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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 3 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 4 | Control of Iodine Deficiency Disorders Following 10-Year Universal Salt Iodization in Hebei Province of China显示文摘Objective To evaluate the effectiveness of universal salt iodization(USI) for the control of IDD in Hebei province since it was implemented in 1995,identify the problems currently encountered in the implementation of USI and provide practical proposals for addressing these problems.Methods Probability proportionate to size sampling(PPS) was employed in the surveillance of IDD,for which a total of 1200 school children aged 8-10 years were randomly selected from 30 counties around the whole province during each IDD survey.The iodine content of salt was determined quantitatively with the titration method.The iodine content of urinary samples was measured by the method of ammonium persulfate oxidation.Results The coverage of iodized salt increased from 65.0% in 1995 to 98.0% in 1999,then decreased to 88.1% in 2005 which was below the national standard of 90%.The median urinary iodine of children aged 8-10 years varied between 160.1 μg/L and 307.4 μg/L,which was above the national standard.The proportion of urinary samples with iodine content above 300 μg/L was over 30% in 2005,implying exorbitant iodine nutrition among the children.The goiter rate(TGR) among children aged 8-10 years dropped from 11.8% in 1995 to 2.7% in 2005,indicating that the spread of endemic goiter was under control.Conclusion Preliminary elimination of IDD was achieved by USI in Hebei province.Nevertheless,some problems still existed in USI such as non-iodized salt competition,over iodization and un-standardized iodization.In order to address these problems,the management and supervision of salt market needs to be strengthened to prevent non-iodized salt from reaching households updating equipment and modifying techniques are also necessary to ensure the quality of iodized salt to clarify the causes of excessive urinary iodine content,the various sources of iodine from the diet need to be investigated in the future. | SHENG-MIN LV LI-JUN XIE RONG-HUA ZHOU ZHEN-SHUI CHONG LI-HUI JIA JING MA JUN ZHAO DONG XU | 2009 | Biomedical and Environmental Sciences2009，22，6： | 6 |
| 5 | Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells显示文摘动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素,它是否能调整 LPL 的表示,仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇,免费胆固醇,和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物,例如 interleukin-6 (IL-6 ) , interleukin-1 (IL-1 ) 和肿瘤坏死 factor-alpha (TNF-) 。apelin-13 禁止了由西方的污点和即时 PCR 分析揭示了的 LPL 的表示,这也被发现。生物信息学分析和双酶的记者试金直接显示了那 miR-361-5p downregulated 由指向 LPL 的 3UTR 的 LPL 的表示。另外, apelin-13 + miR-361-5p 显著地模仿 downregulated 在房间的 LPL 的表示。最后,我们表明了那 apelin-13 downregulated 通过激活 PKC 的活动的 LPL 的表示。一起拿,我们的结果显示出那 apelin-13 downregulated 经由激活在 THP-1 导出巨噬细胞的泡沫房间表明小径的 APJ/PKC/miR-361-5p 的 LPL 的表示,导致类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制。因此,我们的研究由 apelin-13 提供重要新卓见进类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制,并且在动脉粥样硬化作为一个有希望的治疗学的目标加亮 apelin-13。 | Xin Zhang Qiong Ye Duo Gong Yuan Lv Haipeng Cheng Chong Huang Lingyan Chen Zhenwang Zhao Liang Li Xie Wei Min Zhang Xiaodan Xia Xiaohua Yu Xilong Zheng Shuzhi Wang Zongbao Wang Chaoke Tang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 6 |
| 6 | Phosphoglycerate mutase 1 prostate cancer cell growth, knockdown inhibits migration, and invasion显示文摘(PGAM1 ) Phosphoglycerate 变位酶 1 是在许多癌症类型的 upregulated 并且在房间增长,移植,侵略,和 apoptosis 包含。然而,在 PGAM1 和前列腺癌症之间的关系糟糕被理解。现在的学习与正常前列腺纸巾相比在前列腺癌症纸巾在 PGAM1 表示调查了变化并且检验了有 clinicopathological 变量的 PGAM1 和它的关系的细胞的函数。Immunohistochemistry 并且西方的弄污表明那 PGAM1 表情是在前列腺癌症纸巾和房间线的 upregulated。PGAM1 表示与格利森分数被联系(P = 0.01 ) 并且 T 阶段(P = 0.009 ) 。由在 PC-3 和 22Rv1 前列腺癌症房间线的 siRNA 的 PGAM1 击倒禁止的房间增长,移植,和侵略和提高的癌症房间 apoptosis。在一个裸体老鼠异种皮移植模特儿, PGAM1 击倒的显著地压制的肿瘤生长。PGAM1 的删除导致了 MMP-2 的 Bcl-2, Bax 的提高的表示, caspases-3 和抑制的减少的表示和 MMP-9 表示。我们的结果显示 PGAM1 可以在前列腺癌症前进和攻击性起一个重要作用,并且它可能为前列腺癌症是差的预后和一个潜在的治疗学的目标的一个珍贵标记。 | Yao-An Wen Bo-Wei Zhou Dao-Jun Lv Fang-Peng Shu Xian-Lu Song Bin Huang Chong Wang Shan-Chao Zhao | 2018 | Asian Journal of Andrology2018，20，2： | 6 |
| 7 | High-entropy ferroelastic(10RE_(0.1))TaO_(4) ceramics with oxygen vacancies and improved thermophysical properties显示文摘The primary purpose of this work is to optimize the thermophysical properties of rare-earth tan-talate ceramics using the high-entropy effect.Here,the high-entropy rare-earth tantalate ceramic(Y_(0.1)Nd_(0.1)Sm_(0.1)Gd_(0.1)Dy_(0.1)Ho_(0.1)Er_(0.1)Tm_(0.1)Yb_(0.1)Lu_(0.1))TaO_(4)((10RE_(0.1))TaO_(4))is synthesized successfully.The lat-tice distortion and oxygen vacancy concentration are characterized firstly in the rare-earth tantalates.Notably,compared with single rare-earth tantalates,the thermal conductivity of(10RE_(0.1))TaO_(4) is reduced by 16%-45%at 100℃ and 22%-45%at 800℃,and it also presents lower phonon thermal conductivity in the entire temperature range from 100 to 1200℃.The phonon thermal conductivity(1.0-2.2 W m^(-1) K^(-1),100-1200℃)of(10RE_(0.1))TaO_(4) is lower than that of the currently reported high-entropy four-,five-and six-component rare-earth tantalates.This is the result of scattering by the ferroelastic domain,lattice distortion associated with size and mass disorder,and point defects,which target low-,mid-and high-frequency phonons.Furthermore,(10RE_(0.1))TaO_(4),as an improved candidate for thermal barrier coatings materials(TBCs),has a higher thermal expansion coefficient(10.5×10^(-6)K^(-1) at 1400℃),lower Young’s modulus(123 GPa)and better high-temperature phase stability than that of single rare-earth tantalates. | Jun Wang Xiaoyu Chong Liang Lv Yuncheng Wang Xiaolan Ji Haitao Yun Jing Feng | 2023 | Journal of Materials Science & Technology2023，，26： | 4 |
| 8 | Microstructures and mechanical properties of a newly developed high-pressure die casting Mg-Zn-RE alloy显示文摘A newly developed Mg-4Zn-2La-3Y alloy with high strength was fabricated by high-pressure die casting method,and its microstructures were thoroughly studied using transmission electron microscopy.The results demonstrate that it owns fine grains and approximately highly interconnected intermetallic phase skeletons,and exhibits ultra-high strength at both room and high temperatures.Interestingly,the eutectic intermetallic skeleton of this alloys is consisted of numerous fine particles,which are mainly consisted of two intermetallic phases,namely W and Mg12RE.Multiple{101}twins and SFs were found in the Mg12RE phase while a few of SFs in the W phase.Additionally,minor long-period stacking ordered phase was observed in the eutectoid phase,and it probably nucleated on the Mg12RE phase following a certain OR as(0002)14H//(110)Mg12REand[1120]14H//[111]Mg12RE,or(0002)14H//(211)Mg12REand[1120]14H//[111]Mg12RE.This special intermetallic skeleton with many interfaces and planar faults can efficiently transfer dislocations across grain boundaries,and this is the key factor for the outstanding mechanical properties of the studied alloy. | Xiru Hua Qiang Yang Dongdong Zhang Fanzhi Meng Chong Chen Zihao You Jinghuai Zhang Shuhui Lv Jian Meng | 2020 | Journal of Materials Science & Technology2020，52，18： | 3 |
| 9 | A bifunctional and recyclable catalyst:Amine and ionic liquid grafting on MOFs for the one-pot synthesis of N-aryl oxazolidin-2-ones显示文摘A bifunctional heterogeneous catalyst was designed and synthesized,denoted DMEDA/IL–NH2-MIL-101.The structure and physical-chemical characterization of DMEDA/IL–NH2-MIL-101 and its precursors were characterized by SEM,N2 adsorption-desorption,XPS,FT-IR,PXRD,elemental analysis,and TGA techniques.The date showed that the two catalytic components of N,N-dimethylethylenediamine(DMEDA)and 1-butyl-3-methylimidazolium bromide(BmimBr)were chemically immobilized in NH2-MIL-101 nanocages.The amine of DMEDA was grafted onto carrier NH2-MIL-101 by N–Cr coordinate covalent bonds and the ionic liquid of BmimBr(IL(Br-))was anchored in the NH2-MIL-101 nanocages by'ship-in-a-bottle'method,in which the amidogen of NH2-MIL-101 condensed with N,N-carbonyldiimidazole(CDI)firstly,and then alkylated with 1-bromo butane.This novel heterogeneous catalyst with two different active sites can efficiently catalyze the synthesis of N-aryl oxazolidin-2-ones from carbon dioxide(CO2),epoxides,and anilines in one-pot under mild solvent-free conditions.It not only showed good stability and recoverability after five cycles but also exhibited shape selectivity for the substrate due to the synergic catalysis of amine,ionic liquid,and NH2-MIL-101.This novel bifunctional material is a promising solid catalyst for the green synthesis of N-aryl oxazolidin-2-ones. | Siying Chong Tongtong Wang Haijun Zhong Lingfei Xu Hailong Xu Zhongwu Lv Min Ji | 2020 | Green Energy & Environment2020，5，2： | 3 |
| 10 | Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques显示文摘Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential immunization.The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type. | Wei Deng Qi Lv Fengdi Li Jiangning Liu Zhiqi Song Feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing Jia Kai Gao Jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 11 | Tea polyphenols inhibit the growth and angiogenesis of breast cancer xenografts in a mouse model显示文摘Objective:To investigate the anti-angiogenic effect of tea polyphenols(TPS)on breast cancer and normal tissues in a mouse model.Methods:Breast cancer was successfully implanted into 48 BALB/c mice,which were then randomly divided into a TP oral gavage group,a TP local injection group,a ginsenoside Rg3 group,and a model control group according to a random number table.The tumor inhibitory rates of each group were calculated,while microvessel density(MVD)and the expression of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),and tissue inhibitor of metalloproteinase(TIMP-2)were detected by immunohistochemistry.Results:TPs could inhibit the growth of breast cancer xenografts in the mouse model.The tumor inhibition rates of the TP oral gavage and TP local injection groups were 37.43%and 40.94%,respectively.Compared with the model control group,MVD and VEGF and bFGF expression was downregulated(all P<.05),whereas TIMP-2 expression was elevated in the TP oral gavage and TP local injection groups(P=.015 and P=.032).TPs showed no significant effect on MVD and VEGF and TIMP-2 expression in the heart,brain,and kidney of the mouse model.Conclusion:TPs can restrict the growth of breast cancer by specifically inhibiting the angiogenesis of breast tumor tissue while having little effect on the normal tissue of important organs including the heart,brain,and kidney. | Peng Lv Fengqin Shi Xinyi Chen Li Xu Chong Wang Shaodan Tian Heng Yang Li Hou | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 2 |
| 12 | Nitrogen removal through different pathways in an aged refuse bioreactor treating mature landfill leachate显示文摘 | Xie Bing Lv Zhuo Hu Chong | 2013 | Applied Microbiology and Biotechnology2013，97，20： | 1 |
| 13 | An integrated hy- pothesis that considers drusen as biomarkers of immune- mediated processes at the RPE-Bruch' s membrane inter- face in aging and age-related macular degeneration显示文摘 | HAGEMAN GS LUTHERT P J VICTOR CHONG NH JOHN- SON LV ANDERSON DH MULLINS RF | 2001 | Prog Retin Eye Res2001，20，6： | 1 |
| 14 | Direct access to β-seleno sulfones at room temperature through selenosulfonylation of alkenes显示文摘A new protocol has been developed for the formation of C.Se and C.S bonds by the direct selenosulfonylation of alkenes.This protocol is operationally simplistic, has a wide substrate scope, uses readily available seleno and sulfonyl sources, and is amenable to gram-scale synthesis. This reaction represents a significant addition to the limited number of reactions available for the intermolecular selenide difunctionalization of alkenes and would be useful for the synthesis of sulfur-and selenium-containing molecules. | Kai Sun Yunhe Lv Zuodong Shi Fangfang Fu Chong Zhang Zhiguo Zhang | 2017 | Science China Chemistry2017，60，6： | 1 |
| 15 | Detection of Salmonella enterica serovar Dublin by polymerase chain reaction in multiplex format显示文摘 | Ligong Zhai Xiaohan Kong Zhaoxin Lu Fengxia Lv Chong Zhang Xiaomei Bie | 2014 | Journal of Microbiological Methods2014，，： | 1 |
| 16 | Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study显示文摘 | Song Wu Peide Huang Chong Li Yi Huang Xianxin Li Yongqiang Wang Chao Chen Zhaojie Lv Aifa Tang Xiaojuan Sun Jingxiao Lu Weiping Li Jie Zhou Yaoting Gui Fangjian Zhou Daping Wang Zhiming Cai | 2013 | European Urology2013，，： | 1 |
| 17 | Off-line Chinese signature verification based on support vector machines显示文摘 | Lv Hairong Wang Wenyuan Chong Wang | 2005 | Pattern Recognition Letters2005，26，： | 1 |
| 18 | Tailoring of random lasing characteristics in dye-doped nematic liquid crystals显示文摘 | Lihua Ye Cong Hou Changgui Lv Chong Zhao Zhile Yin Yiping Cui Yanqing Lu | 2014 | Applied Physics B2014，，3： | 1 |
| 19 | Offline Chinese signature verification based on support vectormachines显示文摘 | LV HAIRONG WANG WENYUAN WANG CHONG | 2005 | Pat- tern Recognition2005，26，： | 1 |
| 20 | Off-line Chinese signature verification based on support vector machines显示文摘 | Lv Hai-rong Wang Wen-yuan Wang Chong | 2005 | Pattern Recognition2005，，： | 1 |
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