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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Treadmill exercise produces larger perfusion defects than dipyridamole stress N- 13 ammonia positron emission tomography显示文摘 | Chow BJ Beanlands RS Lee A | 2006 | J Am Coll Cardial2006，47，2： | 1 |
| 3 | Impact of massage therapyon motor outcomes in very low-birthweight infants:randomizedcontrolled pilot study显示文摘 | HO YB LEE RS CHOW CB | 2010 | J Pediatric Int2010，52，3： | 1 |
| 4 | Identification of enteric pathogens by heat shock protein 60 kDa (HSP60) gene sequences显示文摘 | Wong RS Chow AW | 2002 | FEMS Microbio Lett2002，206，1： | 1 |
| 5 | Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated显示文摘 | Zhao Y Chow TF Puckrin RS | 2007 | Nat Chem Biol2007，3，： | 1 |
| 6 | Impact of massage therapy on motor outcomes in very low-birthweight infants: randomized con- trolled pilot study显示文摘 | Ho YB Lee RS Chow CB | 2010 | Pediatr Int2010，52，3： | 1 |
| 7 | Comparing human skeletal muscle architecture parameters of cadavers with in vivo ultrasonographic measurements显示文摘 | Martin DC Medri MK Chow RS | 2001 | J Anat2001，199，4： | 1 |
| 8 | 低舒张压与再发心血管事件相关:Framingham心脏研究显示文摘低舒张压是否是单纯收缩期高血压患者再发心血管事件的危险因素仍有争议。研究者分析了来源于Framingham心脏研究原始与后代队列中初发心血管事件的791例患者[平均年龄75岁,47%为女性,随访(8±6)年]舒张压〈70 mm Hg(225例,1 mm Hg=0.133kPa)与70-89 mm Hg(566例)的资料。 | 赵狄 练桂丽 Franklin SS Gokhale SS Chow VH Larson MG Levy D Vasan RS Mitchell GF Wong ND | 2014 | 中华高血压杂志2014，22，12： | 1 |
| 9 | Comparing human skeletal muscle architectural parameters of cadavers with in vivo ultrasono-graphic measurements显示文摘 | Martin DC Medri MK Chow RS | 2001 | J Anat2001，199，4： | 1 |
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