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| 1 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 2 | Double-bullet radioimmunotargeting therapy in 31 patients with primary liver cancer显示文摘Doublebuletradioimmunotargetingtherapyin31patientswithprimarylivercancerWUYingDe1,ZHOUDeNan2,GANGYouQuan2,HUXiaoHua1,LIZ... | WU Ying De 1, ZHOU De Nan 2, GANG You Quan 2, HU Xiao Hua 1, LI Zhi Ge 1, SONG Xiang Qun 1, HE Hai Ping 2, YANG Ke Zheng 1 and HUANG Bing Yan 1 1Department of Chemotherapy, Affiliated Cancer Hospital, Guangxi Medical University, | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
| 3 | Neoadjuvant chemotherapy for locally advanced cervix cancer显示文摘 | Neoadjuvant Chemotherapy for Cervical Cancer Meta-analysis Collaboration (NACCCMA) Collaboration | | 0，，： | 1 |
| 4 | Non small Cell Lung Cancer Collaborative Group 显示文摘 | Chemotherapy in non-small cell lung cancer= a meta-analysis u- sing updated data on individual patients from 52 randomised clinical trials | 1995 | BMJ1995，311，7010： | 1 |
| 5 | Neoadjuvant chemotherapy for locally advanced cervical cancer:a systematic review and meta-analysis of individual patient data from 21 randomised trials显示文摘 | Neoadjuvant chemotherapy for locally advanced cervical cancer Meta-analysis Collaboration | 2003 | Eur J Cancer2003，39，17： | 1 |
| 6 | Neoadjuvant chemotherapy for locally advanced cervix cancer 显示文摘 | Neoadjuvant chemotherapy for Cervical Cancer Mata-Analysis Collaboration(NACCCMA) Collaboration | 2004 | Cochrane Database Syst Rev2004，，00： | 1 |
| 7 | 10 trial experience显示文摘 | Gauthier I Ding K Winton T etaX Impact of hemoglobin levels on outcomes of adjuvant chemotherapy in resected nonsmall cell lung cancer:The JBR | 2007 | Lung Cancer2007，55，： | 1 |
| 8 | Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta-analysis of individual patient data from 21 randomised trials 显示文摘 | Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer Meta-analysis Collaboration | 2003 | Eur J Cancer2003，39，17： | 1 |
| 9 | Combination chemotherapy of 5-fluorouracil and low-dose cisplatin in advanced and recurrent gastric cancer:a multicenter retrospective study in Nagasaki,Japan显示文摘 | Enjoji A:The Nagasaki Digestive Organ Cancer Chemotherapy Study Group Japan | 2002 | Anticancer Res2002，22，2： | 1 |
| 10 | Antimicrobial prophylaxis in neurosurgery and after head injury 显示文摘 | Infection in Neurosurgery W orking Party of the British Society for Antimicrobial Chemotherapy | 1994 | Lancet1994，344，8936： | 1 |
| 11 | Head Neck Oncol显示文摘 | Yokoyama J Ohba S Ito S et al Impact of lymphatic chemotherapy targeting metastatic lymph nodes in patients with tongue cancer (cT3N2bM0) using intra-arterial chemotherapy | | 0，，02： | 1 |
| 12 | Non-small Cell Lung Cancer Collaborative Group显示文摘 | Chemotherapy in non-small cell lung cancer:a meta-analysis using updated data on individual patients from 52 randomise- clinical trials | 1995 | BMJ1995，311，7010： | 1 |
| 13 | Posttreatment plasma with the overall survival of cell lung cancer treated with 显示文摘 | An S J Huang YS Chen ZH VEGF levels may be associated patients with advanced non-small bevacizumab plus chemotherapy | 2012 | Med Oncol2012，29，2： | 1 |
| 14 | Non-small Cell Lung Cancer Collaborative Group显示文摘 | Chemotherapy in non-small cell lung cancer A meta-analysis using updated data on individual patients from 52 randomised clinical trials | 1995 | BMJ1995，311，7010： | 1 |
| 15 | Neoadjuvant chemotherapy for locally advanced cervical cancer:a systematic review and meta-analysis of individual patient data from 21 randomised trials显示文摘 | Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer Meta-analysis Collaboration | 2003 | Eur J Cancer2003，39，17： | 1 |
| 16 | Neoadjuvant chemotherapy for locally advanced cervix cancer 显示文摘 | Neoadjuvant Chemotherapy for Cervical Cancer Meta - Analysis Collaboration ( NACCCMA ) Collaboration | 2004 | Cochrane Database Syst Rev2004，，00： | 1 |
| 17 | Innovative cancer therapy for tomorrow显示文摘 | Chemotherapy Foundation Symposium XV | 1998 | Cancer Invest1998，16，1： | 1 |
| 18 | Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta - analysis of individual patient data from 21 randomised trials 显示文摘 | Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer Meta - analysis Collaboration | 2003 | Eur J Cancer2003，39，17： | 1 |
| 19 | International collaboration of trialists显示文摘 | Neoadjuvant cisplatin methotrexate and vinblastine chemotherapy for muscle-invasive bladder cancer:a randomized controlled trial | 1999 | Lancet1999，354，9178： | 1 |
| 20 | Ana- lysis in ovarian carcinoma patients with low and high survival显示文摘 | Raspollini MR Amunni G Villanucci A et aL Increased cyclooxy- genase-2(COX-2) and P-glycoprotein-170(MDRl) expression is associated with chemotherapy resistance and poor prognosis | 2005 | Int J Gynecol Cancer2005，15，2： | 1 |
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