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| 1 | Melatonin enhances salt tolerance by promoting MYB108A-mediated ethylene biosynthesis in grapevines显示文摘The signal molecules melatonin and ethylene play key roles in abiotic stress tolerance.The interplay between melatonin and ethylene in regulating salt tolerance and the underlying molecular mechanism of this interplay remain unclear.Here,we found that both melatonin and 1-aminocyclopropane-1-carboxylic acid(ACC,a precursor of ethylene)enhanced the tolerance of grapevine to NaCl;additionally,ethylene participated in melatonin-induced salt tolerance.Further experiments indicated that exogenous treatment and endogenous induction of melatonin increased the ACC content and ethylene production in grapevine and tobacco plants,respectively.The expression of MYB108A and ACS1,which function as a transcription factor and a key gene involved in ethylene production,respectively,was strongly induced by melatonin treatment.Additionally,MYB108A directly bound to the promoter of ACS1 and activated its transcription.MYB108A expression promoted ACC synthesis and ethylene production by activating ACS1 expression in response to melatonin treatment.The suppression of MYB108A expression partially limited the effect of melatonin on the induction of ethylene production and reduced melatonin-induced salt tolerance.Collectively,melatonin promotes ethylene biosynthesis and salt tolerance through the regulation of ACS1 by MYB108A. | Lili Xu Guangqing Xiang Qinghua Sun Yong Ni Zhongxin Jin Shiwei Gao Yuxin Yao | 2019 | Horticulture Research2019，6，1： | 7 |
| 2 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 3 | Polyimide-derived carbon nanofiber membranes as anodes for high-performance flexible lithium ion batteries显示文摘The strategy of N-doping in carbon materials could provide additional Li-ion storage sites to improve their electrochemical properties. Heteroatom-containing polymers could serve as good precursors to fabricate doped carbons due to the capability to in situ dope heteroatoms into the structures. In this work,electrospun heterocyclic polyimide(PI) nanofiber membranes containing biphenyl and pyrimidine rings were carbonized to fabricate freestanding and flexible heteroatoms-containing carbon membranes.When the polymer membranes were subjected to various calcination temperatures(from 550℃ to950℃) and durations(0.5-10 h), the structural evolutions strongly affect their electrochemical properties as anodes for lithium ion batteries. It demonstrated that the reversible specific capacity of obtained sample treated at 650℃ for 3 h could achieve 695 mAh/g at 0.1 A/g and retain 245 mAh/g at 1.5 A/g after300 cycles. Furthermore, the electrospun membrane maintains a good electrochemical performance at bending state as a flexible electrode. | Fangyuan Zhao Xin Zhao Bo Peng Feng Gan Mengyao Yao Wenjun Tan Jie Dong Qinghua Zhang | 2018 | Chinese Chemical Letters2018，29，11： | 5 |
| 4 | Smooth fractal surfaces derived from bicubic rational fractal interpolation functions显示文摘Dear editor,Fractal geometry is an important and active branch of nonlinear science.It has attracted more and more attention[1,2].As an important research field of fractal geometry,fractal interpola- | Fangxun BAO Xunxiang YAO Qinghua SUN Yunfeng ZHANG Caiming ZHANG | 2018 | Science China(Information Sciences)2018，61，9： | 3 |
| 5 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 6 | Glacier in the upstream Manla Reservoir in the Nianchu River Basin,Tibet:shrinkage and impacts显示文摘Glaciers in the upstream Manla Reservoir in the Nianchu River Basin are crucial for agriculture and hydropower in the 'One River and Two Streams' area.Rising temperature has caused widespread retreat of glaciers on the Tibetan Plateau during the last few decades.In this study,glacier variations under climate change in the Nianchu River Basin are quantified and their influence are evaluated by analyzing 1980 aerial topographic maps,1990 Landsat TM,2000 Landsat ETM+,and 2005 CBERS remotely sensed images.It is found that from 1980 to 2005,the debris-free glacier area shrank by 7.3% (13.42 km2).Glacier shrinkage will have a positive effect on agriculture,hydropower and eco-environment in the near future.However,because the large number of small glaciers (<2 km2) will rapidly retreat and disappear in future years,melt water will decrease,ultimately resulting in a long term water shortage.Glacial lakes exhibited rapid expansion due to accelerating glacier retreat during 1980-2005,increasing the possibility of glacial lake outburst floods. | ZhiGuo Li TanDong Yao LiDe Tian QingHua Ye Bamhart Laura | 2011 | Research in Cold and Arid Regions2011，3，2： | 2 |
| 7 | Enantioseparation of amino acid derivatives on an immobilized network polymer derived from L-tartaric acid显示文摘 | WENG Wen WANG Qinghua YAO Bixia | 2004 | J Chromatogr: A2004，1042，： | 1 |
| 8 | An improved evolutionary extreme learning machine based on parti- cle swarm optimization显示文摘 | Han Fang Yao Haifen Ling Qinghua | 2013 | Neurocomputing2013，116，20： | 1 |
| 9 | Asset allocation for a DC pension fund with stochastic income and mortality risk:A multi-period mean-variance framework显示文摘 | Haixiang Yao Yongzeng Lai Qinghua Ma Minjie Jian | 2014 | Insurance:Mathematics and Economics2014，，54： | 1 |
| 10 | The new study of low chlorine and low earlystrength concrete agent显示文摘 | Yao Bingwen Wang Yanping Wang Qinghua etal | 2006 | China Concrete and Ce-ment Products2006，149，3： | 1 |
| 11 | Dynamic interaction of neutrophils and RFP-labelled Vibrio parahaemolyticus in zebrafish(Danio rerio)显示文摘Vibrio parahaemolyticus(Vp)is an aquatic zoonotic pathogen that causes vibriosis in marine animals as well as sepsis,gastroenteritis and wound infection in human.In vertebrates,the innate immune system plays a critical defense mechanism against Vp infection including transmigration of neutrophils.In this study,we have examined the genetic recombination and infectious process of Vp in the zebrafish(Danio rerio),a vertebrate model system extensively used for studying host-pathogen interactions.A pathogenic Vp strain,Vp57,tagged with red fluorescent protein(RFP)(Vp57^(RFP))was introduced into larval zebrafish at 3 days post fertilization(dpf),in which the innate immunity is present whereas the adaptive immunity has not yet developed.Vp57 and Vp57^(RFP)showed similar LD50 and induced similar symptoms and pathological changes in the hosts.We microinjected 579 colony-forming units(CFU)Vp57^(RFP)into the zebrafish caudal vein,and observed that neutrophils were recruited to the injection site and within 3 h post infection(hpi)Vp57^(RFP)were mainly distributed in the tail,eyes,heart and optic vesicle.After 3 hpi,the fish died with slight spine bending.Several Vp57^(RFP)were also detected in somites,the phagocytosis of neutrophils was activated through the progress of bacterial infections.We found that chemotaxis and phagocytosis of neutrophils occurs when zebrafish is infected by Vp57^(RFP),whereas Vp57^(RFP)can escape from neutrophils and colonize other remote regions using the blood circulation system. | Qiuyue Zhang An Ding Qianwen Yue Weiming Li Yao Zu Qinghua Zhang | 2017 | Aquaculture and Fisheries2017，2，6： | 1 |
| 12 | Numerical and Experimental Distribution of Temperature and Stress Fields in API Round Threaded Connection显示文摘 | Yuan Guangjie Yao Zhenqiang Wang Qinghua | 2006 | Engineering Failure Analysis2006，13，： | 1 |
| 13 | Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis显示文摘 | Yibing Yao Yu Fan Jun Wu Haisu Wan Jing Wang Stephen Lam Wan L. Lam Luc Girard Adi F. Gazdar Zhihao Wu Qinghua Zhou | 2012 | Biochemical and Biophysical Research Communications2012，，3： | 1 |
| 14 | Causes of longitudinal cracking on new rehabilitated PCC pavements显示文摘 | YAO Jialiang WENG Qinghua | 2012 | Journal of Performance of Constructed Facilities2012，26，1： | 1 |
| 15 | Numerical and experimental distribution of temperature and stress fields in API round threaded connection显示文摘 | Yuan Guangjie Yao Zhenqiang Wang Qinghua | 2006 | Engineering Failure Analysis2006，13，8： | 1 |
| 16 | Causes of Longitudinal Cracking on New Rehabilitated PCC Pavements 显示文摘 | YAO Jialiang WENG Qinghua | 2012 | Journal of Performance of Constructed Facilities2012，26，1： | 1 |
| 17 | 3D finite-element modeling of Earth induced electromagnetic field and its potential applications for geomagnetic satellites显示文摘The accumulated large amount of satellite magnetic data strengthens our capability of resolving the electrical conductivity of Earth’s mantle.To invert these satellite magnetic data,accurate and efficient forward modeling solvers are needed.In this study,a new finite-element based forward modeling solver is developed to accurately and efficiently compute the induced electromagnetic field for a realistic 3D Earth.Firstly,the nodal-based finite element method with linear shape function on tetrahedral grid is used to assemble the final system of linear equations for the magnetic vector potential and electric scalar potential.The FGMRES solver with algebraic multigrid(AMG)preconditioner is used to quickly solve the final system of linear equations.The weighted moving least-square method is employed to accurately recover the electromagnetic field from the numerical solutions of magnetic vector and electric scalar potentials.Furthermore,a local mesh refinement technique is employed to improve the accuracy of the estimated electromagnetic field.At the end,two synthetic models are used to verify the accuracy and efficiency of our newly developed forward modeling solver.A realistic 3D Earth model is used to simulate the induced magnetic field at 450 and 200 km altitudes which are the planned flying altitudes of Macao’s geomagnetic satellites.The simulation indicates that(1)the amplitude of the mantle-induced magnetic field can reach 10–30 nT at 450 km altitude,which is 10–30%of the primary magnetic field.The induced magnetic field at 200 km altitude has larger amplitudes.These mantleinduced magnetic fields can be measured by Macao geomagnetic satellites;(2)the amplitude of the ocean-induced magnetic field can reach 5–30 nT at satellite altitudes,which needs to be carefully considered in the interpretation of satellite magnetic data.We are confident that our newly developed forward modeling solver will become a key tool for interpreting satellite magnetic data. | Hongbo YAO Zhengyong REN Jingtian TANG Yufeng LIN Changchun YIN Xiangyun HU Qinghua HUANG Keke ZHANG | 2021 | Science China Earth Sciences2021，64，10： | 1 |
| 18 | An improved extreme learning machine based on particle swarm optimization显示文摘 | HAN Fei YAO Haifen LING Qinghua | 2012 | Bio-Inspired Computing and Applications Lecture Notes in Computer Science2012，6840，： | 1 |
| 19 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 20 | An improved evolutionary extreme learning machine based on particle swarm optimization显示文摘 | HAN Fei YAO Haifen LING Qinghua | 2013 | Neurocomputing2013，116，： | 1 |
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