|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An HBV-encoded miRNA activates innate immunity to restrict HBV replication显示文摘We previously identified that hepatitis B virus(HBV)encodes a microRNA(HBV-miR-3)that restrains HBV replication by targeting the HBV transcript.However,whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear.Here,we examined the vital functions of HBV-miR-3 in the innate immune response after HBV infection.We found that HBV-miR-3 expression gradually increased in a dose-and time-dependent manner in HBV-infected HepG2-NTCP cells.HBV-miR-3 activated the JAK/STAT signaling pathway by downregulating SOCS5 in hepatocytes,thereby enhancing the IFN-induced anti-HBV effect.In addition,HBVmiR-3 in exosomes facilitated the Ml polarization of macrophages.Furthermore,exosomes containing HBV-miR-3 enhanced the secretion of IL-6 via inhibiting the SOCS5-mediated ubiquitination of EGFR.In short,these results demonstrate that HBV-miR-3 activates the innate immune response to restrain HBV replication by multiple pathways,which may suppress HBV-induced acute liver cell injury and affect the progression of persistent HBV infection. | Xiaoqing Zhao Lu Sun Ting Mu Jianying Yi Chaoqun Ma Hong Xie Min Liu Hua Tang | 2020 | Journal of Molecular Cell Biology2020，12，4： | 17 |
| 2 | Role of ultrasonic oscillation in chemical processes in microreactors:A mesoscale issue显示文摘The integration of microreactor and ultrasound represents an emerging area for process intensification and has attracted considerable attention in recent years.One of the most important meso-scientific issues in ultrasound techniques is acoustic cavitation,which plays a vital role in the macroscopic performance of an ultrasonic microreactor.In this review,we first briefly summarize the latest research on acoustic cavitation phenomena in microreactors.The effects of channel configuration,solvent properties,and ultrasound parameters are systematically reviewed.In addition,the role of acoustic cavitation in various chemical processes(e.g.,mixing,absorption,emulsification,and particle synthesis)is presented from a mesoscale perspective,which in turn provides guidance for ultrasound applications.A thorough under-standing of the ultrasound intensification mechanism will contribute to the future development of this promising technology. | Shuainan Zhao Chaoqun Yao Zhengya Dong Guangwen Chen Quan Yuan | 2020 | Particuology2020，18，1： | 3 |
| 3 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 4 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 5 | Autonomous live working robot navigation with real-time detection and motion planning system on distribution line显示文摘In this study,an autonomous robot navigation system is designed for live working on distribution line.The developed system features a real-time detection and motion planning system,incorporating a manipulator capable of grasping power components.In order to accurately identify targets,the authors propose an object detection method based on the Larger Scale‘You Only Look Once’Version 4(LS-YOLOv4)algorithm for detecting the insulators and drop fuses.The LS-YOLOv4 extracts features of power components by Convolutional Neural Network(CNN),and then performs feature fusion.Then the authors develop a motion planning method based on the Node Control Optimal Rapidly Exploring Random Trees(NC-RRT*),which can drive the robot to realise the autonomous robot motion planning and obstacle avoidance.On the grasping function,the authors present a reliable Lightweight-based Convolutional Neural Network(L-CNN)grasping point detection method.Finally,the authors evaluate fully autonomous robotic system in both simulated and real-world experiments.The experimental results demonstrate that the proposed system can effectively identify the target and complete the grasping task in an efficient way.Notably,the proposed motion planning method can take into account both planning efficiency and accuracy to manipulation tasks. | Haoning Zhao Chaoqun Wang Rui Guo Xuewen Rong Jiamin Guo Qixun Yang Lecheng Yang Yuliang Zhao Yibin Li | 2022 | High Voltage2022，7，6： | 2 |
| 6 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 7 | AMERICAN OPTION PRICING UNDER GARCH DIFFUSION MODEL: AN EMPIRICAL STUDY显示文摘 | WU Xinyu YANG Wenyu MA Chaoqun ZHAO Xiujuan | 2014 | Journal of Systems Science & Complexity2014，27，1： | 2 |
| 8 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 9 | Characteristics of slug flow with inertial effects in a rectangular microchannel 显示文摘 | Yao Chaoqun Zhao Yuchao Ye Chunbo Dang Minhui Dong Zhengya Chen Guangwen | 2013 | Chemical Engineering Science2013，95，： | 1 |
| 10 | Game Cross Efficiency for Systems with Two-Stage Structures显示文摘 | Chaoqun Ma Debin Liu Zhongbao Zhou Wei Zhao Wenbin Liu Pu-yan Nie | 2014 | Journal of Applied Mathematics2014，，： | 1 |
| 11 | A joint synchronization and channel estimation algorithm for MIMO-OFDM Sys- tem 显示文摘 | Gao Jingpeng Zhao Danfeng Wu Chaoqun | 2013 | Telkomnika2013，12，11： | 1 |
| 12 | The Type III Secretion System of Vibrio Alginolyticus Induces Rapid Apoptosis,Cell Rounding,and Osmotic Lysis of Fish Cells显示文摘 | ZHAO Zhe CHEN Chang HU Chaoqun | 2010 | Microbiology2010，156，9： | 1 |
| 13 | Characteristics of slug flow with inertial effects in a rectangular microchannel 显示文摘 | Yao Chaoqun Zhao Yuchao Ye Chunbo | 2013 | Chemical Engineering Science2013，95，： | 1 |
| 14 | Expression and characterization of rice putative PAUSED gene显示文摘在 Arabidopsis,暂停了(PSD ) 编码 los1p/exportin-t 的 ortholog,它调停在酵母和哺乳动物的转移 RNA (tRNA ) 的原子出口。在象米饭那样的 monocot 植物,然而,相应 ortholog 的知识被限制,并且它在生长开发和生产率的效果仍然保持未知。在这研究,我们验证了一根米饭 transfer-DNAinsertional 异种 psd 线并且分析了它的显型;异种与野类型的米饭相比包括延迟的开发和低富饶显示了严重词法缺点。与在野类型、变异的叶织物之间的北污点分析在细胞质、原子的部分检验 intronless tRNA-Tyr 和包含 intron pre-tRNA-Ala 表示层次建议米饭 PSD 可能从原子核涉及 tRNA 出口到细胞质。另外,反向的抄写聚合酶链反应分析表明那个 PSD 抄本在整个正常米饭植物开发被表示,并且 subcellular 本地化试金证明那米饭 PSD 蛋白质在原子核和细胞质是在场的。在摘要,我们的数据暗示通常认为的 PSD 基因可能为正常米饭开发是不可缺少的,它的函数可能与 Arabidopsis PSD 的一样。 | Chengguo Yao Liangfa Ge Wei Li Botao Zhao Chaoqun Li Kangcheng Ruan Hongxuan Lin Youxin Jin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 1 |
| 15 | Character- istics of slug flow with inertial effects in rectangular mi- crochannel显示文摘 | YAO Chaoqun ZHAO Yuchao YE Chunbo | 2013 | Chemical Engineering Science2013，95，： | 1 |
| 16 | Microsatellite and mitochondrial DNA assessment of the genetic diversity of captive Saiga antelopes(Saiga tatarica) in China显示文摘To estimate the genetic diversity of the only captive Saiga antelope(Saiga tatarica) population in China,40 umbilical cord samples were collected and mitochondrial(control region) and nuclear(microsatellite) variabilities were assessed.Both of the markers revealed low genetic variability(or high genetic homogeneity) within the population.The microsatellites yielded monitoring ranges of 2-6 alleles.The observed heterozygosities ranged from 0.28 to 0.83,and the expected heterozygosities were between 0.27 and 0.71.The Shannon information index(Shannon I) and Polymorphic Information Content(PIC) presented overall means of 0.87 and 0.43,respectively.The gene diversity was 0.49.We found only two haplotypes in the population,and the haplotype and nucleotide diversities were 39.1% and 1.13%,respectively.Founder events,bottlenecks and inbreeding have contributed to the low genetic variation observed in this population.Our findings revealed the extent of genetic diversity maintained in the present population and the urgency of implementing a protection plan,introducing animals from other populations to enhance saiga's genetic variation. | ZHAO ShaSha XU ChaoQun LIU Gang LIU ShuQiang ZHAO ChongXue CUI YaXiong HU DeFu | 2013 | Chinese Science Bulletin2013，58，17： | 1 |
| 17 | Improving the intrinsic electronic conductivity of NiMo0_(4) anodes by phosphorous doping for high lithium storage显示文摘Heteroatom doping is one of the most promising strategies toward regulating intrinsically sluggish electronic conductivity and kinetic reaction of transition metal oxides for enhancing their lithium storage.Herein,we designed phosphorus-doped NiMo0_(4) nanorods(P-NiMo0_(4))by using a facile hydrothermal method and subsequent low-temperature phosphorization treatment.Phosphorus doping played an indispensable role in significantly improving electronic conductivity and the Li+diffusion kinetics of NiMo0_(4) materials.Experimental investigation and density functional theory calculation demonstrated that phosphorus doping can expand the interplanar spacing and alter electronic structures of NiMo0_(4) nanorods.Meanwhile,the introduced phosphorus dopant can generate some oxygen vacancies on the surface of NiMo0_(4),which can accelerate Li+diffusion kinetics and provide more active site for lithium storage.As excepted,P-NiMo0_(4) electrode delivered a high specific capacity(1,130 mA·g^(-1) at 100 mA·g^(-1) after 100 cycles),outstanding cycling durability(945 mA·g^(-1) at 500 mA·g^(-1) over 200 cycles),and impressive rate performance(640 mA·g^(-1)at 2,000mA·g^(-1))for lithium ion batteries(LIBs).This work could provide a potential strategy for improving intrinsic conductivity of transition metal oxides as high-performance anodes for LIBs. | Luchao Yue Chaoqun Ma Shihai Yan Zhenguo Wu Wenxi Zhao Qian Liu(ISl) Yonglan Luo Benhe Zhong Fang Zhang Yang Liu Abdulmohsen AN Alshehri Khalid Ahmed Alzahrani Xiaodong Guo Xuping Sun | 2022 | Nano Research2022，15，1： | 1 |
| 18 | Assessing the conservation impact of Chinese indigenous chicken populations between ex-situ and in-situ using genome-wide SNPs显示文摘Conservation programs require rigorous evaluation to ensure the preservation of genetic diversity and viability of conservation populations. In this study, we conducted a comparative analysis of two indigenous Chinese chicken breeds, Gushi and Xichuan black-bone, using whole-genome SNPs to understand their genetic diversity, track changes over time and population structure. The breeds were divided into five conservation populations(GS1, 2010, ex-situ;GS2, 2019, ex-situ;GS3, 2019, in-situ;XB1, 2010, in-situ;and XB2, 2019, in-situ) based on conservation methods and generations. The genetic diversity indices of three conservation populations of Gushi chicken showed consistent trends, with the GS3 population under in-situ strategy having the highest diversity and GS2 under ex-situ strategy having the lowest. The degree of inbreeding of GS2 was higher than that of GS1 and GS3. Conserved populations of Xichuan black-bone chicken showed no obvious changes in genetic diversity between XB1 and XB2. In terms of population structure, the GS3 population were stratified relative to GS1 and GS2. According to the conservation priority, GS3 had the highest contribution to the total gene and allelic diversity in GS breed, whereas the contribution of XB1 and XB2 were similar. We also observed that the genetic diversity of GS2 was lower than GS3, which were from the same generation but under different conservation programs(in-situ and ex-situ). While XB1 and XB2 had similar levels of genetic diversity. Overall, our findings suggested that the conservation programs performed in ex-situ could slow down the occurrence of inbreeding events, but could not entirely prevent the loss of genetic diversity when the conserved population size was small, while in-situ conservation populations with large population size could maintain a relative high level of genetic diversity. | Wenting Li Chaoqun Gao Zhao Cai Sensen Yan Yanru Lei Mengya Wei Guirong Sun Yadong Tian Kejun Wang Xiangtao Kang | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 19 | Design of nanozymes for inflammatory bowel disease therapy显示文摘Nanozymes,the functional nanomaterials with enzyme-like activities,have been widely explored for both in vitro and in vivo applications(Wei and Wang,2013;Wu et al.,2019;Huang et al.,2019;Liang and Yan,2019).Particularly,by modulating the levels of reactive oxygen species(ROS)in vivo,numerous therapeutic nanozymes have been developed to treat diseases,ranging from cancer to neurodegenerative diseases(Fan et al.,2018;Kwon et al.,2018). | Chaoqun Cheng Sheng Zhao Yuan Cheng Yufeng Liu Hui Wei | 2021 | Science China(Life Sciences)2021，64，8： | 0 |
| 20 | High Jc Epitaxial Superconducting YBa_2Cu_3O_(7-x) Thin Films显示文摘Excellent epitaxial growth of supercon-ducting YBa2 Cu3 O7-x thin films have beenrealized on(100)SrTiO3 and(100)ZrO2substrates by a planar rf or DC-magnetronsputtering apparatus with UHV system.Thequality of growth and the epitaxial orientationof the film strongly depended on substratetemperature,the substrate orientation and ox-ygen partial pressure.The films exhibitedsuperconducting onset at 92K and zero resist-ance at 90K with critical current density | Chen Lanfeng Zhou Li Wang Chaoqun General Research Institute of Non-ferrous Metals.Beijing,China Li Lin Zhao Bairu Zhang Yinzi Qiu Xianggang Institute of Physics,Academia Sinica,Beijing.China Pang Shijing Beijing Laboratory of Vacuum Physics,China Kou Yuanheng Department of Physics.Peking University,Beijing,China | 1990 | Rare Metals1990，10，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员