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| 1 | Primary dolostone formation related to mantle-originated exhalative hydrothermal activities,Permian Yuejingou section,Santanghu area, Xinjiang,NW China显示文摘The Permian Lucaogou Formation is an important hydrocarbon source rock in the Junggar, Turpan, and Santanghu basins in Xinjiang, NW China. For the first time, dolostones associated with mantle-originated exhalative hydrothermal fluid flows are discovered in Yuejingou section in the Santanghu Basin area. They include dolomicrite, doloarenite, and a small amount of dolorudite, and are finely (0.05-0.15 cm thick) interlaminated with lime micrite and dolomicritic analcime laminites. Alkali feldspar and analcime grains are common in doloarenite and are interpreted as having been derived from analcime phonolites and peralkaline magmatic rocks. These magmatic fragments were brought up from subsurface by hydrothermal fluid flow and had experienced exhalative brecciation, transport, and deposition on the lake floor. The matrix consists dominantly of dolomite and ankerite smaller than 0.01 mm. The dolostones can be subdivided into four types on the basis of mineral composition and content. The detrital analcime and alkaline feldspar grains and tuff lithics are interpreted as intraclasts, which were deposited in an under-filled starved lake basin. The δ18OPDB values of dolostones are -5‰ to -21.1‰, and -11.9‰ on average; the 87Sr/86Sr ratios of dolostones are 0.70457 to 0.706194, and 0.705005 on average. These values, in combination with evidence of multi-episodes of peralkaline extrusion, suggest a mantle origin of the hydrothermal fluids, which may have promoted primary dolomite formation. The fluid from the upper mantle caused serpentinization of ultramafic rocks that intruded into the lower crust to obtain Mg2+ and Fe2+, and injected the ions into the lake water as the Mg and Fe sources for dolomite and ankerite. Hydro- thermal fluids associated with peralkaline magmatic rocks also provided Ca2+, Mg2+, Fe2+, and CO32-. Explosive breccias formed and dolostones were convoluted near the vent of hydrothermal fluid exhalation, whereas laminated dolostones formed farther away from the vent. The dolostones are primary dolomite deposition in an intracontinental rift basin and associated with mantle-originated hydrothermal fluids. They provide an insight into the origin of dolomite formation in the geologic history and clues to understand the sedimentary environments and tectonic conditions in northern Xinjiang during the late Paleozoic. | LIU YiQun JIAO Xin LI Hong YUAN MingSheng YANG Wan ZHOU XiaoHu LIANG Hao ZHOU DingWu ZHENG ChaoYang SUN Qin WANG ShuangShuang | 2012 | Science China Earth Sciences2012，55，2： | 17 |
| 2 | An experimental research of Weining granule in treating gastric precancerous lesions显示文摘目的将在胃的癌症前期的损害的治疗调查 Weining 小粒的潜在的治疗学的效果和机制。六十只老鼠随机被分到一个空白的组或一个模型组或到的方法收到酸或高的 retinoic -- ,中等 -- 或低 -- Weining 的剂量小粒。动物的一般条件在治疗前后被遵守。在胃的 mucosal pathohistology, telomerase 活动,增长索引(PI ) 和 apoptosis 索引(AI ) 的变化被测量。结果将军调节,包括活动并且吃,与肠的组织变形(IM ) ,不正常的增生(ATP ) 或是比在模型的那些显著地低的积极 telomerase 活动组织的老鼠有的数字在所有 Weining-granule-treated 组被改进(P <
0.05 或 P <
0.01 ) 。与模型组相比, Weining 小粒的所有剂量显著地减少了 PI (P <
0.01 ) 并且增加的 AI (P <
0.05 ) 。结论 Weining 小粒可以由禁止 telomerase 活动和胃的癌症房间并且由加速他们的 apoptosis 的增长为胃的癌症前期的损害的治疗提供一个治疗学的好处。 | Xing Deng Jian Liang Donghua Liu Chaoyang Zhu Longhua Li Likui Qin | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 6 |
| 3 | The Effects of Microwave Ablation and Surgical Resection on Hematogenous Dissemination of Cancer Cells in Treating Patients with Small Primary Hepatocellular Carcinoma显示文摘OBJECTIVE To conduct a comparative study of the effects of treatment using microwave ablation versus surgical resection on hematogenous dissemination of cancer cells, and on the level of immune cells of the peripheral blood in patients with small primary hepatocellular carcinoma (PHC,≤5 cm). METHODS Forty patients with small PHC (maximal diameter≤5 cm) were divided into a microwave group (19 cases) and a surgical operation group (21 cases). A real-time (RT) quantitative nested RT-PCR examination was performed for peripheral blood alpha-fetoprotein (AFP) mRNA. Studies were conducted to determine the level of CD3, CD4, CD8 and CD4/CD8 cells and for liver function at 30 min before, and 30 min,1 day and 3 days after the treatment. RESULTS Compared to the value before ablation, no obvious changes of CD3, CD4, CD8 and CD4/CD8 cells were found in patients of the microwave group within 7 days after ablation, but CD3, CD4 and CD4/CD8 cells in the operation group were lower compared to that before operation. The copy number of AFP mRNA in the peripheral blood samples of the patients of the 2 groups before operation was determined in 67.5% of the patients (27/40). There was an rise in the expression after treatment but no statistical difference was found in comparing the 2 groups. Follow-up of the patients was conducted for 1 to 16 months. For patients with continuous expression of peripheral blood AFP mRNA, the possibility of relapse and metastasis was increased. CONCLUSION Surgical resection or microwave ablation can cause more exfoliation of hepatoma carcinoma cells in the peripheral blood of patients with small PHC. The immune function of peripheral blood cells decreased in the patients after surgical resection, however, the immune function was better protected following microwave ablation. Microwave ablation causes minor reduction in liver function, and the treatment method presents a definite value for PHC therapy. | Chaoyang Wen Boowei Dong Ping Liang Xiaoling Yu Li Su Dejiang Yu Honglian Xia | 2006 | Chinese Journal of Clinical Oncology2006，3，4： | 6 |
| 4 | Study on Property of Salicylaldehyde Schiff Base Metal Complexes for Catalytic Oxidation of Model Sulfides显示文摘Seven kinds of Schiff base metal complexes(C1-C7)were synthesized by the reaction of substituted salicylaldehyde Schiff base with cobalt nitrate,nickel nitrate,and copper nitrate,respectively.The oxygen carrying performance,and the catalytic property of complexes for the oxidation of model sulfides 1-hexanethiol,dibutyl sulfide,and 2-methylthiophene along with their influencing factors were explored,while the oxidized products of the model sulfides were also analyzed and characterized.The results show that the catalytic oxidation property of the complexes is determined by their oxygen carrying performance and solubility in n-octane.The oxygen carrying performance of the complexes is mainly affected by the central ion species,the electronic effects,and the spatial effects of the substituents as well as the degree of conjugation.More specifically,the oxygen carrying performance can be improved by enhancing the oxygenation capacity of the central metal ions,increasing the electron donating ability of the ligand substituent,and diminishing the steric hindrance as well as extending the conjugated chain.Complexes C7 were found to be with high oxygen carrying capacity and high solubility in n-octane,which shows the best catalytic oxidation property,and the oxidation conversion rates for 1-hexylthiol,dibutyl sulfide,and 2-methylthiophene are 74.2%,65.1%,and 22.7%,respectively.Upon using the oxidation catalyst of Schiff base metal complexes,three sulfides can be oxidized by oxygen to form sulfones and sulfoxides.1-Hexanethiol and dibutyl sulfide will continue to be oxidized to form sulfates and sulfites. | Jia Chaoyang Liang Shuyuan Liu Lei Shao Xue Zhang Longli Wang Fangzhu Jiang Cuiyu | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 2 |
| 5 | Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis显示文摘Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to facilitate their survival and growth. Prion protein(PrP) is a glycosylated cell surface protein that has been shown to be up-regulated in many cancer cells. Since PrP is a protein prone to misfolding, ER stress can result in under-glycosylated PrP, which in turn may activate ER stress. To assess whether ER stress leads to the production of under-glycosylated PrP and whether underglycosylated PrP may contribute to ER stress thus leading to cancer cell apoptosis, we treated different cancer cells with brefeldin A(BFA), thapsigargin(Thps), and tunicamycin(TM). We found that although BFA, Thps, and TM treatment activated UPR, only ATF4 was consistently activated by these reagents, but not other branches of ER stress. However, the canonical PERK-eIF2α-ATF4 did not account for the observed activation of ATF4 in lung cancer cells. In addition, BFA,but neither Thps nor TM, significantly stimulated the expression of cytosolic PrP. Finally, we found that the levels of PrP contributed to anti-apoptosis activity of BFA-induced cancer cell death. Thus, the pathway of BFA-induced persistent ER stress may be targeted for lung and pancreatic cancer treatment. | Zhenxing Gao Min Peng Liang Chen Xiaowen Yang Huan Li Run Shi Guiru Wu Lili Cai Qibin Song Chaoyang Li | 2019 | Virologica Sinica2019，34，2： | 2 |
| 6 | Acute kidney injury following adult lung transplantation显示文摘Background:Acute kidney injury(AKI)is a common and serious complication following lung transplantation(LTx),and it is associated with high mortality and morbidity.This study assessed the incidence of AKI after LTx and analyzed the associated perioperative factors and clinical outcomes.Methods:This retrospective study included all adult LTx recipients at the China-Japan Friendship Hospital in Beijing between March 2017 and December 2019.The outcomes were AKI incidence,risk factors,mortality,and kidney recovery.Multivariate analysis was performed to identify independent risk factors.Survival analysis was presented using the Kaplan-Meier curves.Results:AKI occurred in 137 of the 191 patients(71.7%),with transient AKI in 43(22.5%)and persistent AKI in 94(49.2%).AKI stage 1 occurred in 27/191(14.1%),stage 2 in 46/191(24.1%),and stage 3 in 64/191(33.5%)of the AKI patients.Renal replacement therapy(RRT)was administered to 35/191(18.3%)of the patients.Male sex,older age,mechanical ventilation(MV),severe hypotension,septic shock,multiple organ dysfunction(MODS),prolonged extracorporeal membrane oxygenation(ECMO),reintubation,and nephrotoxic agents were associated with AKI(P<0.050).Persistent AKI was independently associated with pre-operative pulmonary hypertension,severe hypotension,post-operative MODS,and nephrotoxic agents.Severe hypotension,septic shock,MODS,reintubation,prolonged MV,and ECMO during or after LTx were related to severe AKI(stage 3)(P<0.050).Patients with persistent and severe AKI had a significantly longer duration of MV,longer duration in the intensive care unit(ICU),worse downstream kidney function,and reduced survival(P<0.050).Conclusions:AKI is common after LTx,but the pathogenic mechanism of AKI is complicated,and prerenal causes are important.Persistent and severe AKI were associated with poor short-and long-term kidney function and reduced survival in LTx patients. | Lei Jing Wenhui Chen Li Zhao Lijuan Guo Chaoyang Liang Jingyu Chen Chen Wang | 2022 | Chinese Medical Journal2022，，2： | 2 |
| 7 | Understanding the macroscopical flexibility/fragility of nanoporous Ag:Depending on network connectivity and micro-defects显示文摘The effective engineering applications of nanoporous metals(NPMs)in flexible energy storage and wearable healthcare biosensor monitoring require its uniform ligaments network,specifically crack-free and flexible monolithic bodies.However,the macroscopic fragility of NPMs restricts their applications in wearable electronics fields.Here we focus on the synthetization of highly flexible NPMs.The effects of structural factors,e.g.ligament-network connectivity and micro-cracks on the mechanical properties of nanoporous Ag(np Ag)are investigated.The well-interconnected np Ag metal exhibits higher tensile strength,nanohardness and Vickers hardness than those for the ill-interconnected np Ag metal.The quality of the network connectivity dominates the strength and hardness of the np Ag.The flexibility/fragility is determined by the micro-crack in np Ag.The crack-free np Ag exhibits good flexible behavior.When micro-cracks are introduced,the np Ag becomes fragile.The control of soft volume shrinkage rate(Vsr)and slow surface diffusivity(Ds)effectively suppresses the crack initiation and propagation of as-formed np Ag.These results provide useful insights to synthesize more flexible and crack-free NPM materials for effective use in public wearable electronics and diverse flexible engineering applications in the future. | Chaoyang Wang Shengli Zhu Yanqin Liang Zhenduo Cui Shuilin Wu Chunling Qin Shuiyuan Luo Akihisa Inoue | 2020 | Journal of Materials Science & Technology2020，52，18： | 1 |
| 8 | New‐onset diabetes after liver transplantation and its impact on complications and patient survival;肝移植后的新发糖尿病及其对并发症和预后的影响显示文摘 | Chaoyang Lv Yao Zhang Xianying Chen Xiaowu Huang Mengjuan Xue Qiman Sun Ting Wang Jing Liang Shunmei He Jian Gao Jian Zhou Mingxiang Yu Jia Fan Xin Gao | 2015 | Journal of Diabetes2015，，6： | 1 |
| 9 | Quasi-reciprocal reflective optical voltage sensor based on Pockels effect with digital closed-loop detection technique显示文摘 | Chunxi Zhang Xiujuan Feng Sheng Liang Chaoyang Zhang Chuansheng Li | 2010 | Optics Communications2010，，20： | 1 |
| 10 | Clinical Study on the Treatment of Low Anal Fistula in Infants and Young Children by Anal Gland Excision and Virtual Hanging Procedure显示文摘Objective:To compare the efficacy of anal adenectomy with virtual hanging wire and anal fistulotomy in the treatment of low anal fistula in infants and children.Methods:60 children with low anal fistula who were admitted to our hospital from October 2021 to March 2022 and met the inclusion criteria were randomly divided into two groups of 30 cases each;the treatment group was treated with anal adenectomy and virtual hanging wire surgery,and the control group was treated with anal fistula resection.The clinical efficacy after treatment was compared.Results:The total effective rate of both groups was 96.67%and the difference between the two groups was not statistically significant(P>0.05).The postoperative pain score of the treatment group was lower than that of the control group(P<0.05).The length of hospitalization and healing time of the treatment group was lower than that of the control group(P<0.05).The anal function of the patients in both groups was normal,and there was no adverse reaction.Conclusion:Anal gland excision and virtual hanging surgery for the treatment of low anal fistula in infants and children have the advantages of mild pain,reduced length of hospitalization,short healing time,and better patient experience as compared to anal fistula excision. | Hongbo Su Linmei Sun Yimiao Liang Jiansheng Hu Yongli Zhang Ni Wei Chaoyang Li Lin Tang | 2024 | Journal of Clinical and Nursing Research2024，8，3： | 0 |
| 11 | Result of proton beam energy calibration of GECAM satellite charged particle detector显示文摘Purpose A charged particle detector(CPD)is one of two main detectors on the GECAM satellite.It was designed to detect charged particles.Electrons and protons are space’s mainly charged particles.So,a research on the proton detection ability of a CPD and deriving the energy response to charged particles of the CPD in the two designed operating modes is important.Method The proton calibration tests of the CPD under diferent working modes were carried out at the Heavy Ion Research Facility in Lanzhou.Result and conclusion Through testing and analysis,it was concluded that when CPD works in semi-component mode,it can detect the maximum energy,and when working in full-component mode,it can provide better energy resolution. | Chaoyue Zhang Xiaohua Liang Yanbing Xu Wenxi Peng Jianjian He Dongya Guo Ke Gong Yaqing Liu Zhenghua An Dali Zhang Sheng Yang Xiaojing Liu Xiangyang Wen Rui Qiao Jinzhou Wang Min Gao Shaolin Xiong Fan Zhang Xinqiao Li Xingzhu Cui Chaoyang Li Jilong Tang Xiaohua Wang Dengkui Wang Zhipeng Wei | 2022 | Radiation Detection Technology and Methods2022，6，1： | 0 |
| 12 | pIIIA/N2期非小细胞肺癌患者外科治疗的预后分析(英文)显示文摘Objective: The aim of the study was to identify prognostic factors in non-small-cell lung cancer (NSCLC) with N2 nodal involvement.Methods: A retrospective analysis of disease free survival and 5-year survival for NSCLC patients who underwent primary surgical resection without neoadjuvant chemotherapy were performed.Between January 1998 and May 2004,133 patients were enrolled.Several factors such as age,sex,skip metastasis,number of N2 lymph node stations,type of resection,histology,adjuvant therapy etc.,were recorded and analyzed.SPSS 16.0 software was used.Results: Overall 5-year survival for 133 patients was 32.33%,5-year survival for single N2 station and multiple N2 stations sub-groups were 39.62% and 27.50% respectively,and 5-year survival for cN0–1 and cN2 sub-groups were 37.78% and 20.93% respectively.COX regression analysis revealed that number of N2 station (P = 0.013,OR: 0.490,95% CI: 0.427–0.781) and cN status (P = 0.009,OR: 0.607,95% CI: 0.372–0.992) were two favorable prognostic factors of survival.Conclusion: Number of N2 station and cN status were two favorable prognostic factors of survival.In restrict enrolled circumstances,after combined therapy made up of surgery and postoperative adjuvant therapy have been performed,satisfied survival could be achieved. | Zhenrong Zhang Deruo Liu Yongqing Guo Bin Shi Yanchu Tian Zhiyi Song Yanning Shou Haitao Zhang Chaoyang Liang Zaiyong Wang Tong Bao Qjanli Ma | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，1： | 0 |
| 13 | DEYA2在肺腺癌中表达升高(英文)显示文摘Objective:Lung cancer has emerged as a leading cause of cancer death in the world.Eyes Absent (EYA) is an important and conserved transcriptional regulator of development.The aim of the present study was to identify the expression of Drosophila Eyes Absent Homologue 2 (EYA2) in non-small cell lung cancer (NSCLC) and to investigate their correlation with clinical parameters.Methods:Fresh,paired lung samples (n=59) of NSCLC were obtained by surgical resection at the Department of Thoracic Surgery of the People's Liberation Army General Hospital.Expression of EYA2 were examined by Western blot and immunohistochemical analysis in specimens of NSCLC and paired normal lung tissue.Clinical data,patho-logic result and Ki67 expression were collected and subsequent correlation with EYA2 expression was analyzed.Results:EYA2 expression was found located in cytoplasm and nucleus,but mostly in cytoplasm.The expression of EYA2 increased in NSCLC by Western blot and immunohistochemistry,which was correlated with histology type,but not correlated with gender,age,pTNM stage,histological differentiation and lymph node metastasis.Compared with normal lung tissue,the expres-sion of EYA2 significantly was up-regulated in lung adenocarcinoma,while no significant difference in lung squamous cell carcinoma.Expression of EYA2 was uncorrelated with expression of Ki67 in NSCLC.Conclusion:Expression of EYA2 was augmented in lung adenocarcinoma.EYA2 is likely participating in tumorigenesis and development of lung adenocarcinoma as transcriptional activator. | Juntang Guo Chaoyang Liang Lihua Ding Naikang Zhou Qinong Ye | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，12： | 0 |
| 14 | Stable dispersibility of bentonite-type additive with gemini ionic liquid intercalation structure for oil-based drilling显示文摘In this study,the direct intercalation of gemini ionic liquids(ILs)with different alkyl chains into the bentonite(BT)interlayer as a high-performance lubricating additive for base oil 500SN was investigated.The purpose of modifying BT with an IL is to improve the dispersion stability and lubricity of BT in lubricating oil.The dispersibility and tribological properties of IL–BT as oil-based additives for 500SN depend on the increase in interlamellar space in BT and improve as the chain length is increased.More importantly,the IL–BT nanomaterial outperforms individual BT in improving wear resistance,owing to its sheet layers were deformed and sprawled in furrows along the metal surface,thereby resulting in low surface adhesion.Because of its excellent lubrication performance,IL-modified BT is a potential candidate for the main component of drilling fluid.It can be used as a lubricating additive in oil drilling and oil well construction to reduce equipment damage and ensure the normal operation of equipments. | Chaoyang ZHANG Rui DONG Xingang WANG Yijing LIANG Ming ZHANG Qiangliang YU Zhongping TANG Huiying LV Liping WANG Meirong CAI Feng ZHOU Weimin LIU | 2023 | Friction2023，11，2： | 0 |
| 15 | Quantum Secure Undeniable Signature for Blockchain-Enabled Cold-Chain Logistics System显示文摘Data security and user privacy are two main security concerns in the cold-chain logistics system(CCLS).Many security issues exist in traditional CCLS,destroying data security and user privacy.The digital signature can provide data verification and identity authentication based on the mathematical difficulty problem for logistics data sharing in CCLS.This paper first established a blockchain-enabled cold-chain logistics system(BCCLS)based on union blockchain technology,which can provide secure data sharing among different logistics nodes and guarantee logistics data security with the untampered blockchain ledger.Meanwhile,a lattice-based undeniable signature scheme is designed to strengthen the security of logistics data and user privacy against quantum attacks.This scheme is based on the lattice assumption,which can provide anti-quantum security for BCCLS in the future quantum computer age.It also establishes the undeniable mechanism that guarantees that the actual signer cannot deny a valid signature.Then,security proof shows that this undeniable signature scheme is correct and safe,and an efficiency comparison shows that it is more efficient than other schemes in similar literature.The performance evaluations of transaction throughput and latency show that the proposed BCCLS is efficient and practical.This work can improve the security and efficiency of logistics data management and promote the reform and development of the logistics industry. | Chaoyang Li Hongxue Shen Xiayang Shi Hui Liang | 2023 | Computers, Materials & Continua2023，，5： | 0 |
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