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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | Precise localization of small pulmonary nodules using Pre-VATS with Xper-CT in combination with real-time fluoroscopy-guided coil:report of 15 patients显示文摘Purpose: This study aimed to evaluate the value of precise localization of nodules using pre-video-assisted thoracic surgery(VATS) Xper–CT in combination with real-time fluoroscopy-guided coil in the resection of pulmonary nodules using VATS. Materials and Methods: Precise localization of nodules using Xper-CT in combination with real-time fluoroscopy-guided coil and wedge resection using VATS were conducted on 15 patients with 17 small pulmonary nodules(diameter 0.5–1.5 cm) from April 2015 to January 2016. The value of localization was evaluated in terms of procedure time, type of coils, associated complications of localization, and VATS success rate. Results: The success rate of coil localization was found to be 100% in the primary stage(as shown by the CT scan), and the average procedure time was 30–45 min(35.6 ± 3.05 min). No deaths or major complications occurred. Minor complications included five incidents of pneumothorax(the morbidity was 29.4%, 5/17; no patient required chest tube drainage). The dislocation of coil was found in one patient. The results of pathological examination of 17 small pulmonary nodules revealed 11 primary lung cancers, 1 mesenchymal tumor, 3 nonspecific chronic inflammations, 1 hamartoma, and 1 tuberculosis. Two patients with primary lung cancer underwent lobectomy with mediastinal lymph node dissection. Conclusion: The preoperative precise localization of small pulmonary nodules using Xper-CT-guided coil is an effective and safe technique. It helps in the resection of nodules using VATS. It increases the rate of lung wedge resection with few complications and allows for proper diagnosis with a low thoracotomy conversion rate. | Jiemin Cheng Changyu Li Liangwen Wang Jiting Liang Zhiping Yan Jiani Hu Huibing Shi | 2018 | Journal of Interventional Medicine2018，1，2： | 8 |
| 3 | High power and stable P-doped yolk-shell structured Si@C anode simultaneously enhancing conductivity and Li^(+)diffusion kinetics显示文摘Silicon is a low price and high capacity ancxje material for lithium-ion batteries.The yolk-shell structure can effectively accommodate Si expansion to improve stability.However,the limited rate performance of Si anodes can't meet people's growing demand for high power density.Herein,the phosphorus-doped yolk-shell Si@C materials(P-doped Si@C)were prepared through carbon coating on P-doped Si/SiO_(x)matrix to obtain high power and stable devices.Therefore,the as-prepared P-doped Si@C electrodes delivered a rapid increase in Coulombic efficiency from 74.4%to 99.6%after only 6 cycles,high capacity retention of-95%over 800 cycles at 4 A·g^(-1),and great rate capability(510 mAh·g^(-1)at 35 A·g^(-1)).As a result,P-doped Si@C anodes paired with commercial activated carbon and LiFePO_(4)cathode to assemble lithium-ion capacitor(high power density of〜61,080 W·kg^(-1)at 20 A·g^(-1))and lithium-ion full cell(good rate performance with 68.3 mAh·g^(-1)at 5 C),respectively.This work can provide an effective way tofurther improve power density and stability for energy storage devices. | Ming Chen Qinnan Zhou Jiantao Zai Asma Iqbal TsegayeTadesse Tsega Boxu Dong Xuejiao Liu Yuchi Zhang Changyu Yan Liang Zhao Ali Nazakat SharelPeisan E CheeTongJohn Low Xuefeng Qian | 2021 | Nano Research2021，14，4： | 5 |
| 4 | Effects of cerium precursors on surface properties of mesoporous CeMnO_x catalysts for toluene combustion显示文摘Mesoporous CeMnOx composite oxides catalysts were prepared by surfactant-assisted co-precipitation method and used for the catalytic oxidation of toluene.The effect of different cerium precursors[Ce(NO3)3 and(NH4)2 Ce(NO3)6] on catalyst structure,surface properties and toluene combustion activities of mesoporous CeMnOx catalysts were investigated.The Ce(Ⅲ)MnOx catalyst prepared from Ce(NO3)3 precursor shows higher catalytic activity,with a 90% conversion temperature of 240℃,which is better than the Ce(Ⅳ)MnOx catalyst derived from[(NH4)2 Ce(NO3)6] precursor.On the basis of characterizations,it reveals that abundant surface content of Mn4+,better redox behavior and larger concentration of surface active oxygen species are responsible for the excellent catalytic performance. | Changyu Zhang Wei Chu Feng Chen Lei Li Ruiyu Jiang Jinlong Yan | 2020 | Journal of Rare Earths2020，38，1： | 4 |
| 5 | Design Aspects of Hybrid HVDC System显示文摘Hybrid high voltage direct current transmission(Hybrid HVDC)is a new type of HVDC technology developed in recent years.It combines the characteristics of large-capacity and low cost of the line commutated converters(LCC)and non-commutation failure and dynamic reactive power support of the voltage sourced converters(VSCs)in one HVDC system.It has technical advantages in the fields of unidirectional power transmission and in the application of improving the stability of multi-infeed HVDCs,giving it broad application prospects.This paper defines the basic form of hybrid HVDC first and discusses the characteristics and challenges of different hybrid HVDCs.Then,it analyzes the matching characteristics between LCC and VSC in the station-station hybrid HVDC,studies the key technologies,such as VSC topologies and control strategies for clearing the DC overhead line faults,and introduces the key technologies for analyzing and suppressing the high-frequency resonances between VSC and the power grid.In this paper,using the Wudongde UHV multi-terminal HVDC as an example,the proposed key technologies are analyzed and verified. | Hong Rao Yuebin Zhou Changyue Zou Shukai Xu Yan Li Liu Yang Weihuang Huang | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 2 |
| 6 | VqMYB154 promotes polygene expression and enhances resistance to pathogens in Chinese wild grapevine显示文摘Resveratrol plays a crucial phytoalexin role in the grapevine and is beneficial to human health.However,the molecular mechanism of resveratrol accumulation in the enhancement of disease resistance is unclear.Here,we report that the transcription factor VqMYB154 from Vitis quinquangularis accession Danfeng-2 is strongly expressed under artificial inoculation with Uncinula necator and regulates resveratrol accumulation.Unlike its homolog,VqMYB154 has a pathogen-induced promoter and responds to stimulation by U.necator,Pseudomonas syringae,and other treatments.Yeast one-hybrid and GUS activity assays confirmed that VqMYB154 can activate the stilbene synthase genes VqSTS9,VqSTS32,and VqSTS42 by directly binding to their promoters.Overexpression of VqMYB154 in grape leaves resulted in activation of the stilbene pathway,upregulation of STS genes,and accumulation of stilbenoids.In addition,heterologous overexpression of VqMYB154 in Arabidopsis activated resistance-related genes and resulted in greater programmed cell death and accumulation of reactive oxygen species,which led to resistance against P.syringae.These results suggest that the transcription factor VqMYB154 from V.quinquangularis accession Danfeng-2 participates in the regulatory mechanism that improves the biosynthesis and accumulation of stilbenes and enhances resistance to disease in grapevine. | Changyue Jiang Dan Wang Jie Zhang Yan Xu Chaohong Zhang Jianxia Zhang Xiping Wang Yuejin Wang | 2021 | Horticulture Research2021，8，1： | 2 |
| 7 | Discovery of ferrocene-carborane derivatives as novel chemical antimicrobial agents against multidrug-resistant bacteria显示文摘Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim of this study was to explore the potential application of three ferrocene-carborane derivatives as new promising agents to confront the problem of increasing antibiotic resistance. The results of agar diffusion bioassay, minimal inhibitory concentrations (MIC) testing and time-kill assay illustrate their broad-spectrum antimicrobial activities to both American Type Culture Collection (ATCC) control strains and MDR clinical isolates. It is evident that the relevant antimicrobial properties are all in a dose-dependent manner and gradually transform into a bactericidal effect from a bacteriostatic effect with the increasing of the drug concentration. Furthermore, these ferrocene-carborane derivatives have no/little toxic effect on normal cells like HELF cells and lead to little hemolysis at their MICs. This raises the possibility to develop novel antimicrobial drugs using these new ferrocene carborane derivants. | LI ShuiHong WU ChangYu LV XiaYi TANG Xiao ZHAO XinQing YAN Hong JIANG Hui WANG XueMei | 2012 | Science China Chemistry2012，55，11： | 2 |
| 8 | Flow characteristics and rheological properties of natural gas hydrate slurry in the presence of anti-agglomerant in a flow loop apparatus显示文摘 | YAN Kele SUN Changyu CHEN Jun | 2014 | Chemical Engineering Science2014，106，3： | 1 |
| 9 | Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells显示文摘 | Wensheng Xiang Aili Gao Hongsheng Liang Changyu Li Jiguo Gao Qing Wang Bao Shuang Ji Zhang Yijun Yan Xiangjing Wang | 2010 | Toxicology in Vitro2010，，6： | 1 |
| 10 | A new approach to model strain change of gelled waxy crude oil under con- stant stress显示文摘 | Lei Hou Changyu Song Wei Yan | 2014 | Rheologica Acta2014，53，4： | 1 |
| 11 | Evaluation of typical rheological models fitting for polycarbonate squeeze flow显示文摘 | Wei Cao Tao Wang Yue Yan Yanhui Qi Shixun Zhang Qian Li Changyu Shen | 2015 | J. Appl. Polym. Sci2015，，29： | 1 |
| 12 | Diversity of oligotrich ciliates(Ciliophora, Spirotrichea) in the northern coast of South China Sea as revealed in LSU rDNA sequences显示文摘Although the taxonomy of oligotrich ciliates has been widely investigated,yet the species diversity remains poorly known.We newly designed a pair of oligotrich-specific LSU rDNA primers covering the 600-bp D1/D2 region,and it was effective for detecting oligotrich species.Using the primers,we constructed the cloning libraries to investigate the species diversity of oligotrichs in the northern coastal waters of the South China Sea.In total,165 oligotrich sequences were obtained from five widely separated sampling sites.Sixty operational taxonomic units(OTUs)were obtained at 99%similarity threshold,and low-abundance OTUs with no more than two sequences contributed most of these(about 78%).Our findings are consistent with previous morphological studies,Strombidium was found the most abundant and widely distributed genus in this area.In addition,the BLAST search in the NCBI database resulted in 95%OTUs matching with named oligotrich species in similarity below 99%.Therefore,oligotrich morphospecies diversity has been underestimated as low-abundance species,and the LSU rDNA oligotrich sequence database needs to be better promoted. | LU Kaihui LIU Weiwei Alan WARREN XU Yusen ZHU Changyu ZHAO Yan YI Zhenzhen | 2020 | Journal of Oceanology and Limnology2020，38，1： | 1 |
| 13 | New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(Ⅱ)-arene complex显示文摘Bacterial biofilms are inherently resistant to antimicrobial agents and are difficult to eradicate with conventional antimicrobial agents, resulting in many persistent and chronic bacterial infections. In this contribution, a new strategy for reversing the biofilm-associated antibiotic resistance has been explored by induction of a carborane ruthenium(II)-arene complex (FcRuSB). Our results demonstrate that the FcRuSB could be utilized as an inducer to efficiently reverse the biofilm-associated antibiotic resistance of multidrug-resistant (MDR) clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The induced effect of FcRuSB is correlated with a considerable decrease in the expression of extracellular matrix proteins (EMP) of the two strains. The considerable decrease of the EMP of induced cells, resulting in the reduction of adherence and biofilm formation ability of the two types of MDR pathogens, and then can cause significantly enhanced sensitivity of them to antibiotics. | LI ShuiHong WU ChangYu TANG Xiao GAO ShengPing ZHAO XinQing YAN Hong WANG XueMei | 2013 | Science China Chemistry2013，56，5： | 0 |
| 14 | 高产酒精肺炎克雷伯菌引起的非酒精性脂肪肝病显示文摘文章简介非酒精性脂肪肝(NAFLD)具有进展为肝硬化和肝细胞癌的风险,其潜在病因多种多样,目前认为NAFLD与肠道微生物群的变化有关,然而,它们之间的因果关系尚不清楚。研究团队发现肠道菌群中高产酒精的肺炎克雷伯菌(HiAlc Kpn)可能是NAFLD的一个病因。在NAFLD患者人群中,高达60%的患者肠道菌群中含有HiAlc Kpn。 | 袁静 Chen Chen Jinghua Cui Jing Lu Chao Yan Xiao Wei Xiangna Zhao NanNan Li Shaoli Li Guanhua Xue Weiwei Cheng Boxing Li Huan Li Weishi Lin Changyu Tian Jiangtao Zhao Juqiang Han Daizhi An Qiong Zhang Hong Wei Minghua Zheng Xuejun Ma Wei Li Xiao Chen Zheng Zhang Hui Zeng Sun Ying JianXin Wu Ruifu Yang 刘翟 | 2020 | 科学新闻2020，，2： | 0 |
| 15 | Variations in terrestrial oxygen sources under climate change显示文摘The terrestrial ecosystem is an important source of atmospheric oxygen, and its changes are closely related to variations in atmospheric oxygen level. However, few studies have focused on the characteristics and driving forces behind terrestrial ecosystem oxygen sources. In this study, based on observations and net carbon flux simulations from the Sixth Coupled Model Intercomparison Project, we investigated temporal and spatial variations in terrestrial oxygen sources. As the largest source of atmospheric oxygen, the terrestrial ecosystem can produce approximately 7.10±0.38 gigatons of oxygen per year, and the tropics are the main oxygen producing regions. Notably, there are many “non-oxygen-producing lands”, where the lands no longer provide oxygen to the atmosphere, located in the high latitudes and around the deserts of Central Asia. Long-term analysis reveals that anthropogenic activities and climate change are responsible for the variations in terrestrial oxygen sources owing to land-use changes and competing effects between net photosynthesis and heterotrophic respiration. By 2100, more oxygen will be produced from the low-middle latitudes, while the high latitudes will serve as a larger oxygen sink due to extreme land-use type changes and drastic increases in soil respiration. Through this study, we supplement the understanding of the modern oxygen cycle and help provide better estimates for future variations in atmospheric oxygen level. | Lei DING Jianping HUANG Changyu LI Dongliang HAN Xiaoyue LIU Haiyun LI Yan BAI Jiping HUANG | 2022 | Science China Earth Sciences2022，65，9： | 0 |
| 16 | The On-site Verification of Key Technologies for Kunbei-Liuzhou-Longmen Hybrid Multi-terminal Ultra HVDC Project显示文摘Hybrid high voltage direct current transmission(Hybrid HVDC)is a new type of HVDC technology developed in recent years.It combines the characteristics of large-capacity and low cost of the line commutated converters(LCC)and non-commutation failure and dynamic reactive power support of voltage sourced converters(VSCs)in one HVDC system.It has technical advantages in the fields of unidirectional power transmission and in the application of improving the stability of multi-infeed HVDCs,giving it broad application prospects.The Kunbei-Liuzhou-Longmen(KBL)project is the first hybrid ultra HVDC project.It was put into service on Dec.27th,2020.This paper introduces the KBL project,analyzes the operation characteristics of hybrid HVDC system,and provides on-site verification of KBL project,including operation of LCC-VSC hybrid system,ultra-high voltage VSC technology using the series of two valve groups,the DC fault ride-though of hybrid VSC without using DC breaker,the connection and disconnection of a third station,and etc. | Hong Rao Changyue Zou Shukai Xu Xipeng Cai Yan Li Xiaobin Zhao Yuebin Zhou Yu Yang Wei Wei Jun Chen Tianliu Wei | 2022 | CSEE Journal of Power and Energy Systems2022，8，5： | 0 |
| 17 | Engineering hierarchical heterostructure material based on metal-organic frameworks and cotton fiber for high-efficient microwave absorber显示文摘Rational construction of hierarchical multi-component materials with abundant heterostructure is evolving as a promising strategy to achieve excellent metal-organic frameworks(MOFs)based electromagnetic wave(EMW)absorbers.Herein,hierarchical heterostructure WS_(2)/CoS_(2)@carbonized cotton fiber(CCF)was fabricated using the ZIF-67 MOFs nanosheets anchored cotton fiber(ZIF-67@CF)as a precursor through the tungsten etching,sulfurization,and carbonization process.Apart from the synergetic effect of dielectric-magnetic dual-loss mechanism,the hierarchical heterostructure and multicomponent of WS_(2)/CoS_(2)@CCF also display improved impedance matching.Furthermore,numerous W-S-Co bands and heterojunction interfaces of heterogeneous WS_(2)/CoS_(2)are beneficial to promoting additional interfacial/dipole polarization loss and conductive loss,thereby enhancing the EMW attenuation performance.Based on the percolation theory,a good balance between impedance matching and EMW absorption capacity was achieved for the WS_(2)/CoS_(2)@CCF/paraffin composite with 20 wt.%filler loading,exhibiting strong EMW absorption capability with a minimum reflection loss(RLmin)value of−51.26 dB at 17.36 GHz with 2 mm thickness and a maximum effective absorption bandwidth(EABmax)as wide as 6.72 GHz.Our research will provide new guidance for designing high-efficient MOFs derived EMW absorbers. | Yan Guo Hu Liu Dedong Wang Zeinhom M.El-Bahy Jalal T.Althakafy Hala M.Abo-Dief Zhanhu Guo Ben Bin Xu Chuntai Liu Changyu Shen | 2022 | Nano Research2022，15，8： | 0 |
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