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| 1 | Rapidly in situ forming biodegradable hydrogels by combining alginate and hydroxyapatite nanocrystal显示文摘The in situ forming biodegradable polymer scaffolds are important biomaterials for tissue engineering and drug delivery.Hydrogels derived from natural proteins and polysaccharides are ideal tissue engineering scaffolds since they resemble the extracellular matrices of the tissue comprising various amino acids and sugar based macromolecules.This work presented an injectable system from partially oxidized alginate and hydroxyapatite(HAP) nanocrystal for tissue engineering and drug delivery applications.In situ release of calcium cations from HAP nanocrystal was adopted through lowering the pH with slow hydrolysis of D-glucono-δ-lactone(GDL) and homogeneous alginate gels were formulated as scaffolds with defined dimensions.The gelation time could be controlled to be in 10-15 min.The SEM observations confirmed the porous 3D hydrogel structure with interconnected pores ranging from 20 to 300 μm and the HAP particles dispersed in the scaffolds uniformly.The potential applications such as tissue engineering scaffold and injectable drug delivery system were demonstrated by subcutaneous implant test in test rats. | Lu Lu YuSha Qi ChangRen Zhou YanPeng Jiao | 2010 | Science China(Technological Sciences)2010，53，1： | 6 |
| 2 | Effect of chitooligosaccharides on cyclin D1,bcl-xl and bcl-2 mRNA expression in A549 cells using quantitative PCR显示文摘Chitooligosaccharide (COS) is derived from the chemical and enzymatic hydrolysis of chitosan and has been reported to have potent antitumor activity.Our study investigated the effects of five chitooligomers ranging from the dimer form to the hexamer form (chitobiose,chitotriose,chitotetraose,chitopentaose,chitohexaose) on the expression of cyclin D1,bcl-2 and bcl-xl mRNA in A549 cells using reverse transcription quantitative real-time PCR.We demonstrated that,of the five chitooligomers used,chitohexaose (COS6) had the most potent inhibitory effect on A549 cell proliferation.COS6 also significantly down regulated cyclin D1 and bcl-xl mRNA expression levels.Our data suggested that COS6 exerts its antitumor activity by two different mechanisms:(1) COS6-mediated inhibition of Cyclin D1 levels leads to suppression of tumor cell proliferation;and (2) COS6-mediated down-regulation of the pro-survival protein,Bcl-xl,promotes the apoptosis of tumor cells. | LI Xian WANG Ju CHEN XiaoJia TIAN JinHuan LI LiHua ZHAO MingYan JIAO YanPeng ZHOU ChangRen | 2011 | Chinese Science Bulletin2011，56，15： | 5 |
| 3 | A thermostability perspective on enhancing physicochemical and cytological characteristics of octacalcium phosphate by doping iron and strontium显示文摘Investigation of thermostability will lead the groundbreaking of unraveling the mechanism of influence of ion-doping on the properties of calcium phosphates.In this work,octacalcium phosphate(OCP),a metastable precursor of biological apatite,was used as a stability model for doping ions(Fe^(3+)and Sr^(2+))with different ionic charges and radii.After treated under hot air at different temperatures(110-200◦C),the phase,morphology,structure,physicochemical properties,protein affinity,ions release,and cytological responses of the ion-doped OCPs were investigated comparatively.The results showed that the collapse of OCP crystals gradually occurred,accompanying with the dehydration of hydrated layers and the disintegration of plate-like crystals as the temperature increased.The collapsed crystals still retained the typical properties of OCP and the potential of conversion into hydroxyapatite.Compared to the undoped OCP,Fe-OCP,and Sr-OCP had lower and higher thermostability respectively,leading to different material surface properties and ions release.The adjusted thermostability of Fe-OCP and Sr-OCP significantly enhanced the adsorption of proteins(BSA and LSZ)and the cytological behavior(adhesion,spreading,proliferation,and osteogenic differentiation)of bone marrow mesenchymal stem cells to a varying extent under the synergistic effects of corresponding surface characteristics and early active ions release.This work paves the way for understanding the modification mechanism of calcium phosphates utilizing ion doping strategy and developing bioactive OCP-based materials for tissue repair. | Haishan Shi Xiaoling Ye Jing Zhang Tingting Wu Tao Yu Changren Zhou Jiandong Ye | 2021 | Bioactive Materials2021，6，5： | 3 |
| 4 | Protein adsorption on the poly(L-lactic acid) surface modified by chitosan and its derivatives显示文摘Surface modification of biomaterials has been adopted over the years to improve their biocompatibility. In this study, aiming to promote hydrophilicity and to introduce natural recognition sites onto poly(L-lactic acid) (PLLA) films, chitosan and its derivatives, carboxymethyl chitosan(CMC) and N-methylene phosphonic chitosan (NPC), were used to modify the surface of PLLA films by an entrapment method. Radiolabeled (125I) proteins were used to measure the amount of protein adsorbed to PLLA surfaces. Fibronectin (Fn) was used to study the protein adsorption on the modified PLLA surfaces, including isotherm adsorption and adsorption kinetics of single protein, competitive adsorption of binary proteins system and serum multi-proteins and the desorption behavior in serum solution. The results showed that in the isotherm adsorption, Fn had a larger adsorption capacity on the CS-modified surface at lower concentrations, but had a high adsorption capacity at CMC-modified surface at higher concentrations. In the study of absorption kinetics, Fn had a fastest adsorption equilibrium and a highest equilibrium adsorption capacity at the CS-modified surface, while it was opposite at the PCS-modified surface. When BSA and serum were added, it had the greatest effect on the adsorption of Fn on the PCS-modified surface. After 6 hours soaking in the desorption study, Fn had reached desorption equilibrium on all the modified surfaces, which had different effects on the desorption rate and the remaining percentage of Fn. | JIAO YanPeng ZHOU ChangRen LI LiHua DING Shan LU Lu LUO BingHong LI Hong | 2009 | Chinese Science Bulletin2009，54，18： | 2 |
| 5 | Preparation and degradation of PLA/chitosan composite materials 显示文摘 | LI Lihua DING Shan ZHOU Changren | 2004 | J Appl Polym Sci2004，91，1： | 1 |
| 6 | Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy显示文摘Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy. | Guodong Sun Shenghui Zeng Xu Liu Haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu | 2019 | Nano-Micro Letters2019，11，2： | 1 |
| 7 | 显示文摘 | Zhou Changren Yi Zhengji | 1999 | Biomaterials1999，20，22： | 1 |
| 8 | A novel hierarchical method of ship detection from spaceborne optical image based on shape and texture features显示文摘 | Zhu Changren Zhou Hui Wang Runsheng | 2010 | IEEE Transaction on Geoscience and Remote Sensing2010，48，9： | 1 |
| 9 | Fabrication and properties of poly(L-lactide)/hydroxyapatite/chitosan fiber ternary composite scaffolds for bone tissue engineering显示文摘 | Jianhao Zhao Chunhong Luo Wanqing Han Mei Tu Rong Zeng Zhengang Cha Changren Zhou | 2012 | Journal of Polymer Engineering2012，32，45： | 1 |
| 10 | A novel hierarchical method of ship detection from space borne optical image based on shape and texture features 显示文摘 | Changren Zhu Hui Zhou Runsheng Wang | 2010 | IEEE Transactions on Geosciences and Remote Sensing2010，48，9： | 1 |
| 11 | Polymer/liquid crystal composite membranes:a new membrane system for crown mediated ion transport显示文摘 | ZHOU CHANGREN LIN S | 1998 | Eur Polym J1998，34，11： | 1 |
| 12 | A novel hierarchical method of ship detection from spaceborne optical image based on shape and texture features显示文摘 | ZHU Changren ZHOU Hui WANG Runsheng | 2010 | IEEE Transactions on Geoscience and Remote Sensing2010，48，9： | 1 |
| 13 | Polysaccharides-based nanoparticles as drug delivery systems显示文摘 | Zonghua Liu Yanpeng Jiao Yifei Wang Changren Zhou Ziyong Zhang | 2008 | Advanced Drug Delivery Reviews2008，，15： | 1 |
| 14 | Study on osteoinductivity of injectable calcium phosphate cement scaffold 显示文摘 | Hua Liu Changren Zhou Hong Li Zhizhong Li | 2008 | Advanced Materials Research2008，4750，： | 1 |
| 15 | Bio-inspired Cell Membrane Ingredient Cholesterol-conjugated Chitosan as a Potential Material for Bone Tissue Repair显示文摘 | LI Zhenzhen WEN Jianhua JIA Weijian DING Shan XIA Xiaohui ZHOU Changren HUANG Yadong | 2016 | Chemical Research in Chinese Universities2016，32，3： | 1 |
| 16 | Effect of Liquid Crystal Properties on the Hemocompatibility of Polymer/Liquid Crystal Compositc Membranes显示文摘 | Changren Zhou Zhengii Yi, Mei Tu and Sansong Mu(Institute of Biomedical Engineering, Jinan University, Guangzhou 510630, China) | 1999 | Chinese Journal of Biomedical Engineering(English Edition)1999，8，3： | 1 |
| 17 | Blood-compatibility of polyurethane/liquid crystal composite membranes显示文摘 | Zhou Changren Yi Zhengji | 1999 | Biomaterials1999，20，22： | 1 |
| 18 | A novel hierarchical method of ship detection from spaceborne optical image based on shape and texture feature显示文摘 | ZHU Changren ZHOU Hui WANG Runsheng | 2010 | IEEE Transactions on Geoscience and Remote Sensing2010，48，9： | 1 |
| 19 | 显示文摘 | Changren Zhou Zhengji Yi | 1999 | Biomaterials1999，20，22： | 1 |
| 20 | In vitro and in vivo Characterization of Homogeneous Chitosan-based Composite Scaffolds显示文摘With a homogeneous distribution of hydroxyapatite (HAP) crystals in polymer matrix, composite scaffolds chitosan/ HAP and chitosan/collagen/HAP were fabricated in the study. XRD, SEM and EDX were used to characterize their components and structure, in vitro cell culture and in vivo animal tests were used to evaluate their biocompatibility. HAP crystals with rod-like shape embeded in chitosan scaffold, while HAP fine-granules bond with collagen/chitosan scaffold compactly. A homogenous distribution of Ca and P elements both in chitosan/HAP scaffold and chitosan/collagen/HAP scaffold was defined by EDX pattern. The presence of collagen brought a more homogenous distribution of HAP due to its higher ability to induce HAP precipitation. The results of in vitro cell culture showed that the composite's biocompatibility was enhanced by the homogenous distribution of HAP. In vivo animal studies showed that the in vivo biodegradation was effectively improved by the addition of HAP and collagen, and was less influenced by the homogeneous distribution of HAP when compared with a concentrated distribution one. The composite scaffolds with a homogeneous HAP distribution would be excellent alternative scaffolds for bone tissue engineering. | 李红 ZHOU Changren ZHU Minying TIAN Jinhuan RONG Jianhua | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，1： | 0 |
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