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| 1 | Damage Identification in Simply Supported Bridge Based on Rotational-Angle Influence Lines Method显示文摘To locate and quantify local damage in a simply supported bridge, in this study, we derived a rotational-angle influence line equation of a simply supported beam model with local damage. Using the diagram multiplication method, we introduce an analytical formula for a novel damage-identification indicator, namely the diff erence of rotational-angle influence linescurvature(DRAIL-C). If the initial stiff ness of the simply supported beam is known, the analytical formula can be effectively used to determine the extent of damage under certain circumstances. We determined the effectiveness and anti-noise performance of this new damage-identification method using numerical examples of a simply supported beam, a simply supported hollow-slab bridge, and a simply supported truss bridge. The results show that the DRAIL-C is directly proportional to the moving concentrated load and inversely proportional to the distance between the bridge support and the concentrated load and the distance between the damaged truss girder and the angle measuring points. The DRAIL-C indicator is more sensitive to the damage in a steel-truss-bridge bottom chord than it is to the other elements. | Yu Zhou Shengkui Di Changsheng Xiang Wanrun Li Lixian Wang | 2018 | Transactions of Tianjin University2018，24，6： | 10 |
| 2 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 3 | Starch grain analysis reveals Late Neolithic plant utilization in the middle reaches of the Ganjiang River显示文摘Plant utilization is poorly known in South China as compared to North China.Fanchengdui, Zhuweicheng, Shinianshan, and Yinjiaping, which date back to 5-4 ka BP, are typical Neolithic sites located at the middle reaches of the Ganjiang River in Jiangxi Province.Due to the lack of systematic plant archaeological work, only rice straw and husk residues have been found in some archaeological sites in Jiangxi Province.Thirteen stone tools excavated from these sites were examined in this study.The results showed that among the plants utilized are Coix spp., Oryza spp., Vigna spp., plants from the tribe Triticeae, roots from some plants of Zingiberaceae, and other species of roots and tubers.More than 457 grains were retrieved from the 13 stone tools.The fact that Coix spp.were found in all stone tools suggests that these species were a major food source during the Neolithic era.In addition, 28 starch grains of Oryza spp.were found in 8 stone tools.The analysis also revealed that not only seeds of Gramineae but also those of Leguminosae, Zingiberaceae and other species of roots and tubers are among the plants utilized in the four Fanchengdui culture sites.These results indicate that ancient plant utilization was rather diverse, and this study elucidates the prehistoric agricultural systems of South China. | WAN ZhiWei YANG XiaoYan GE QuanSheng FAN ChangSheng ZHOU GuangMing JIANG MeiXin | 2012 | Science China Earth Sciences2012，55，12： | 5 |
| 4 | Methods for assessing the grooving corrosion of high-frequency electric resistance welded pipes显示文摘Grooving corrosion is a major form of corrosion and is prone to occur when high-frequency electric resistance welded (HFW) pipes are being used.Therefore,grooving corrosion is one of the performance indexes of HFW products.Grooving corrosion usually occurs along the welding fusion line,resulting in one or more corrosion grooves.The main factors affecting grooving corrosion include the contents of alloying elements and impurities (especially sulphur) in the steel,the microstructure of the welds and the steel substrate,welding parameters and the service environment as well.In this study,the existing methods for assessing grooving corrosion were systematically reviewed,improvements and new methods were proposed and developed to overcome the shortcomings of the existing methods,such as inaccuracy and excessive research time.By comparison with the existing methods,the operational procedures and the characteristics of the new methods are introduced,and issues regarding the behavior of grooving corrosion and their assessment methods,which both need further research,are discussed in this study. | WANG Wei QI Huibin LIU Changsheng ZHOU Qingjun QIAN Yuhai SHEN Jianlan | 2010 | Baosteel Technical Research2010，4，3： | 5 |
| 5 | Robust Tracking Control of Uncertain MIMO Nonlinear Systems with Application to UAVs显示文摘In this paper, we consider the robust adaptive tracking control of uncertain multi-input and multi-output(MIMO) nonlinear systems with input saturation and unknown external disturbance. The nonlinear disturbance observer(NDO)is employed to tackle the system uncertainty as well as the external disturbance. To handle the input saturation, an auxiliary system is constructed as a saturation compensator. By using the backstepping technique and the dynamic surface method,a robust adaptive tracking control scheme is developed. The closed-loop system is proved to be uniformly ultimately bounded thorough Lyapunov stability analysis. Simulation results with application to an unmanned aerial vehicle(UAV) demonstrate the effectiveness of the proposed robust control scheme. | Yanlong Zhou Mou Chen Changsheng Jiang | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，1： | 3 |
| 6 | NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis显示文摘Lung cancer,which is exacerbated by environmental pollution and tobacco use,has become the most common cause of cancer-related deaths worldwide,with a five-year overall survival rate of only 19%(Siegel et al.,2020;Yang et al.,2020;Yu and Li,2020).Nearly 85%of lung cancers are non-small cell lung cancers,of which lung adenocarcinoma is the most common subtype accounting for 50%of non-small cell lung cancer cases.At present,radiotherapy is the primary therapeutic modality for lung cancer at different stages,with significant prolongation of survival time(Hirsch et al.,2017;Bai et al.,2019;Shi et al.,2020). | Lisha ZHOU Changsheng DONG Zhuoming XU Xinran WANG Luyi ZHANG Siyuan CHEN Jiahao CHEN Yingying ZHU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 2 |
| 7 | Physicochemical properties and volatile components of hempseed oils in Bama region显示文摘A comparison study has been performed in hempseed oils (HSO) extracted from different cultivars in Bama region. Squeezing properties, chemical compositions, thermal stability and flavor profile of pressed HSO were determined in this study. Results indicated that there were no significant differences in crude fat, protein, fiber of different hempseeds and fatty acid composition in HSOs. Hempseeds with small size and dark-colored peel have lower squeezing oil yield than big ones. Average content of total phytosterol, tocopherol and phenol in HSO from small seeds were 872.0 mg/100 g, 124.1 mg/100 g and 15.5 mg SA/100 g respectively. Thermal oxidation by differential scanning calorimetry (DSC) revealed three step oxidation of HSO with mean onset and oxidation temperature at 124oC and 135-315oC. Oxidation temperature of HSO from small seeds was higher than that from big seeds (big size and light-colored peel). Main volatile ingredients in HSO contained 11 kinds of monoterpene and 7 kinds of sesquiterpene. Volatile terpene content in HSO from small seeds was nearly 30% higher than that of big seeds. Quality of HSO with different peel feature has significant difference in squeezing yield, thermal stability and volatile flavors. This work may be useful to produce high quality hempseed oils through quality evaluation. | Qi Zhou Fenghong Huang Chang Zheng Pingmei Guo Wenlin Li Changsheng Liu Chuyun Wan | 2017 | Oil Crop Science2017，2，1： | 2 |
| 8 | Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation显示文摘许多 G 联合蛋白质的受体(GPCR ) 被报导涉及多重硬化(MS ) 的致病,并且 ~40% 所有识别 GPCR 依靠 Gq/11 G 蛋白质家庭刺激肌醇类脂化合物发信号。然而,在 MS 致病的 G 子单元的功能仍然是未知的。在这研究,我们试图在试验性的自体免疫的脑脊髓炎(EAE ) 的致病决定 Gq 的角色, MS 的一个著名老鼠模型。我们发现与野类型的老鼠相比, Gq 大美人老鼠展出了不太严重的 EAE 症状,与更低的临床的分数,减少的白血球渗入和不太广泛的 demyelination。而且, Th17 房间的一个显著地更低的百分比,在 MS 致病的关键播放器之一,在 Gq 大美人 EAE 老鼠被观察。在 vitro 的研究证明在 CD4 + T 房间的 Gq 的那缺乏直接损害了 Th17 区别。另外, Gq 的缺乏显著地损害了表明 DC 涉及减少的 IL-6 生产的小径的导出 DC 的 IL-6 生产,因此禁止的 Th17 区别和 Gq-PLC-PKC 和 Gq-MAPKs。在摘要,我们的数据在调整 Th17 区别和 MS 致病加亮 Gq 的关键角色。 | Weiming Lai Yingying Cai Jinfeng Zhou Shuai Chen Chaoyan Qin Cuixia Yang Junling Liu Xin Xie Changsheng Du | 2017 | Cellular & Molecular Immunology2017，14，6： | 2 |
| 9 | Adaptive integral dynamic surface control based on fully tuned radial basis function neural network显示文摘An adaptive integral dynamic surface control approach based on fully tuned radial basis function neural network (FTRBFNN) is presented for a general class of strict-feedback nonlinear systems,which may possess a wide class of uncertainties that are not linearly parameterized and do not have any prior knowledge of the bounding functions.FTRBFNN is employed to approximate the uncertainty online,and a systematic framework for adaptive controller design is given by dynamic surface control. The control algorithm has two outstanding features,namely,the neural network regulates the weights,width and center of Gaussian function simultaneously,which ensures the control system has perfect ability of restraining different unknown uncertainties and the integral term of tracking error introduced in the control law can eliminate the static error of the closed loop system effectively. As a result,high control precision can be achieved.All signals in the closed loop system can be guaranteed bounded by Lyapunov approach.Finally,simulation results demonstrate the validity of the control approach. | Li Zhou Shumin Fei Changsheng Jiang | 2010 | Journal of Systems Engineering and Electronics2010，21，6： | 2 |
| 10 | Preparation of ammonium diuranate particles by external gelation process of uranium in INET显示文摘 | Zhou Xiangwen Ma Jingtao Hao Shaochang Zhao Xingyu Wang Yang Deng Changsheng Liang Tongxiang Guo Wenli Tang Yaping Tang Chunhe | 2012 | Nuclear Engineering and Design2012，，： | 1 |
| 11 | Mechanical properties, water-swelling behavior, and morphology of water-swellable rubber prepared using erosslinked sodium polyacrylate显示文摘 | Changsheng Liu Junping Ding Lang Zhou | 2006 | Journal of Applied Polymer Science2006，，102： | 1 |
| 12 | Numerical simulation of impact - echo method identify the depth of honeycomb damage in unballasted track 显示文摘 | ZHOU Changsheng WANG Ping HU Zhipeng | 2014 | Ap-plied Mechanics and Materials2014，，： | 1 |
| 13 | Determination of pore size and pore size distribution on the surface of hollow-fiber filtration membranes:A review of methods显示文摘 | Zhao Changsheng Zhou Xuesong Yue Yilun | 2000 | Desalination2000，129，2： | 1 |
| 14 | Thin-film composite membranes formed by interfacial polymerization with natural material sericin and trimesoyl chloride fornanofiltration显示文摘 | Zhou Choumou Shi Yalan Sun Changsheng | 2014 | Journal of Membrane Science2014，471，： | 1 |
| 15 | Research Progress on the Problem of Fluid,Heat and Energy Distribution near the Earthquake Source Area显示文摘As the basic problems in seismology, fluid, heat and energy distribution near earthquake sources during earthquake generation have been the leading subjects of concern to seismologists. Currently, more and more research shows fluid around earthquake source areas, which plays an important role in the process of earthquake preparation and generation. However, there is considerable controversy over the source of fluid in the deep crust. As for the problem of heat around earthquake source areas, different models have been proposed to explain the stress heat flow paradox. Among them, the dynamic weakening model has been thought to be the key to solving the heat flow paradox issue. After large earthquakes, energy distribution is directly related to friction heat. It is of timely and important practical significance to immediately implement deep drilling in-site surveying to gain understanding of fluid, friction heat and energy distribution during earthquake generation. The latest international progress in fluid, heat and energy distribution research has been reviewed in this paper which will bring important inspiration for the understanding of earthquake preparation and occurrence. | Yan Rui Jiang Changsheng Shao Zhigang Zhou Longquan Li Yingchun | 2011 | Earthquake Research in China2011，25，4： | 1 |
| 16 | Experimental research on cohesion and internal friction angle of the double-base propellant显示文摘 | ZHANG Jianbin JU Yutao ZHOU Changsheng | 2013 | Propellants Explosives Pyrotechnics2013，38，3： | 1 |
| 17 | Molecular chain movements and transitions of SEBS above room temperature studied by moving- window two- dimensional correlation infrared spectroscopy显示文摘 | Tao Zhou Aiming Zhang Changsheng Zhao | 2007 | Macromolecules2007，11，： | 1 |
| 18 | A simulation modellinking crop growth and soil biogeochemistry for sustainable agri culture显示文摘 | YU Zhang LI Changsheng ZHOU Xiuji | 2002 | Ecological Modelling2002，151，1： | 1 |
| 19 | Mechanical properties,water-swelling behavior,and morphology of waterswellable rubber prepared using crosslinked sodium polyacrylate显示文摘 | Liu Changsheng Ding Junping Zhou Lang | 2006 | Journal of Applied Polymer Science2006，102，： | 1 |
| 20 | Quality, fatty acid composition and oxidation stability of ten cold-pressed seed oils显示文摘 | Chang Zheng Mei Yang Qi Zhou Wenlin Li Changsheng Liu Miao Zhang Fenghong Huang | 2016 | Oil Crop Science2016，1，4： | 1 |
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