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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | A Phase-Dependent Hypothesis for Locomotor Functions of Human Foot Complex显示文摘The human foot is a very complex structure comprising numerous bones, muscles, ligaments and synovial joints. As the only component in contact with the ground, the foot complex delivers a variety of biomechanical functions during human locomotion, e.g. body support and propulsion, stability maintenance and impact absorption. These need the human foot to be rigid and damped to transmit ground reaction forces to the upper body and maintain body stability, and also to be compliant and resilient to moderate risky impacts and save energy. How does the human foot achieve these apparent conflicting functions? In this study, we propose a phase-dependent hypothesis for the overall locomotor functions of the human foot complex based on in-vivo measurements of human natural gait and simulation results of a mathematical foot model. We propse that foot functions are highly dependent on gait phase, which is a major characteristics of human locomotion. In early stance just after heel strike, the foot mainly works as a shock absorber by moderating high impacts using the viscouselastic heel pad in both vertical and horizontal directions. In mid-stance phase (~80% of stance phase), the foot complex can be considered as a springy rocker, reserving external mechanical work using the foot arch whilst moving ground contact point forward along a curved path to maintain body stability. In late stance after heel off, the foot complex mainly serves as a force modulator like a gear box, modulating effective mechanical advantages of ankle plantiflexor muscles using metatarsal-phalangeal joints. A sound understanding of how diverse functions are implemented in a simple foot segment during human locomotion might be useful to gain insight into the overall foot locomotor functions and hence to facilitate clinical diagnosis, rehabilitation product design and humanoid robot development. | Lei Ren David Howard Lu-quan Ren Chris Nester Li-mei Tian | 2008 | Journal of Bionic Engineering2008，5，3： | 2 |
| 4 | The Cost-Effectiveness of an Extended Course (12 + 12 Weeks) of Varenicline Compared with Other Available Smoking Cessation Strategies in the United States: An Extension and Update to the BENESCO Model显示文摘 | Chris Knight Paul Howard Christine L. Baker Jeno P. Marton | 2010 | Value in Health2010，，： | 2 |
| 5 | Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study显示文摘 | Kenneth Rockwood Sandra E. Black Xiaowei Song David B. Hogan Serge Gauthier Chris MacKnight Robert Vandorpe Antonio Guzman Patrick Montgomery Andrew Kertesz Remi W. Bouchard Howard Feldman | 2005 | Journal of the Neurological Sciences2005，，1： | 2 |
| 6 | Yoga Asana Ses- sions Increase Brain GABA Levels:A Pilot study 显示文摘 | Chris CS Jensen JE Howard JC | 2007 | Journal of Alternative and Complementary Medicine2007，13，4： | 1 |
| 7 | A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer显示文摘 | Johanna C. Bendell Suzanne F. Jones Lowell Hart David R. Spigel Cassie M. Lane Chris Earwood Jeffrey R. Infante John Barton Howard A. Burris | 2015 | Investigational New Drugs2015，，1： | 1 |
| 8 | Flight Control Role in RLV Configuration Development显示文摘 | Hussein Youssef Howard Lee Chris Cotting | 2000 | AIAA-2000-3962 20002000，3962，： | 1 |
| 9 | Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress HER-2/ neu #显示文摘 | Howard Safran David Iannitti Ramesh Ramanathan Jonathan D. Schwartz Margaret Steinhoff Chris Nauman Paul Hesketh Ritesh Rathore Robert Wolff Umadevi Tantravahi Marilyn Hughes Chris Maia Terry Pasquariello Lisa Goldstein Thomas King James Y. Tsai Teresa Ke | 2004 | Cancer Investigation2004，，5： | 1 |
| 10 | Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress HER-2/ neu #显示文摘 | Howard Safran David Iannitti Ramesh Ramanathan Jonathan D. Schwartz Margaret Steinhoff Chris Nauman Paul Hesketh Ritesh Rathore Robert Wolff Umadevi Tantravahi Marilyn Hughes Chris Maia Terry Pasquariello Lisa Goldstein Thomas King James Y. Tsai Teresa Ke | 2004 | Cancer Investigation2004，，5： | 1 |
| 11 | MgAl2O4 spinel stabilized calcium oxide absorbents with improved durability for high-temperature COz capture 显示文摘 | Li Liyu David L King Nie Zimin Li Xiaohong Shari Chris Howard | 2010 | Energy & Fuels2010，24，： | 1 |
| 12 | Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol显示文摘 | James P. Thomas Kendra D. Tutsch James F. Cleary Howard H. Bailey Rhoda Arzoomanian Dona Alberti Kris Simon Chris Feierabend Kimberly Binger Rebecca Marnocha Amy Dresen George Wilding | 2002 | Cancer Chemotherapy and Pharmacology2002，，6： | 1 |
| 13 | Curriculum evaluation-a new approach显示文摘 | Chris Sconce John Howard | 1994 | Nurse Education Today1994，14，4： | 1 |
| 14 | Estimation of leaded (Pb) gasoline’s continuing material and health impacts on 90 US urbanized areas显示文摘 | Howard W. Mielke Mark A.S. Laidlaw Chris R. Gonzales | 2010 | Environment International2010，，1： | 1 |
| 15 | Nonlinear association between soil lead and blood lead of children in metropolitan New Orleans, Louisiana: 2000–2005显示文摘 | Howard W. Mielke Chris R. Gonzales Eric Powell Morten Jartun Paul W. Mielke | 2007 | Science of the Total Environment2007，，1： | 1 |
| 16 | 学会质疑显示文摘头脑就像降落伞——在打开的时候工作得最好。在地球没有被证明是圆的以前,人们普遍接受的“事实”是:它是扁平的。这个“事实”得到了广泛的认同,以至于没人敢去验证它是否正确,因为大家担心如果航行的船只一跨过地平线,就会从边界上掉下去。换句话说,因为大家都相信这件事情不能做,于是就没有人去做。 | Chris Howard 小青 | 2005 | 新东方英语(中学版)2005，0，4： | 0 |
| 17 | 用于品牌推广和市场营销的最佳颜色显示文摘我们对于颜色有着天生的敏感。我们看一种产品或者材料,最先注意到的东西之一就是颜色。我们对于这些颜色的看法会从心理上影响我们的感觉和看法。它们甚至会影响我们的购买欲望。 | Jim Howard Heather Kirk Chris Howard | 2007 | 消费电子2007，，14： | 0 |
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