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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients显示文摘The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. | Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai | 2016 | Science China(Life Sciences)2016，59，7： | 18 |
| 3 | Global convergence property of s-dependent GFR conjugate gradient method显示文摘An \%S\%_dependent GFR method and a generalized conjugate gradient method are designed. Two estimated values of upper bounds for the ratio of β k to β FR k are given. The two convergence theorems are proved. The global convergent properties of \%s\%_dependent GFR method are obtained adopting several choice strategies of steplength and some results in recent literature are extended. | WANG Changyu 1,2 and ZHANG Yuzhong\+1 1. Institute of Operations Research in Qufu Normal University, Qufu 273165, China 2. Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing 100080, China | 1998 | Chinese Science Bulletin1998，43，23： | 10 |
| 4 | High power and stable P-doped yolk-shell structured Si@C anode simultaneously enhancing conductivity and Li^(+)diffusion kinetics显示文摘Silicon is a low price and high capacity ancxje material for lithium-ion batteries.The yolk-shell structure can effectively accommodate Si expansion to improve stability.However,the limited rate performance of Si anodes can't meet people's growing demand for high power density.Herein,the phosphorus-doped yolk-shell Si@C materials(P-doped Si@C)were prepared through carbon coating on P-doped Si/SiO_(x)matrix to obtain high power and stable devices.Therefore,the as-prepared P-doped Si@C electrodes delivered a rapid increase in Coulombic efficiency from 74.4%to 99.6%after only 6 cycles,high capacity retention of-95%over 800 cycles at 4 A·g^(-1),and great rate capability(510 mAh·g^(-1)at 35 A·g^(-1)).As a result,P-doped Si@C anodes paired with commercial activated carbon and LiFePO_(4)cathode to assemble lithium-ion capacitor(high power density of〜61,080 W·kg^(-1)at 20 A·g^(-1))and lithium-ion full cell(good rate performance with 68.3 mAh·g^(-1)at 5 C),respectively.This work can provide an effective way tofurther improve power density and stability for energy storage devices. | Ming Chen Qinnan Zhou Jiantao Zai Asma Iqbal TsegayeTadesse Tsega Boxu Dong Xuejiao Liu Yuchi Zhang Changyu Yan Liang Zhao Ali Nazakat SharelPeisan E CheeTongJohn Low Xuefeng Qian | 2021 | Nano Research2021，14，4： | 5 |
| 5 | Effects of cerium precursors on surface properties of mesoporous CeMnO_x catalysts for toluene combustion显示文摘Mesoporous CeMnOx composite oxides catalysts were prepared by surfactant-assisted co-precipitation method and used for the catalytic oxidation of toluene.The effect of different cerium precursors[Ce(NO3)3 and(NH4)2 Ce(NO3)6] on catalyst structure,surface properties and toluene combustion activities of mesoporous CeMnOx catalysts were investigated.The Ce(Ⅲ)MnOx catalyst prepared from Ce(NO3)3 precursor shows higher catalytic activity,with a 90% conversion temperature of 240℃,which is better than the Ce(Ⅳ)MnOx catalyst derived from[(NH4)2 Ce(NO3)6] precursor.On the basis of characterizations,it reveals that abundant surface content of Mn4+,better redox behavior and larger concentration of surface active oxygen species are responsible for the excellent catalytic performance. | Changyu Zhang Wei Chu Feng Chen Lei Li Ruiyu Jiang Jinlong Yan | 2020 | Journal of Rare Earths2020，38，1： | 4 |
| 6 | Drag reduction and shear resistance properties of ionomer and hydrogen bond systems based on lauryl methacrylate显示文摘Based on molecular dynamics simulation results,a lauryl methacrylate polymer with drag reduction and shear resistance properties was designed,and synthesized by emulsion polymerization using 2-vinyl pyridine and methyl methacrylate as the polar polymerization monomer.After ionization of lauryl methacrylate polymer,an ion-dipole interaction based drag reduction agent (DRA) was obtained.The existence of ion-dipole interaction was proven through characterization of the drag-reducing agent from its infrared (IR) spectrum.The pilot-scale reaction yield of the DRA under optimum conditions was investigated,and the drag reduction and shear resistance properties were measured.The results show that:1) The ion-dipole or hydrogen bonding interaction can form ladder-shaped chains,therefore the synthesized DRA has shear resistance properties;2) The larger the molecular weight (MW) and more concentrated the distribution of MW,the better the drag reduction efficiency and the performance of the ionomer system was superior to that of the hydrogen bonding system;3) With increasing shear frequency,the drag-reduction rates of both the DRAs decreased,and the drag reduction rate of the ionomer system decreased more slowly than of the corresponding hydrogen bonding system.From the point of view of drag reduction rate and shear resistance property,the ionomer system is more promising than the hydrogen bonding | Yu Ping Li Changyu Zhang Changqiao Chen Shiwei Fang Shu Sun Hui | 2011 | Petroleum Science2011，8，3： | 3 |
| 7 | Histopathological Study of Trabeculum after Excimer Laser Trabeculectomy ab Interno显示文摘Purpose: To study the clinical manifestations and histopathologic changes of trabeculum after excimer laser trabeculectomy ab interno (ELT), and to investigate the mechanisms of ELT in reducing intraocular pressure.
Methods : ELT was performed on ten rabbit eves and postoperative responses were documented. Comeoscleral tissue samples were harvested consecutively each week until the 5th postoperative week and these samples were examined under light and electrical microscopy.
Results: Mild stimulation signs were present postoperatix'ely in nine of ten eyes, but no serious complications were experienced. Obvious inflammation was observed in one rabbit eye as a result of iris damage during the surgical manipulations. Local kactures on the trabecular meshwork and openings into Schlemm' s canal were detected in all tissue samples under light microscope. Mitochondria were found to be turgescent and dilated like vacuoles and endoplasmic reticula were found to be dilated under electrical microscope in the early postoperative period. Later, all trabecular cells returned normal and no fihroblast cells were ever detected.
Conclusions: Permanent openings through trabecular meshwork into the inner wall of Schlemm's canal can be created with ELT. The outflow resistance of aqueous humor can be reduced with these openings and intraocular pressure can be controlled thereafter. Eye Science 2001; 17:11 ~ 15. | Shengsong Huang,Minbin Yu,Guangqiang Feng,Ping Zhang,Changyu QiuZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060 , China | 2001 | Eye Science2001，17，1： | 3 |
| 8 | Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold显示文摘Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. | Fengwu Tang Jiaguang Tang Yannan Zhao Jiaojiao Zhang Zhifeng Xiao Bing Chen Guang Han Na Yin Xianfeng Jiang Changyu Zhao Shixiang Cheng Ziqiang Wang Yumei Chen Qiaoling Chen Keran Song Zhiwei Zhang Junjie Niu Lingjun Wang Qin Shi Liang Chen Huilin Yang Shuxun Hou Sai Zhang Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，5： | 3 |
| 9 | Clinical significance of miRNA-106a in non-small cell lung cancer patients who received cisplatin combined with gemcitabine chemotherapy显示文摘Objective:Research has demonstrated that microRNA(miR)-106a is related to cisplatin resistance.We investigated the expression of miR-106a in the serum of patients with non-small cell lung cancer(NSCLC)and their sensitivity to chemotherapy by cisplatin combined with gemcitabine.Methods:Eighty-five NSCLC patients,who completed four cycles of gemcitabine and cisplatin chemotherapy,volunteered for this study and their serum samples were collected.Serum samples from 60 healthy subjects were used as controls.Real-time quantitative polymerase chain reaction(real-time q PCR)was used to quantify the level of miR-106a in the serum.Demographic and survival data of these patients were collected for the analysis.Results:The expression of miR-106a in the serum of NSCLC patients was significantly higher than that of healthy subjects(P<0.001).The expression of miR-106a was not correlated with patients'gender,age,tumor size,lymphatic metastasis,and pathological types;but was correlated with patients'tumor staging(P=0.003).After chemotherapy,serum miR-106a expression decreased in patients.The decrease in miR-106a expression in the chemotherapy-sensitive group was much higher than that in the chemotherapy-resistant group.Survival analysis shows that NSCLC patients with high expression of miR-106a have a poorer prognosis.The overall survival of NSCLC patients in the chemotherapy-sensitive group was significantly higher than that in the chemotherapy-resistant group.Conclusions:High expression of miR-106a may be involved in the development of NSCLC.Mi R-106a has significance in the prognosis of NSCLC.The level of miR-106a in the serum can be a useful parameter in screening for drug resistance during cisplatin-based chemotherapy. | Ye Tian Changyu Sun Limeng Zhang Yuan Pan | 2018 | Cancer Biology & Medicine2018，15，2： | 3 |
| 10 | VqMYB154 promotes polygene expression and enhances resistance to pathogens in Chinese wild grapevine显示文摘Resveratrol plays a crucial phytoalexin role in the grapevine and is beneficial to human health.However,the molecular mechanism of resveratrol accumulation in the enhancement of disease resistance is unclear.Here,we report that the transcription factor VqMYB154 from Vitis quinquangularis accession Danfeng-2 is strongly expressed under artificial inoculation with Uncinula necator and regulates resveratrol accumulation.Unlike its homolog,VqMYB154 has a pathogen-induced promoter and responds to stimulation by U.necator,Pseudomonas syringae,and other treatments.Yeast one-hybrid and GUS activity assays confirmed that VqMYB154 can activate the stilbene synthase genes VqSTS9,VqSTS32,and VqSTS42 by directly binding to their promoters.Overexpression of VqMYB154 in grape leaves resulted in activation of the stilbene pathway,upregulation of STS genes,and accumulation of stilbenoids.In addition,heterologous overexpression of VqMYB154 in Arabidopsis activated resistance-related genes and resulted in greater programmed cell death and accumulation of reactive oxygen species,which led to resistance against P.syringae.These results suggest that the transcription factor VqMYB154 from V.quinquangularis accession Danfeng-2 participates in the regulatory mechanism that improves the biosynthesis and accumulation of stilbenes and enhances resistance to disease in grapevine. | Changyue Jiang Dan Wang Jie Zhang Yan Xu Chaohong Zhang Jianxia Zhang Xiping Wang Yuejin Wang | 2021 | Horticulture Research2021，8，1： | 2 |
| 11 | In situ observation of the dissolution kinetics of Al_(2)O_(3) particles in CaO–Al_(2)O_(3)–SiO_(2) slags using laser confocal scanning microscopy显示文摘The dissolution kinetics of Al_(2)O_(3) in CaO-Al_(2)O_(3) SiOslags was studied using a high-temperature confocal scanning laser microscope at 1773 to 1873 K.The results show that the controlling step during the Al_(2)O_(3) dissolution was the diffusionin molten slag.It was found that the dissolution curves of Al_(2)O_(3) particles were hardly agreed with the traditional boundary layer diffusion model with the increase of the CaO/Al_(2)O_(3) ratio of slag.A modified diffusion equation considering slag viscosity was developed to study the dissolution mechanism of Al_(2)O_(3) in slag.Diffusion coefficients of Al_(2)O_(3) in slag were calculated as 2.8×10to 4.1×10m~2/s at the temperature of 1773-1873 K.The dissolution rate of Al_(2)O_(3) increased with higher temperature,CaO/Al_(2)O_(3),and particle size.A new model was shown to be v_(Al_(2)O_(3))=0.16×r_(0)^(1.58)×x^(3.52)×(T-T_(mp))^(1.11)to predict the dissolution rate and the total dissolution time of Al_(2)O_(3) inclusions with various sizes,where vAl_(2)O_(3) is the dissolution rate of Al_(2)O_(3) in volume,μm^(3)/s;x is the value of CaO/Al_(2)O_(3) mass ratio;R_(0) is the initial radius of Al_(2)O_(3),μm;T is the temperature,K;T_(mp) is the melting point of slag,K. | Changyu Ren Caide Huang Lifeng Zhang Ying Ren | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，2： | 1 |
| 12 | Classification of L2 Vocabulary Learning Strategies:Evidence from Exploratory and Confirmatory Factor Analyses显示文摘 | Zhang Bo Li Changyu | 2011 | RELC Journal2011，42，2： | 1 |
| 13 | Steady-state module of cooling analysis in injection molding显示文摘 | Shen ChangYu Shi Xian Zhang Zhao Zhen Feng | 2007 | Polymer-Plastics Technology & Engineering2007，46，6： | 1 |
| 14 | Creep Analysis of the Pipe with Local Thinning Defect under Pressure and Moment at High Temperature显示文摘 | Changyu Zhou Jilin Xue Guodong Zhang | 2008 | Journal of Pressure Equipment and Systems2008，6，1： | 1 |
| 15 | Investigation on Upconversion Luminescence of Tm^(3+)/Yb^(3+)-Codoped Oxychloride Tellurite Glasses显示文摘Tm 3+/Yb 3+-codoped oxychloride tellurite glasses were prepared. Thermal stability, Raman spectra and upconversion luminescence spectra were studied, and upconversion luminescence mechanisms were analyzed. The results show that the intense blue and relatively weak red emissions centered at 476 and 649 nm corresponding to the transitions 1G4→3H6 and 1G4→3H4 of Tm 3+, respectively, were simultaneously observed at room temperature under 980 nm LD excitation. With increasing while PbCl2 content, thermal stability of host glasses increases, phonon energy of host glasses decreases, and upconversion luminescence intensities increase, which indicate that Tm 3+/Yb 3+-codoped oxychloride tellurite glasses can be used as potential host materials for upconversion blue lasers. | Xu Shiqing Zhao Shilong Zhang Liyan Shen Changyu Chen Liang | 2005 | Journal of Rare Earths2005，23，5： | 1 |
| 16 | Creep analysis of lhe pipe with local thinning defect under pressure and moment at high temperature显示文摘 | Zhou Changyu Xue Jilin Zhang Guodong | 2008 | Journal of Pressure Equipment and Systems2008，6，1： | 1 |
| 17 | Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells显示文摘 | Wensheng Xiang Aili Gao Hongsheng Liang Changyu Li Jiguo Gao Qing Wang Bao Shuang Ji Zhang Yijun Yan Xiangjing Wang | 2010 | Toxicology in Vitro2010，，6： | 1 |
| 18 | Preparation and Properties of Flame Retardant Polypropylene with an Intumescent System Encapsulated by Thermoplastic Polyurethane显示文摘 | Xuejun Lai Xingrong Zeng Hongqiang Li Feng Liao Haili Zhang Changyu Yin | 2012 | Journal of Macromolecular Science Part B2012，，1： | 1 |
| 19 | Numerical Simulation of Welding Residual Stress and Post weld Heat Treatment for Dissimilar Steel Welded Joint 显示文摘 | Guodong ZHANG Changyu ZHOU | 2008 | Materials Science Forum2008，，： | 1 |
| 20 | Fuzzy stochastic generalized reliability studies on embankment systems based on first-order approximation theorem显示文摘In order to address the complex uncertainties caused by interfacing between the fuzziness and randomness of the safety problem for embankment engineering projects, and to evaluate the safety of embankment engineering projects more scientifically and reasonably, this study presents the fuzzy logic modeling of the stochastic finite element method (SFEM) based on the harmonious finite element (HFE) technique using a first-order approximation theorem. Fuzzy mathematical models of safety repertories were introduced into the SFEM to analyze the stability of embankments and foundations in order to describe the fuzzy failure procedure for the random safety performance function. The fuzzy models were developed with membership functions with half depressed gamma distribution, half depressed normal distribution, and half depressed echelon distribution. The fuzzy stochastic mathematical algorithm was used to comprehensively study the local failure mechanism of the main embankment section near Jingnan in the Yangtze River in terms of numerical analysis for the probability integration of reliability on the random field affected by three fuzzy factors. The result shows that the middle region of the embankment is the principal zone of concentrated failure due to local fractures. There is also some local shear failure on the embankment crust. This study provides a referential method for solving complex multi-uncertainty problems in engineering safety analysis. | Wang Yajun Zhang Wohua Jin Weiliang Wu Changyu Ren Dachun | 2008 | Water Science and Engineering2008，1，4： | 1 |
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