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| 1 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 2 | Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors显示文摘Normal cells become cancer cells after a malignant transformation,but whether cancer cells can be reversed to normal status remains elusive.Here,we report that the combination of hepatocyte nuclear factor IA (HNFIA),HNF4A and forkhead box protein A3 (FOXA3)synergistically reprograms hepatocellular carcinoma (HCC)cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps).Our results show that rHeps lose the malignant phenotypes of cancer cells and retrieve hepatocyte-specific characteristics including hepatocyte-like morphology;global expression pattern of genes and specific biomarkers of hepatocytes;and the unique hepatic functions of albumin (ALB)secretion,glycogen synthesis,low-density lipoprotein (LDL)uptake,urea production, cytochrome P450 enzymes induction and drug metabolism.Intratumoral injection of these three factors efficiently shrank patientderived tumor xenografts and reprogrammed HCC cells in vivo.Most importantly,transplantation of rHeps in the liver of fumarylacetoacetate hydrolase-deficient (Fah^-/-)mice led to the reconstruction of hepatic lobules and the restoration of hepatic function.Mechanistically,exogenous expression of HNF1A,HNF4A and FOXA3 in HCC cells initiated the endogenous expression of numerous hepatocyte nuclear factors,which promoted the conversion of HCC cells to hepatocyte-like cells.Collectively,our results indicate the successful conversion of hepatoma cells to hepatocyte-like cells,not only extending our current knowledge of cell reprogramming but also providing a route towards a novel therapeutic strategy for cancer. | Zhuo Cheng Zhiying He Yongchao Cai Cheng Zhang Gongbo Fu Hengyu Li Wen Sun Changcheng Liu Xiuliang Cui Beifang Ning Daimin Xiang Tengfei Zhou Xiaofeng Li Weifen Xie Hongyang Wang Jin Ding | 2019 | Cell Research2019，29，2： | 3 |
| 3 | Oxygen‑Deficient β‑MnO_(2)@Graphene Oxide Cathode for High‑Rate and Long‑Life Aqueous Zinc Ion Batteries显示文摘Recent years have witnessed a booming interest in grid-scale electrochemical energy storage,where much attention has been paid to the aqueous zinc ion batteries(AZIBs).Among various cathode materials for AZIBs,manganese oxides have risen to prominence due to their high energy density and low cost.However,sluggish reaction kinetics and poor cycling stability dictate against their practical application.Herein,we demonstrate the combined use of defect engineering and interfacial optimization that can simultaneously promote rate capability and cycling stability of MnO_(2) cathodes.β-MnO_(2) with abundant oxygen vacancies(VO)and graphene oxide(GO)wrapping is synthesized,in which VO in the bulk accelerate the charge/discharge kinetics while GO on the surfaces inhibits the Mn dissolution.This electrode shows a sustained reversible capacity of~129.6 mAh g^(−1) even after 2000 cycles at a current rate of 4C,outperforming the state-of-the-art MnO_(2)-based cathodes.The superior performance can be rationalized by the direct interaction between surface VO and the GO coating layer,as well as the regulation of structural evolution ofβ-MnO_(2) during cycling.The combinatorial design scheme in this work offers a practical pathway for obtaining high-rate and long-life cathodes for AZIBs. | Shouxiang Ding Mingzheng Zhang Runzhi Qin Jianjun Fang Hengyu Ren Haocong Yi Lele Liu Wenguang Zhao Yang Li Lu Yao Shunning Li Qinghe Zhao Feng Pan | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 4 | Molecular transport under extreme confinement显示文摘Mass transport through the nanoporous medium is ubiquitous in nature and industry.Unlike the macroscale transport phenomena which have been well understood by the theory of continuum mechanics,the relevant physics and mechanics on the nanoscale transport still remain mysterious.Recent developments in fabrication of slit-like nanocapillaries with precise dimensions and atomically smooth surfaces have promoted the fundamental research on the molecular transport under extreme confinement.In this review,we summarized the contemporary progress in the study of confined molecular transport of water,ions and gases,based on both experiments and molecular dynamics simulations.The liquid exhibits a pronounced layered structure that extends over several intermolecular distances from the solid surface,which has a substantial influence on static properties and transport behaviors under confinement.Latest studies have also shown that those molecular details could provide some new understanding on the century-old classical theory in this field. | FengChao Wang JianHao Qian JingCun Fan JinChuan Li HengYu Xu HengAn Wu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，6： | 3 |
| 5 | Coupling effects of urea types and subsoiling on nitrogen–water use and yield of different varieties of maize in northern China显示文摘 | Hengyu Hu Tangyuan Ning Zengjia Li Huifang Han Zongzheng Zhang Shujun Qin Yanhai Zheng | 2013 | Field Crops Research2013，，： | 2 |
| 6 | Fully Roll‑to‑Roll Processed Efficient Perovskite Solar Cells via Precise Control on the Morphology of PbI_(2):CsI Layer显示文摘Perovskite solar cells(PSCs)have attracted tremendous attention as a promising alternative candidate for clean energy generation.Many attempts have been made with various deposition techniques to scale-up manufacturing.Slot-die coating is a robust and facile deposition technique that can be applied in large-area roll-to-roll(R2R)fabrication of thin film solar cells with the advantages of high material utilization,low cost and high throughput.Herein,we demonstrate the encouraging result of PSCs prepared by slot-die coating under ambient environment using a twostep sequential process whereby PbI_(2):CsI is slot-die coated first followed by a subsequent slot-die coating of organic cations containing solution.A porous PbI_(2):CsI film can promote the rapid and complete transformation into perovskite film.The crystallinity and morphology of perovskite films are significantly improved by optimizing nitrogen blowing and controlling substrate temperature.A power conversion efficiency(PCE)of 18.13%is achieved,which is promising for PSCs fabricated by two-step fully slot-die-coated devices.Furthermore,PSCs with a 1 cm2 area yield a champion PCE of 15.10%.Moreover,a PCE of 13.00%is obtained on a flexible substrate by the roll-to-roll(R2R)coating,which is one of the highest reported cells with all layers except for metal electrode fabricated by R2R process under ambient condition. | Hengyue Li Chuantian Zuo Dechan Angmo Hasitha Weerasinghe Mei Gao Junliang Yang | 2022 | Nano-Micro Letters2022，14，5： | 2 |
| 7 | Coupling effects of urea types and subsoiling on nitrogen-water use and yield of differ- ent varieties of maize in northern China 显示文摘 | Hu Hengyu Ning Tangyuan Li Zengjia | 2013 | Field Crops Research2013，142，： | 1 |
| 8 | Does environmental infrastructure investment contribute to emissions reduction?A case of China显示文摘Environmental infrastructure investment(EII)is an important environmental policy instrument on responding to greenhouse gas(GHG)emission and air pollution.This paper employs an improved stochastic impact by regression on population,affluence and technology(STRIPAT)model by using panel data from 30 Chinese provinces and municipalities for the period of 2003–2015 to investigate the effect of EII on CO2 emissions,SO2 emissions,and PM2.5 pollution.The results indicate that EII has a positive and significant effect on mitigating CO2 emission.However,the effect of EII on SO2 emission fluctuated although it still contributes to the reduction of PM2.5 pollution through technology innovations.Energy intensity has the largest impact on GHG emissions and air pollution,followed by GDP per capita and industrial structure.In addition,the effect of EII on environmental issues varies in different regions.Such findings suggest that policies on EII should be region-specific so that more appropriate mitigation policies can be raised by considering the local realities. | Xiaoqian SONG Yong GENG Ke LI Xi ZHANG Fei WU Hengyu PAN Yiqing ZHANG | 2020 | Frontiers in Energy2020，14，1： | 1 |
| 9 | High Output Performance and Ultra-Durable DC Output for Triboelectric Nanogenerator Inspired by Primary Cell显示文摘Triboelectric nanogenerator(TENG)is regarded as an effective strategy to convert environment mechanical energy into electricity to meet the distributed energy demand of large number of sensors in the Internet of Things(IoTs).Although TENG based on the coupling of triboelectrification and air-breakdown achieves a large direct current(DC)output,material abrasion is a bottleneck for its applications.Here,inspired by primary cell and its DC signal output characteristics,we propose a novel primary cell structure TENG(PC-TENG)based on contact electrification and electrostatic induction,which has multiple working modes,including contact separation mode,freestanding mode and rotation mode.The PC-TENG produces DC output and operates at low surface contact force.It has an ideal effective charge density(1.02 m Cm^(-2)).Meanwhile,the PC-TENG shows a superior durability with 99% initial output after 100,000 operating cycles.Due to its excellent output performance and durability,a variety of commercial electronic devices are powered by PC-TENG via harvesting wind energy.This work offers a facile and ideal scheme for enhancing the electrical output performance of DC-TENG at low surface contact force and shows a great potential for the energy harvesting applications in IoTs. | Shaoke Fu Wencong He Huiyuan Wu Chuncai Shan Yan Du Gui Li Ping Wang Hengyu Guo Jie Chen Chenguo Hu | 2022 | Nano-Micro Letters2022，14，9： | 1 |
| 10 | Layer-by-layer slot-die coated high-efficiency organic solar cells processed using twin boiling point solvents under ambient condition显示文摘Layer-by-layer (LbL) strategy has been developed to form bulk heterojunction (BHJ) structure for processing efficient organic solar cells (OSCs). Herein, LbL slot-die coating with twin boiling point solvents (TBPS) strategy was developed to fabricate highly efficient OSCs, which matches with large-scale, high throughput roll-to-roll (R2R) industrialized mass process. The TBPS strategy could produce high-quality thin film without any additive, leading to the optimized vertical phase separation with interpenetrating nanostructures, as well as the enhanced charge transport and extraction. Thus, the power conversion efficiency up to 14.42% was achieved for [(2,6-(4,8-bis(5-(2-ethylhexyl-3-fluoro)thiophen-2-yl)-benzo [1,2-b:4,5-b′]dithiophene))-alt-(5,5-(1′,3′-di-2-thienyl-5′,7′-bis(2-ethylhexyl)benzo[1′,2′-c:4′,5′-c′]dithiophene-4,8-dione)]:2,2′-((2Z,2′Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,3″:4″,5″]thieno[2′,3′:4,5]pyrrolo[3,2-g]thieno[2′,3′:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene)) bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile (PM6:Y6) OSCs fabricated via sequentially LbL slot-die coating using the TBPS strategy under ambient condition. The research provides a potential route for industrialized production of high-efficiency and large-area OSC devices. | Yu Yang Erming Feng Hengyue Li Zichao Shen Wanrong Liu Jingbo Guo Qun Luo Jidong Zhang Guanghao Lu Changqi Ma Junliang Yang | 2021 | Nano Research2021，14，11： | 1 |
| 11 | The therapeutic efficacy of glutamine for rats with smoking inhalation injury显示文摘 | Wuquan Li Xiaochen Qiu Junjie Wang Hengyu Li Yu Sun Fang Zhang Haichao Jin Jinfeng Fu Zhaofan Xia | 2013 | International Immunopharmacology2013，，2： | 1 |
| 12 | Apoptin selectively induces the apoptosis of tumor cells by suppressing the transcription of HSP70显示文摘 | Lijie Yuan Liqiu Zhang Xingli Dong Hengyu Zhao Shuyan Li Dong Han Xinghan Liu | 2013 | Tumor Biology2013，，1： | 1 |
| 13 | The therapeutic efficacy of Ulinastatin for rats with smoking inhalation injury显示文摘 | Xiaochen Qiu Shizhao Ji Junjie Wang Hengyu Li Ting Xia Bohan Pan Shichu Xiao Zhaofan Xia | 2012 | International Immunopharmacology2012，，3： | 1 |
| 14 | A Self‑Powered,Highly Embedded and Sensitive Tribo‑Label‑Sensor for the Fast and Stable Label Printer显示文摘Label-sensor is an essential component of the label printer which is becoming a most significant tool for the development of Internet of Things(IoT).However,some drawbacks of the traditional infrared label-sensor make the printer fail to realize the high-speed recognition of labels as well as stable printing.Herein,we propose a selfpowered and highly sensitive tribo-label-sensor(TLS)for accurate label identification,positioning and counting by embedding triboelectric nanogenerator into the indispensable roller structure of a label printer.The sensing mechanism,device parameters and deep comparison with infrared sensor are systematically studied both in theory and experiment.As the results,TLS delivers 6 times higher signal magnitude than traditional one.Moreover,TLS is immune to label jitter and temperature variation during fast printing and can also be used for transparent label directly and shows long-term robustness.This work may provide an alternative toolkit with outstanding advantages to improve current label printer and further promote the development of IoT. | Xindan Hui Zhongjie Li Lirong Tang Jianfeng Sun Xingzhe Hou Jie Chen Yan Peng Zhiyi Wu Hengyu Guo | 2023 | Nano-Micro Letters2023，15，2： | 1 |
| 15 | MAPK regulates cell cycle progression in pig oocytes and fertilized eggs显示文摘Oocytes collected from prepubertal gilt ovaries were matured in vitro (IVM), and fertilized in vitro (IVF) or electrically activated. Phosphorylation of mitogen-activated protein kinase (MAPK) was detected with SDS-PAGE and Western blotting, and translocation of ERK2 was observed with immunofluorescent cytochemistry. We found that the quantity of MAPK kept unchanged during oocyte maturation. There was no phosphorylated MAPK in porcine oocytes at the germinal vesicle (GV) stage; a little MAPK was phosphorylated at 20 h of IVM; a high level phosphory-lation was detected at 30 h, while MAPK phosphorylation decreased at 36 h; and then MAPK phosphorylation increased again to the peak level from 40 to 60 h. ERK2 translocated from the peripheral cytoplasm to inner cytoplasm and nuclear area during oocyte maturation. There was nearly no phosphorylated MAPK at 18 and 20 h of electrically activated oocytes, but phosphorylation increased at 22 h. There was no phosphorylated MAPK at 12 h of IVF, while | LI Manyu FAN Hengyu TONG Chao CHEN Dayuan XIA Guoliang SUN Qingyuan | 2002 | Chinese Science Bulletin2002，47，10： | 1 |
| 16 | Coupling effects of urea types and subsoiling on nitrogen–water use and yield of different varieties of maize in northern China显示文摘 | Hengyu Hu Tangyuan Ning Zengjia Li Huifang Han Zongzheng Zhang Shujun Qin Yanhai Zheng | 2013 | Field Crops Research2013，，： | 1 |
| 17 | Real-time object segmentation based on convolutional neural network with saliency optimization for picking显示文摘This paper concerns the problem of object segmentation in real-time for picking system. A region proposal method inspired by human glance based on the convolutional neural network is proposed to select promising regions, allowing more processing is reserved only for these regions. The speed of object segmentation is significantly improved by the region proposal method.By the combination of the region proposal method based on the convolutional neural network and superpixel method, the category and location information can be used to segment objects and image redundancy is significantly reduced. The processing time is reduced considerably by this to achieve the real time. Experiments show that the proposed method can segment the interested target object in real time on an ordinary laptop. | CHEN Jinbo WANG Zhiheng LI Hengyu | 2018 | Journal of Systems Engineering and Electronics2018，29，6： | 1 |
| 18 | Enhanced performance of triboelectric mechanical motion sensor via continuous charge supplement and adaptive signal processing显示文摘The development of automation industry is inseparable from the progress of sensing technology.As a promising self-powered sensing technology,the durability and stability of triboelectric sensor(TES)have always been inevitable challenges.Herein,a continuous charge supplement(CCS)strategy and an adaptive signal processing(ASP)method are proposed to improve the lifetime and robustness of TES.The CCS uses low friction brushes to increase the surface charge density of the dielectric,ensuring the reliability of sensing.A triboelectric mechanical motion sensor(TMMS)with CCS is designed,and its electrical signal is hardly attenuated after 1.5 million cycles after reasonable parameter optimization,which is unprecedented in linear TESs.After that,the dynamic characteristics of the CCS-TMMS are analyzed with error rates of less than 1%and 2%for displacement and velocity,respectively,and a signal-to-noise ratio of more than 35 dB.Also,the ASP used a signal conditioning circuit for impedance matching and analog-to-digital conversion to achieve a stable output of digital signals,while the integrated design and manufacture of each hardware module is achieved.Finally,an intelligent logistics transmission system(ILTS)capable of wirelessly monitoring multiple motion parameters is developed.This work is expected to contribute to automation industries such as smart factories and unmanned warehousing. | Zitang Yuan Xiaosong Zhang Hengyu Li Ping Shen Jianming Wen Zhong Lin Wang Tinghai Cheng | 2023 | Nano Research2023，16，7： | 0 |
| 19 | Amorphous Cu^0 on Carbon Nanofiber as Recyclable Heterogeneous Catalyst for N-Arylation Reactions显示文摘A novel heterogeneous catalyst,amorphous Cu^0 on the carbon nanofibers was developed and characte-rized by means of several characterization techniques.The prepared Cu^0 was investigated as a heterogeneous catalyst for N-arylation reaction.The results show it is an excellent catalyst with recyclability,high consistency and catalytic activity.After the catalyst was used for 5 cycles in the N-arylation reaction,amorphous Cu^0 reunited into crystalline copper nanoparticles with different particle sizes and its good heterogeneity in the catalytic system was confirmed after the catalyst recovery. | WANG Junzhong LI Hengyu ZHANG Dongdong BAI Jie | 2019 | Chemical Research in Chinese Universities2019，35，2： | 0 |
| 20 | Single-cell DNA methylome analysis of circulating tumor cells显示文摘Objective: Previous investigations of circulating tumor cells(CTCs) have mainly focused on their genomic or transcriptomic features, leaving their epigenetic landscape relatively uncharacterized. Here, we investigated the genome-wide DNA methylome of CTCs with a view to understanding the epigenetic regulatory mechanisms underlying cancer metastasis.Methods: We evaluated single-cell DNA methylome and copy number alteration(CNA) in 196 single cells,including 107 CTCs collected from 17 cancer patients covering six different cancer types. Our single-cell bisulfite sequencing(sc BS-seq) covered on average 11.78% of all Cp G dinucleotides and accurately deduced the CNA patterns at 500 kb resolution.Results: We report distinct subclonal structures and different evolutionary histories of CTCs inferred from CNA and DNA methylation profiles. Furthermore, we demonstrate potential tumor origin classification based on the tissue-specific DNA methylation profiles of CTCs.Conclusions: Our work provides a comprehensive survey of genome-wide DNA methylome in single CTCs and reveals 5-methylcytosine(5-m C) heterogeneity in CTCs, addressing the potential epigenetic regulatory mechanisms underlying cancer metastasis and facilitating the future clinical application of CTCs. | Hengyu Chen Zhe Su Ruoyan Li Ning Zhang Hua Guo Fan Bai | 2021 | Chinese Journal of Cancer Research2021，33，3： | 0 |
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