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| 1 | Overexpression of SGR Results in Oxidative Stress and Lesion-mimic Cell Death in Rice Seedlings显示文摘It is thought that the Stay Green Rice(SGR)gene is involved in the disaggregation of the light harvesting complex and in the subsequent breakdown of chlorophyll and apo-protein during senescence.In this study,we found that overexpression of SGR(Ov-SGR)resulted in the generation of singlet oxygen and other reactive oxygen species and produced a chlorophyll-dependent regional cell death phenotype on leaves of rice seedlings.Transcriptome analyses using Affymetrix Rice GeneChips revealed that Ov-SGR rice seedlings exhibited a number of signs of singlet oxygen response.The genes and their associated biochemical pathways identified provide an insight into how rice plants respond to singlet oxygen at the molecular and physiologic level. | Huawu Jiang Yaping Chen Meiru Li Xingian Xu Guojiang Wu | 2011 | Journal of Integrative Plant Biology2011，53，5： | 16 |
| 2 | CRISPR/Cas9-introduced single and multiple mutagenesis in strawberry显示文摘CRISPR/Cas9-mediated genome editing is a powerful tool for life science research.Recently,strawberry (Fragaria × ananassa),an important horticultural crop,has emerged as a model organism for investigating the regulatory mechanisms of fruit development and ripening (Shulaev et al.,2011;Jia et al.,2013,2017;Kang et al.,2013;Han et al.,2015).While most cultivated strawberries (e.g.,F.× ananassa)are octoploid,most wild strawberries (e.g.,F.vesca)are diploid.Although CRISPR/Cas9 methods have been established in many plants,the use of this tool in strawberry needs to be further explored (Zhou et al.,2018). | Sinian Xing Meiru Jia Lingzhi Wei Wenwen Mao Usman Ali Abbasi Yaoyao Zhao Yating Chen Minglin Cao Kai Zhang Zhengrong Dai Zhechao Dou Wensuo Jia Bingbing Li | 2018 | Journal of Genetics and Genomics2018，45，12： | 4 |
| 3 | Elevated Serum Periostin Levels in Patients with Bone Metastases from Breast but not Lung Cancer显示文摘 | Hidefumi Sasaki Chih-Yi Yu Meiru Dai Carmen Tam Massimo Loda Daniel Auclair Lan Bo Chen Anthony Elias | 2003 | Breast Cancer Research and Treatment2003，，3： | 2 |
| 4 | Genome-wide analysis of the WRKY gene family in physic nut ( Jatropha curcas L.)显示文摘 | Wangdan Xiong Xueqin Xu Lin Zhang Pingzhi Wu Yaping Chen Meiru Li Huawu Jiang Guojiang Wu | 2013 | Gene2013，，2： | 2 |
| 5 | Particle size distributions of oil mists in workplace at- mospheres and their exposure concentrations to workers in a fastener manufacturing industry 显示文摘 | Chen Meiru Tsai Perngjy Chang Chihching | 2007 | Journal of Hazardous Materials2007，146，12： | 1 |
| 6 | Effects of Pressure Overload on Extracellular Matrix Expression in the Heart of the Atrial Natriuretic Peptide–Null Mouse显示文摘 | Dajun Wang Suzanne Oparil Ji An Feng Peng Li Gilbert Perry Lan Bo Chen Meiru Dai Simon W.M. John Yiu-Fai Chen | 2003 | Hypertension: Journal of the American Heart Association2003，，1： | 1 |
| 7 | Modulation of IFN-γ Receptor 1 Expression by AP-2α Influences IFN-γ Sensitivity of Cancer Cells显示文摘 | Changguo Chen Liang Guo Ming Shi Ming Hu Meiru Hu Ming Yu Tianyou Wang Lun Song Beifen Shen Lu Qian Ning Guo | 2012 | The American Journal of Pathology2012，，： | 1 |
| 8 | Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma显示文摘Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and recurrence.Nevertheless,the efficacy of FAK phosphorylation inhibitors is currently limited.Thus,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis.This study examined the correlation between FAK expression and the prognosis of HCC.Additionally,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor model.The expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying mechanisms.The results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in vivo.Increased expression of E-cadherin and decreased expression of vimentin indicated that EMT was inhibited.Consequently,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs. | XINFENG ZHANG SHUANG LI MEIRU SONG YUE CHEN LIANGZHENG CHANG ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU | 2024 | Oncology Research2024，32，4： | 0 |
| 9 | Multi-photon Up-conversion Luminescence of ErP_(5)O_(14) Noncrystalline显示文摘In this paper we report the observation of multi-photon up-conversion luminescence phenomenon of ErP_(5)O_(14) noncrystalline induced by pulse DCM dye laser and clarify that the mechanism of up-conversion is the step by step absorption of single Er^(3+)ion. | CHEN Xiaobo ZHANG Guangyin WANG Hong LIU Yanbin LI Jiaji CHEN Jinkai ZHANG Wanlin SHANG Meiru | 1993 | Chinese Physics Letters1993，10，4： | 0 |
| 10 | The 450 nm Up-Conversion Fluorescence of Crystalline TmP_(5)O_(14)显示文摘This paper reports the 450 nm up-conversion Buorescence of the crystalline TmP_(5)O_(14) at room temperature induced by pulsed DCM dye laser.It is iound that the up-conversion mechanism is the excited st&te absorption. | CHEN Xiaobo ZHANG Guangyin CHEN Jinkai SHANG Meiru LI Jiangwei | 1993 | Chinese Physics Letters1993，10，11： | 0 |
| 11 | Knockdown of LjALD1, AGD2‐like defense response protein 1, influences plant growth and nodulation in Lotus japonicus显示文摘The discovery of the enzyme L,L‐diaminopimelate aminotransferase(LL‐DAP‐AT, EC 2.6.1.83) uncovered a unique step in the L‐lysine biosynthesis pathway in plants. In Arabidopsis thaliana, LL‐DAP‐AT has been shown to play a key role in plant‐pathogen interactions by regulation of the salicylic acid(SA) signaling pathway. Here, a full‐length cDNA of LL‐DAP‐AT named as LjALD1 from Lotus japonicus(Regel)Larsen was isolated. The deduced amino acid sequence shares 67% identity with the Arabidopsis aminotransferase AGD2‐LIKE DEFENSE RESPONSE PROTEIN1(AtALD1) and is predicted to contain the same key elements: a conserved aminotransferase domain and a pyridoxal‐5'‐phosphate cofactor binding site.Quantitative real‐time PCR analysis showed that LjALD1 was expressed in all L. japonicus tissues tested, being strongest in nodules. Expression was induced in roots that had been infected with the symbiotic rhizobium Mesorhizobium loti or treated with SA agonist benzo‐(1, 2, 3)‐thiadiazole‐7‐carbothioic Researchacid. LjALD1 Knockdown exhibited a lower SA content, an increased number of infection threads and nodules, and a slight reduction in nodule size. In addition, compared with wild‐type,root growth was increased and shoot growth was suppressed in LjALD1 RNAi plant lines. These results indicate that LjALD1 may play important roles in plant development and nodulation via SA signaling in L. japonicus. | Wei Chen Xueliu Li Lu Tian Pingzhi Wu Meiru Li Huawu Jiang Yaping Chen Guojiang Wu | 2014 | Journal of Integrative Plant Biology2014，56，11： | 0 |
| 12 | An international comprehensive benchmarking analysis of synthetic biology in China from 2015 to 2020显示文摘As a new interdisciplinary field,synthetic biology has led to valuable innovations in the fields of medicine,chemistry,agriculture,energy and environment.In this paper,we systematically review the development status of global synthetic biology in the past six years,and make an in-depth benchmarking analysis of the field in China.With the aid of Scopus and SciVal,we analyze the scholarly output of synthetic biology in the world and individual countries,including publication distribution,popular journals and eminent institutions.Furthermore,the research focus and concepts,citation impact and collaborations are also examined using numerical index methods such as the field-weighted citation impact(FWCI)and relative activity index(RAI),showing the differences between data more intuitively.This study aims to offer a comprehensive understanding of the research status of synthetic biology in China and the world,offering a benchmarked overview of the results as a reference to guide the development of this field in the future. | Meiru Jiang Cong Chen Tao Chen Chao Zhao Zhiwen Wang | 2022 | Chinese Journal of Chemical Engineering2022，35，8： | 0 |
| 13 | Electromagnetic field-enhanced chiral dimanganese trioxide nanoparticles mitigate Parkinson’s disease显示文摘The misfolding and aggregation ofα-synuclein(α-syn)is closely associated with Parkinson’s disease(PD).Here,chiral dimanganese trioxide(Mn_(2)O_(3))nanoparticles(NPs)were prepared for PD treatment enhanced by a noninvasive electromagnetic field(MF).The affinity constants of D-NPs towardα-syn monomer(mono)orα-syn fibril were 3.5 times or 5.2 times higher,respectively,than those of L-NPs,and the mechanical force generated by NPs under a MF further promoted the interaction between NPs andα-syn to amplify the difference between L-NPs and D-NPs.As the synergy effect of the preferentially affinity ability and MF-induced mechanical forces,D-NPs exhibited a better inhibitory efficiency onα-syn fibrillization than L-NPs.Furthermore,after differentially cellular uptake of L-/D-NPs via the caveolin-mediated pathway,as reactive oxygen species(ROS)-scavengers,D-NPs possess higher efficiency in decreasing intracellular ROS level than L-NPs to provide higher cytoprotective efficiency to neuron cells.In vivo data showed that after treatment with D-NPs under a MF for 60 days,α-syn concentration in the cerebrospinal fluid of PD mice decreased 81%,while dopamine level in the brain of PD mice increased 2.3-fold.These findings indicated the potential of utilizing the synergic interplay of chiral NPs and MF for treating disease and opened a new path to explore the nanoscale chirality for regulating the biological effect. | Xiuxiu Wang Jing Zhao Weiwei Wang Meiru Lu Aihua Qu Maozhong Sun Xiaoqing Gao Chen Chen Hua Kuang Chuanlai Xu Liguang Xu | 2022 | Science China Chemistry2022，65，10： | 0 |
| 14 | Chiral Cu_(x)Co_(y)S Supraparticles Ameliorate Parkinson’s Disease显示文摘Protein aggregation causes alpha-synuclein(α-syn)to change from its original physiological role to a pathological state,which is a potential pathogenic mechanism in Parkinson’s disease(PD).Chiral _(L/D)-Cu_(x)Co_(y)S supraparticles(_(L/D)-SPs)with a circular dichroism value of 35 mdeg at 805 nm were fabricated using a simple wet-chemical method.The _(L/D)-SPs prevented the α-syn monomers from forming fibrils and triggered the α-syn fibrils to turn into monomers under 808 nm near-infrared(NIR)light.In living MN9D cells,D-SPs reduced cellular damage,neuronal functional deficits,and neuron loss caused by α-syn fibrils after NIR spectroscopy treatment within 10 min to prevent α-syn aggregation.Significantly,the reactive oxygen species produced by _(D)-SPs were 1.42 times higher than those produced by _(L)-SPs.In vivo experiments showed that _(D)-SPs had a protective effect on neuron damage caused by α-syn aggregate deposition,reduced the symptoms in a mouse model of PD,and restored cognitive ability.After NIR light treatment,the amount of α-syn in a mouse model of PD decreased by more than 67.5%.At the same time,_(D)-SPs gradually decomposed into small nanoparticleswithin 60 days and were excreted through the blood-brain barrier.This discovery paves theway for the treatment of neurodegenerative diseases using chiral SPs under NIR light irradiation. | Baimei Shi Aihua Qu Weiwei Wang Meiru Lu Zhuojia Xu Chen Chen Changlong Hao Maozhong Sun Liguang Xu Chuanlai Xu Hua Kuang | 2022 | CCS Chemistry2022，4，7： | 0 |
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