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| 1 | Bone status assessment in Japanese subjects using speed of sound along the tibia | Nobuyuki Miyatake Hiroko Muta Chigusa Murota Mari Haga Masafumi Fujii | 2002 | Chinese Medical Journal2002，，2： | 9 |
| 2 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 3 | Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘 | Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka | 2013 | International Journal of Clinical Oncology2013，，2： | 2 |
| 4 | Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment显示文摘 | Chigusa Shimono Kazuhiro Suwa Morio Sato Shintaro Shirai Katsuyuki Yamada Yasushi Nakamura Masatoshi Makuuchi | 2009 | International Journal of Clinical Oncology2009，，4： | 2 |
| 5 | Further observation of paternal transmission of Drosophila mitochondrial DNA by PCR selective amplification method显示文摘 | KONDO R MATSUURA E T CHIGUSA S I | 1992 | Genet Res1992，59，02： | 1 |
| 6 | High level of CA19-9,CA50 and CEA-producible human cholangiocarcinoma cell linechanges in the secretion ratios in vitro or in vivo显示文摘 | Watanabe M Chigusa M Takahashi H | 2000 | In Vitro Cell Dev BiolAnim2000，36，2： | 1 |
| 7 | High level of CA19-9,CA50, and CEA-producible human cholangiocarcinoma cell line changes in the secretion ratios in vitro or in vivo显示文摘 | Watanabe M Chigusa M Takahashi H | 2000 | In Vitro Cell Dev Biol Anim2000，36，2： | 1 |
| 8 | Further observation of paternal transmission of Drosophila mitochondrial DNA by PCR selective amplification method显示文摘 | KONDO R MATSUURA E T CHIGUSA S I | 1992 | Genetical Research1992，59，02： | 1 |
| 9 | High level of CA19-9,CA50, and CEA-producible human cholangiocarcinoma cell line changes in the secretion ratios in vitro or in vivo 显示文摘 | Watanabe M Chigusa M Takahashi H | 2000 | In Vitro Cell Dev Biol Anim2000，36，2： | 1 |
| 10 | Geographic pathology of latent prostatic carcinoma显示文摘 | Yatani R Chigusa I Akazaki K | 1982 | Int J Cancer1982，29，6： | 1 |
| 11 | High level of CA19-9,CA50 andCEA-Producible human cholangio carcinoma cell line changes in the secretion ratios in vitro or in vivo显示文摘 | Watanade M Chigusa M Takahashi H | 2000 | In vitro Cell Dev Biol Ainm2000，36，： | 1 |
| 12 | A Phase 1I study of S-1 in gemeitabine-refractory metastatic pancreatic cancer显示文摘 | Chigusa M Takuji O Junji F | 2009 | Cancer Chcmother Pharamcol2009，63，2： | 1 |
| 13 | Treatment of wastewater from oil manufacturing plant by yeast显示文摘 | Chigusa K Hasegawa T Yamamoto N | 1996 | War Sci Technol1996，34，11： | 1 |
| 14 | Treatment of wastewater from oil manufacturing plant by yeasts显示文摘 | Chigusa K Hasegawa T Yamamoto N | 1996 | Water Science and Technology1996，34，11： | 1 |
| 15 | Age-dependent of apolipoprotein E genotypes with stroke subtypes in a Japanese rural population显示文摘 | Yoshihiro K Anisul HC Chigusa D | 2000 | Stroke2000，31，6： | 1 |
| 16 | Imagingdiagnosis of schis to somiasis japonica the use injapan and a plication for field stud in thepresent endemic area显示文摘 | OHMAE H S OS CHIGUSA Y | 2003 | Parasitol Int2003，52，4： | 1 |
| 17 | Rapid Evolution of the Male-Specific Antibacterial Protein Andropin Gene in Drosophila显示文摘 | Atsuko Date-Ito Kumiko Kasahara Hiromi Sawai Sadao I. Chigusa | 2002 | Journal of Molecular Evolution2002，，5： | 1 |
| 18 | Simultaneous determination of dive sweeteners in foods by HPLC显示文摘 | CHIGUSA K MITSUO N YUKA K | 1999 | Journal of the Food Hygienic Society of Japan1999，40，2： | 1 |
| 19 | Clinicalassessment of bortezomib for multiple myeloma incomparison with thalidomide显示文摘 | MITSUTOSHI S RIEKO O CHIGUSA Y | 2011 | J Pharm PharmaceutSci2011，14，： | 1 |
| 20 | High levelof CA199, CA50 and CEA-producible human cholangio-carcinoma cell line changes in the secretion ratiosin vitro-orin vivo显示文摘 | Watanabe M Chigusa M Takahashi H | 2000 | In VitroCell Dev Biol Anim2000，36，2： | 1 |
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