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| 1 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 2 | L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway显示文摘As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute ischemic stroke. The activated Akt kinase pathway can prevent the death of nerve cells and exhibit neuroprotective effects in the brain after stroke. This study provides the hypothesis that l-3-n-butylphthalide has a certain therapeutic effect on vascular dementia, and its mechanism depends on the activation of the Akt kinase pathway. A vascular dementia mouse model was established by cerebral repetitive ischemia/reperfusion, and intragastrically administered l-3-n-butylphthalide daily for 28 consecutive days after ischemia/reperfusion, or 7 consecutive days before ischemia/reperfusion. The Morris water maze test showed significant impairment of spatial learning and memory at 4 weeks after operation, but intragastric administration of l-3-n-butylphthalide, especially pretreatment with l-3-n-butylphthalide, significantly reversed these changes. Thionine staining and western blot analylsis showed that preventive and therapeutic application of l-3-n-butylphthalide can reduce loss of pyramidal neurons in the hippocampal CA1 region and alleviate nerve damage in mice with vascular demen-tia. In addition, phosphorylated Akt expression in hippocampal tissue increased significantly after l-3-n-butylphthalide treatment. Experimental findings demonstrate that l-3-n-butylphthalide has preventive and therapeutic effects on vascular dementia, and its mechanism may be mediated by upregulation of phosphorylated Akt in the hippocampus. | Yaping Huai Yanhong Dong Jing Xu Nan Meng Chunfeng Song Wenbin Li Peiyuan Lv | 2013 | Neural Regeneration Research2013，8，19： | 17 |
| 3 | Petrology, Geochemistry and Geochronology of Gabbros from the Zhongcang Ophiolitic Mélange, Central Tibet: Implications for an Intra-Oceanic Subduction Zone within the Neo-Tethys Ocean显示文摘In order to investigate the evolution of Shiquanhe-Yongzhu-Jiali ophiolitic mélange belt, the gabbros from new discovered Zhongcang ophiolitic mélange are studied through petrology, whole-rock geochemistry, zircon U-Pb dating and Lu-Hf isotope. The gabbros investigated in this paper contain cumulate gabbro and gabbro dike, and they have undergone greenschist-amphibolite facies metamorphism. The chondrite normalized rare earth element(REE) patterns of most of these rocks show flat types with slightly light REE(LREE) depletion and the N-MORB normalized incompatible elements diagrams indicate depletion in high field strength elements(HFSE)(Nb, Ta) and enrichment in large ion lithophile elements(LILE). These gabbros have island arc and mid-ocean ridge basalt affinities, suggesting that they were originated in an oceanic back arc basin. Whole rock geochemistry and high positive εNd(t) values show that these gabbros were derived from ~30% partial melting of a spinel lherzolite mantle, which was enriched by interaction with slab-derived fluids and melts from sediment. U-Pb analyses of zircons from cumulate gabbro yield a weighted mean age of 114.3±1.4 Ma. Based on our data and previous studies, we propose that an intra-oceanic subduction system and back arc basin operated in the Neo-Tethy Ocean of central Tibet during Middle Jurassic and Early Cretaceous, resembling modern active intra-oceanic subduction systems in the western Pacific. | Mengjing Xu Cai Li Wei Xu Chaoming Xie Peiyuan Hu Ming Wang | 2014 | Journal of Earth Science2014，25，2： | 11 |
| 4 | Opening of the Longmu Co–Shuanghu–Lancangjiang ocean:constraints from plagiogranites显示文摘This paper reports new zircon U-Pb ages,and Hf isotope and whole-rock major and trace element data for Cambrian plagiogranites from the Tuobeiling ophiolite in central Qiangtang,Tibetan Plateau.Zircon SIMS and LAICP-MS U-Pb dating of the plagiogranites yield weighted mean ages of 504.8±4.2 and 491.6±1.5 Ma,respectively.The zircons from plagiogranites exhibit positive eHf(t)values(ranging from 11.46 to 15.16),indicating that the plagiogranites are derived from depleted mantle.These plagiogranites are characterized by high SiO2and Na2O,low K2O,low REE contents,and flat REE distribution patterns.These rocks have geochemical compositions typical of oceanic plagiogranite and,considered along with their petrography and field relationships,are interpreted to have derived from anatexis of hydrated amphibolites by ductile shearing during transports of the oceanic crust.The formation age of such type of plagiogranite is slightly younger than that of the associated section of oceanic crust.Thus the new results from these plagiogranites suggest that the Longmu Co–Shuanghu–Lancangjiang ocean had probably opened before the Middle Cambrian. | Peiyuan Hu Cai Li Yanwang Wu Chaoming Xie Ming Wang Jiao Li | 2014 | Chinese Science Bulletin2014，59，25： | 9 |
| 5 | Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration显示文摘The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro.However,conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives.Here,we established a novel intestinal organoid culture system composed of 8 components,mainly including VPA,EPZ6438,LDN193189,and R-Spondin 1 conditioned medium,which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury;therefore,these organoids were designated hyperplastic intestinal organoids(Hyper-organoids).Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5+stem cells or Clu+revival stem cells.Further analysis revealed that VPA and EPZ6438 were indispensable for epigenome reprogramming and regeneration in Hyper-organoids,which functioned through epigenetically regulating YAP signaling.Furthermore,VPA and EPZ6438 synergistically promoted regenerative response in gut upon damage in vivo.In summary,our results demonstrated a new in vitro organoid model to study epithelial regeneration,highlighting the importance of epigenetic reprogramming that pioneers tissue repair. | Molong Qu Liang Xiong Yulin Lyu Xiannian Zhang Jie Shen Jingyang Guan Peiyuan Chai Zhongqing Lin Boyao Nie Cheng Li Jun Xu Hongkui Deng | 2021 | Cell Research2021，31，3： | 9 |
| 6 | Petrology, Geochemistry and Tectonic Significance of the Metamorphic Peridotites from Longmuco-Shuanghu Ophiolitic Melange belt, Tibet显示文摘Taoxinghu metamorphic peridotite is a firstly reported mantle sequence of ophiolite since Longmuco-Shuanghu-Lancangjiang suture zone (LSLSZ) was proposed, and it is also an important discovered for ophiolite studying in central Qiangtang. Based on detailed analyses of whole-rock geochemistry of Taoxinghu metamorphic peridotites and contrast to metamorphic peridotites in typical ophiolites worldwide, the paper investigates their petrogenesis and geological implication. The petrologic results show that the protolith of Taoxinghu metamorphic perdotites have the mineral assemblage and texture characteristic of mantle peridotite. Most metamorphic peridotites hav near global abyssal peridotites major elements contents, while the few is similar to SSZ-type peridotites. They exhibit typically U-shaped REE patterns, characterized by slight enrichment of LREE and HREE relative to MREE and a low fractionated LREE to HREE segment. Trace elements contents are low and all samples are strong enrichment in Cs, U, Pb, weak enrichment in Ba and depletion in Th, but negative Nb anomalies are only observed in few samples. That suggests Taoxinghu metamorphic peridotites have depletion mantle and suprasubduction affinities. A two-stage evolution history is considered: Taoxinghu metamorphic peridotites originated as the residue from melting at a ridge with 7%-20% degree of fraction melting and were subsequently modified by interaction with mafic melt and aqueous fluid within mantle wedge on subducted zone. Combined with previous studies, we preliminarily propose Taoxinghu metamorphic peridotites may be the Products of initial rifting of palo-Tethys, forming at middle Ordivician-upper Cambrian, and they may be the direct evidences for spreading of palo-Tethys. | WU Yanwang LI Cai XIE Chaoming WANG Ming HU Peiyuan | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 9 |
| 7 | Dynamic tubulation of mitochondria drives mitochondrial network formation显示文摘 | Chong Wang Wanqing Du Qian Peter Su Mingli Zhu Peiyuan Feng Ying Li Yichen Zhou Na Mi Yueyao Zhu Dong Jiang Senyan Zhang Zerui Zhang Yujie Sun Li Yu | 2015 | Cell Research2015，25，10： | 8 |
| 8 | Progress of the satellite laser ranging system TROS1000显示文摘The mobile satellite laser ranging system TROS1000, successfully developed in 2010, achieves a high repetition rate and enables daytime laser ranging. Its measurement range has reached up to 36000 km with an accuracy as precise as 1 cm. Using recent observations in Wuhan, Jiufeng, Xianning, and Rongcheng, Shandong, we introduce the progress made using this mobile observation system. | Guo Tangyong Wang Peiyuan Li Xin Zhu Wei Zou Tong Li Shipeng Luo Qingshan | 2015 | Geodesy and Geodynamics2015，6，1： | 7 |
| 9 | Biocatalytic desymmetrization of 3-substituted glutaronitriles by nitrilases. A convenient chemoenzymatic access to optically active (S)-Pregabalin and (R)-Baclofen显示文摘Desymmetrization of prochiral 3-substituted glutaronitriles offers a new approach to access(S)-Pregabalin and(R)-Baclofen. A number of nitrilases from diverse sources were screened with 3-isobutylglutaronitriles(1a) or 3-(4′-chlorophenyl)glutaronitriles(1b) as the substrate. Some nitrilases were found to catalyze the desymmetric hydrolysis of 1a and 1b to form optically active 3-(cyanomethyl)-5-methylhexanoic acid(2a) and 3-(4′-chlorophenyl)-4-cyanobutanoic acid(2b) with high enantiomeric excesse(ee), respectively. This cannot be achieved using traditional chemical hydrolysis. Among them, AtNIT3 generated(R)-2b, whereas BjNIT6402 and HsNIT produced the opposite(S)-enantiomer with high conversions and ee values. Not only the nitrilases showed different activities and stereoselectivities toward these 3-substituted glutaronitriles, the 3-substituent of the substrates also exerted great effect on the enzyme activity and stereoselectivity.(S)-2a and(S)-2b were prepared with high yields and ee values using BjNIT6402 and HsNIT as the biocatalysts, respectively. A straightforward Curtius rearrangement of(S)-2a and(S)-2b, followed by the acidic hydrolysis, afforded(S)-Pregabalin and(R)-Baclofen. This offers a new platform methodology for the synthesis of optically active β-substituted γ-amino acids of pharmaceutical importance. | DUAN YiTao YAO PeiYuan REN Jie HAN Chao LI Qian YUAN Jing FENG JinHui WU QiaQing ZHU DunMing | 2014 | Science China Chemistry2014，57，8： | 6 |
| 10 | Population Genetic Structure and Genetic Differentiation of the Pufferfish Takifugu Rubripes and Takifugu Pseudommus Revealed by RAPD Analysis显示文摘RAPD analysis is used to assay the population genetic structure and genetic differentiation of pufferfish T. rubripes and T. pseudommus. One hundred and twenty fragments are amplified with 21 random sequence 10-mer primers. The proportion of polymorphic fragments of T. rubripes populations from the coast of China (TRC), the coast of Japan (TRJ), general population of T. rubripes both from China and Japan (TRCJ), and the population of T. pseudommus are 31.7%, 33.3%, 35.0% and 39.2% respectively. The mean expected heterozygosities of the four populations are 0.116, 0.125, 0.126, and 0.144, respectively. Low genetic distances (ranging from 0.0118 to 0.0309) and Fst estimates (0.020 to 0.024) among the populations indicated that there is no significant differentiation between T. rubripes and T. pseudommus and suggested that only one species is involved. | 宋林生 LI Honglei CUI Zhaoxia Xiang Jianhia Qian Peiyuan | 2003 | High Technology Letters2003，9，1： | 5 |
| 11 | Key technologies implementation of high-repetition-rate satellite laser ranging显示文摘Satellite laser ranging (SLR) is one of the major space geodetic instruments, which has various applications in earth science. In this paper, we introduce several issues regarding the key technology implementation of high-repetition-rate SLR system. Compared with traditional technology, using kHz and 8ps pulse width laser component, the data quantity and quality of high-repetition-rate satellite laser ranging (SLR) can be significantly improved. The characteristics of high-repetition-rate laser ranging and the key technologies are presented, including the event timer with the precision of picosecond, the generation of range gate signal, and so on. All of them are based on the Field Programmable Gate Arrays (FPGA) and tested on China mobile SLR system-TROS1000. Finally, the observations of satellite Beacon-C are given. | Wang Peiyuan Guo Tangyong Gao Hao Li Xin Zhu Wei Zou Tong Li Shipeng | 2013 | Geodesy and Geodynamics2013，4，1： | 4 |
| 12 | A holistic approach to aligning geospatial data with multidimensional similarity measuring显示文摘Semantically aligning the heterogeneous geospatial datasets(GDs)produced by different organizations demands efficient similarity matching methods.However,the strategies employed to align the schema(concept and property)and instances are usually not reusable,and the effects of unbalanced information tend to be neglected in GD alignment.To solve this problem,a holistic approach is presented in this paper to integrally align the geospatial entities(concepts,properties and instances)simultaneously.Spatial,lexical,structural and extensional similarity metrics are designed and automatically aggregated by means of approval voting.The presented approach is validated with real geographical semantic webs,Geonames and OpenStreetMap.Compared with the well-known extensional-based aligning system,the presented approach not only considers more information involved in GD alignment,but also avoids the artificial parameter setting in metric aggregation.It reduces the dependency on specific information,and makes the alignment more robust under the unbalanced distribution of various information. | Li Yu Peiyuan Qiu Xiliang Liu Feng Lu Bo Wan | 2018 | International Journal of Digital Earth2018，11，8： | 4 |
| 13 | Genome-wide association study and transcriptome analysis reveal new QTL and candidate genes for nitrogen-deficiency tolerance in rice显示文摘The development of rice cultivars with improved nitrogen use efficiency(NUE)is desirable for sustainable agriculture.Achieving this goal depends in part on understanding how rice responds to low soil nitrogen(N)and identifying causative genes underlying this trait.To identify quantitative trait loci(QTL)or genes associated with low N response,we conducted a genome-wide association study(GWAS)using a diverse panel of 230 rice accessions and performed a transcriptomic investigation of rice accessions with differential responses to low N stress at two N levels.We detected 411 GWAS-associated genes in 5 QTL and 2722 differentially expressed genes in response to low N,of which 24 were identified by both methods and ranked according to gene annotations,literature queries,gene expression,and genetic diversity analysis.The large-scale datasets obtained from this study reveal low N-responsive characteristics and provide insights towards understanding the regulatory mechanisms of N-deficiency tolerance in rice,and the candidate genes or QTL would be valuable resources for increasing rice NUE via molecular biotechnology. | Qing Li Xueli Lu Changjian Wang Lan Shen Liping Dai Jinli He Long Yang Peiyuan Li Yifeng Hong Qiang Zhang Guojun Dong Jiang Hu Guangheng Zhang Deyong Ren Zhenyu Gao Longbiao Guo Qian Qian Li Zhu Dali Zeng | 2022 | The Crop Journal2022，10，4： | 3 |
| 14 | Anti-epileptic effects of neuropeptide Y gene transfection into the rat brain显示文摘Neuropeptide Y gene transfection into normal rat brain tissue can provide gene overexpression,which can attenuate the severity of kainic acid-induced seizures.In this study,a recombinant adeno-associated virus carrying the neuropeptide Y gene was transfected into brain tissue of rats with kainic acid-induced epilepsy through stereotactic methods.Following these transfections,we verified overexpression of the neuropeptide Y gene in the epileptic brain.Electroencephalograms showed that seizure severity was significantly inhibited and seizure latency was significantly prolonged up to 4 weeks after gene transfection.Moreover,quantitative fluorescent PCR and western blot assays revealed that the mRNA and protein expression of the N-methyl-D-aspartate receptor subunits NR1,NR2A,and NR2B was inhibited in the hippocampus of epileptic rats.These findings indicate that neuropeptide Y may inhibit seizures via down-regulation of the functional expression of N-methyl-D-aspartate receptors. | Changzheng Dong Wenqing Zhao Wenling Li Peiyuan Lv Xiufang Dong | 2013 | Neural Regeneration Research2013，8，14： | 2 |
| 15 | ^(40)Ar/^(39)Ar Thermochronology Constraints on Jurassic Tectonothermal Event of Nyainrong Microcontinent显示文摘To reveal the Jurassic tectonothermal event occurring to the Nyainrong microcontinent which is gripped among the Bangong-Nujiang suture zone,40Ar/39Ar dating was carried out on the basement orthogneiss and Jurassic granitc gneiss in the microcontinent.In the heating stage,four samples exhibited a flat plateau age,with the value Tp concentrated in the range of 166–176 Ma;isochron age Ti was concentrated in the range of 165–175 Ma,and their corresponding ages were the consistent within allowable range.The ages should be representative of the era of the final deformation of the Amdo gneiss and cooling emplacement of the magmatic rock in the Jurassic.The geochronological studies have shown that the final deformation of microcontinent crystalline basement and the cooling of the Mesozoic large-scale tectonothermal events occurred in late Middle Jurassic.In Middle Jurassic,Nyainrong microcontinent experienced strong tectonic movement.Combining with the geochronological with isotope geochemistry for the microcontinent,the cause of the tectonothermal event should be attributed to the collision between the Nyainrong microcontinent and South Qiangtang Block following the northward subduction of Bangong-Nujiang oceanic crust. | Chaoming Xie Cai Li Yanwang Wu Ming Wang Peiyuan Hu | 2014 | Journal of Earth Science2014，25，1： | 2 |
| 16 | Effects of Angelica sinensis extracts on lipid oxidation in fish feeds and growth performance of juvenile Jian carp(Cyprinus carpio var. Jian)显示文摘The study was to explore the effect of the extracts of Angelica sinensis(EAs) on lipid oxidation in fish feeds compared with ethoxyquin(EQ) and the effect of dietary EAs on growth performance of carp(Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract ethyl acetate extract(EAE), acetone extract, ethanol extract(EE) and aqueous extract(AQE) of Angelica sinensis, except for the control. The results showed that EAs and EQ inhibited lipid oxidation in fish feed(P < 0.05). Of all of the examined EAs, EAE showed the strongest protective effects against lipid oxidation(P < 0.05). Moreover, EAE at high concentrations showed a stronger effect on lipid oxidation compared with EQ(P < 0.05). Then, 7 experimental diets respectively supplemented with 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg of EAE were fed to the respective treatment groups for 30 d. Four replicates were performed for each treatment group; 20 carp(mean weight: 12.10 ± 0.13 g) were in each replicate. The result indicated that dietary EAE improved the growth performance in carp(P < 0.05). The appropriate con centration of EAE for carp growth was estimated to be 3.643 g/kg diet. Thus, EAE could be used as a natural antioxidant in feeds for Jian carp. | Huatao Li Dandan Yang Zhihao Li Mingquan He Fengyi Li Jun Jiang Siyi Tang Peiyuan Peng Wenhao Du Yuting Ma Ying Liu | 2019 | Animal Nutrition2019，，1： | 2 |
| 17 | Tumor Microenvironment Cascade‑Responsive Nanodrug with Self‑Targeting Activation and ROS Regeneration for Synergistic Oxidation‑Chemotherapy显示文摘Carrier-free nanodrug with exceptionally high drug payload has attracted increasing attentions.Herein,we construct a pH/ROS cascade-responsive nanodrug which could achieve tumor acidity-triggered targeting activation followed by circularly amplified ROS-triggered drug release via positive-feedback loop.The di-selenide-bridged prodrug synthesized from vitamin E succinate and methotrexate(MTX)self-assembles into nanoparticles(VSeM);decorating acidity-cleavable PEG onto VSeM surface temporarily shields the targeting ability of MTX to evade immune clearance and consequently elongate circulation time.Upon reaching tumor sites,acidity-triggered detachment of PEG results in targeting recovery to enhance tumor cell uptake.Afterward,the VSeM could be dissociated in response to intracellular ROS to trigger VES/MTX release;then the released VES could produce extra ROS to accelerate the collapse of VSeM.Finally,the excessive ROS produced from VES could synergize with the released MTX to efficiently suppress tumor growth via orchestrated oxidation-chemotherapy.Our study provides a novel strategy to engineer cascade-responsive nanodrug for synergistic cancer treatment. | Yang Li Jinyan Lin Peiyuan Wang Qiang Luo Fukai Zhu Yun Zhang Zhenqing Hou Xiaolong Liu Jingfeng Liu | 2020 | Nano-Micro Letters2020，12，12： | 2 |
| 18 | The Stability for the Hyperneutral Type Nonlinear Time Varying Control Systems(1)显示文摘InRef.[1],theauthorshadprovedtheequivalenceoflineartimevaryingcontrolsystemX(t)=A(1)(t)X(t)+B(t)U(t)Y(t)=C(t)X(t){andthehyper... | Mong Peiyuan Li Yeping | 1998 | Wuhan University Journal of Natural Sciences1998，3，3： | 2 |
| 19 | Resource and trajectory optimization in UAV-powered wireless communication system显示文摘The unmanned aerial vehicle(UAV) is a promising enabler of Internet of Things(IoT) owing to its highly flexible features. Combined with wireless power transfer(WPT) techniques, a UAV can provide energy for IoT nodes, which can extend the lifetime of energy constrained communication systems. This paper studies resource and trajectory optimization in UAV-powered wireless communication systems, which consists of two UAVs and two ground nodes(GNs). The system works in a way that the two UAVs alternately charge the two GNs through wireless power transfer and two GNs also alternately send their information to the corresponding UAV with the harvested energy, which can effectively reduce the interference while receiving the information of GNs. Aiming to maximize the minimum throughput of two GNs, wireless resource and UAVs’ trajectories are jointly optimized with the constraints of UAV collision avoidance, flying speed, and transmit power. Successive convex programming(SCP) and block coordinate descent(BCD) are utilized to solve the optimization problem. Simulation results show that the proposed scheme achieves larger minimum throughput than the benchmark scheme. | Weidang LU Peiyuan SI Fangwei LU Bo LI Zilong LIU Su HU Yi GONG | 2021 | Science China(Information Sciences)2021，64，4： | 2 |
| 20 | Electroless plating of copper on surface-modified glass substrate显示文摘 | Wei Su Libei Yao Fang Yang Peiyuan Li Juan Chen Lifang Liang | 2011 | Applied Surface Science2011，，18： | 1 |
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