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| 1 | 2型糖尿病患者及其一级亲属和非糖尿病者骨骼肌的胰岛素信号传导显示文摘2型糖尿病与骨骼肌和其他组织的葡萄糖利用能力下降有关。胰岛素抵抗可能与遗传因素和糖尿病本身的代谢异常如高血糖或非脂化脂肪酸(NEFA)升高有关。遗传因素和继发的胰岛素抵抗代谢异常可能是由于调节葡萄糖代谢的胰岛素受体和受体后信号传导的改变引起。胰岛素与其受体结合后,受体自身磷酸化,受体激酶活化,一些细胞间的底物磷酸化,其中在骨骼肌细胞中胰岛素受体底物-1(IRS-1)最重要。酪氨酸磷酸化的IRS与脂肪激酶磷脂酚肌醇3’(PI3’) | Meyer MM Levin K Grimmsmann T Beck-Nielsen H Klein HH Diabetologia 叶华 | 2003 | 中国糖尿病杂志2003，11，2： | 3 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | 促进创面愈合的抗菌肽外用制剂的现状与前景显示文摘慢性创面感染和随后产生的抗生素耐药是影响全世界数百万人的严重临床问题。当机体接触病原体后,可通过产生抗菌肽快速有效杀灭病原体。抗菌肽是包含多达100个L-氨基酸残基的线性或圆形寡肽,可形成二级结构。虽然氨基酸序列不尽相同,似得益于碱性残基、类似细胞膜的两亲性结构和疏水性序列的普遍存在,绝大多数抗菌肽可凭借其阳离子特性与微生物细胞膜上的阴离子磷脂发生静电相互作用。 | 孙佳辰(编译) 申传安(审校) Thapa RK Diep DB TФnnesen HH | 2021 | 中华烧伤杂志2021，37，12： | 2 |
| 4 | Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis 显示文摘 | Horiuchi T Dietrich HH Hongo K | 2002 | Stroke2002，33，3： | 1 |
| 5 | In vitro differentiation and mineralization of human dental pulp cells induced by dentin extract显示文摘 | Liu J Jin T Ritehie HH | 2005 | In Vitro Cell Dev Biol Anim2005，41，7： | 1 |
| 6 | Cortical activity in precision-versus power-grip tasks:An fMRI study显示文摘 | Ehrsson HH Fagergren A Jonsson T | 2000 | Neurophysiol2000，83，1： | 1 |
| 7 | Mutations in the type Ⅳcollagen alpha-3 (COL4 A3) gene in autosomal recessive Alport syndrome显示文摘 | Lemmink HH Mochizuki T van den Heuvel LP | 1994 | Hum Molec Genet1994，3，： | 1 |
| 8 | Clinical and pathologic correlations in traumatic spondylolisthesis of the axis显示文摘 | Sherk HH Howard T | | 0，，174： | 1 |
| 9 | Complications during the wada test显示文摘 | Loddenkemper T Morris HH M6ddel G | 2008 | Epilepsy Behav2008，13，55： | 1 |
| 10 | Effects of smoking and solid-fuel use on COPD, lung cancer, and tuberculosis in China:a time-based, multiple risk factor, modelling study显示文摘 | Lin HH Murray M Cohen T | 2008 | Lancet2008，372，9648： | 1 |
| 11 | Bone mineral density and serum biochemical predictors of hone loss in patients with CKD-51) 显示文摘 | Malluche HH Davenport DL Cantor T | 2014 | Clin Am Soc Nephro12014，9，7： | 1 |
| 12 | Comparison of three tech- niques for preparing oval - shaped root canal 显示文摘 | Taha NA Ozawa T Messer HH | 2010 | J Endod2010，36，3： | 1 |
| 13 | Course of brain shift during microsurgical resection of supratentorial cerebral lesions:limits of conventional neuronavigation显示文摘 | Reinges MH Nguyen HH Krings T | 2004 | Acta Neurochir (Wien)2004，146，4： | 1 |
| 14 | Course of brain shift during microsurgical resection of supratentorial cerebral lesions:limits of conventional neuronavigation 显示文摘 | Reinges MH Nguyen HH Krings T | 2004 | Acta Neurochir (Wien)2004，146，4： | 1 |
| 15 | Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-betal can abrogate this resistance 显示文摘 | Chodon T Sugihara T Igawa HH | 2000 | Am J Patholog2000，157，5： | 1 |
| 16 | Increased peritoneal membrane permeability is associated with abnormal peritoneal surface layer显示文摘 | Wang T Cheng HH Liu SM | 2001 | Petit Dial Int2001，213，： | 1 |
| 17 | Recent HIV-1 infection detection: comparison of incidence estimates derived by laboratory assays and repeat testing data显示文摘 | Truong HH Kellogg T Louie B | 2009 | J Acquit Immune Defic Syndr2009，51，4： | 1 |
| 18 | Association of plasma triglyceride concentration and LDL partice diameter den sity and chemical composition with premature coronary artery disease in men and women显示文摘 | kwiterovich PO smith HH | 1993 | J Lipid Res1993，34，： | 1 |
| 19 | Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis显示文摘 | Horiuchi T Dietrich HH Hongo K | 2002 | Stroke2002，33，： | 1 |
| 20 | KPNA2 expression is an Independent adverse predictor of biochemical recurrence after rad- ical prostatectomy显示文摘 | Mortezavi A Hermanns T Seifert HH | 2011 | Clin Cancer Res2011，17，5： | 1 |
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