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| 1 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 2 | Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells显示文摘Natural exosomes can express specific proteins and carbohydratemolecules on the surface and hence have demonstrated the great potentials for gene therapy of cancer.However,the use of natural exosomes is restricted by their low transfection efficiency.Here,we report a novel targeting tLyp-1 exosome by gene recombinant engineering for delivery of siRNA to cancer and cancer stem cells.To reach such a purpose,the engineered tLyp-1-lamp2b plasmids were constructed and amplified in Escherichia coli.The tLyp-1-lamp2b plasmids were further used to transfect HEK293T tool cells and the targeting tLyp-1 exosomes were isolated from secretion of the transfected HEK293T cells.Afterwards,the artificially synthesized siRNA was encapsulated into targeting tLyp-1 exosomes by electroporation technology.Finally,the targeting siRNA tLyp-1 exosomes were used to transfect cancer or cancer stem cells.Results showed that the engineered targeting tLyp-1 exosomes had a nanosized structure(approximately 100 nm)and high transfection efficiency into lung cancer and cancer stem cells.The function verifications demonstrated that the targeting siRNA tLyp-1 exosomes were able to knock-down the target gene of cancer cells and to reduce the stemness of cancer stem cells.In conclusion,the targeting tLyp-1 exosomes are successfully engineered,and can be used for gene therapy with a high transfection efficiency.Therefore,the engineered targeting tLyp-1 exosomes offer a promising gene delivery platform for future cancer therapy. | Jing Bai Jialun Duan Rui Liu Yafei Du Qian Luo Yinuo Cui Zhanbo Su Jiarui Xu Ying Xie Wanliang Lu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 5 |
| 3 | China's FDI Net Inflow and Deterioration of Terms of Trade: Paradox and Explanation显示文摘从在中国的家之间的矛盾开始在外国直接投资(FDI ) 支撑了生长网流入和贸易的学期的恶化,自从 1990,这篇论文分析 FDI sectoral 结构的特征。而且,认为国际市场是竞争环境,这篇论文给影响机制的具体分析并且断定 FDI 流进劳动密集型的出口部门引起了中国贸易的学期的恶化。改进它贸易的术语,中国需要指导 FDI 流入进资本密集型、技术集中的部门和服务性行业。 | Huizhong Li Ping Huang Jialun Li | 2007 | China & World Economy2007，15，1： | 4 |
| 4 | Accelerated Landweber iteration based control allocation for fault tolerant control of reusable launch vehicle显示文摘This paper presents a novel Fault Tolerant Control(FTC)scheme based on accelerated Landweber iteration and redistribution mechanism for a horizontal takeoff horizontal landing reusable launch vehicle(RLV).First,an adaptive law based on fixed-time non-singular fast terminal sliding mode control(NFTSMC),which focuses on the attitude tracking controller design for RLV in the presence of model couplings,parameter uncertainties and external disturbances,is proposed to produce virtual control command.On this basis,a novel Control Allocation(CA)based on accelerated Landwber iteration is presented to realize proportional allocation of virtual control command among the actuators according to the effective gain as well as the distance from the current position of actuator to corresponding saturation limit.Meanwhile a novel redistribution mechanism is introduced to redistribute oversaturated command among healthy actuators(non-faulty or redundant).The proposed method can be applied to a real-time FTC system so that the controller reconfiguring is not required in case of actuator faults.Finally,the effectiveness of the proposed method is demonstrated by numerical simulations. | Changzhu WEI Mingze WANG Baogang LU Jialun PU | 2022 | Chinese Journal of Aeronautics2022，35，2： | 4 |
| 5 | A Better Zn-Ion Storage Device:Recent Progress for Zn-Ion Hybrid Supercapacitors显示文摘As a new generation of Zn-ion storage systems,Zn-ion hybrid supercapacitors(ZHSCs)garner tremendous interests recently from researchers due to the perfect integration of batteries and supercapacitors.ZHSCs have excellent integration of high energy density and power density,which seamlessly bridges the gap between batteries and supercapacitors,becoming one of the most viable future options for large-scale equipment and portable electronic devices.However,the currently reported two configurations of ZHSCs and corresponding energy storage mechanisms still lack systematic analyses.Herein,this review will be prudently organized from the perspectives of design strategies,electrode configurations,energy storage mechanisms,recent advances in electrode materials,electrolyte behaviors and further applications(micro or flexible devices)of ZHSCs.The synthesis processes and electrochemical properties of well-designed Zn anodes,capacitor-type electrodes and novel Zn-ion battery-type cathodes are comprehensively discussed.Finally,a brief summary and outlook for the further development of ZHSCs are presented as well.This review will provide timely access for researchers to the recent works regarding ZHSCs. | Jialun Jin Xiangshun Geng Qiang Chen Tian-Ling Ren | 2022 | Nano-Micro Letters2022，14，4： | 3 |
| 6 | Classification of Sitting States for the Humanoid Robot SJTU-HR1显示文摘 | Jialun Yang Feng Gao | 2011 | Journal of Bionic Engineering2011，8，1： | 3 |
| 7 | Extraction and analysis of saline soil deformation in the Qarhan Salt Lake region (in Qinghai, China) by the sentinel SBAS-InSAR technique显示文摘The instability of saline soil foundation affects the safety of artificial construction,and may cause ground collapse,building destruction and road damage.It is fundamental to reduce the potential engineering geological disasters by exploring the dynamic evolution of saline soil.Most of the previous researches of saline soil were conducted by simulated experiments and traditional geodetic surveying methods.Restricted to the limited sampling points,the spatiotemporal evolution characteristics of saline soil were difficult to find out in a large scale.This paper exploited SBAS-InSAR method to extract the deformation of the Qarhan Salt Lake(in Qinghai,China)section along Qinghai-Tibet railway,based on 119 image data acquired by Sentinel-1A from 2015 to 2020.The results showed that the deformation trends varied frequently in this saline mud flat.Between the adjacent areas with different deformation trends along Qinghai-Tibet railway,discontinuities caused by uplift and subsidence were very obvious.Besides,among the areas with brine exploitation or artificial construction,the maximum subsidence rate reached50 mm/yr,and the maximum cumulative subsidence exceeded 320 mm in the latest 5 years.In the saline mud flat closed to the rivers and lakes,the deformation trend was continuous uplift.Nevertheless,there were obvious seasonal deformation characteristics in those areas far away from the water body.Further analysis found out a sharply subsidence caused by the salt collapsibility appeared in rainy seasons.While an uplift trend induced by the salt swelling or frost heave was remarkable in dry seasons.Subsequently,the relationships were analyzed between the time series deformation and external environmental fac-tors.Furthermore,the deformation mechanism of saline soilin the Qarhan Salt Lake region was inter-preted then.In general,this study provides complete spatiotemporal evolution information of saline soil,and demonstrates the deformation characteristics of saline soil in the Qarhan Salt Lake region suc-cessfully.Related results would contribute to the safety monitoring for large-scale infrastructure con-struction in the saline soil areas. | Wei Xiang Rui Zhang Guoxiang Liu Xiaowen Wang Wenfei Mao Bo Zhang Jialun Cai Jiawen Bao Yin Fu | 2022 | Geodesy and Geodynamics2022，13，2： | 2 |
| 8 | Analyses of active faults, seismic activities and sea floor unstable factors of the Zhujiang River Mouth Basin and its adjacent areas显示文摘-On the basis of the data of geophysics and seismic activities, the analyses of the active faults, seismic activities and the sea floor unstable factors of the Zhujiang River Mouth Basin have been made so as to study the characteristics of the compressional subactive continental margin of Cathaysian system, arc littoral strongly active fracture zone, the division of seismic subzone and seismic zone of the continental margin of northern South China Sea, the potential focal area, and to analyze the regional stability. We consider that the Zhujiang River Mouth Basin belongs to a stable or a moderately stable region. | Liu Yixuan, Zhang Yixiang, Zhou Jialun , Xie Yixuan, Lu Chengbing, Zhong Jianqiang and Zhan Wenhuan South China Sea Institute of Oceanology, Academia Sinica, Guangzhou, China | 1990 | Acta Oceanologica Sinica1990，9，3： | 2 |
| 9 | Effects of berberine on glucose metabolism in vitro显示文摘 | Jun Yin Renming Hu Mingdao Chen Jinfeng Tang Fengying Li Ying Yang Jialun Chen | 2002 | Metabolism2002，，11： | 2 |
| 10 | Comparison on Adsorptive Separation of n-Paraffins Based on Binderless and Binder-containing Zeolite 5A Pellets显示文摘Binderless zeolite is considered to be a potential alternative for binder-containing zeolite in the industrial applications of adsorptive separation process. Synthesized binderless zeolite and commercial binder-containing product were used in adsorptive separation of n-paraffins from a model oil, with their performance compared. It is indicated that the binderless zeolite exhibits by 25%-35% higher in saturated adsorption capacity and by 115%-130% more adsorption amount at the breakthrough point with much shorter length of mass-transfer zone. Adsorptive separation of n-paraffins from naphtha was carried out in a fixed-bed adsorber containing the synthesized binderless zeolite 5 A under the operating conditions covering a feed space velocity of 90 h-1 and an adsorption temperature of 573 K. As compared to original naphtha, the raffinate shows by 34 units more in research octane number and by around 10% more of potential aromatic content, while the desorption oil exhibits by 13.3% more ethylene yield and by 11.7% higher in total olefins yield. | Kong Ruiqi Jiang Hao Wang Dan Tan Jialun Ren Danni Sun Hui Shen Benxian Liu Jichang Tang Sheng Zhao Deyin Chang Xiaohu | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 2 |
| 11 | New identity-based sequential aggregate signature scheme from RSA显示文摘 | JiaLun Tsai NaiWei Lo TzongChen Wu | 2013 | Biometrics and Security Technologies2013，，： | 1 |
| 12 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 13 | An Extension to SU_f^3 and Dirac Particle of the Transformation between Physical Bases and Symmetry Bases for Dibaryon States | Ping Jialun (Physics Department, Nanjing Normal University,Nanjing 210024)Wang Fan (Center for Theoretical Physics,Nanjing University,Nanjing 210008)T.Goldman (Theoretical Division.Los Alamas National Laboratory,NM87545.USA) | 1994 | Chinese journal of nuclear physics1994，，1： | 1 |
| 14 | A multidetector CT angiography study of variations in the circle of Willis in a Chinese population显示文摘 | Qi Li Jialun Li Fajin Lv Kewei Li Tianyou Luo Peng Xie | 2010 | Journal of Clinical Neuroscience2010，，3： | 1 |
| 15 | Preparation and upconversion emission properties of Yb, Er co-doped Y 2 Ti 2 O 7 upconversion inverse opal显示文摘 | Zhengwen Yang Jialun Zhu Dong Yan Hangjun Wu Rongfei Wang Zhiguo Song Xue Yu Yong Yang Dacheng Zhou Zhaoyi Yin Jianbei Qiu | 2012 | Optical Materials2012，，： | 1 |
| 16 | Determination of carbonate insecticides in Chinese medicinal herbs by gas chromatography with a nitrogen-phosphorus detector 显示文摘 | Wu Jialun Li Qing Zou Yaohua | 2005 | J AOAC Int2005，88，4： | 1 |
| 17 | Effect of microfluidization process on the functional properties of insoluble dietary fiber显示文摘 | Jialun Chen Dongxiao Gao Letian Yang Yanxiang Gao | 2013 | Food Research International2013，，2： | 1 |
| 18 | Interferometric coherence and seasonal deformation characteristics analysis of saline soil based on Sentinel-1A time series imagery显示文摘Affected by the natural environmental and human activity factors,significant seasonal differences appear on the regional scattering characteristic and ground deformation of saline soil.Interferometric decorrelation due to season replacement limits the conventional multi-temporal interferometric synthetic aperture radar(MT-InSAR)technique and its application in such areas.To extend the monitoring capability in the salt desert area,we select a vast basin of saline soil around Howz-e-Soltan Salt Lake of Iran as the study area and present an improved MTInSAR for experimental research.Based on 131 C-band Sentinel-1 A images collected between October 2014 to July 2020,1896 refined interferograms in total are selected from all interferogram candidates.Interferometric coherence analysis shows that the coherence in the saline soil area has an apparent seasonal variation,and the soil moisture affected by the precipitation may be the main factor that leads to the seasonal variation.Subsequently,the deformation characteristics of saline soil under different environmental conditions and human activity factors are compared and analyzed in detail.Related deformation mechanisms of different saline soil types are initially revealed by combining interferometric coherence,meteorological data,and engineering geological characteristics of saline soil.Related results would provide reference for the large-scale infrastructure construction engineering in similar saline soil areas. | ZHANG Rui XIANG Wei LIU Guoxiang WANG Xiaowen MAO Wenfei FU Yin CAI Jialun ZHANG Bo | 2021 | Journal of Systems Engineering and Electronics2021，32，6： | 1 |
| 19 | Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)technology emerges a remarkable potential for cure of refractory cancer like metastatic breast cancer.However,how to efficiently deliver the CRISPR system with non-viral carrier remains a major issue to be solved.Here,we report a kind of targeted core-shell nanoparticles(NPs)carrying dual plasmids(pHR-pCas9)for precise CCCTC-binding factor(CTCF)gene insert to circumvent metastatic breast cancer.The targeted core-shell NPs carrying pHR-pCas9 can accomplishγGTP-mediated cellular uptake and endosomal escape,facilitate the precise insert and stable expression of CTCF gene,inhibit the migration,metastasis,and colonization of metastatic breast cancer cells.Besides,the finding further reveals that the inhibitory mechanism of metastasis could be associated with up-regulating CTCF protein,followed by down-regulating stomatin(STOM)protein.The study offers a universal nanostrategy enabling the robust non-viral delivery of gene-editing system for treatment of severe illness. | Jialun Duan Chunjie Bao Ying Xie Haitao Guo Yixuan Liu Jianwei Li Rui Liu Peishan Li Jing Bai Yan Yan Limin Mu Xueqi Li Guiling Wang Wanliang Lu | 2022 | Bioactive Materials2022，7，5： | 1 |
| 20 | State classifica- tion for human hands 显示文摘 | Yang Jialun Gao Feng Shi I ifeng | 2008 | Journal of Bionic Engineering suppl2008，5，： | 1 |
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