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| 1 | Wnt/β-catenin signalling:function,biological mechanisms,and therapeutic opportunities显示文摘The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.The deregulation of Wnt/β-catenin signalling often leads to various serious diseases,including cancer and non-cancer diseases.Although many articles have reviewed Wnt/β-catenin from various aspects,a systematic review encompassing the origin,composition,function,and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking.In this article,we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.Finally,we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment. | Jiaqi Liu Qing Xiao Jiani Xiao Chenxi Niu Yuanyuan Li Xiaojun Zhang Zhengwei Zhou Guang Shu Gang Yin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 28 |
| 2 | Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing,membrane fusion,and viral infectivity显示文摘Dear Editor,By the end of June 2020,the pandemic of coronavirus diseases 2019(COVID-19)had resulted in more than 10 million individuals,all over the world,being infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).1 The high contagiousness of SARS-CoV-2 virus was largely attributed to the relatively unique sequence composition in its spike(S)glycoprotein,which is in charge of the host entry by interacting with its cellular receptor angiotensin-converting enzyme 2(ACE2).2,3 The S glycoprotein can be processed into an N terminal S1 fragment that is responsible for receptor binding,and a C terminal S2 fragment that functions to promote membrane fusion.4 SARS-CoV-2 is a type of single-stranded positive-sense ribonucleic acid(RNA)virus,and an increasing number of mutations were identified across the SARS-CoV-2 genome,including the region encoding S glycoprotein.Nevertheless,the functional implications of these mutations remain largely unknown,we here reported the mutation analysis of S gene and a functional exploration of the dominant D614G mutation. | Xiaoyi Jiang Zhengrong Zhang Chenxi Wang Hongguang Ren Lihua Gao Haoran Peng Zubiao Niu He Ren Hongyan Huang Qiang Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 3 | Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis显示文摘The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge.The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation.Herein,we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen(PCEI)and multifunctional PCEI-based F127-ε-polypeptide-alginic(FEA)dressing(FEA-PCEI)for accelerating wound healing and hair follicle neogenesis.PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization.The FEA-PCEI dressing showed the temperature-response gelation,injectability,robust antibacterial activity,light-damage-resistant,homeostasis ability,and good cytocompatibility.The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability,reduce the scar formation,and promote the hair follicle neogenesis.This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials. | Wenguang Liu Min Wang Wei Cheng Wen Niu Mi Chen Meng Luo Chenxi Xie Tongtong Leng Long Zhang Bo Lei | 2021 | Bioactive Materials2021，6，3： | 4 |
| 4 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 5 | Recycled low-temperature direct bonding of Si/glass and glass/glass chips for detachable micro/nanofluidic devices显示文摘Silicon and glass are two of the most ideal materials for micro/nanofluidic devices,which have been widely used for research in multidisciplinary fields.However,many micro/nanofluidic devices enable only single use due to the irreversible bonding between Si/glass or glass/glass chips.If the silicon-and glass-based devices are fabricated to be detachable,the substrates can be reused and bonded again without repeating expensive micro/nanofabrication processes.Herein,we present a recycled direct bonding method for Si/glass and glass/glass chips based on oxygen plasma activation and low-temperature annealing processes.Strong bonding strength and void-free bonding interface are obtained after annealing at 150℃.The surfaces and the bonding interfaces are characterized to elucidate the bonding mechanisms.Moreover,immersion tests are carried out to investigate the interfacial corrosion resistance in various chemical and biological solutions as well as explore a detachable method.The bonding strengths are controlled to meet the demand for micro/nanofluidic devices and the bonding interfaces can be separated in ethanol.As a result,we succeed in the experiment of bonding and detaching of glass substrates without fracturing,which is repeated for three times. | Chenxi Wang Hui Fang Shicheng Zhou Xiaoyun Qi Fanfan Niu Wei Zhang Yanhong Tian Tadatomo Suga | 2020 | Journal of Materials Science & Technology2020，42，11： | 1 |
| 6 | The virological impacts of SARS-CoV-2 D614G mutation显示文摘The coronavirus diseases 2019(COVID-19)caused by the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in December 2019 has caused more than 140 million infections worldwide by the end of April 2021.As an enveloped single-stranded positive-sense RNA virus,SARS-CoV-2 underwent constant evolution that produced novel variants carrying mutation conferring fitness advantages.The current prevalent D614G variant,with glycine substituted for aspartic acid at position 614 in the spike glycoprotein,is one of such variants that became the main circulating strain worldwide in a short period of time.Over the past year,intensive studies from all over the world had defined the epidemiological characteristics of this highly contagious variant and revealed the underlying mechanisms.This review aims at presenting an overall picture of the impacts of D614G mutation on virus transmission,elucidating the underlying mechanisms of D614G in virus pathogenicity,and providing insights into the development of effective therapeutics. | Chenxi Wang You Zheng Zubiao Niu Xiaoyi jiang Qiang Sun | 2021 | Journal of Molecular Cell Biology2021，13，10： | 0 |
| 7 | N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding显示文摘Dear Editor,According to the World Health Organization(WHO),as of March 8,2021,the pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)had infected more than 116 million patients with coronavirus disease 2019(COVID-19)(https://covid19.who.int).The high infectivity of SARS-CoV-2 is largely attributable to the unique sequence composition of its spike(S)glycoprotein. | Zubiao Niu Zhengrong Zhang Xiaoyan Gao Peng Du Jingjing Lu Bohua Yan Chenxi Wang You Zheng Hongyan Huang Qiang Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 8 | Identifying the Geography and Determinants of O2O Online Retailers in Megacity in Central China:A Case Study of Zhengzhou City显示文摘In recent years,O2O e-commerce,represented by online group-buying,has developed vigorously,which had significant impacts on urban commercial space.Zhengzhou City is a rising national central city in China,and its e-commerce development level is ahead,but relevant researches are rare.Therefore,the data of online retailers of Meituan.com was collected and combined with Baidu map and Baidu heat map data.Then,we adopted the methods such as spatial statistics and geodetector to explore the geography and determinants of O2O online retailers in Zhengzhou urban area.The main conclusions are 1)The spatial development of O2O online retailers is characterized by significant global high-value agglomeration.2)The agglomeration areas of different types of O2O online retailers are different.Most of them are concentrated in the old urban area within the Third Ring Road of Zhengzhou City,forming five comprehensive agglomeration areas.3)The areas with the high e-commerce development level are mainly concentrated in the northeast and southwest of the x-shaped region formed by the intersection of Lianyungang-Lanzhou and Beijing-Guangzhou railways.Erqi Square and Guomao 360 Plaza are at the highest development level,followed by Zhongyuan Wanda Plaza and Daxue Middle Road.The development level at other areas is relatively low.4)Zhengzhou’s O2O commercial pattern is highly dependent on physical business.The population distribution,especially the population distribution during the nightlife period,plays a vital role in its spatial development,followed by accessibility.The influences of physical distance are slightly larger than that of time cost,but the difference between them is little.In addition,travelling costs have the least impact.This paper could provide certain references for urban commercial planning. | QI Jinghui NIU Shuwen YE Chenxi WANG Luojia WEl Yongna WEN Yuzhao ZHAO Shuling | 2021 | Chinese Geographical Science2021，31，5： | 0 |
| 9 | AIM-CICs: an automatic identification method for cell-in-cell structures based on convolutional neural network显示文摘Whereas biochemical markers are available for most types of cell death, current studies on non-autonomous cell death by entosis rely strictly on the identification of cell-in-cell structures (CICs), a unique morphological readout that can only be quantified manually at present. Moreover, the manual CIC quantification is generally over-simplified as CIC counts, which represents a major hurdle against profound mechanistic investigations. In this study, we take advantage of artificial intelligence technology to develop an automatic identification method for CICs (AIM-CICs), which performs comprehensive CIC analysis in an automated and efficient way. The AIM-CICs, developed on the algorithm of convolutional neural network, can not only differentiate between CICs and non-CICs (the area under the receiver operating characteristic curve (AUC) > 0.99), but also accurately categorize CICs into five subclasses based on CIC stages and cell number involved (AUC > 0.97 for all subclasses). The application of AIM-CICs would systemically fuel research on CIC-mediated cell death, such as high-throughput screening. | Meng Tang Yan Su Wei Zhao Zubiao Niu Banzhan Ruan Qinqin Li You Zheng Chenxi Wang Bo Zhang Fuxiang Zhou Xiaoning Wang Hongyan Huang Hanping Shi Qiang Sun | 2022 | Journal of Molecular Cell Biology2022，14，6： | 0 |
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