|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
| 2 | Tunable Q-factor wavelet transform denoising with neighboring coefficients and its application to rotating machinery fault diagnosis显示文摘Fault diagnosis of rotating machinery is of great importance to the high quality products and long-term safe operation.However,the useful weak features are usually corrupted by strong background noise,thus increasing the difficulty of the feature extraction.Thereby,a novel denoising method based on the tunable Q-factor wavelet transform(TQWT)using neighboring coefficients is proposed in this article.The emerging TQWT possesses excellent properties compared with the conventional constant-Q wavelet transforms,which can tune Q-factor according to the oscillatory behavior of the signal.Meanwhile,neighboring coefficients denoising is adopted to avoid the overkill of conventional term-by-term thresholding techniques.Because of having the combined advantages of the two methods,the presented denoising method is more practical and effective than other methods.The proposed method is applied to a simulated signal,a rolling element bearing with an outer race defect from antenna transmission chain and a gearbox fault detection case.The processing results demonstrate that the proposed method can successfully identify the fault features,showing that this method is more effective than the conventional wavelet thresholding denoising methods,term-by-term TQWT denoising schemes and spectral kurtosis. | HE WangPeng ZI YanYang CHEN BinQiang WANG Shuai HE ZhengJia | 2013 | Science China(Technological Sciences)2013，56，8： | 27 |
| 3 | Simultaneous determination of ten taste and odor compounds in drinking water by solid-phase microextraction combined with gas chromatography-mass spectrometry显示文摘Taste and odor(T&O)problems in drinking water frequently occur because of many compounds present in the water,of which trans-1,10-dimethyl-trans-9-decalol(geosmin)and 2-methylisoborneol(MIB)are well-known.In this study,a fast and efective method was established for simultaneous determination of 10 T&O compounds,including geosmin,MIB,2,4,6-trichloroanisole(TCA),2-methylbenzofuran,2-isopropyl-3-methoxypyrazine(IPMP),2-isobutyl-3-methoxypyrazine(IBMP),cis-3-hexenyl acetate,trans,trans-2,4-heptadienal,trans,cis-2,6-nonadienal,and trans-2-decenal in water samples by headspace solid-phase microextraction(SPME)coupled with gas chromatography-mass spectrometry.An orthogonal array experimental design was used to optimize the efects of SPME fiber,extraction temperature,stirring rate,NaCl content,extraction time,and desorption time.The limits of detection ranged from 0.1 to 73 ng/L were lower than or close to the odor threshold concentrations(OTCs).All the 10 T&O compounds were detected in the 14 water samples including surface water,treatment process water and tap water,taken from a waterworks in Lianyungang City,China.MIB and geosmin were detected in most samples at low concentration.Six T&O compounds(IPMP,IBMP,trans,cis-2,6-nonadienal,2-methylbenzofuran,trans-2-decenal,and TCA)were efectively decreased in water treatment process(sedimentation and filtration)that is diferent from cis-3-hexenyl acetate,MIB and geosmin.It is noted that the TCA concentrations at 15.9–122.3 ng/L and the trans,cis-2,6-nonadienal concentrations at 79.9–190.1 ng/L were over 10 times higher than their OTCs in tap water.The variation of the analytes in the all water samples,especially distribution system indicated that distribution system cannot be ignored as a T&O compounds source. | Xichao Chen Qian Luo Shengguang Yuan Zi Wei Hanwen Song Donghong Wang Zijian Wang | 2013 | Journal of Environmental Sciences2013，25，11： | 21 |
| 4 | LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125显示文摘 | Linlin Li Mengna Zhang Weizhen Chen Ruirui Wang Zi Ye Yanyan Wang Xiao Li Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 20 |
| 5 | Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells显示文摘目的:在 Jurkat cells.Methods 上探索反癌症效果和 gambogic ( GA )的分子的机制:房间生存能力被3-( 4,5-dimethylthiazol-2-yl )估计 -2,5-diphenyltetrazolium 溴化物 assay.Annexin V-fluores-cein-isothiocyanate/propidium 碘化物, DNA 碎片整理,并且彗星试金被用来检测弄污的 apoptosis.Western 被用来学习死亡的表示 inducer-obliterator-1 ( DIO-1 ), Bcl-2 , NF-KAPPA B ,和 pro-caspase 3 ,象 2 激活的 subunits:p17 和 p20.The 潜水艇一样, DIO-1 的细胞的本地化被免疫荧光和 Hoechst33258 staining.Results 检验: GA 与 1.51 ±0 .09 ( 24 h )的50%禁止的集中价值禁止了 Jurkat 房间的增长, 0.98 ±0 .13 ( 48 h ),并且 0.67 ±0 .12 亩 mol/L ( 72 h ) .GA 能导致 Jurkat 房间的 apoptosis 。由 GA 对待, DIO-1 的表示起来调整,并且 Bcl-2 和 NF-KAPPA B 的低调整,导致 3 .GA 导致了的 pro-caspase 的激活到 nucleus.Conclusion 的 DIO-1 的易位: GA 由 apoptosis induction.DIO-1 压制了 Jurkat 房间的增长在 对待GA 的 Jurkat 房间的触发的早阶段的细胞死亡。 | Yong WANG Yan CHEN Zi CHEN Qing WU Wen-juan KE Qiu-ling WU | 2008 | Acta Pharmacologica Sinica2008，29，3： | 15 |
| 6 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 7 | A pseudo wavelet system-based vibration signature extracting method for rotating machinery fault detection显示文摘The rotating machinery,as a typical example of large and complex mechanical systems,is prone to diversified sorts of mechanical faults,especially on their rotating components.Although they can be collected via vibration measurements,the critical fault signatures are always masked by overwhelming interfering contents,therefore difficult to be identified.Moreover,owing to the distinguished time-frequency characteristics of the machinery fault signatures,classical dyadic wavelet transforms(DWTs) are not perfect for detecting them in noisy environments.In order to address the deficiencies of DWTs,a pseudo wavelet system(PWS) is proposed based on the filter constructing strategies of wavelet tight frames.The presented PWS is implemented via a specially devised shift-invariant filterbank structure,which generates non-dyadic wavelet subbands as well as dyadic ones.The PWS offers a finer partition of the vibration signal into the frequency-scale plane.In addition,in order to correctly identify the essential transient signatures produced by the faulty mechanical components,a new signal impulsiveness measure,named spatial spectral ensemble kurtosis(SSEK),is put forward.SSEK is used for selecting the optimal analyzing parameters among the decomposed wavelet subbands so that the masked critical fault signatures can be explicitly recognized.The proposed method has been applied to engineering fault diagnosis cases,in which the processing results showed its effectiveness and superiority to some existing methods. | CHEN BinQiang ZHANG ZhouSuo ZI YanYang YANG ZhiBo HE ZhengJia | 2013 | Science China(Technological Sciences)2013，56，5： | 13 |
| 8 | Activation of Mitochondrial orf355 Gene Expression by a Nuclear-Encoded DREB Transcription Factor Causes Cytoplasmic Male Sterility in Maize显示文摘Coordination between mitochondria and the nucleus is crucial for fertility determination in plants with cytoplasmic male sterility(CMS).Using yeast one-hybrid screening,we identified a transcription factor,ZmDREB1.7,that is highly expressed in sterile microspores at the large vacuole stage and activates the expression of mitochondria-encoded CMS gene orf355.Δpro,a weak allele of ZmDREB1.7 with the loss of a key unfolded protein response(UPR)motif in the promoter,partially restores male fertility of CMS-S maize.ZmDREB1.7 expression increases rapidly in response to antimycin A treatment,but this response is attenuated in theΔpro allele.Furthermore,we found that expression of orf355 in mitochondria activates mitochondrial retrograde signaling,which in turn induces ZmDREB1.7 expression.Taken together,these findings demonstrate that positive-feedback transcriptional regulation between a nuclear regulator and a mitochondrial CMS gene determines male sterility in maize,providing new insights into nucleus-mitochondria communication in plants. | Senlin Xiao Jie Zang Yuanrong Pei Jie Liu Juan Liu Wei Song Zi Shi Aiguo Su Jiuran Zhao Huabang Chen | 2020 | Molecular Plant2020，13，9： | 10 |
| 9 | LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan显示文摘We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou Jing Telescope (GSJT, formerly called the Large sky Area Multi-Object fiber Spectroscopic Telescope - LAMOST). The survey will obtain spectra for 2.5 million stars brighter than r < 19 during dark/grey time, and 5 million stars brighter than r < 17 or J < 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope's design constrains the optimal declination range for observations to 10 < δ < 50 , and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies: disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey will be completed in summer 2012, after a review of the results of the pilot survey. | Li-Cai Deng Heidi Jo Newberg Chao Liu Jeffrey L. Carlin Timothy C. Beers Li Chen Hsu-Tai Lee Carl J. Grillmair Puragra Guhathakurta] Zhan-Wen Han Jin-Liang Hou Sebastien Lepine Jing Li Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Bo Wang Hong-Chi Wang Fan Yang Brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu | 2012 | Research in Astronomy and Astrophysics2012，12，7： | 10 |
| 10 | A data-driven threshold for wavelet sliding window denoising in mechanical fault detection显示文摘Wavelet denoising is an effective approach to extract fault features from strong background noise.It has been widely used in mechanical fault detection and shown excellent performance.However,traditional thresholds are not suitable for nonstationary signal denoising because they set universal thresholds for different wavelet coefficients.Therefore,a data-driven threshold strategy is proposed in this paper.First,the signal is decomposed into different subbands by wavelet transformation.Then a data-driven threshold is derived by estimating the noise power spectral density in different subbands.Since the data-driven threshold is dependent on the noise estimation and adapted to data,it is more robust and accurate for denoising than traditional thresholds.Meanwhile,sliding window method is adopted to set a flexible local threshold.When this method was applied to simulation signal and an inner race fault diagnostic case of dedusting fan bearing,the proposed method has good result and provides valuable advantages over traditional methods in the fault detection of rotating machines. | CHEN YiMin ZI YanYang CAO HongRui HE ZhengJia SUN HaiLiang | 2014 | Science China(Technological Sciences)2014，57，3： | 9 |
| 11 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 12 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 13 | Psychophysiological Effects of Bamboo Plants on Adults显示文摘The present study was conducted to clarify the psychophysiological relaxation effects of viewing bamboo on university students. Forty healthy Chinese participants enrolled in this study to clarify the psychophysiological relaxation effects of viewing bamboo. The effects of visual stimulation using a pot both with and without a bamboo were recorded by measuring the student's blood pressure, EEG and STAI. We observed that viewing bamboo plants resulted in significantly lower systolic(female, P < 0.001; male, P < 0.001; P < 0.05) and diastolic(female,P < 0.001; male, P < 0.001; P < 0.05) blood pressures, but no changes in the pulse rate(female, P = 0.09; male, P = 0.07; P > 0.05) were observed. The results of the EEG analysis indicated brainwave variation(all P < 0.05) and lower anxiety scores(P < 0.01) after 3 min of viewing bamboo compared with the control. These findings indicate that visual stimulation with bamboo plants induced psychophysiological relaxation effects on adults. | Ahmad Hassan CHEN Qi Bing JIANG Tao LYU Bing Yang LI Nian LI Shu SHANGGUAN Zi Yue LI Yun Ting JUN Zhou Li LUO Qian CHEN Xin Yi WANG Yi Yan ZENG Cheng Cheng YANG Jun Muhammad Sohaib Tahir | 2017 | Biomedical and Environmental Sciences2017，30，11： | 8 |
| 14 | Construction of adaptive redundant multiwavelet packet and its application to compound faults detection of rotating machinery显示文摘It is significant to detect the fault type and assess the fault level as early as possible for avoiding catastrophic accidents.Due to diversity and complexity,the compound faults detection of rotating machinery under non-stationary operation turns to be a challenging task.Multiwavelet with two or more base functions may match two or more features of compound faults,which may supply a possible solution to compound faults detection.However,the fixed basis functions of multiwavelet transform,which are not related with the vibration signal,may reduce the accuracy of compound faults detection.Moreover,the decomposition results of multiwavelet transform not being own time-invariant is harmful to extract the features of periodical impulses.Furthermore,multiwavelet transform only focuses on the multi-resolution analysis in the low frequency band,and may leave out the useful features of compound faults.To overcome these shortcomings,a novel method called adaptive redundant multiwavelet packet(ARMP) is proposed based on the two-scale similarity transforms.Besides,the relative energy ratio at the characteristic frequency of the concerned component is computed to select the sensitive frequency bands of multiwavelet packet coefficients.The proposed method was used to analyze the compound faults of rolling element bearing.The results showed that the proposed method could enhance the ability of compound faults detection of rotating machinery. | CHEN JingLong ZI YanYang HE ZhengJia WANG XiaoDong | 2012 | Science China(Technological Sciences)2012，55，8： | 7 |
| 15 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 16 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 17 | Prognostic value of clinical characteristics and immunophenotypic biomarkers in 115 patients with primary central nervous system lymphoma显示文摘 | CHEN Bo-bin XU Xiao-ping SHEN Lin HAN Tian-jie LIN Zhi-guang CHEN Zi KANG Hui HUANG Bo LIN Guo-wei | 2013 | Chinese Medical Journal2013，，3： | 6 |
| 18 | Biomimetic strategies for tendon/ligament-to-bone interface regeneration显示文摘Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex structure,composition,cell population and mechanics of the interface.With rapid advances in tissue engineering,a variety of strategies including advanced biomaterials,bioactive growth factors and multiple stem cell lineages have been developed to facilitate the healing of this tissue interface.Given the important role of structure-function relationship,the review begins with a brief description of enthesis structure and composition.Next,the biomimetic biomaterials including decellularized extracellular matrix scaffolds and synthetic-/natural-origin scaffolds are critically examined.Then,the key roles of the combination,concentration and location of various growth factors in biomimetic application are emphasized.After that,the various stem cell sources and culture systems are described.At last,we discuss unmet needs and existing challenges in the ideal strategies for tendon/ligament-to-bone regeneration and highlight emerging strategies in the field. | Tingyun Lei Tao Zhang Wei Ju Xiao Chen Boon Chin Heng Weiliang Shen Zi Yin | 2021 | Bioactive Materials2021，6，8： | 6 |
| 19 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 20 | Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats显示文摘Objective This study was conducted to investigate the regulation of endoplasmic reticulum stress on Nrf2 signaling pathway in the kidneys of rats. Methods Rats were divided into twelve groups of six animals each. Some groups were pre-administered with bacitracin or tauroursodeoxycholic acid(TUDCA), and all of them were treated with 5-20 μmol/kg cadmium(Cd) for 48 h. The oxidative stress levels were analyzed using kits. The mRNA and protein expression levels of endoplasmic reticulum stress-related factors and Nrf2 signaling pathway-related factors were determined using RT-PCR and western blot. Results Cd exposure resulted in oxidative stress in the kidneys of rats and upregulated the expression of endoplasmic reticulum stress(ERS)-related factors and Nrf2 signaling pathway-related factors, especially at doses of 10 and 20 μmol/kg Cd, and the expression changes were particularly obvious. Moreover, after pretreatment with bacitracin, Cd upregulated the expression of ERS-related factors to a certain extent and, at higher doses, increased the mRNA expression of Nrf2. After pretreatment with TUDCA, Cd reduced the level of ERS to a certain extent; however, at these doses, there were no significant changes in the expression of Nrf2. Conclusion Cadmium can result in ERS and oxidative stress in the kidneys of rats, activate Nrf2, and upregulate the transcriptional expression of phase II detoxification enzymes under these experimental conditions. ERS has a positive regulation effect on Nrf2 signaling pathway but has little effect on the negative regulation of Nrf2 signaling pathway in cadmium toxicity. | CHEN Zhi Jian CHEN Jia Xing WU Li Kang LI Bi Yun TIAN Ya Feng XIAN Min HUANG Zi Pei YU Ri An | 2019 | Biomedical and Environmental Sciences2019，32，1： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员