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| 1 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 2 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 3 | Optimization of annealing treatment and comprehensive properties of Cu-containing Ti6Al4V-xCu alloys显示文摘The Ti6Al4V-Cu alloy was reported to show good antibacterial properties, which was promising to reduce the hazard of the bacterial infection problem. For the purpose of preparing Ti6Al4V-Cu alloy with satisfied comprehensive properties, it’s important to study the heat treatment and the appropriate Cu content of the alloy. In this study, high Cu content Ti6Al4V-x Cu(x = 4.5, 6, 7.5 wt%) alloys were prepared, and firstly the annealing heat treatments were optimized in the α+β+Ti2Cu triple phase region to obtain satisfied tensile mechanical properties. Then the effect of Cu content on the tribological property, corrosion resistance, antibacterial activity and cytotoxicity of the Ti6Al4 V-x Cu alloys were systematically studied to obtain the appropriate Cu content. The results showed that the optimal annealing temperatures for Ti6Al4 V-x Cu(x = 4.5, 6, 7.5 wt%) alloys were 720, 740 and 760℃, respectively, which was resulted from the proper volume fractions of α,β and Ti2Cu phases in the microstructure. The additions of 4.5 wt% and 6 wt% Cu into the medical Ti6Al4 V alloy could enhance the wear resistance and corrosion resistance of the alloy, but the addition of 7.5 wt% Cu showed an opposite effect. With the increase of the Cu content, the antibacterial property was enhanced due to the increased volume fraction of Ti2Cu phase in the microstructure, but when the Cu content was increased to 7.5 wt%, cytotoxicity was presented. A medium Cu content of 6 wt%, with annealing temperature of 740℃ make the alloy possesses the best comprehensive properties of tensile properties, wear resistance, corrosion resistance, antibacterial property and biocompatibility, which is promising for future medical applications. | Cong Peng Yang Liu Hui Liu Shuyuan Zhang Chunguang Bai Yizao Wan Ling Ren Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 3 |
| 4 | Influence of alloplasm on resistance to wheat scab显示文摘Using alloplasmic wheat as test materials, the genetic effect of cytoplasm on wheat scab resistance was studied by three methods including the determination of resistance of explant calli to Gibberella zeae toxin, the identification of inoculating single fixed position and the identification of field resistance. The results showed that among 'the homonucleo_heterocytoplasmic lines', resistance of calli to G. zeae toxin was different; the difference of cytoplasmic effect among different nucleoplasm combinations showed certain nucleoplasm interaction relation. Resistance of hybrid F 1 plants of reciprocal cross between alloplasmic line and disease-sensitive wheat variety to wheat scab was of clear difference. Hybrid F 1 of reciprocal cross between Ae. ventricosa cytoplasmic wheat and disease-sensitive or -resistant wheat variety all exhibited fine resistance effect of alloplasm. Compared with general common wheat variety, most alloplasmic wheats tested have stronger resistance. A few selected lines having Ae. ventricosa cytoplasm have a strong and stable resistance to scab. They can be a finer new resistant source. | Wu Yuwen Ren Shuxin Liu Chunguang Hou Ning Zhang Cuilan Zhang Yan | 1998 | Chinese Science Bulletin1998，43，12： | 2 |
| 5 | Immunosenescence:molecular mechanisms and diseases显示文摘Infection susceptibility,poor vaccination efficacy,age-related disease onset,and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging(known as immunosenescence).During aging,organisms tend to develop a characteristic inflammatory state that expresses high levels of pro-inflammatory markers,termed inflammaging.This chronic inflammation is a typical phenomenon linked to immunosenescence and it is considered the major risk factor for age-related diseases.Thymic involution,naïve/memory cell ratio imbalance,dysregulated metabolism,and epigenetic alterations are striking features of immunosenescence.Disturbed T-cell pools and chronic antigen stimulation mediate premature senescence of immune cells,and senescent immune cells develop a proinflammatory senescence-associated secretory phenotype that exacerbates inflammaging.Although the underlying molecular mechanisms remain to be addressed,it is well documented that senescent T cells and inflammaging might be major driving forces in immunosenescence.Potential counteractive measures will be discussed,including intervention of cellular senescence and metabolic-epigenetic axes to mitigate immunosenescence.In recent years,immunosenescence has attracted increasing attention for its role in tumor development.As a result of the limited participation of elderly patients,the impact of immunosenescence on cancer immunotherapy is unclear.Despite some surprising results from clinical trials and drugs,it is necessary to investigate the role of immunosenescence in cancer and other age-related diseases. | Zaoqu Liu Qimeng Liang Yuqing Ren Chunguang Guo Xiaoyong Ge Libo Wang Quan Cheng Peng Luo Yi Zhang Xinwei Han | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 6 | Ultralong Organic Phosphorescence Modulation of Aromatic Carbonyls and Multi-Component Systems显示文摘Aromatic carbonyls have evoked sustained attention in the field of room-temperature phosphorescence(RTP).The introduction of carbonyl groups is a general way to achieve RTP for their effective intersystem crossing(ISC)by improving spin-orbit coupling(SOC).With further molecular design and processing strategies,aromatic carbonyls materials with multi-functional and high efficiency ultralong organic phosphorescence(UOP)can be obtained.This review summarizes the mechanism of aromatic carbonyls with UOP in pure aromatic carbonyls and their multi-component systems.Some detailed strategies for improving UOP performance are further introduced.The summary and outlook are presented to expound on the advances and lack of aromatic carbonyls.Further development directions and requirements are also put forward. | Chunguang Ren Zhengshuo Wang Tianjie Wang Jiayi Guo Yifeng Dai Hua Yuan Yeqiang Tan | 2022 | Chinese Journal of Chemistry2022，40，16： | 0 |
| 7 | Circulating Current Suppression Method with Adaptive Virtual Impedance for Multi-bidirectional Power Converters Under Unbalanced Conditions显示文摘Multi-paralleled bidirectional power converters(BPCs)are commonly used to improve the power capacity and reliability in an AC/DC hybrid microgrid.However,circulating current through multi-BPCs has been one of the challenges and it can be aggravated in the presence of non-ideal operating conditions,such as unbalanced AC voltages,and the mismatch of hardware parameters.In order to suppress the circulating current,this paper proposes a distributed method based on adaptive virtual impedance,which also employs positive sequence power droop control and voltage deviation compensation control.The traditional positive sequence power droop control is adopted to only regulate the positive components of the BPCs output voltage.The negative sequence power term is fed to an adaptive virtual impedance generator to modify the damping characteristics of the BPCs.Also,an adaptive virtual impedance-based voltage deviation compensation method is proposed to recover the fluctuated output voltage of the BPCs due to droop action and the power fluctuations.The fully distributed regulation of adaptive virtual impedance enables the load power to be shared accurately among BPC modules and thus the circulating current can be effectively suppressed.The proposed control strategy does not require an additional communication system and the precise parameters of hardware equipment and line impedance.Furthermore,the effectiveness of the proposed method is verified by the experimental results. | Baifu Zhang Xiaoqing Han Chunguang Ren Dongxia Zhang Lei Wang Tianhao Song | 2023 | CSEE Journal of Power and Energy Systems2023，9，1： | 0 |
| 8 | Synthesis of AgCl/Ti_(3)C_(2)@TiO_(2)Ternary Composite Photocatalysts for Photocatalytic Oxidation of 1,4-Dihydropyridine and Tetracycline Hydrochloride显示文摘AgCl/Ti_(3)C_(2)@TiO_(2)ternary composites were prepared to form a heterojunction structure between AgCl and TiO_(2)and introduce Ti3C2 as a cocatalyst.The as-prepared AgCl/Ti_(3)C_(2)@TiO_(2)composites showed higher photocatalytic activity than pure AgCl and Ti_(3)C_(2)@TiO_(2)for photooxidation of a 1,4-dihydropyridine derivative(1,4-DHP)and tetracycline hydrochloride(TCH)under visible light irradiation(λ>400 nm).The photocatalytic activity of AgCl/Ti_(3)C_(2)@TiO_(2)composites depended on Ti_(3)C_(2)@TiO_(2)content,and the catalytic activity of the optimized samples were 6.9 times higher than that of pure AgCl for 1,4-DHP photodehydrogenation and 7.3 times higher than that of Ti_(3)C_(2)@TiO_(2)for TCH photooxidation.The increased photocatalytic activity was due to the formation of a heterojunction structure between AgCl and TiO_(2)and the introduction of Ti3C2 as a cocatalyst,which lowered the internal resistance,sped up the charge transfer,and increased the separation efficiency of photogenerated carries.Photogenerated holes and superoxide radical anions were the major active species in the photocatalytic process. | Wu Hanliu Quan Yan Liu Meiling Tian Xuemei Ren Chunguang Wang Zhonghua | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，2： | 0 |
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