|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms显示文摘Background Alzheimer’s disease is a neurodegenerative disorder.Therapeutically,a transplantation of bone marrow mesenchymal stem cells(BMMSCs)can play a beneficial role in animal models of Alzheimer’s disease.However,the relevant mechanism remains to be fully elucidated.Main body Subsequent to the transplantation of BMMSCs,memory loss and cognitive impairment were significantly improved in animal models with Alzheimer’s disease(AD).Potential mechanisms involved neurogenesis,apoptosis,angiogenesis,inflammation,immunomodulation,etc.The above mechanisms might play different roles at certain stages.It was revealed that the transplantation of BMMSCs could alter some gene levels.Moreover,the differential expression of representative genes was responsible for neuropathological phenotypes in Alzheimer’s disease,which could be used to construct gene-specific patterns.Conclusions Multiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD models.Gene expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic effect.The transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer’s disease. | Chuan Qin Yalan Lu Kewei Wang Lin Bai Guiying Shi Yiying Huang Yongning Li | 2020 | Translational Neurodegeneration2020，9，2： | 9 |
| 2 | Mesoporous silica SBA-15 functionalized with phosphonate and amino groups for uranium uptake显示文摘Mesoporous silicas have a very attractive ability of sorption and enrichment of metal ions due to their huge surface area and facile functionalization by organic ligands.In this work,phosphonate-amino bifunctionalized mesoporous silica SBA-15(PA-SBA-15) as U(VI) sorbent was fabricated through post-grafting method.The obtained mesoporous silica was characterized by SEM,XRD,NMR and nitrogen sorption/desorption experiments,which revealed the existence of ordered mesoporous structure with uniform pore diameter and large surface area.The adsorptivity of PA-SBA-15 for U(VI) from aqueous solution was investigated using batch sorption technique under different experimental conditions.The preliminary results show that the U(VI) sorption by PA-SBA-15 is very quick with equilibrium time of less than 1 h,and the U(VI) uptake is as large as 373 mg/g at pH 5.5 under 95 ℃.The sorption isotherm has been successfully modeled by the Langmuir isotherm,suggesting a monolayer homogeneous sorption of U(VI) in PA-SBA-15.The sorption is pH-dependent due to the pH-dependent charge of sorbent in the aqueous solution.The thermodynamics research shows that the sorption is a feasible and endothermic process.Based on these results,PA-SBA-15 could be a promising solid phase sorbent for highly-efficient removal of U(VI) ions from waste water and enrichment of U(VI) from a solution at a very low level. | WANG XiaoLiang YUANLiYong WANG YanFei LI ZiJie LIU YaLan FENG YiXiao ZHAO YuLiang CHAI ZhiFang SHI WeiQun | 2012 | Science China Chemistry2012，55，9： | 6 |
| 3 | A green method of staining DNA in polyacrylamide gel electrophoresis based on fluorescent copper nanoclusters synthesized in situ显示文摘染色的 nucleic 酸的安全染长被认出了是一个问题。广泛的努力被作了寻找最流行却有毒的染色的染料的选择, ethidium 溴化物(EtBr ) 。然而,到目前为止不染色能被保证足够地安全的方法被开发了。在这份报纸,我们在 polyacrylamide 胶化电气泳动报导 DNA 的一个绿染色方法,在的地方在 situ 合成模板 DNA 荧光灯在胶化的铜 nanoclusters (CuNCs ) 被完成在紫外光下面使 DNA 乐队可见。而且,这个染色的方法的表演的全面研究被进行了,试验性的结果证明它有有利敏感,稳定性,和可用性。在我们的动物实验,同时,象综合 CuNCs 一样的二试剂(铜硫酸盐和维生素酸) 被证明了在与皮肤的接触无毒。另外,在这个工作采用的所有试剂是容易地可得到、低的费用,并且过程简单执行。因此,染色方法基于的这篇小说在里面 situ 合成模板 DNA 荧光灯 CuNCs 有许多潜在的应用程序。 | Xiaoli Zhu Hai Shi Yalan Shen Bin Zhang Jing Zhao Genxi Li | 2015 | Nano Research2015，8，8： | 2 |
| 4 | Kinetics process of Tb(Ⅲ)/Tb couple at liquid Zn electrode and thermodynamic properties of Tb-Zn alloys formation显示文摘Electrochemical properties of rare-earth elements in the LiCl-KCl eutectic are important for the pyrometallurgical recycling process of spent nuclear fuels. In this work, the electrochemical properties of Tb(Ⅲ)/Tb(0) couple were studied by the cyclic voltammetry(CV) at a liquid Zn pool electrode. The results showed that this electrochemical reaction is quasi-reversible with mixed reversible diffusion control and the charge transfer control. The diffusion coefficient of Tb(Ⅲ) was determined to be in the order of ~10.5 cm2 s.1. Moreover, kinetic parameters, such as the standard rate constants(ks) and charge transfer coefficient(α) for the electroreduction of Tb(Ⅲ) to Tb(0) at the liquid Zn electrode, were calculated by the Nicholson method at 873 K. Additionally, it was found that Tb-Zn intermetallic compounds were easily to be formed in the measurements. Hence, the reduction process of Tb(Ⅲ)/Tb(0) couple on the Zn-coated Mo electrode was also studied to obtain more information of the Tb-Zn intermetallic compounds. Electrochemical signals stemming from various intermetallic compounds associated with TbZn12, Tb2Zn17, Tb13Zn58, Tb3Zn11, TbZn3, TbZn2 and TbZn, were observed. The thermodynamic data were thereafter estimated by applying the emf method at 823–923 K. The standard formation Gibbs energies and the standard equilibrium constant of each Tb-Zn intermetallic compounds were also calculated. Finally, enthalpies and entropies of formation and the apparent standard potentials of various Tb-Zn intermetallic compounds were also obtained. | LiXia Luo YaLan Liu Ning Liu Kui Liu JinWen Pang LiYong Yuan ZhiFang Chai WeiQun Shi | 2017 | Science China Chemistry2017，60，6： | 2 |
| 5 | A high efficient sorption of U(VI) from aqueous solution using amino-functionalized SBA-15显示文摘 | Yalan Liu Liyong Yuan Yali Yuan Jianhui Lan Zijie Li Yixiao Feng Yuliang Zhao Zhifang Chai Weiqun Shi | 2012 | Journal of Radioanalytical and Nuclear Chemistry2012，，2： | 1 |
| 6 | Uranium(VI) adsorption on graphene oxide nanosheets from aqueous solutions显示文摘 | Zijie Li Fei Chen Liyong Yuan Yalan Liu Yuliang Zhao Zhifang Chai Weiqun Shi | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 7 | Hierarchical and self-supporting honeycomb LaNi_5 alloy on nickel foam for overall water splitting in alkaline media显示文摘Ni-based metallic foams possessing large specific surfaces and open cell structures are of specific interest as catalysts or catalyst carriers for electrolysis of water.Traditional fabrication of Nickel foam limits the element modification choices to several inert transition metals only on polymer foam precursor and subsequent preparation of foam-based catalysts in aqueous solution or organic electrolyte.To expand the modification horizon,molten salt with wide electrochemical window and fast ion diffusion can achieve the reduction of highly active elements.Herein,we reported is a general and facile method to deposit directly of highly reactive element La and prepare hierarchical honeycomb LaNi_(5) alloy on Ni foam(ho-LaNi_(5)/NF).This self-supporting electrode presents excellent electrical coupling and conductivity between the Ni foam and LaNi_(5),which provides a 3D self-supported heterostructure with outstanding electrocatalytic activity and excellent durability for the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).It exhibits excellent overpotential(1.86 V)comparable to commercial coupled IrO_(2)//Pt/C(1.85 V)at a high current density of 100 m A cm^(-2).This work may pave the way for fabricating novel 3D self-supported honeycomb alloy that can be applied as electrode for usage of clean energy. | Yanze Wu Yalan Liu Kui Liu Lin Wang Lei Zhang Degao Wang Zhifang Chai Weiqun Shi | 2022 | Green Energy & Environment2022，7，4： | 1 |
| 8 | Thin-film composite membranes formed by interfacial polymerization with natural material sericin and trimesoyl chloride fornanofiltration显示文摘 | Zhou Choumou Shi Yalan Sun Changsheng | 2014 | Journal of Membrane Science2014，471，： | 1 |
| 9 | Thin-filmcomposite membranes formed by interfacial polymerization withnatural material sericin and trimesoyl chloride fornanofiltration显示文摘 | ZHOU Choumou SHI Yalan SUN Changsheng | 2014 | J Memb Sci2014，471，7： | 1 |
| 10 | High performance of phosphonate- functionalized mesoporous silica for U(VI) sorption from aque- ous solution显示文摘 | YUAN Liyong LIU Yalan SHI Weiqun | 2011 | Dalton Trans2011，40，： | 1 |
| 11 | Synthesis and characterization of novel room temperature vulcanized (RTV) silicone rubbers using Vinyl-POSS derivatives as cross linking agents显示文摘 | Dongzhi Chen Shengping Yi Weibing Wu Yalan Zhong Jun Liao Chi Huang Wenjuan Shi | 2010 | Polymer2010，，17： | 1 |
| 12 | Moxibustion modulates working memory in patients with amnestic mild cognitive impairment:a functional magnetic resonance imaging study显示文摘OBJECTIVE:To investigate the correlation between changes in brain activity associated with working memory and assessment scales of memory scores in amnestic mild cognitive impairment(aMCI)before and after moxibustion therapy.METHODS:aMCI patients were randomized into the moxibustion treatment(MT)group and the placebo moxibustion(PM)group.Each group received either moxibustion therapy or a placebo moxibustion for eight weeks.Neuropsychological performance and functional brain responses to a working memory task were assessed at baseline and at the end of treatment.Memory function was evaluated individually by the Rivermead behavioral memory test(RBMT),and working memory was assessed by the N-back task.RESULTS:Compared with the PM group,RBMT score changes were significant(P<0.05).In the MT group,the accuracy of the N-back texts increased compared with those before the intervention.After moxibustion intervention,the right insula,postcentral gyrus,precentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,calcarine sulcus,posterior cingulate gyrus,middle frontal gyrus and anterior frontal gyrus were significantly activated(P=0.01,Cluster-level Family-Wise Error=0.05).Pearson correlation analysis showed that the insula,lingual gyrus and posterior cingulate gyrus were associated with changes in N-back score.Spearman correlation analysis showed that the postcentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,and posterior cingulate gyrus were correlated with RBMT score changes.CONCLUSION:Moxibustion treatment improved memory in aMCI patients and was associated with the activation of the brain region of the insula,lingual gyrus,posterior cingulate gyrus,postcentral gyrus,superior temporal gyrus,and thalamus,which may be an important mechanism by which moxibustion improves the memory function. | LI Xingjie LIU Qiqi XIA Rui LIU Jun WANG Dan SHI Jiao KUANG Yuxing DAI Yalan HUANG Haoyu TANG Wei CHEN Shangjie | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 1 |
| 13 | Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons显示文摘Midbrain dopaminergic neurons play an important role in the etiology of neurodevelopmental and neurodegenerative diseases.They also represent a potential source of transplanted cells for therapeutic applications.In vitro differentiation of functional midbrain dopaminergic neurons provides an accessible platform to study midbrain neuronal dysfunction and can be used to examine obstacles to dopaminergic neuronal development.Emerging evidence and impressive advances in human induced pluripotent stem cells,with tuned neural induction and differentiation protocols,makes the production of induced pluripotent stem cell-derived dopaminergic neurons feasible.Using SB431542 and dorsomorphin dual inhibitor in an induced pluripotent stem cell-derived neural induction protocol,we obtained multiple subtypes of neurons,including 20%tyrosine hydroxylase-positive dopaminergic neurons.To obtain more dopaminergic neurons,we next added sonic hedgehog(SHH)and fibroblast growth factor 8(FGF8)on day 8 of induction.This increased the proportion of dopaminergic neurons,up to 75%tyrosine hydroxylase-positive neurons,with 15%tyrosine hydroxylase and forkhead box protein A2(FOXA2)co-expressing neurons.We further optimized the induction protocol by applying the small molecule inhibitor,CHIR99021(CHIR).This helped facilitate the generation of midbrain dopaminergic neurons,and we obtained 31-74%midbrain dopaminergic neurons based on tyrosine hydroxylase and FOXA2 staining.Thus,we have established three induction protocols for dopaminergic neurons.Based on tyrosine hydroxylase and FOXA2 immunostaining analysis,the CHIR,SHH,and FGF8 combined protocol produces a much higher proportion of midbrain dopaminergic neurons,which could be an ideal resource for tackling midbrain-related diseases. | Yalan Chen Junxin Kuang Yimei Niu Hongyao Zhu Xiaoxia Chen Kwok-Fai So Anding Xu Lingling Shi | 2024 | Neural Regeneration Research2024，19，4： | 0 |
| 14 | Investigation of Vegetation Resources on City Wall of the Ming Dynasty in Nanjing City and Ecological Evaluation of the City Wall显示文摘Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accounted for the largest ratio.Plants on the city wall are characterized by strong drought resistance and precocity,their seeds can grow out of the wall cracks,and roots secrete acidoid and obtain nutrients from wall bricks.Plants on different wall sections are different,and human interventions influence phyto-groups on the city wall greatly.On this basis,it was concluded that plants had negative influence on city wall,especially plant roots destroyed the wall seriously.Corresponding researches were carried out and prevention suggestions proposed to provide scientific support for the protection of ancient city walls in Nanjing City. | WANG Xiaomei QIN Xiaoying SHI Hao LIU Jingwen QIAN Haili WAN Li LIU Yalan | 2012 | Journal of Landscape Research2012，4，11： | 0 |
| 15 | Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022显示文摘Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in China.It is endemic in 370 counties located in the agricultural and pastoral regions of western China.What is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in 2022.Following a thorough evaluation conducted by provincial CDCs. | Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui Li Peizheng Zhan Hongju Duan Wenbo Luo Benfu Li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue | 2024 | China CDC weekly2024，6，6： | 0 |
| 16 | DNA methylation of SMPD3-based diagnostic biomarkers of NASH and mild fibrosis显示文摘Non-alcoholic fatty liver disease(NAFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with NAFLD have the potential to progress to a more severe form of the condition known as nonalcoholic steatohepatitis(NASH),accompanied by bridging fibrosis.This advancement is more likely if the patient has metabolic risk factors such as obesity or type 2 diabetes that deteriorate over time.Additionally,even slight inflammation or fibrosis in NAFLD can significantly increase the likelihood of progression compared to steatosis alone.This underscores the importance of revising the present methods of monitoring NAFLD patients to ensure early detection and effective management of the disease. | Na Wu Mofan Feng Siran Yue Xinyu Shi Nan Tang Yalan Xiong Jianying Wang Lei Zhang Hualing Song Yi Shi Guang He Guang Ji Baocheng Liu | 2024 | Genes & Diseases2024，11，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员