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| 1 | Zircon U-Pb age and Hf isotope of Quanyishang A-type granite in Yichang: Signification for the Yangtze continental cratonization in Paleoproterozoic显示文摘Zircon U-Pb age and Hf isotope, and major and trace element compositions were reported for granite at Quanyishang, which intruded into the Kongling complex in Yichang, Hubei Province. The results show that the Quanyishang granite is rich in silicon and alkalis but poor in calcium and magnesium, and displays enrichment in Ga, Y, Zr, Nb but depletion in Sr and Ba, exhibiting the post-orogenic A-type affinity. 90% zircons from the granite are concordant, and give a middle Paleoproterozoic magmatic crystallization age (mean 1854 Ma). Initial Hf isotope ratios (176Hf/177Hf)i of the middle Paleoproterozoic zircons range from 0.280863 to 0.281134 and they have negative εHf(t) values with a minimum of -26.3. These zircons give the depleted mantle model ages (TDM) of 2.9―3.3 Ga (mean 3.0 Ga), and the average crustal model ages (Tcrust) of 3.6―4.2 Ga (mean 3.8 Ga). A Mesoarchean grain with 207Pb/206Pb age of 2859 Ma has a slightly high TDM (3.4 Ga) but similar Tcrust (3.8 Ga) to the Paleoproterozoic zircons. All these data suggest that the source materials of the Quanyishang A-type granite are unusually old, at least ≥2.9 Ga (even Eoarchean). The event of crustal remelting, which resulted in the formation of the Quanyishang granite in the middle Paleoproterozoic, recorded the cratonization of the Yangtze conti- nent. The process may have relation to the extension and collapse of the deep crust with Archean ages, in response to the transition stage of the assembly and breakup of the Columbia supercontinent. | XIONG Qing HENG JianPing YU ChunMei SU YuPing TANG HuaYun ZHANG ZhiHai | 2009 | Chinese Science Bulletin2009，54，3： | 46 |
| 2 | Effects of insoluble Zn,Cd,and EDTA on the growth,activities of antioxidant enzymes and uptake of Zn and Cd in Vetiveria zizanioides显示文摘A root-bag experiment was conducted to study the effects of insoluble Zn,Cd,and ethylenediaminetetraacetic acid(EDTA) on the plant growth,activities of antioxidant enzymes,proline,glutathione(GSH),water-soluble proteins and malondialdehyde(MDA) of Vetiveria zizanioides.The V.zizanioides uptake capacity of Zn and Cd also determined.The results showed that plant growth of V.zizanioides was inhibited by Zn and Cd.The shoot dry weight(SDW) and root dry weight(RDW) decrease by 14.2%,14.1%,17.0% and 17.3%,32.5%,35.7%,respectively,compared to the control without EDTA addition.After adding EDTA,shoot and root dry weight decreased over 10% and 15%,respectively.The toxicity from insoluble Zn and Cd in soil on SDW and RDW of V.zizanioides was in order:Zn+Cd > Cd > Zn.The activities of superoxide dismutase(SOD),peroxidase(POD) and catalase(CAT),and contents of MDA and proline increased significantly,while the contents of GSH and water-soluble proteins decreased markedly with increasing Zn and Cd toxicity.With EDTA,shoot and root Zn concentrations increased in the Zn treatment by 7.3% and 37.4%,and Cd concentrations in the combined Zn and Cd treatment increased by 18.6% and 391.9% compared to the treatment without EDTA.However,Zn and Cd concentrations in shoot and roots decreased in the Cd treatment compared to the plants grown in absence of EDTA,with exception of root Cd concentration in the presence of EDTA. | XU Weihong LI Wenyi HE Jianping Balwant Singh XIONG Zhiting | 2009 | Journal of Environmental Sciences2009，21，2： | 16 |
| 3 | In vitro and in vivo antibacterial activity of Pogostone显示文摘 | Peng Fu Wan Feng Xiong Liang Peng Cheng Dai Min Chen Jianping | 2014 | Chinese Medical Journal2014，，23： | 11 |
| 4 | Subduction-zone peridotites and their records of crust-mantle interaction显示文摘Subduction is the core process of plate tectonics. The mantle wedge in subduction-zone systems represents a key tectonic unit, playing a significant role in material cycling and energy exchange between Earth's layers. This study summarizes research progresses in terms of subduction-related peridotite massifs, including supra-subduction zone(SSZ) ophiolites and mantle-wedge-type(MWT) orogenic peridotites. We also provide the relevant key scientific questions that need be solved in the future. The mantle sections of SSZ ophiolites and MWT orogenic peridotites represent the mantle fragments from oceanic and continental lithosphere in subduction zones, respectively. They are essential targets to study the crust-mantle interaction in subduction zones. The nature of this interaction is the complex chemical exchanges between the subducting slab and the mantle wedge under the major control of physical processes. The SSZ ophiolites can record melt/fluid-rock interaction, metamorphism,deformation, concentration of metallogenic elements and material exchange between crust and mantle, during the stages from the generation of oceanic lithosphere at spreading centers to the initiation, development, maturation and ending of oceanic subduction at continental margins. The MWT orogenic peridotites reveal the history of strong metamorphism and deformation during subduction, the multiple melt/fluid metasomatism(including silicatic melts, carbonatitic melts and silicate-bearing C-HO fluids/supercritical fluids), and the complex cycling of crust-mantle materials, during the subduction/collision and exhumation of continental plates. In order to further reveal the crust-mantle interaction using subduction-zone peridotites, it is necessary to utilize high-spatial-resolution and high-precision techniques to constrain the complex chemical metasomatism, metamorphism,deformation at micro scales, and to reveal their connections with spatial-temporal evolution in macro-scale tectonics. | Jianping ZHENG Qing XIONG Yi ZHAO Wenbo LI | 2019 | Science China Earth Sciences2019，62，7： | 8 |
| 5 | Hierarchical TiO2-B nanowire@α-Fe2O3 nanothorn core-branch arrays as superior electrodes for lithium-ion microbatteries显示文摘这份报纸为层次 TiO 的合成报导一个简单还有效的方法 < 潜水艇 class= “ a-plus-plus ” > 2 -B nanowire@-Fe < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 3 nanothorn 核心分支基于一条逐步的热水的途径穿。同样制作的混合数组为锂离子电池作为高能力的阳极显示出出色的性能。在这研究的关键设计是核心分支混血儿体系结构,它提供大表面不仅为锂离子插入 / 抽取的活跃地点,而且为电子和锂离子由于减少的散开路径启用快费用运输。 TiO 的属性的古怪联合<潜水艇class=“ a-plus-plus ”> 2 (好结构的稳定性)和 Fe <潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 3 (大特定的能力)向混合数组电极提供几理想电气化学的特征:大可逆能力(800 mAstalline 和大区域瞬间 < 潜水艇 class= “ a-plus-plus ” > 由化学蒸汽免职方法的 2 层。先锋的数量的小心的控制在大区域的合成被发现到关键因素高度水晶的薄片。层的厚度被拉曼光谱学和原子力量显微镜学证实。光性质和化学作文被光致发光(PL ) 和 X 光检查光电子光谱学学习。在 1.82 eV 的强壮的直接激子的排出物的出现(A 激子,与规范的 PL i 械 ? 械?? | Hui Xia Wen Xiong Chiew Keat Lim Qiaofeng Yao Yadong Wang Jianping Xie | 2014 | Nano Research2014，7，12： | 7 |
| 6 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 7 | Determination of critical slip surface of fractured rock slopes based on fracture orientation data显示文摘The critical slip surface of a fractured rock slope tends to extend along the fractures.Thus,fracture orientation plays a critical role in determining the critical slip surface.Based on fracture orientation data,this paper examines the critical slip surfaces of fractured rock slopes.Given that the surface of a fractured rock slope extends along the fracture surfaces,or the wedges,with each composed of two arbitrary fractures,the critical slip surface is determined via stochastic dynamics.In addition,a fracture frequency method is proposed as a means of analyzing the critical slip surface.According to this method,the critical slip surface slips in whichever direction has the lowest fracture frequency.Based on the stochastic dynamics method and the fracture frequency method,the critical slip surface of the slope is finally determined,that is,the critical slip surface takes the form of a plane passing the slope toe with a dip of 120° and a dip angle of 45°. | ZHANG Wen CHEN JianPing ZHANG Wu L Yan MA YuFei XIONG Hui | 2013 | Science China(Technological Sciences)2013，56，5： | 5 |
| 8 | Coordination engineering of cobalt phthalocyanine by functionalized carbon nanotube for efficient and highly stable carbon dioxide reduction at high current density显示文摘Coordination engineering can enhance the activity and stability of the catalyst in heterogeneous catalysis.However,the axial coordination engineering between different groups on the carbon carrier and molecular catalysts in the electrocatalytic carbon dioxide reduction reaction(CO_(2)RR)has been studied rarely.Through coordination engineering strategy,a series of amino(NH_(2)),hydroxyl(OH),and carboxyl(COOH)groups functionalized carbon nanotubes(CNT)immobilized cobalt phthalocyanine(CoPc)catalysts are designed.Compared with no groups,OH groups and COOH groups,NH_(2)groups can effectively change the coordination environment of the central metal Co,thereby significantly increasing the turnover frequency(TOF)(31.4 s^(-1)at-0.6 V vs.RHE,CoPc/NH_(2)-CNT>CoPc/OH-CNT>CoPc/COOH-CN>CoPc/CNT).In the flow cell,the CoPc/NH_(2)-CNT catalyst has high carbon monoxide(CO)selectivity at high current density(~100%at-225 mA·cm^(-2),~96%at-351 mA·cm^(-2)).Importantly,the CoPc/NH_(2)-CNT catalyst can operate stably for 100 h at 225 mA·cm^(-2).Theoretical calculations reveal that CoPc/NH_(2)-CNT catalyst is beneficial to the formation of^(*)COOH and desorption of^(*)CO,thus promoting CO_(2)RR.This work provides an excellent platform for understanding the effect of coordination engineering on electrocatalytic performance and promotes a way to explore efficient and stable catalysts in other applications. | Hongdong Li Yue Pan Zuochao Wang Yaodong Yu Juan Xiong Haoyang Du Jianping Lai Lei Wang Shouhua Feng | 2022 | Nano Research2022，15，4： | 2 |
| 9 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 10 | Age and Body Size of the Shangcheng Stout Salamander Pachyhynobius shangchengensis(Caudata:Hynobiidae)from Southeastern China显示文摘Age and body size a re critical for understanding life history evolution and ecology.In this study,the age and body size of the Shangcheng stout salamander,Pachyhynobius shangchengensis,from a population in Anhui Province,China,were studied by skeletochronology.The mean age was 8.8±0.2(mean±SD)years in females and 9.6±0.2 in males and ranged 5-13 years for both sexes.The mean age was significantly different between sexes.The mean body size and mass were(100.21±0.91)mm and(31.76±0.73)g in females,and(105.31±1.23)mm and(37.14±1.12)g in males,respectively.Males were significantly larger and heavier than females,indicating sexual size dimorphism.There was a significant positive correlation among body size,body mass,and age,suggesting that the oldest individuals are larger and heavier.The growth rate in males was significantly higher than in females.The present study provides preliminary data on life-history traits which can be helpful for future studies of this species and other hynobiid salamanders. | Jianli XIONG Jianping GOU Yong HUANG Baowei ZHANG Hongtao REN Tao PAN | 2020 | Asian Herpetological Research2020，11，3： | 2 |
| 11 | The partitioning behavior of trace elements in subduction zones:Advances and prospects显示文摘The partitioning behavior of trace elements is of key importance for understanding the geochemical process and material cycle mechanism in subduction zones.This paper focuses on the advances and prospects on the studies of trace element partitioning in subduction zones from the following four aspects.(1)The properties of fluids derived from subducting slabs and their ability in element transport.How slab-derived solute-rich fluids and supercritical fluids are formed and what the roles and key control factors of these fluids are in transferring of elements(especially the high field strength elements)from slab to wedge are discussed.We point out that the detailed investigations of supercritical fluids may provide a new perspective for the element migration mechanism,material cycle process,arc magma genesis and so on.(2)The behavior of transition elements during mantle wedge melting.The behavior of the first row transition elements(Sc,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn)in the mantle partial melting process is compatible or incompatible,depending on residual mineral assemblage and physicochemical conditions.The partitioning behavior of the elements such as Sc,Ti,Co,Ni and Zn whose valence states do not change in the melting process mainly depends on the residual mineral assemblage and temperature,whereas the partitioning behavior of the multivalent elements such as V and Fe is also the function of oxygen fugacity(fO_(2))in addition to mineral assemblage and temperature.Therefore,the partitioning behavior of transition elements has important applications in tracing lithologic inhomogeneity and fO_(2)of the mantle wedges.(3)The specificity of element partitioning behavior during arc magma evolution.Garnet has Dy/Yb partitioning behavior different from amphibole,and rutile has Nb/Ta partitioning behavior different from amphibole.Dy/Yb and Nb/Ta partitioning differences for these minerals enable to distinguish the specific evolution process of arc magmas.The Dy/Yb and Nb/Ta generally decrease with the increase of SiO_(2)in arc magmas,indicating that amphibole fractionation should be the most important during arc magma differentiation.(4)The behavior of sulfur and chalcophile elements and porphyry metallogeny.In subduction zones,the behavior of chalcophile elements such as Cu and Au is controlled by sulfide and fluid.Therefore,the stability of sulfide,the time at which the fluid exsolves from the melt relative to sulfide saturation,the fluid/sulfide mass ratio and fluid/melt Cu and Au partition coefficients in intermediate-felsic magma-H_(2)O systems are especially important in understanding Cu and Au enrichment in magma-hydrothermal processes.Intermediate-felsic magmas mainly originate from the differentiation of arc magmas at lower crustal reservoirs,and thus the fluid exsolution from the lower crustal reservoirs and the fluid/melt and fluid/sulfide partition coefficients of Cu and Au should be the keys to understanding quantitatively how Cu and Au are migrated from the deep crust to the shallow site of mineralization. | Xiaolin Xiong Xingcheng Liu Li Li Jintuan Wang Wei Chen Mengfei Ruan Ting Xu Zhongxing Sun Fangfang Huang Jianping Li&Lei Zhang | 2020 | Science China Earth Sciences2020，63，12： | 2 |
| 12 | Speculative Trading and Stock Prices: Evidence from the Chinese A-B Share Premia 显示文摘 | Mei Jianping Sheinkman Jose Xiong W | 2009 | Annals of Economics and Finance2009，10，2： | 1 |
| 13 | Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide(GLP-1) secretion function of the mouse intestine显示文摘IF1(ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to control ATP production.IF1 activity remains unknown in the regulation of GLP-1 activity.In this study,IF1 was examined in the diet-induced obese mice using the gene knockout(If1-KO) mice.The mice gained more body weight on a high fat diet without a change in food intake.Insulin tolerance was impaired,but the oral glucose tolerance was improved through an increase in GLP-1 secretion.The KO mice exhibited an improved intestine structure,mitochondrial superstructure,enhanced mitophagy,reduced apoptosis and decreased adenine nucleotide translocase 2(ANT2) protein in the intestinal epithelial cells together with preserved gut microbiota.The data suggest that GLP-1 secretion was enhanced in the obese If1-KO mice to preserve glucose tolerance through a signaling pathway of ANT2/mitochondria/L-cells/GLP-1/insulin.IF1 is a potential mitochondrial target for induction of GLP-1 secretion in L-cells. | Ying Wang Jiaojiao Zhang Xinyu Cao Yaya Guan Shuang Shen Genshen Zhong Xiwen Xiong Yanhong Xu Xiaoying Zhang Hui Wang Jianping Ye | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 14 | Integration of as-built and as-designed models for positioning control during construction显示文摘 | Liang Xiong Lu Ming Zhang Jianping | | 0，，03： | 1 |
| 15 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 16 | Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients on peritoneal dialysis显示文摘 | Jianping Jiang Pingyan Chen Jianghua Chen Xueqing Yu Di Xie Changlin Mei Fei Xiong Wei Shi Wei Zhou Xusheng Liu Shiren Sun Ping Zhang Xiao Yang Yixiang Zhang Yanmin Zhang Xinling Liang Zhimin Zhang Qizhan Lin Yan Yu Toshio Miyata Jianwei Tian Min Liang We | 2012 | Atherosclerosis2012，，1： | 1 |
| 17 | Reversal of Adriamycin Resistance of Hepatocellular Carcinoma by Targeting with Recombined Adenovirus Caning Antisense mdr1 RNA显示文摘OBJECTIVE Chemotherapy is an important therapy for hepatocellular carcinoma (HCC). However, it is not effective in many cases due to recurrence and metastasis even if the initial treatment produces a response. Multidrug resistance (MDR) is considered to be one of the considerable causes. The aim of this study was to reverse MDR of HepG2/ADM cells by blocking mdr1 with an adenovirus vector carrying antisense mdr1 in a tumor transplantated in athymic mice. METHODS pCMV IE was removed from the pshuttle vector. A 0.3 kb AFP promoter was inserted into the pshuttle vector and pCMV changed into pAFP. The pAFP and asmdr1 PCR products were doubly digested with Kpnl and Apal, the digested products were ligated by T4 ligase, the asmdrl gene was inserted into pAFP and a newly plasmid pAFP-asmdr1 was constructed. Following digestion with PI-Scel/l-Ceu l, pAFP-asmdr1 was ligated with Adeno-X genome DNA and amplified in E.coli XL 1-Blue. The HEK293 cells were transfected and virus collected. The HepG2 MDR cells (HepG2/ADM) were induced by graded resistance to ADM and were inoculated into athymic mice. After adeno-asmdr1 was injected, the expression of mdr1 -mRNA and the volume of the transplantated tumor and its cells were observed. RESULTS Following injection with Adeno-asmdr1, the tumor volume in the ADM+Adeno-asmdr1 group did not increase. However the tumor volume in the PBS plus ADM group did significantly increase (P<0.05). In the tumor xenograft cells, mdr1 mRNA in the xenografts was assessed by RT-PCR and was found to be reduced at 1 week and 4 weeks in the ADM+asmdr1 group, but it was stable in the ADM group. It was only 20% in the ADM+asmdr1 group compared to the ADM group at the 4th week (P<0.05). Evidence of apoptosis was observed in the tumor xenograft cells treated with Adeno-asmdr1, but there was rare or no apoptosis in the group treated with ADM and PBS. CONCLUSION Adenovirus carrying antisense mdr1 RNA can partially reverse the MDR of HepG2/ADM cells and inhibit tumor growth by down-regulating mdr1 mRNA resulting in tumor cell apoptosis. | Xiong Ding Ying Mei Yujun Shi Jianping Gong Xuhong Li Yong Peng Yong Liu Chang'an Liu | 2006 | Chinese Journal of Clinical Oncology2006，3，1： | 1 |
| 18 | 改良腹腔镜经肛门拖出低位直肠癌切除术(英文)显示文摘Objective:We described the applicability and evaluated the advantages of improved laparoscopic transanal pull-through(ILTPT) for low-rectal cancer resection.Materials:ILTPT was performed in 4 patients.Five or 4 ports were used.After isolation and section of the inferior mesenteric vessels,the rectum and sigmoid colon was mobilized.Total mesorectal excision and dissection of the distal rectum from the puborectalis muscle was carried out under laparoscopic guidance.The sigmoid colon and rectum were exteriorized via the anus.The rectum was divided proximally.Next,a purse-string suture was placed in the proximal segment,and the distal end of the sigmoid colon was returned to the pelvic cavity.The distal rectum was divided with Curved cutter staplermade by Jonson-Jonson company.Dislodging specimen,the continuity of the intestinal tract was restored using PROXIMATE ILS Curved and Straight Intraluminal Staplers CDH29/33(Ethicon) through the rectum.Results:None of the cases were converted to open surgery.Average operation time was 180 min(range,160-210 min).No blood loss or any other complications were noted.Average postoperative stay was 9 days.Complications such as necrosis,anastomotic leakage and stricture,and genitourinary disorders were not found in any of the patients at the 1 m follow-up.Conclusion:This report suggests that ILTPT is feasible and safe in Anus-Conserving Operation for low Rectal Cancer without auxiliary incision.If only we hold the applicability of ILTPT less trauma,more beautiful. | Taiyuan Li Jianping Gong Jinzhong Duanmu Haitao Zhang Xiong Lei | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，10： | 1 |
| 19 | The effects of rapid urbanization on the levels in tropospheric nitrogen dioxide and ozone over East China显示文摘 | Jianping Huang Chenhong Zhou Xuhui Lee Yunxuan Bao Xiaoyan Zhao Jimmy Fung Andreas Richter Xiong Liu Yiqi Zheng | 2013 | Atmospheric Environment2013，，： | 1 |
| 20 | On-orbit real-time magnetometer bias determination for micro-satellites without attitude information显示文摘Due to the disadvantages such as complex calculation, low accuracy of estimation, and being non real time in present methods, a new real-time algorithm is developed for on-orbit magnetometer bias determination of micro-satellites without attitude knowledge in this paper. This method uses the differential value approach. It avoids the impact of quartic nature and uses the iterative method to satisfy real-time applications. Simulation results indicate that the new real-time algorithm is more accurate compared with other methods, which are also tested by an experiment system using real noise data. With the new real-time algorithm, a magnetometer calibration can be taken on-orbit and will reduce the demand for computing power effectively. | Zhang Zhen Xiong Jianping Jin Jin | 2015 | Chinese Journal of Aeronautics2015，28，5： | 1 |
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