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| 1 | 血管疾病中叶酸和B族维生素的使用不能降低高半胱氨酸浓度显示文摘 | Lonn E Yusuf S Arnold MJ 菅鑫妍 | 2006 | 中国处方药2006，5，6： | 137 |
| 2 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 3 | 严重颅脑创伤患儿入院72h内开始营养支持与良好预后有关:二次分析一项治疗性低体温随机对照试验显示文摘目的了解严重颅脑损伤(severe traumatic brain injury,TBI)患儿营养支持开始时机与预后的关系。设计二次分析一项关于治疗性低体温的随机对照研究(Pediatric Traumatic Brain Injury Consortium: Hypothermia, also known as the Cool Kids Trial(NCT 00222742)。 | Meinert E Bell MJ Buttram S 方伯梁(译) 钱素云(校) | 2018 | 中国小儿急救医学2018，25，6： | 12 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 6 | CD40-CD40L interactions in atherosclerosis 显示文摘 | Lutgens E Daemen MJ | 2002 | Trends Cardiovasc Med2002，12，： | 1 |
| 7 | Trends and outcomes after prenatal diagnosis of congenital cardiac malformations by fetal echocardiography in a well defined birth population,Atlanta,Georgia,1990-1994显示文摘 | Montana E Khoury MJ Cragan JD | 1996 | J Am Col Cardiol1996，28，7： | 1 |
| 8 | Comparative in vitro study of the antimicrobial activities of different commercial antibiotic products for intravenous admin istration显示文摘 | Silva E Diaz JA Arias MJ | 2010 | BMC Clin Pharmacol2010，29，10： | 1 |
| 9 | Propofol reduces perioperative remifentanil requirements in asynergistic manner : response surface modeling of perioperative remifentanil propofol interactions显示文摘 | Mertens MJ Olofsen E Engbers FH | 2003 | Anest Hesiol2003，99，： | 1 |
| 10 | Removal ofreal-time reverse transcription polymerase chain reaction(RT-PCR)inhibitors associated with cloacal swab samples and tissuesfor improved diagnosis of avian influenza virus by RT-PCR显示文摘 | Das A Spackman E Pantin-Jackwood MJ | 2009 | JVet Diagn Invest2009，21，： | 1 |
| 11 | Pathologist variation in reporting cervical borderline epithelial abnormalities and cervical intraepithelial neoplasia显示文摘 | Creagh T Bridger JE Kupek E Fish DE Martin-Bates E Wilkins MJ | 1995 | J Clin Pathol1995，48，1： | 1 |
| 12 | Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development显示文摘 | Takeda K Smyth MJ Cretney E | 2002 | J Exp Med2002，195，2： | 1 |
| 13 | Bladder wall abnormalities in myelodysplastic bladders: a eomputer assisted morphometrie analysis 显示文摘 | Shapiro E Becich MJ Perlman E | 1991 | J Urol1991，145，5： | 1 |
| 14 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 15 | A 700year record of combus-tion-derived pollution in northern Spain : tools to identify the Ho-locene/ Anthropocene transition in coastal environments 显示文摘 | Leorri E Mitra S Irabien MJ | 2013 | Sci TotalEnviron2013，，： | 1 |
| 16 | Highly recurrent TERTpromoter mutations in human melanoma显示文摘 | Huang FW Hodis E Xu MJ | 2013 | Science2013，339，6122： | 1 |
| 17 | The Edmonton Symptom Assessment System (ESAS):a simple method for the assess- ment of palliative care patients 显示文摘 | Bruera E Kuehn N Miller MJ | 1991 | J Palliat Care1991，7，2： | 1 |
| 18 | Detectionof tumor PIK3CA status in metastatic breast cancer using periph-eral blood显示文摘 | HIGGINS MJ JELOVAC D BARNATHAN E | 2012 | Clin Cancer Res2012，18，12： | 1 |
| 19 | Cerebral hemodynamic changes gauged by transcranial Doppler ultrasonography in patients with pesttraumatic brain swelling treated by surgical decompression 显示文摘 | Bor-Seng-Shu E Hirsch R Teixeira MJ | 2006 | J Neuresurg2006，104，1： | 1 |
| 20 | Glossopharyngeal neuralgia:neurosurgical treatment and differential diagnosis显示文摘 | Teixcira MJ de Siqueira SR Bor-Seng-Shu E | 2008 | Acta Neurochir (Wien)2008，150，5： | 1 |
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