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| 1 | Wnt/β-catenin signalling:function,biological mechanisms,and therapeutic opportunities显示文摘The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.The deregulation of Wnt/β-catenin signalling often leads to various serious diseases,including cancer and non-cancer diseases.Although many articles have reviewed Wnt/β-catenin from various aspects,a systematic review encompassing the origin,composition,function,and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking.In this article,we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.Finally,we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment. | Jiaqi Liu Qing Xiao Jiani Xiao Chenxi Niu Yuanyuan Li Xiaojun Zhang Zhengwei Zhou Guang Shu Gang Yin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 28 |
| 2 | Allowance and allocation of industrial volatile organic compounds emission in China for year 2020 and 2030显示文摘As an effective pollution control method, emission allowance and allocation just implemented in volatile organic compounds(VOCs) control strategy of China in 2016. This article presents a possible way to set the emission allowance targets and establishes an allowance allocation model for the object year, 2020 and 2030, using 2010 as the reference year. On the basis of regression and scenario analysis method, the emission allowance targets were designed,which were 17.902 Tg and 18.224 Tg for 2020 and 2030, with an increasing rate of 28.75% and31.06% compared to 2010. From the perspective of industries, processes using VOCscontaining products, like machinery and equipment manufacturing, would continue to be the most significant industrial VOCs emission sources in the future of China. Four allocation indicators were selected, which are per capita GDP of each province, per capita industrial VOCs emission of each province, the economic contribution of industrial sector to regional economy of each province, and the emission intensity per land area of each province, respectively.Based on information entropy, the weights of the indicators were calculated and an emission allocation model was established, and the results showed that provinces like Shandong,Jiangsu, Guangdong, Zhejiang and Fujian were calculated to obtain more emission allowance while burden more reduction responsibility. Meanwhile, provinces like Guizhou, Ningxia,Hainan, Qinghai and Xizang were on the contrary. This paper suggests governments to enhance or ease to industrial VOCs reduction burden of each province in order to stimulate its economy or change its way of economy development. | Jiani Zhang Jingfang Xiao Xiaofang Chen Xiaoming Liang Liya Fan Daiqi Ye | 2018 | Journal of Environmental Sciences2018，30，7： | 13 |
| 3 | Collinear holographic data storage technologies显示文摘In the era of information explosion,the demand of data storage is increased dramatically.Holographic data storage technology is one of the most promising next-generation data storage technologies due to its high storage density,fast data transfer rate,long data life time and less energy consumption.Collinear holographic data storage technology is the typical solution of the holographic data storage technology which owns a more compact,compatible and practical system.This paper gives a brief review of holographic data storage,introduces collinear holographic data storage technology and discusses phase modulation technology being used in the holographic data storage system to achieve higher storage density and higher data transfer rate. | Xiao Lin Jinpeng Liu Jianying Hao Kun Wang Yuanying Zhang Hui Li Hideyoshi Horimai Xiaodi Tan | 2020 | Opto-Electronic Advances2020，3，3： | 8 |
| 4 | Cells derived from iPSC can be immunogenic -- Yes or No?显示文摘导致的 pluripotent 干细胞(iPSCs ) ,在体的房间由 reprogramming 因素的宫外的表示发源,能潜在地为再生药提供无限的自体同源的房间。在理论,没有任何有免疫力的拒绝,从耐心的 iPSCs 导出的自体同源的房间应该是由主人容忍的免疫者。然而,我们的最近的研究发现了那平 syngeneic 导出 iPSC 的细胞能在由使用一个 teratoma 移植模型的 syngeneic 宿主产生免疫性(自然 474:212215, 2011 ) 。最近,二个研究组区分了 iPSCs 进不同细菌层或房间,移植了那些房间到 syngeneic 主人,并且评估了那些房间的 immunogenicity。尽管他们在 iPSC 衍生物宣称可以忽略的任何一个或 immunogenicity 的缺乏,两个都,二,研究支持我们肯定的一些然而并非从 iPSCs 导出的所有纸巾能是产生免疫性的结论(自然 494:100104, 2013;房间干细胞 12:407412, 2013 ) 。到测试,区分开来与人的 iPSCs 的临床上珍贵的房间的 immunogenicity 突现地为 iPSC 技术的翻译被要求到诊所。 | Jiani Cao Xiaoyan Li Xiao Lu Chao Zhang Honghao Yu Tongbiao Zhao | 2014 | Protein & Cell2014，5，1： | 6 |
| 5 | Energy dissipation mechanism and experiment of particle dampers for gear transmission under centrifugal loads显示文摘 | Wangqiang Xiao Yuxiang Huang Hong Jiang Hong Lin Jiani Li | 2016 | Particuology2016，14，4： | 2 |
| 6 | Vibro-acoustic Radiation Characteristics Analysis of Railway Vehicle Wheel with Damping Ridges Based on Modal Strain Energy显示文摘The existing researches on the damping wheel mainly focus on investigating the influence of damping structure change on the vibro-acoustic control.The changes include the geometric size of the damping structure,the damping material parameters,and the placement,and so on.In order to further understand the mechanism in reducing the acoustic radiation of railway wheel with layer damping treatment,in this paper,the wheel is simply modified by a full-sized circular plate.The circle plate side has stuck circumference constrained damping ridges and radial constrained damping ridges on it.Based on a hybrid finite element method-boundary element method(FEM-BEM),the paper develops a vibro-acoustic radiation model for such a distributed constrained damping structure.The vibration and acoustic radiation of the circular plate is analyzed.In the analysis,the dynamic response of the system is obtained by using the 3D finite model superposition method.The obtained vibration response is used as the initial boundary condition in solving Helmholtz boundary integral equation for the sound radiation analysis.In the procedure,firstly,the modal analysis of the circular plate is performed to get the distribution of the system modal strain energy.Secondly,the vibro-acoustic radiation characteristics of the plate with different kinds of circumference damping ridges and radial damping ridges are compared in order to try to find the best effective damping ridge structure.Thirdly,using the distribution of the plate modal strain energy investigates the effect of the ridge distribution locations on the circular plate on its vibro-acoustic radiation.The calculation and analysis research results show that,the sticking circumference and radial damping ridges on the plate can control the vibro-acoustic radiation of the plate effectively in different frequency range.The distribution of the constrained damping ridge has an effect on reduction in vibro-acoustic radiation of the circular plate.The present research is very useful in the design of railway wheel with low noise level. | HE Bin XIAO Xinbiao JIN Xuesong FANG Jianying | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 2 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | Lensless complex amplitude demodulation based on deep learning in holographic data storage显示文摘To increase the storage capacity in holographic data storage(HDS),the information to be stored is encoded into a complex amplitude.Fast and accurate retrieval of amplitude and phase from the reconstructed beam is necessary during data readout in HDS.In this study,we proposed a complex amplitude demodulation method based on deep learning from a single-shot diffraction intensity image and verified it by a non-interferometric lensless experiment demodulating four-level amplitude and four-level phase.By analyzing the correlation between the diffraction intensity features and the amplitude and phase encoding data pages,the inverse problem was decomposed into two backward operators denoted by two convolutional neural networks(CNNs)to demodulate amplitude and phase respectively.The experimental system is simple,stable,and robust,and it only needs a single diffraction image to realize the direct demodulation of both amplitude and phase.To our investigation,this is the first time in HDS that multilevel complex amplitude demodulation is achieved experimentally from one diffraction intensity image without iterations. | Jianying Hao Xiao Lin Yongkun Lin Mingyong Chen Ruixian Chen Guohai Situ Hideyoshi Horimai Xiaodi Tan | 2023 | Opto-Electronic Advances2023，6，3： | 1 |
| 9 | Serum tumor markers CAl99, CA125,CA242,CEA detection for different stages of the correlation analysis of pancreatic cancer 显示文摘 | JIA Ang XIAO JianYing L1U Xin | 2011 | Journal of Chongqing Medicine2011，，35： | 1 |
| 10 | Advances in particulate matter filtration:Materials,performance,and application显示文摘Air-borne pollutants in particulate matter(PM)form,produced either physically during industrial processes or certain biological routes,have posed a great threat to human health.Particularly during the current COVID-19 pandemic,effective filtration of the virus is an urgent matter worldwide.In this review,we first introduce some fundamentals about PM,including its source and classification,filtration mechanisms,and evaluation parameters.Advanced filtration materials and their functions are then summarized,among which polymers and MOFs are discussed in detail together with their antibacterial performance.The discussion on the application is divided into end-of-pipe treatment and source control.Finally,we conclude this review with our prospective view on future research in this area. | Xuzheng Ji Jianying Huang Lin Teng Shuhui Li Xiao Li Weilong Cai Zhong Chen Yuekun Lai | 2023 | Green Energy & Environment2023，8，3： | 1 |
| 11 | Dual-Energy Computed Tomography Imaging of Thyroid Nodule Specimens: Comparison With Pathologic Findings显示文摘 | Ming Li Xiangpeng Zheng Jianying Li Yanli Yang Chen Lu Hua Xu Bo Yu Li Xiao Guozhen Zhang Yanqing Hua | 2012 | Investigative Radiology2012，，1： | 1 |
| 12 | Liver dynamic contrast‐enhanced MRI for staging liver fibrosis in a piglet model显示文摘 | Li Zhou Tian‐wu Chen Xiao‐ming Zhang Zhi Yang Hong‐jie Tang Dan Deng Nan‐lin Zeng Li‐ying Wang Xiao‐li Chen Hang Li Chun‐ping Li Li Li Xian‐yong Xie Jiani Hu | 2014 | J. Magn. Reson. Imaging2014，，4： | 1 |
| 13 | Transcriptome and metabolome analysis reveal that oral secretions from Helicoverpa armigera and Spodoptera litura influence wound-induced host response in cotton显示文摘Cotton(Gossypium hirsutum)is an important fiber crop worldwide.Insect attack causes cotton yield and quality losses.However,little is known about the mechanism of cotton response to insect attack.We simulated insect feeding by applying insect oral secretions(OS)to wounds,and combined transcriptome and metabolome analysis to investigate how OS from two major pest species(Helicoverpa armigera and Spodoptera litura)affect cotton defense responses.We found that respectively 12,668 and 13,379 genes were differentially expressed in comparison with wounding alone.On addition of OS,the jasmonic acid signaling pathway was rapidly and strongly induced,whereas genes involved in salicylic acid biosynthesis were downregulated.On constructing a coexpression gene network,we identified a hub gene encoding a leucine-rich repeat receptor kinase that may play an important role in early signal recognition and transduction.OS from the two insect species altered the abundance of flavonoid-related compounds in different patterns.Gossypol remained in lower concentration after OS application than after wounding alone,suggesting a suppressive effect of OS on cotton defense response.This study illustrated transcriptional and metabolic changes of cotton in responding to OS from two chewing insect species,identified potential key response genes,and revealed evidence for OS inhibition of wounding-induced cotton defense response. | Huan Si Hongling Liu Yiwen Sun Zhongping Xu Sijia Liang Bo Li Xiao Ding Jianying Li Qiongqiong Wang Lin Sun Xianlong Zhang Shuangxia Jin | 2020 | The Crop Journal2020，8，6： | 1 |
| 14 | Risk Factors for Gestational Diabetes Mellitus(GDM)in Subsequent Pregnancy Among Women Without GDM History in China:A Multicenter Retrospective Study显示文摘Objective:This study aimed to determine the likelihood of gestational diabetes mellitus(GDM)in subsequent pregnancy among women without GDM history and to identify risk factors for GDM in subsequent pregnancy.Methods:This retrospective cohort study involved participants who delivered twice in same hospital of 18 research centers when delivered the second baby from January 2018 to December 2018.Finally 6204 women were enrolled and 5180 women without GDM history were analyzed further.Women were categorized as non-GDM or GDM based on the blood glucose values of the subsequent pregnancy,and the characteristics and GDM risk of these groups were compared.A univariate analysis of potential risk factors was performed using the Chi-squared test and/ort-test for qualitative or quantitative variables,respectively.Associations withP values<0.1 were chosen to be included in the multivariate binary logistic regression model.Results:In primary analysis of 6204 women,the incidence of GDM in subsequent pregnancy is 48.9%(490/1002)in women with GDM history and 16.1%(835/5202)in women without GDM history.In a further analysis for 5180 women without GDM at index pregnancy,compared with the non-GDM group,the GDM group had a significantly higher age,prepregnancy body mass index,and blood glucose value at each oral glucose tolerance test(OGTT)timepoint(fasting,1 h and 2 h)during the index and subsequent pregnancies,as well as higher weight retention during the interval between the two pregnancies(P<0.001).Age above 35 years in subsequent pregnancy(odds ratio(OR)=1.540,95%confidence interval(CI)=1.257-1.886,P<0.001),macrosomia in index pregnancy(OR=1.749,95%CI=1.277-2.395,P=0.001),OGTT blood glucose values in index pregnancy(fasting,OR=2.487,95%CI=1.883-3.285,P<0.001;1 h,OR=1.142,95%CI=1.051-1.241,P=0.002;2 h,OR=1.290,95%CI=1.162-1.432,P<0.001)and weight retention(OR=1.052,95%CI=1.035-1.068,P<0.001)were independent risk factors for GDM in subsequent pregnancy.Conclusion:For women without GDM history,GDM risk factors including age,macrosomia history,OGTT value,and weight retention,these can be evaluated before a subsequent pregnancy.Early warning and interventions are needed for women at high risk. | Geng Song Yumei Wei Juan Juan Rina Su Jianying Yan Mei Xiao Xianlan Zhao Meihua Zhang Yuyan Ma Haiwei Liu Jingxia Sun Kejia Hu Huixia Yang | 2023 | Maternal-Fetal Medicine2023，5，1： | 1 |
| 15 | Prevalence and characteristics of macrosomia in the first and subsequent pregnancy: a multi-center retrospective study显示文摘To the Editor:Macrosomia is of growing prevalence and concern worldwide.In China,there has been a marked increase in the prevalence of macrosomia over the past few decades as a result of economic development and improvements in living standards. | Juan Juan Huixia Yang Yumei Wei Geng Song Rina Su Xu Chen Ruiqin Shan Jianying Yan Mei Xiao Ying Li Shihong Cui Xianlan Zhao Shangrong Fan Ling Feng Meihua Zhang Yuyan Ma Zishan You Haixia Mengn Haiwei Liu Jingxia Sun Yan Cai Kejia Hu | 2022 | Chinese Medical Journal2022，，12： | 1 |
| 16 | Understanding the change of land space utilization efficiency with different functions and its coupling coordination: A case study of Urban Agglomeration in the Middle Reaches of the Yangtze River, China显示文摘Land spaces function in capacities of urban development,agricultural production,and ecological conservation,among many others.Research of land space utilization efficiency(LSUE)and coupling coordination relationships among its subsystems are significant for sustainable land space development.In this study,taking the Urban Agglomeration in the Middle Reaches of the Yangtze River(UAMRYR)as the study area,we establish a measurement index system to evaluate the LSUE(2000–2018)and analyze its coupling coordination degree by utilizing an improved coupling coordination model.The main results include the following.(1)The average efficiency levels of urban space and agricultural space in the UAMRYR increased 2000–2018,while the average efficiency of ecological space declined.(2)The spatial pattern of the LSUE values varied greatly,with the distributions of high-efficiency and low-efficiency levels significantly different.(3)The coupling degree of LSUE includes three types,i.e.,high-level coupling,break-in,and antagonism.Each coupling degree type was characterized by change over time.(4)The proportion of areas with high coupling coordination and moderate coupling coordination increased from 2000 to 2018,while the proportion of areas with basic coupling coordination,moderate imbalance,and serious imbalance declined during this period.Given that the spatial differentiation of the LSUE and its coupling coordination,it is necessary to implement a differential land space development strategy in the UAMRYR.This study is helpful to promote the efficient utilization and coordinated development of land space utilization systems. | YANG Bin YANG Jun TAN Li XIAO Jianying | 2023 | Journal of Geographical Sciences2023，33，2： | 1 |
| 17 | Improved phase retrieval in holographic data storage based on a designed iterative embedded data显示文摘Embedded data are used to retrieve phases quicker with high accuracy in phase-modulated holographic data storage(HDS).We propose a method to design an embedded data distribution using iterations to enhance the intensity of the high-frequency signal in the Fourier spectrum.The proposed method increases the antinoise performance and signal-to-noise ratio(SNR)of the Fourier spectrum distribution,realizing a more efficient phase retrieval.Experiments indicate that the bit error rate(BER)of this method can be reduced by a factor of one after 10 iterations. | Changyu YU Suping WANG Ruixian CHEN Jianying HAO Qijing ZHENG Jinyu WANG Xianying QIU Kun WANG Dakui LIN Yi YANG Hui LI Xiao LIN Xiaodi TAN | 2021 | Frontiers of Optoelectronics2021，14，4： | 0 |
| 18 | Clinical research of biphenotypic acute leukemia witht(8;21)(q22;q22)显示文摘Objective:To report 4 cases of biphenotypic acute leukemia(BAL)with t(8;21)(q22;q22),and analyze the characteristics of morphology,immune phenotype,chromosome karyotype(MIC)and clinical manifestations.Methods:The BAL patients with t(8;21)(q22;q22)(group A)were compared with the randomly selected BAL patients with other clonical chromo- somal changes(group B)and acute myeloid leukemia M2 cases with t(8;21)(q22;q22)(group C)in MIC and clinical features. Results:BAL with t(8;21)(q22;q22)showed acute myeloid leukemia with high percentages of blast cells morphologically; revealed co-positive to B-lymphoid and myeloid lineages,frequent and high expressions of CD34 and CD33;were responsive to chemotherapy for myeloid and lymphocytic leukemia simultaneously well.Conclusion:A new subset of BAL with t(8;21)(q22;q22)was reported,and this suggests that the leukemia colony with t(8;21)(q22;q22)might originate from early phase of hematopoiesis. | Guangsheng He Ling Zhou Depei Wu Yongquan Xue Mingqing Zhu Jianying Liang Aining Sun Zhengming Jin Huiying Qiu Miao Miao Xiaowen Tang Zhengzheng Fu Xiao Ma Xiuli Wang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 0 |
| 19 | Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts显示文摘OCT4 and NANOG are two important tran-scription factors for maintaining the pluripotency and self-renewal abilities of embryonic stem(ES)cells.Meanwhile they play key roles in the induced pluripotent stem(iPS)cells.In this study,recombinant transcript factors TAT-NANOG and TAT-OCT4,which contained a fused powerful protein transduction domain(PTD)TAT from human immunodeficiency virus(HIV),were produced.Each fusion protein could be transported into human adultfibroblasts(HAF)successfully and activated the endogen-ous transcription of both nanog and oct4.Our study revealed the inter-regulation and autoregulation abilities of solo oct4 or nanog in the process of iPS cell reprogram-ming.Meanwhile the transduction of TAT-NANOG could accelerate the growth rate of HAF cells,and the key cell cycle regulator cdc25a was up-regulated.Thus cdc25a may be involved in the regulation of cell growth by NANOG.In addition,the TAT fusion protein technology provided a novel way to improve cell growth that is more controllable and safer. | Jiani CAO Zhifeng XIAO Bing CHEN Yuan GAO Chunying SHI Jinhuan WANG Jianwu DAI | 2010 | Frontiers in Biology2010，5，5： | 0 |
| 20 | A STOCHASTIC NEWTON METHOD FOR NONLINEAR EQUATIONS显示文摘In this paper,we study a stochastic Newton method for nonlinear equations,whose exact function information is difficult to obtain while only stochastic approximations are available.At each iteration of the proposed algorithm,an inexact Newton step is first computed based on stochastic zeroth-and first-order oracles.To encourage the possible reduction of the optimality error,we then take the unit step size if it is acceptable by an inexact Armijo line search condition.Otherwise,a small step size will be taken to help induce desired good properties.Then we investigate convergence properties of the proposed algorithm and obtain the almost sure global convergence under certain conditions.We also explore the computational complexities to find an approximate solution in terms of calls to stochastic zeroth-and first-order oracles,when the proposed algorithm returns a randomly chosen output.Furthermore,we analyze the local convergence properties of the algorithm and establish the local convergence rate in high probability.At last we present preliminary numerical tests and the results demonstrate the promising performances of the proposed algorithm. | Jiani Wang Xiao Wang Liwei Zhang | 2023 | Journal of Computational Mathematics2023，41，6： | 0 |
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