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| 1 | Time-sensitivity of the Kaiser effect of acoustic emission in limestone and its application to measurements of in-situ stress显示文摘Measuring in-situ stress by using the Kaiser effect in rocks has such advantages as time- effi ciency, low cost and little limitation, but the precision of the method is dependent on rock properties and delay time of the measurement. In this paper, experiments on the Kaiser effect in limestones were performed, and it was found that the limestones had good ability to retain a memory of their recent stress history and high time-sensitivity. The longer the experiment was delayed from the extraction of the stone, the larger the Felicity ratio was. As the Felicity ratio approached 1, signifi cant Kaiser effect was observed. In-situ stress should be determined by the limestone measurements when the delay time was 40-120 days. Finally, the in-situ stress in a limestone formation could be successfully measured in practice. | Jin Yan Qi Zili Chen Mian Zhang Guangqing Xu Guangqiang | 2009 | Petroleum Science2009，6，2： | 15 |
| 2 | Quantitative Geoscience and Geological Big Data Development: A Review显示文摘After long-term development, mathematical geology has today become an independent discipline. Big Data science, which has become a new scientific paradigm in the 21 st century, gives rise to the geological Big Data, i.e. mathematical geology and quantitative geoscience. Thanks to a robust macro strategy for big data, China's quantitative geoscience and geological big data's rapid development meets present requirements and has kept up with international levels. This paper presents China's decade-long achievements in quantitative prediction and assessment of mineral resources, geoscience information and software systems, geological information platform development, etc., with an emphasis on application of geological big data in informatics, quantitative mineral prediction, geological environment and disaster management, digital land survey, digital city, etc. Looking ahead, mathematical geology is moving towards 'Digital Geology', 'Digital Land' and 'Geological Cloud', eventually realizing China's grand 'Digital China' blueprint, and these valuable results will be showcased on the international academic arena. | CHEN Jianping XIANG Jie HU Qiao YANG Wei LAI Zili HU Bin WEI Wei | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 8 |
| 3 | Temperature dependence of the point defect properties of GaN thin films studied by terahertz time-domain spectroscopy显示文摘The dielectric functions of GaN for the temperature and frequency ranges of 10–300 K and 0.3–1 THz are obtained using terahertz time-domain spectroscopy.It is found that there are oscillations of the dielectric functions at various temperatures.Physically,the oscillation behavior is attributed to the resonance states of the point defects in the material.Furthermore,the dielectric functions are well fitted by the combination of the simple Drude model together with the classical damped oscillator model.According to the values of the fitting parameters,the concentration and electron lifetime of the point defects for various temperatures are determined,and the temperature dependences of them are in accordance with the previously reported result.Therefore,terahertz time-domain spectroscopy can be considered as a promising technique for investigating the relevant characteristics of the point defects in semiconductor materials. | FANG HeNan ZHANG Rong LIU Bin LI YeCao FU DeYi LI Yi XIE ZiLi ZHUANG Zhe ZHENG YouDou WU JingBo JIN BiaoBing CHEN Jian WU PeiHeng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 6 |
| 4 | Analysis of the ore-controlling structure of the Shihu gold deposit, Hebei Province and deep-seated ore-prospecting prediction显示文摘Under the guidance of the theory of mantle-branch structure-associated metallogenesis and on the basis of the geological characteristics, analysis of the ore-forming and ore-controlling structures, the geochemical characteristics of metallogenesis, the source of ore-forming materials, changes in the physical and chemical conditions of metallogenesis, changes in the vertical width of ore veins, and changes in gold grade of the Shihu gold deposit, the mechanism of its metallogenesis was discussed and the rules of vertical variation of ore veins were summarized in this study. It is pointed out that the orebodies under exploitation at present time should be in the middle and upper portions of gold veins in the Shihu gold mining district. Particularly on the basis of the characteristics of mantle-branch structure-associated metallogenesis, it is indicated that metallogenesis is controlled mainly by such ore-forming conditions as temperature and pressure. Deep-seated ore-forming fluids are characterized mainly by injection and precipitation. So the vein bodies in the adjacent metallogenic structures are of obvious comparability, and there would be great prospects for ore search both at depth and in the periphery of the Shihu gold deposit. Therefore, ore prospecting should be strengthened both at depth and in the peripheries. | NIU Shuyin WANG Baode SUN Aiqun CHEN Chao WANG Zili MA Baojun WANG Wenxue JIANG Xiaoping ZHAO Yongli GAO Yincang LIU Huabin QIU Jianping | 2009 | Chinese Journal Of Geochemistry2009，28，4： | 6 |
| 5 | MMC-MTDC Transmission System with Partially Hybrid Branches显示文摘This paper proposes a hybrid submodule modular multilevel converter(MMC)topology which is suitable for multi terminal direct current(MTDC)transmission systems.Each arm of the proposed MMC topology consists of a half-bridge submodule(HBSM)branch and two parallel full-bridge submodule(FBSM)branches.Comparing with the conventional MTDC transmission system,the proposed topology can selectively block the DC fault current and isolate the corresponding fault line without expensive DC circuit breakers(DCCBs).Thus,the influence range of the DC fault can be reduced and the reliability of the power supply can be improved as well.The corresponding modulation and voltage balancing strategies are developed for the proposed hybrid MMC topology.The feasibility of the proposed topology and control strategy is verified in the MATLAB/Simulink simulation. | Yongyang Chen Shangzhi Pan Meng Huang Zili Zhu Yushuang Liu Xiaoming Zha | 2021 | CES Transactions on Electrical Machines and Systems2021，5，2： | 4 |
| 6 | Significance of neuroglobin in serum of acute atherosclerotic cerebral infarction patients显示文摘This study sought to examine neuroglobin (NGB) in the serum of acute cerebral infarction patients with double-antibody sandwich enzyme-linked immunosorbent assay to identify all risk factors, calculate infarct size, assess neurological impairment, and analyze the relation between NGB and each of these factors. The double-antibody sandwich assay indicated that levels of NGB in serum were unaltered within 6 hours following acute cerebral infarction compared with normal levels. NGB levels then underwent a distinct change, peaking at 24 hours then returning to normal levels in 72 hours. The results suggest that the level of NGB might be related to infarct size and low-density lipoprotein at 24 hours after acute cerebral infarction. There were no significant differences in neurological impairment scores and infarct size at different periods following infarction. The findings indicated that the level of NGB in serum of acute cerebral infarction patients was correlated with infarct time. | Shoucai Zhao Zhaohu Chu Lingsong Ma Yinong Chen Lei Wang Benxiao Wang Zili Huang Jun Zhang | 2011 | Neural Regeneration Research2011，6，27： | 4 |
| 7 | Progress on AlGaN-based solar-blind ultraviolet photodetectors and focal plane arrays显示文摘Solar-blind ultraviolet(UV)photodetectors(PDs)have attracted tremendous attention in the environmental,industrial,military,and biological fields.As a representative Ill-nitride material,AlGaN alloys have broad development prospects in the field of solar-blind detection due to their superior properties,such as tunable wide bandgaps for intrinsic UV detection.In recent decades,a variety of AlGaN-based PDs have been developed to achieve high-precision solar-blind UV detection.As integrated optoelectronic technology advances,AlGaN-based focal plane arrays(FPAs)are manufactured and exhibit outsta nding solar-blind imaging capability.Con sidering the rapid development of AlGaN detection techniques,this paper comprehensively reviews the progress on AlGaN-based solar-blind UV PDs and FPAs.First,the basic physical properties of AlGaN are presented.The epitaxy and p-type doping problems of AlGaN alloys are then discussed.Diverse PDs,including photoconductors and Schottky,metal-semiconductor-metal(MSM),p-i-n,and avalanche photodiodes(APDs),are dem on strated,and the physical mechanisms are analyzed to improve device performance.Additionally,this paper summarizes imaging technologies used with AlGaN FPAs in recent years.Benefit!ng from the development of AlGaN materials and optoelectronic devices,solar-blind UV detection technology is greeted with significant revolutions. | Qing Cai Haifan You Hui Guo Jin Wang Bin Liu Zili Xie Dunjun Chen Hai Lu Youdou Zheng Rong Zhang | 2021 | Light(Science & Applications)2021，10，6： | 4 |
| 8 | Treatment of spinal tuberculosis with ultrashort-course chemotherapy in conjunction with partial excision of pathologic vertebrae显示文摘 | Zili Wang Zhaohui Ge Weidong Jin Yongdong Qiao Huiqiang Ding Haoning Zhao Zhikai Lin Jun Chen Weiyu Yang | 2007 | The Spine Journal2007，，6： | 3 |
| 9 | Naringenin is a Potential Immunomodulator for Inhibiting Liver Fibrosis by Inhibiting the cGAS-STING Pathway显示文摘Background and Aims:Naringenin is an anti-inflammatory flavonoid that has been studied in chronic liver disease.The mechanism specific to its antifibrosis activity needs further investigation This study was to focused on the cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)pathway in hepatic stellate cells and clarified the antifibrosis mechanism of naringenin.Methods:The relationship between the cGAS-stimulator of interferon genes(STING)pathway and liver fibrosis was analyzed using the Gene Expression Omnibus database.Histopathology,immunohistochemistry,fluorescence staining,Western blotting and polymerase chain reaction were performed to assess gene and protein expression levels associated with the cGAS pathway in clinical liver tissue samples and mouse livers.Molecular docking was performed to evaluate the relationship between naringenin and cGAS,and western blotting was performed to study the expression of inflammatory factors downstream of cGAS in vitro.Results:Clinical database analyses showed that the cGAS-STING pathway is involved in the occurrence of chronic liver disease.Naringenin ameliorated liver injury and liver fibrosis,decreased collagen deposition and cGAS expression,and inhibited inflammation in carbon tetrachloride(CCl4)-treated mice.Molecular docking found that cGAS may be a direct target of naringenin.Consistent with the in vivo results,we verified the inhibitory effect of naringenin on activated hepatic stellate cells(HSCs).By using the cGAS-specific agonist double-stranded(ds)DNA,we showed that naringenin attenuated the activation of cGAS and its inflammatory factors affected by dsDNA.We verified that naringenin inhibited the cGAS-STING pathway,thereby reducing the secretion of inflammatory factors by HSCs to ameliorate liver fibrosis.Conclusions:Interrupting the cGAS-STING pathway helped reverse the fibrosis process.Naringenin has potential as an antihepatic fibrosis drug. | Li Chen Siwei Xia Shuqi Wang Yuanyuan Zhou Feixia Wang Zhanghao Li Yang Li Desong Kong Zili Zhang Jiangjuan Shao Xuefen Xu Feng Zhang Shizhong Zheng | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 10 | Comparison between the Xishimen gold deposit and the Shihu gold deposit in western Hebei and analysis of the potential for ore exploration显示文摘The Xishimen gold deposit is located in the tectonic zone southeast to the Shihu gold deposit, both of which belong to the same orefield. Then, how is the prospecting potential for the Xishimen gold deposit? A com-parison was made between the Xishimen gold deposit and the Shihu gold deposit on the basis of their geological background of metallogenesis, geological characteristics of the ore deposits, the sources of ore-forming materials, etc. The results showed that both the deposits possess many similarities in the respects mentioned above. And their met-allogeneses can be compared. Therefore, there is great potential for ore prospection in the periphery or at the deep levels of the Xishimen gold deposit. Ore exploration should be well programmed on the basis of a better dissection of the tectonic setting of the orefield. A breakthrough in ore prospection of the Xishimen gold deposit will be of great instructive significance in regionally geological prospecting. | CHEN Chao NIU Shuyin WANG Zili GUO Zhong SUN Aiqun WANG Baode GAO Yincang | 2011 | Chinese Journal Of Geochemistry2011，30，3： | 3 |
| 11 | Quantitative behavior of vibrational excitation in AC plasma assisted dry reforming of methane显示文摘Quantitative behavior of non-equilibrium excitation by direct electron impact in low-temperature dry reforming of methane was investigated by integrated studies of experimental validation and kinetic modeling.A plasma chemistry kinetic mechanism incorporating the reactions involving vibrational excitation of CH4,CO2,H2 and CO molecules as well as the low temperature He/CH4/CO2 conversion pathways was developed and validated.The calculation results showed that at lower E/N values(<150 Td)large population of energized electrons generated in a He/CH4/CO2 discharge resulted in an intensification of vibrational excitation.Despite the large generation of vibration,the vibrationally excited molecules in a 0.5/0.25/0.25 of He/CH4/CO2 discharge mixture were easy to relax,due to the strong coupling of the vibration of different molecules in a gas mixture.The results showed that the moderate levels of the vibrational excitation,such as CO2(v10,11,...,18)and CO(v9,10),presented most efficient in the stimulation of species generation including CO,CH2 O,CH3 OH,C2 H4 and C2 H6.Specifically,under conditions of E/N of 108 Td,14.9%of CO formation was estimated from the recombination of CO2(v)with CH3 and H,CO2(v)+CH3→CH3 O+CO,CO2(v)+H→CO+OH.Also,4.8%of C2 H4 formation was from the recombination reaction CH4(v)+CH→C2 H4+H.These results highlight the strong roles of vibrational states in a complex plasma chemistry system. | Jintao Sun Qi Chen Yuanwei Guo Zili Zhou Yang Song | 2020 | Journal of Energy Chemistry2020，29，7： | 3 |
| 12 | Music snippet extraction via melody-based repeated pattern discovery显示文摘In this paper,we present a complete set of procedures to automatically extract a music snippet,defined as the most representative or the highlighted excerpt of a music clip. We first generate a modified and compact similarity matrix based on selected features and distance metrics,and then several improved techniques for music repeated pattern discovery are utilized because a music snippet is usually a part of the repeated melody,main theme or chorus. During the process,redundant and wrongly detected patterns are discarded,boundaries are corrected using beat information,and final clusters are also further sorted according to the occurrence frequency and energy information. Subsequently,following our methods,we designed a music snippet extraction system which allows users to detect snippets. Experiments performed on the system show the superiority of our proposed approach. | XU JiePing ZHAO Yang CHEN Zhe LIU ZiLi | 2009 | Science in China(Series F)2009，52，5： | 2 |
| 13 | Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis显示文摘Senescence of activated hepatic stellate cells(aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression.Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype(SASP).But little is known about how alanine-serine-cysteine transporter type-2(ASCT2),a high affinity glutamine transporter,affects HSC senescence and SASP during liver fibrosis.Here,we identified ASCT2 is mainly elevated in aHSCs and positively correlated with liver fibrosis in human and mouse fibrotic livers.We first discovered ASCT2 inhibition induced HSCs to senescence in vitro and in vivo.The proinflammatory SASP were restricted by ASCT2 inhibition at senescence initiation to prevent paracrine migration.Mechanically,ASCT2 was a direct target of glutaminolysisdependent proinflammatory SASP,interfering IL-1α/NF-κB feedback loop via interacting with precursor IL-1α at Lys82.From a translational perspective,atractylenolide Ⅲ is identified as ASCT2 inhibitor through directly bound to Asn230 of ASCT2.The presence of -OH group in atractylenolide Ⅲ is suggested to be favorable for the inhibition of ASCT2.Importantly,atractylenolide Ⅲ could be utilized to treat liver fibrosis mice.Taken together,ASCT2 controlled HSC senescence while modifying the proinflammatory SASP.Targeting ASCT2 by atractylenolide Ⅲ could be a therapeutic candidate for liver fibrosis. | Feixia Wang Zhanghao Li Li Chen Ting Yang Baoyu Liang Zili Zhang Jiangjuan Shao Xuefen Xu Guoping Yin Shijun Wang Hai Ding Feng Zhang Shizhong Zheng | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 14 | High-efficiency green micro-LEDs with GaN tunnel junctions grown hybrid by PA-MBE and MOCVD显示文摘We fabricated p-i-n tunnel junction(TJ)contacts for hole injection on c-plane green micro-light-emitting diodes(micro-LEDs)by a hybrid growth approach using plasma-assisted molecular beam epitaxy(PA-MBE)and metal–organic chemical vapor deposition(MOCVD).The TJ was formed by an MBE-grown ultra-thin unintentionally doped In Ga N polarization layer and an n^(++)∕n^(+)-GaN layer on the activated p^(++)-Ga N layer prepared by MOCVD.This hybrid growth approach allowed for the realization of a steep doping interface and ultrathin depletion width for efficient inter-band tunneling.Compared to standard micro-LEDs,the TJ micro-LEDs showed a reduced device resistance,enhanced electroluminescence intensity,and a reduced efficiency droop.The size-independent J-V characteristics indicate that TJ could serve as an excellent current spreading layer.All these results demonstrated that hybrid TJ contacts contributed to the realization of high-performance micro-LEDs with long emission wavelengths. | YAOZHENG WU BIN LIU FEIFAN XU YIMENG SANG TAO TAO ZILI XIE KE WANG XIANGQIAN XIU PENG CHEN DUNJUN CHEN HAI LU RONG ZHANG YOUDOU ZHENG | 2021 | Photonics Research2021，9，9： | 2 |
| 15 | RELATION BETWEEN PRECIPITATION AND INITIATION OF DEBRIS FLOWS IN THE JIANGJIA RAVINE,YUNNAN PROVINCE,SOUTHWEST CHINA显示文摘In the Jiangjia Ravine, debris flows are often triggered by short-duration rainstorms frequently. To reveal the unique initiation process of debris flows, rainfall and debris flow initiation in an upstream area was continually observed. It is concluded that flash floods resulting from short-duration rainstorms play a key role in the initiation of debris flows. Surface runoff forms flash floods due to special topographic conditions. The flash floods mobilize the sediment deposits in the upper section of the branch gullies,hence, high density viscous debris flows initiate. The initiation of debris flows in the Jiangjia Ravine has a close relation with precipitation. Applying the Takahashi model of debris flow initiation, it is concluded that: to mobilize cohesive deposits in the gully bed the depth of flash floods must exceed a critical depth. This critical depth of floods makes the definition of thresholds of rainfall intensity possible. Considering the change in the initial infiltration rate at different initial water content of bank slopes, and the influence of antecedent precipitation on the initial water content, the relation between the thresholds of rainfall intensity and the antecedent precipitation show good agreement with the empirical relation established by previous research. | Zili FENG Peng CUI Xiaoqing CHEN Jie CHEN | 2006 | International Journal of Sediment Research2006，21，4： | 2 |
| 16 | Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function显示文摘Sleep benefits the restoration of energy metabolism and thereby suppo rts neuronal plasticity and cognitive behaviors.Sirt6 is a NAD+-dependent protein deacetylase that has been recognized as an essential regulator of energy metabolism because it modulates various transcriptional regulators and metabolic enzymes.The aim of this study was to investigate the influence of Sirt6 on cerebral function after chronic sleep deprivation(CSD).We assigned C57BL/6J mice to control or two CSD groups and subjected them to AAV2/9-CMV-EGFP or AAV2/9-CMV-Sirt6-EGFP infection in the prelimbic cortex(PrL).We then assessed cerebral functional connectivity(FC) using resting-state functional MRI,neuron/astrocyte metabolism using a metabolic kinetics analysis;dendritic spine densities using sparse-labeling;and miniature excitato ry postsynaptic currents(mEPSCs) and action potential(AP) firing rates using whole-cell patchclamp recordings.In addition,we evaluated cognition via a comprehensive set of behavioral tests.Compared with controls,Sirt6 was significantly decreased(P<0.05) in the PrL after CSD,accompanied by cognitive deficits and decreased FC between the PrL and accumbens nucleus,piriform cortex,motor co rtex,somatosensory co rtex,olfactory tubercle,insular cortex,and cerebellum.Sirt6 ove rexpression reve rsed CSD-induced cognitive impairment and reduced FC.Our analysis of metabolic kinetics using [1-13C] glucose and [2-13C] acetate showed that CSD reduced neuronal Glu4and GABA2synthesis,which could be fully restored via forced Sirt6 expression.Furthermore,Sirt6 ove rexpression reversed CSD-induced decreases in AP firing rates as well as the frequency and amplitude of mEPSCs in PrL pyramidal neurons.These data indicate that Sirt6 can improve cognitive impairment after CSD by regulating the PrL-associated FC network,neuronal glucose metabolism,and glutamatergic neurotransmission.Thus,Sirt6 activation may have potential as a novel strategy for treating sleep disorder-related diseases. | Jinpiao Zhu Chang Chen Zhen Li Xiaodong Liu Jingang He Ziyue Zhao Mengying He Binbin Nie Zili Liu Yingying Chen Kuanpin Su Xiang Li Juxiang Chen Hongbing Xiang Fuqiang Xu Kangguang Lin Zongze Zhang Jie Wang | 2023 | Neural Regeneration Research2023，18，11： | 1 |
| 17 | A study of quality control method for IMRT planning based on prior knowledge and novel measures derived from both OVHs and DVHs 显示文摘 | Zhou Zhengdong Chen Yuanhua Yu Zili | 2014 | Bio-Medical Materials and Engineering2014，24，6： | 1 |
| 18 | Least squares finite element method with high continuity NURBS ba- sis for incompressible Navier-Stokes equations 显示文摘 | CHEN Dexiang XU Zili LIU Shi | 2014 | Journal of Computational Physics2014，260，： | 1 |
| 19 | TGF-β_1,ADAM12和HB-EGF在原发性肝癌组织中的表达(英文)显示文摘Objective: To detect the expression and location of TGF-β1, ADAM12 and HB-EGF in primary hepatic carcinoma and study their effect on the growth and metastasis of hepatoma carcinoma cell. Methods: TGF-β1, ADAM12 and HB-EGF were detected by RT-PCR and immunohistochemistry in 30 cases of hepatic carcinoma tissues, 30 cases of adjacent carci- noma tissues and 5 cases of normal hepatic tissues. Results: RT-PCR analyses showed that the mRNA expression of TGF-β1, ADAM12 and HB-EGF were markedly increased in each hepatic carcinoma tissue compared with its adjacent tissue (P < 0.01), but no signal was detected in normal hepatic tissue. Immunohistochemistry showed the same outcome on the expression of above three factors in hepatic tissues as RT-PCR. Proteins location analyses showed the proteins of TGF-β1, ADAM12 and HB-EGF all distributed in the stroma of hepatic carcinoma tissues. The positive correlation was found between TGF-β1 and ADAM12 (r = 0.6137, P < 0.05), as well as ADAM12 and HB-EGF (r = 0.5763, P < 0.05). The protein expression of TGF-β1, ADAM12 and HB-EGF were correlated with the size of tumors, degree of differentiation of hepatoma carcinoma cells, portal vein thrombus and the metastasis of absorbent glands, especially with hepatic cirrhosis caused by hepatitis B virus. Conclu- sion: TGF-β1, ADAM12 and HB-EGF possibly play an important role in the process of growth, invasion and metastasis of hepatoma carcinoma cell, meanwhile, the above three factors may collectively participate in the transition from hepatic cirrhosis caused by hepatitis B virus to hepatocellular carcinoma. | Hailin Cheng De'an Tian Xudong Hu Mei Liu Zili Dan Bo Wang Peiyuan Li Xiaoping Chen | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，12： | 1 |
| 20 | The temperature dependence of optical properties of InGaN alloys显示文摘In our experiments,the PL spectra of several In x Ga 1 x N alloy samples with In contents x=0.1,0.15 and 0.25 were measured as a function of temperature ranging from 10 K to 300 K.S-shaped temperature dependencies were observed in all InGaN samples and a sharp decrease in the full width at half maximum occurred with decreasing temperature in the moderate temperature region.It was found that both phenomena are relative to localization effects.In addition,the degree of localization effects in three samples was investigated using the band-tail model.Our findings are presented in this paper. | ZHAO ChuanZhen ZHANG Rong LIU Bin FU DeYi CHEN Hui LI Ming XIE ZiLi XIU XiangQian GU ShuLin ZHENG YouDou | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，3： | 1 |
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