| 2 | Preparation and Anti-ultraviolet Aging Performance of Organic Layered Double Hydroxides/Bitumen Composites显示文摘Layered double hydroxides(LDHs) with the physical property of high ultraviolet(UV)reflectance were used to enhance the anti-UV aging performance of bitumen. In view of the poor compatibility of LDHs with bitumen, three organic anions, namely, sodium dodecyl benzenesulfonate(SDBS), sodium dodecyl sulfate(SDS) and sodium dodecyl sulfonate(SDSO), were used as modifiers to prepare organic LDHs(OCLDHs) through regeneration process, and the crystal structure, chemical composition, morphological feature and UV shielding capability of synthesized OCLDHs were analyzed. Then the OCLDHs were added into bitumen to evaluate the storage stability and anti-UV aging property of OCLDHs/bitumen composites.The results show that the organic anions are inserted into the interlayers of LDHs, the intercalation expands the interlayer distance of LDHs, makes the particle shapes become more irregular and complicated, and enhances the absorption ability within the range from 200 to 300 nm while has little influence on the UV reflection ability.Result of high temperature storage stability indicates the organic modification ameliorates the compatibility of LDHs with bitumen. Compared with LDHs, OCLDHs decrease the deteriorations of bitumen’s properties during UV exposure test, exhibiting better effect in enhancing anti-UV aging performance of bitumen. Furthermore,among the three OCLDHs, LDHs intercalated by SDBS exhibit the most effective improvement due to the best compatibility with bitumen and comparatively good UV shielding effect. | 徐松 YU Jianying KE Yunbin XUE Lihui HU Changbin | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 2 |
| 3 | N-methyl-D-aspartate receptor effects on p38 mitogen activated protein kinase and its role in a rat model of diabetic neuropathic pain显示文摘BACKGROUND:Activated N-methyl-D-aspartate(NMDA) receptor is involved in the formation of chronic neuropathic pain,and its antagonist,ketamine,exhibits effective amelioration of diabetic neuropathic pain(DNP).However,the mechanisms of NMDA receptor participation in the formation and maintenance of DNP remain poorly understood. OBJECTIVE:To evaluate the role NMDA receptor plays in DNP and effects on p38 mitogen activated protein kinase(p38 MAPK) in a rat model of DNP. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Human Embryonic Stem Cell Research Institute of Yunyang Medical College Affiliated Taihe Hospital between July 2005 and September 2007. MATERIALS:Streptozotocin was provided by Sigma,USA;p38 MAPK inhibitor(SB203580) was provided by Shanghai KangChen Biotech,China;NMDA receptor antagonist(MK-801) was purchased from Shanghai Yope Biotech,China. METHODS:A total of 128 healthy,Wistar rats of clean grade,aged 3 months and weighing 180- 220 g,were randomly assigned to 4 groups:control,DNP model,p38 MAPK,and NMDA receptor. Each group contained 32 rats.DNP was established in all groups except for the control group by intraperitoneal injection of streptozocin(65 mg/kg).Subsequently,1 mg/kg SB203580 and 1 mg/kg MK-801 were injected once each week via intraperitoneal injection in the p38 MAPK and NMDA receptor groups,respectively. MAIN OUTCOME MEASURES:At the end of 2,4,6,and 8 weeks following streptozotocin injection, mechanical withdrawal threshold was measured in 8 animals from each group following von Frey filament stimulation.The rats were anesthetized and nerve conduction velocity of the left sciatic nerve was measured.Subsequently,the right sciatic nerve,the lumbar segment of the spinal cord, and dorsal root ganglia were removed from the L_(3-6) segment for microscopic examination.p38 MAPK expression was determined using immunohistochemistry and Western blot analysis. Expression of NMDA receptor 1 mRNA in dorsal root ganglion and spinal cord neurons was detected using RT-PCR. RESULTS:Mechanical withdrawal threshold and nerve conduction velocity were significantly reduced,and p38 MAPK and NMDA receptor 1 mRNA expression in the spinal cord and dorsal root ganglia were significantly increased,in the model,p38 MAPK,and NMDA receptor groups compared with the control group at all time points(P<0.05).At 4-8 weeks following successful DNP model establishment,SB203580 and MK-801 increased mechanical withdrawal threshold,accelerated nerve conduction velocity,and attenuated p38 MAPK expression,compared with the model group. The NMDA receptor group exhibited downregulated mRNA expression of NMDA receptor 1 compared with the model and p38 MAPK groups(P<0.05). CONCLUSION:NMDA receptor was highly expressed in the brains of DNP rats and was involved in DNP development via activation of the p38 MAPK signal pathway. | Changbin Ke Xiaoxia Huang Xianghong Luo Xiancheng Xu Chengming Qin Xianyu Wang Juying Liu | 2009 | Neural Regeneration Research2009，4，11： | 0 |
| 4 | The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike显示文摘Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions. | Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu Botao Ye Xuchang Yu Ziying Wang Danni Liu Yuanfeng Hao Fei Lu Zifeng Guo | 2024 | The Crop Journal2024，12，1： | 0 |
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