reprograms hepatocellular carcinoma (HCC)cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps).Our results show that rHeps lose the malignant phenotypes of cancer cells and retrieve hepatocyte-specific characteristics including hepatocyte-like morphology;global expression pattern of genes and specific biomarkers of hepatocytes;and the unique hepatic functions of albumin (ALB)secretion,glycogen synthesis,low-density lipoprotein (LDL)uptake,urea production, cytochrome P450 enzymes induction and drug metabolism.Intratumoral injection of these three factors efficiently shrank patientderived tumor xenografts and reprogrammed HCC cells in vivo.Most importantly,transplantation of rHeps in the liver of fumarylacetoacetate hydrolase-deficient (Fah^-/-)mice led to the reconstruction of hepatic lobules and the restoration of hepatic function.Mechanistically,exogenous expression of HNF1A,HNF4A and FOXA3 in HCC cells initiated the endogenous expression of numerous hepatocyte nuclear factors,which promoted the conversion of HCC cells to hepatocyte-like cells.Collectively,our results indicate the successful conversion of hepatoma cells to hepatocyte-like cells,not only extending our current knowledge of cell reprogramming but also providing a route towards a novel therapeutic strategy for cancer. | Zhuo Cheng Zhiying He Yongchao Cai Cheng Zhang Gongbo Fu Hengyu Li Wen Sun Changcheng Liu Xiuliang Cui Beifang Ning Daimin Xiang Tengfei Zhou Xiaofeng Li Weifen Xie Hongyang Wang Jin Ding | 2019 | Cell Research2019，29，2： | 3 |
| 2 | Realization of high-performance tri-layer graphene saturable absorber mirror fabricated via a one-step transfer process显示文摘Graphene,as a saturable absorber(SA),has attracted much attention for its application in ultrashort pulse fiber lasers due to its ultrafast interband carrier relaxation and ultra-broadband wavelength operation.Nevertheless,during the stacking process of monolayer graphene layer,the induced nonuniform contact at the interface of graphene layers deteriorate the device performance.Herein,we report the fabrication of graphene saturable absorber mirrors(SAMs)via a one-step transfer process and the realization of the much enlarged modulation depth and the much reduced nonsaturable loss with tri-layer graphene(TLG)than single-layer graphene(SLG)due to the improved uniform contact at the interface.Moreover,the operation of 1550 nm mode-locked Er-doped fiber laser with the TLG SAM exhibits excellent output characteristics of the maximum output power of 9.9 mW,a slope efficiency of 2.4%and a pulse width of 714 fs.Our findings are expected to pave the way toward high-performance ultrashort pulse fiber lasers based on graphene SAs. | Cheng Jiang Xu Wang Jian Liu Jiqiang Ning Changcheng Zheng Xiaohui Li Ziyang Zhang | 2020 | Journal of Semiconductors2020，41，1： | 2 |
| 3 | Studi-es on flue gas desulfurization by chemical absorption usingan ethylenediamine phosphoric acid solution显示文摘 | TANG Zhigang ZHOU Changcheng CHEN Cheng | 2004 | Ind EngChem Res2004，43，21： | 1 |
| 4 | Facile Fab- rication of Light, Flexible and Multifunctional Graphene Fibers 显示文摘 | Dong Zelin Jiang Changcheng Cheng Huhu | 2012 | Advanced Materials2012，24，14： | 1 |
| 5 | Facile fabrication of light,f1exible and multifunctional graphene fibers显示文摘 | Dong Zeilin Jiang Changcheng Cheng Huhu | 2012 | Advanced Materials2012，24，14： | 1 |
| 6 | Studies on flue gas desulfurization by chemical absorption using an ethylenediamine-phosphoric acid solution显示文摘 | TANG Zhigang ZHOU Changcheng CHEN Cheng | 2004 | Ind Eng Chem Res2004，43，21： | 1 |
| 7 | Experimental Study on Fire Characteristics of Building External Thermal Insulation Composite Systems Based on Polystyrene Foam 显示文摘 | Lei Xu Xudong Cheng Changcheng Liu | 2014 | Advanced Materials Research2014，，893： | 1 |
| 8 | Studies on flue gas desulfurization by chemical absorption using an ethylenediamine phosphoric acid solution 显示文摘 | TANG Zhigang ZHOU Changcheng CHEN Cheng | 2004 | Ind Eng Chem Res2004，43，21： | 1 |
| 9 | Facile Fabrication of Light,Flexible and Multifunctional Graphene Fibers显示文摘 | Dong Zelin Jiang Changcheng Cheng Huhu | | 0，，14： | 1 |
| 10 | Studies on flue gas desulfurization by chemical absorption using an ethylenediamine phosphoric acid solution显示文摘 | Tang Zhigang Zhou Changcheng Chen Cheng | 2004 | Industrial Engineering Chemistry Research2004，43，21： | 1 |
| 11 | Distillability sudden death for two-qutrit states under an XY quantum environment显示文摘distillability sudden death;;bound entangled states;;negativity;;realignment criterion;;entanglement | Yao Wang ChangCheng Cheng BingBing Chai JinLiang Guo | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，2： | 1 |
| 12 | Studies on flue gas desulfurization by chemical absorption using an ethylenediamine-phosphoric acid solution 显示文摘 | Tang Zhigang Zhou Changcheng Chen Cheng | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 13 | Facile fabrication of light, flexible and multifunctional graphene fibers 显示文摘 | Zelin Dong Changcheng Jiang Cheng H | 2012 | Advanced Materials2012，24，18： | 1 |
| 14 | Highly Compression‐Tolerant Supercapacitor Based on Polypyrrole‐mediated Graphene Foam Electrodes显示文摘 | Yang Zhao Jia Liu Yue Hu Huhu Cheng Chuangang Hu Changcheng Jiang Lan Jiang Anyuan Cao Liangti Qu | 2012 | Adv Mater2012，，4： | 1 |
| 15 | Studies on flue gas desulfurization by chemical absorption u- sing an ethylenediamine-phosphoric acid solution显示文摘 | Tang Zhigang Zhou Changcheng Chen Cheng | 2004 | Industry Engineering Chemical Research2004，43，： | 1 |
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