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| 1 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 2 | The potential role of retinoic acid receptor on glomerulosclerosis in rats and podocytes injury is associated with the induction of MMP2 and MMP9显示文摘Retinoic 酸受体(RAR ) 在肾疾病起一个关键作用。然而,在 glomerulosclerosis (GS ) 的内在的机制仍然不是清楚的。在 adriamycin (ADR ) 的 RAR 的角色劝诱了 GS 老鼠模型,在导致 ADR 的 podocyte,在 vitro 的损害被调查。RAR 在 GS 老鼠是过去表示的,并且浆液,尿和肾样品是镇定的检测受体的表示的正式就职。RAR 表示被禁止或在跟随损害,由 morphometric 试金示威了的有教养的 podocytes 过去表示房间毒性,和矩阵 metalloproteinase (MMP ) 酶的活动。RAR 在 GS 老鼠显示了一个 renoprotective 角色,导致一个更低的 GS 索引, podocyte 脚过程熔化,和 proteinuria,减少的浆液 creatinine 和血脲氮。进一步的实验显示 RAR 禁止了 TGF-1,光滑的肌肉肌动朊,骨胶原 IV,和 fibronectin 的累积,当它导致了 MMP2 和 MMP9 时在在 vitro 的 podocytes 的过多的表示。RAR 改进了肾的功能并且稀释了与 MMP2 和 MMP9 的在表示上被联系的 GS 的前进。 | Xiuping Chen Yuanhan Qin Tianbiao Zhou Ling Jiang Fengying Lei He Qin Lei Zhang Zhiqiang Zhou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 3 |
| 3 | Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway显示文摘The aberrant changes of fussion/fission-related proteins can trigger mitochondrial dynamics imbalance,which cause mitochondrial dysfunctions and result insulin resistance(IR).However,the relationship between the inner mitochondrial membrane fusion protein optic atrophy 1(Opa1)and hepatic IR as well as the specific molecular mechanisms of signal transduction has not been fully elucidated.In this study,we explore whether abnormalities in the Opa1 cause hepatic IR and whether berberine(BBR)can prevent hepatic IR through the SIRT1/Opa1 signalling pathway.High-fat diet(HFD)-fed mice and db/db mice are used as animal models to study hepatic IR in vivo.IR,morphological changes,and mitochondrial injury of the liver are examined to explore the effects of BBR.SIRT1/Opa1 protein expression is determined to confirm whether the signalling pathway is damaged in the model animals and is involved in BBR treatment-mediated mitigation of hepatic IR.A palmitate(PA)-induced hepatocyte IR model is established in HepG2 cells in vitro.Opa1 silencing and SIRT1 overexpression are induced to verify whether Opa1 deficiency causes hepatocyte IR and whether SIRT1 improves this dysfunction.BBR treatment and SIRT1 silencing are employed to confirm that BBR can prevent hepatic IR by activating the SIRT1/Opa1 signalling pathway.Western blot analysis and JC-1 fluorescent staining results show that Opa1 deficiency causes an imbalance in mitochondrial fusion/fission and impairs insulin signalling in HepG2 cells.SIRT1 and BBR overexpression ameliorates PA-induced IR,increases Opa1,and improves mitochondrial function.SIRT1 silencing partly reverses the effects of BBR on HepG2 cells.SIRT1 and Opa1 expressions are downregulated in the animal models.BBR attenuates hepatic IR and enhances SIRT1/Opa1 signalling in db/db mice.In summary,Opa1 silencing-mediated mitochondrial fusion/fission imbalance could lead to hepatocyte IR.BBR may improve hepatic IR by regulating the SIRT1/Opa1 signalling pathway,and thus,it may be used to treat type-2 diabetes. | Jia Xu Yining Zhang Zhiyi Yu Yueqi Guan Yuqian Lv Meishuang Zhang Ming Zhang Li Chen Xiaoyan Lv Fengying Guan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 3 |
| 4 | Understanding the spatial representativeness of air quality monitoring network and its application to PM_(2.5)in the China's Mainland显示文摘Air pollution has seriously endangered human health and the natural ecosystem during the last decades.Air quality monitoring stations(AQMS)have played a critical role in providing valuable data sets for recording regional air pollutants.The spatial representativeness of AQMS is a critical parameter when choosing the location of stations and assessing effects on the population to long-term exposure to air pollution.In this paper,we proposed a methodological framework for assessing the spatial representativeness of the regional air quality monitoring network and applied it to ground-based PM_(2.5)observation in the mainland of China.Weighted multidimensional Euclidean distance between each pixel and the stations was used to determine the representativeness of the existing monitoring network.In addition,the K-means clustering method was adopted to improve the spatial representativeness of the existing AQMS.The results showed that there were obvious differences among the representative area of 1820 stations in the mainland of China.The monitoring stations could well represent the PM_(2.5)spatial distribution of the entire region,and the effectively represented area(i.e.the area where the Euclidean distance between the pixels and the stations was lower than the average value)accounted for 67.32%of the total area and covered 93.12%of the population.Forty additional stations were identified in the Northwest,North China,and Northeast regions,which could improve the spatial representativeness by 14.31%. | Ling Su Chanchan Gao Xiaoli Ren Fengying Zhang Shanshan Cao Shiqing Zhang Tida Chen Mengqing Liu Bingchuan Ni Min Liu | 2022 | Geoscience Frontiers2022，13，3： | 3 |
| 5 | Seismic studies of coal bed methane content in the west coal mining area of Qinshui Basin显示文摘The coal bed methane content(CBMC)in the west mining area of Jincheng coalfield,southeastern Qjnshui Basin,is studied based on seismic data and well-logs together with laboratory measurements.The results show that the Shuey approximation has better adaptability according to the Zoeppritz equation result;the designed fold number for an ordinary seismic data is sufficient for post-stack data but insufficient for pre-stack data regarding the signal to noise ratio(SNR).Therefore a larger grid analysis was created in order to improve the SNR.The velocity field created by logging is better than that created by stack velocity in both accuracy and effectiveness.A reasonable distribution of the amplitude versus offset(AVO)attributes can be facilitated by taking the AVO response from logging as a standard for calibrating the amplitude distribution.Some AVO attributes have a close relationship with CBMC.The worst attribute is polarization magnitude,for which the correlation coefficient is 0.308;and the best attribute is the polarization product from intercept,of which the correlation coefficient is-0.8136.CBMC predicted by AVO attributes is better overall than that predicted by direct interpolation of CBMC;the validation error of the former is 14.47%,which is lower than that of the latter 23.30%.CBMC of this area ranges from2.5 m^3/t to 22 m^3/t.Most CBMC in the syncline is over 10m^3/t,but it is below 10m^3/t in the anticline;on the whole,CBMC in the syncline is higher than that in anticline. | Zou Guangui Peng Suping Yin Caiyun Xu Yanyong Chen Fengying Liu Jinkai | 2013 | International Journal of Mining Science and Technology2013，23，6： | 2 |
| 6 | Adenine Phosphoribosyl Transferase 1 is a Key Enzyme Catalyzing Cytokinin Conversion from Nucleobases to Nucleotides in Arabidopsis显示文摘在植物,细胞激动素包括细胞激动素生合成,互变现象, inactivation,和降级,新陈代谢的进程在细胞激动素动态平衡和植物开发的规定起关键作用。嘌呤新陈代谢的酶被暗示了在以前的工作催化细胞激动素互变现象。在这研究,我们报导腺嘌 Phosphoribosyl Transferase 1 (APT1 ) 是高剂量的细胞激动素抵抗的异种的原因的基因。APT1 从免费的底催化细胞激动素变换到核苷酸,并且在 Arabidopsis 腺嘌 Phosphoribosyl Transferase 家庭的五个成员之中是机能上地占优势的。在工厂的 APT1 活动的损失导致细胞激动素底的过量累积,因此唤起无数调整细胞激动素的回答例如推迟的叶老朽, anthocyanin 累积,和下游的基因表示。因此,我们的学习把 APT1 定义为由 phosphoribosylation 参予细胞激动素 inactivation 的关键新陈代谢的酶。 | Xinyan Zhang Yutao Chen Xin Lin Xinyu Hong Ying Zhu Wenyang Li Wenrong He Fengying An Hongwei Guo | 2013 | Molecular Plant2013，6，5： | 2 |
| 7 | Effects of berberine on glucose metabolism in vitro显示文摘 | Jun Yin Renming Hu Mingdao Chen Jinfeng Tang Fengying Li Ying Yang Jialun Chen | 2002 | Metabolism2002，，11： | 2 |
| 8 | High pressure effects on the crystal structure andelectric conductivity of perovskite like (Ca/Sr)_2CuO_2Cl_2 compounds显示文摘The crystal structure stability as well as electric conductance of (Sr/Ca)_2CuO_2Cl_2 compound with K_2NiF_4 structure was investigated up to 31 GPa using diamond anvil technique. It seems that (Sr/Ca)_2CuO_2Cl_2 is quite stable under pressure but with obvious anisotropic compressibility. The equation of state (EOS) obtained shows relative large bulk modulus. | LIU QingQing WANG FuRen LI FengYing CHEN LiangChen YU RiCheng JIN ChangQing LI YanChun LIU Jing | 2008 | Chinese Science Bulletin2008，53，18： | 2 |
| 9 | Vinyl-functionalized multicolor benzothiadiazoles: design,synthesis, crystal structures and mechanically-responsive performance显示文摘Benzothiadiazole(BTD) has been extensively used as a building block in optical materials. In this work, a class of π-conjugated BTD-based luminogens BTD-685, BTD-580, BTD-675 and BTD-565 were designed by varying donor units and facilely synthesized by Heck coupling reaction. It was found that their emission in solid state covered the regio from orange, red to near infrared fluorescence. Investigation on photo-physical property manifested that they had strong solvatochromic behavior except symmetric 2-vinylpyridine substituted BTD-565. Crystal X-ray diffraction analysis revealed that they involved in multi weak intermolecular interactions. And loose molecular packing implied that they can be easily rearranged under external force stimuli.Indeed, all compounds showed reversible mechanically-responsive behavior in solid state. Interestingly, the vinylpyridinecontaining BTD-565 exhibited hypochromatic mechanochromic behavior, whereas others showed bathochromic mechanochromism behavior. It was worth mentioning that BTD-675 had self-recovery behavior after grinding. The powder X-ray diffraction study showed that these chromic processes may be mainly attributed to the reversible morphological changes between crystalline and amorphous phase upon grinding or fuming. These observations suggested that the vinyl-functionalized benzothiadiazoles can be considered as a type of excellent candidates in mechanically-responsive chromic materials. | Jianhua Chen Fengying Ye Yan Lin Zhao Chen Shenghua Liu Jun Yin | 2019 | Science China Chemistry2019，62，4： | 2 |
| 10 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 11 | Estimation of laser solid forming process based on temperature measure- ment显示文摘 | Tan Hua Chen Jing Zhang Fengying | 2010 | Optics & Laser Technology2010，42，： | 1 |
| 12 | A delta-class glutathione transferase from the Chinese mitten crab Eriocheir sinensis : cDNA cloning, characterization and mRNA expression显示文摘 | Daxian Zhao Liqiao Chen Chuanjie Qin Hao Zhang Ping Wu Fengying Zhang | 2010 | Fish and Shellfish Immunology2010，，4： | 1 |
| 13 | Induction of apoptosis of gastric cancer cells SGC7901 in vitro by a cell-free fraction of Tibetan kefir 显示文摘 | Jie Gao Fengying Gu Hui Ruan Qihe Chen | 2013 | lnternational Dairy Jour- nal2013，30，： | 1 |
| 14 | 查看详情显示文摘 | Chang C Z Zhang J Feng X Shen J Zhang Z C Guo MH LiK OuYB WeiP WangLL JiZQ FengY Ji S H Chen X Jia J F Dai X Fang Z Zhang S C He K Wang Y Y Lu L Ma X C Xue Q K | | 0，，： | 1 |
| 15 | Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes显示文摘 | Libin Zhou Xiao Wang Ying Yang Ling Wu Fengying Li Rong Zhang Guoyue Yuan Ning Wang Mingdao Chen Guang Ning | 2010 | BBA - Molecular Basis of Disease2010，，4： | 1 |
| 16 | Effect of hepatocyte growth factor signaling pathway activation on Plasmodium berghei infection显示文摘Objective:To explore the effect of hepatocyte growth factor signaling pathway activation on Plasmodium berghei infection.Methods:In this study,hepatocyte growth factor was detected by ELISA and Western blotting assay.Hepatocyte injury was detected by FITC-dextran absorption assay,and hepatocyte growth factor expression was shown to be expressed in the same injury cells by immunofluorescence against hepatocyte growth factor.In addition,Activation of hepatocyte growth factor and its receptor signaling pathway was detected with immunoprecipitation and detection of phosphorylation status.Results:It was found that injury of hepatocytes by sporozoite migration induced the secretion of hepatocyte growth factor and it was hepatocyte growth factor that rendered hepatocytes susceptible to Plasmodium sporozoite infection.In addition,hepatocyte infections depended on activation of the hepatocyte growth factor and its receptor signaling pathway.Conclusions:Our results indicate that hepatocyte growth factor and its receptor may possibly be potential targets for new approaches to malaria treatment. | Nantian Zhong Fengying Huang Guanghong Tan Jiege Jiao Yingzhi Lin CaichunWang Hua Wang Songlin Zhou Yonghao Huang Fan Chen Yingying Lin | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 1 |
| 17 | Oral delivery of superoxide dismutase by lipid polymer hybrid nanoparticles for the treatment of ulcerative colitis显示文摘Protein-based drugs have received extensive attention in the field of drug research in recent years.However,protein-based drug activity is difficult to maintain during oral delivery,which limits its application.This study developed bifunctional oral lipid polymer hybrid nanoparticles(R8-PEG-PPNPs)that deliver superoxide dismutase(SOD)for the treatment of ulcerative colitis(UC).R8-PEG-PPNPs was composed of PCADK,PLGA,lecithin,and co-modified with stearic acid-octa-arginine and polyethylene glycol.The nanoparticles(NPs)are uniformly dispersed with a complete spherical structure.In vitro stability and release studies showed that R8-PEG-PPNPs exhibited good stability and protection.In vitro cell culture experiments demonstrated that R8-PEG-PPNPs as carriers have no significant toxic effects on cells at concentration below 1000µg/mL and promote cellular uptake.In experiments with ulcerative colitis mice,R8-PEG-PPNPs were able to enhance drug absorption by intestinal epithelial cells and accumulate effectively at the site of inflammation.Its therapeutic effect further demonstrates that R8-PEG-PPNPs are a promising delivery system for oral delivery of protein-based drugs. | Yaxin Cui Tianyu Zhu Xueyan Zhang Jicong Chen Fengying Sun Youxin Li Lesheng Teng | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 18 | Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase显示文摘 | Jing Li Yue Pan Mujie Kan Xuanang Xiao Yunjing Wang Fengying Guan Xuewen Zhang Li Chen | 2014 | Life Sciences2014，，1： | 1 |
| 19 | Tailoring grain morphology in Ti-6Al-3Mo through heterogeneous nucleation in directed energy deposition显示文摘A common challenge in direct energy deposition(DED)is eliminating the anisotropy in mechanical performance associated with microstructure and the formation of coarse columnar grains.In this work,a heterogeneous nucleation mechanism was introduced into the melt pool,and,from this mechanism,an almost fully equiaxed grain morphology was obtained in the DED of Ti-6 Al-3 Mo.Three types of grain morphologies in DED Ti-6 Al-3 Mo,including full columnar grains,near-equiaxed grains and almost fully equiaxed grains were obtained from premixed and satellite powder blends from Ti,6 wt.%Al and 3 wt.%Mo,respectively.Combined with the analysis of the interactions between powder particles and the melt pool in DED,the formation mechanism of the equiaxed grains caused by the incomplete melting of high melting point Mo particles was revealed.As the prior-βgrains transformed from coarse columnar grains to fine-equiaxed grains,the strong<100>fiber texture along the deposition direction was weakened,while the size of theα-laths in the prior-βgrains slightly decreased,and the selection ofα-variants was weakened.Due to the transformation of the prior-βgrains from coarse columnar grains to fine-equiaxed grains,the tensile strength of the deposited samples increased from 982 MPa to 1082 MPa,while the yield strength increased from 840 MPa to 922 MPa,and the elongation of the as-deposited alloy also increased from 9.0%to 9.8%,which confirmed that the presence of fine-equiaxed grains is beneficial to the strength and plasticity of the DED alloy.This work further demonstrates the role that satelliting powders can play in terms of enhancing the columnar to equiaxed transition(CET)behavior associated with DED. | Fengying Zhang Panpan Gao Hua Tan Yao Li Yongnan Chen Min Mei Adam T.Clare Lai-Chang Zhang | 2021 | Journal of Materials Science & Technology2021，，29： | 1 |
| 20 | Front and Back contact engineering for high-efficient and low-cost hydrothermal derived Sb_(2)(S, Se)_(3) solar cells by using FTO/SnO_(2) and carbon显示文摘Antimony chalcogenide Sb_(2)(S, Se)_(3) is attracting a lot of attention as photovoltaic absorber owing to its rewarding photoelectric properties, low toxicity, and earth abundance. However, its device efficiency is still limited by the absorber material quality and device interface recombination. In this work, a fluorinedoped tin oxide(FTO) substrate with ultra-thin SnO_(2) layer and a low-cost stabilized carbon paste are introduced as a front and back contact layer respectively in Sb_(2)(S, Se)_(3) based planar solar cells. Over 5.2% efficiency is demonstrated in the structure of FTO/SnO_(2)/Cd S/Sb_(2)(S, Se)_3/Carbon/Ag, where the Sb_(2)(S, Se)_(3) is prepared by hydrothermal technique. The complementary device physics characterizations reveal that the interfacial recombination between TCO and Cd S is significantly suppressed by the introduction of ultra-thin SnO_(2) layer, which is profited from the leakage protection and bandgap offset engineering by its high resistivity and suitable conduction band minimum. Meanwhile, the successful adoption of the lowcost stabilized carbon as a back contact here shows an enormous potential to replace the conventional organic hole transport materials and noble metal. We hope this work can provide positive guidance to optimize Sb_(2)(S, Se)_(3) based planar solar cells in the future. | Liquan Yao Limei Lin Hui Liu Fengying Wu Jianmin Li Shuiyuan Chen Zhigao Huang Guilin Chen | 2020 | Journal of Materials Science & Technology2020，58，23： | 1 |
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