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| 1 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 2 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 3 | Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guerin vaccine revaccinated in Chinese infants显示文摘Objective:To investigate whether there is an association between diameter of bacille CalmetteGuerin(BCG)sears and effect of purified protein derivative(PPD)reaction anil to determine whether vitamin A(VA)combined vitamin I)(VD)supplementation influences the immune response to BCG revueeinated in Chinese infants.Methods:A cross-section and 3-month community-randomised trial was conducted.A total of 5 629 infants at 3,6 and 12 months of age in Junan County of China were examined for BCG scar fonnation.Then,597 revuccinated infants were randomly assigned to supplementation(n=307)and control(n=290)groups.The supplementation group were daily assigned to 1 500 IU VA and 500 IU VD for 3 months.Then all infants were subjected to skin test with PPD.Results:The diameter of BCG sears was positively con-elated with diameter of skin indurations of PPD(r=0.17,P<0.05)in the 5 629 infants.The rate of positive response to PP1)was higher in the supplementation group than in the control group(96.1%versus 89.7%,P<0.05,prevalence ratio 1.07.95%CI 1.02-1.12).The prevalence ralio of PPD response for the supplementation group compared with that for the control group was 1.07(95%CI 1.01-1.13)for the males and 1.08(95%CI 1.00-1.17)for the females.For the supplementation group,the males got larger tuberculin induration than the females[(0.73±0.2l)cm versus(0.67±0.20)cm.P<0.05)after intervention.Conclusions:The diameter of BCG scars was effectively correlated with PPD response,which indicates BCG scar formation may be an useful tool Io evaluate the effect of tuberculosis prevention.VA combined VD supplementation may play an immunoregulatory rale in BCG revuecination.This may contribute to the prevention of childhood tuberculosis. | Ying Zheng Xue-Gang Li Qiu-Zhen Wang Ai-Guo Ma Ib Christian Bygbjerg Yong-Ye Sun Yong Li Ming-Ci Zheng Xi Wang | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，2： | 3 |
| 4 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 5 | Exposure to herbicides reduces larval sensitivity to insecticides in Spodoptera litura (Lepidoptera: Noctuidae)显示文摘Herbicides and insecticides are widely used in modern agriculture. It has been reported in various studies that application of insecticides can increase tolerance of herbivorous insects to insecticides. However, limited information exists on susceptibility to insecticides when insects are exposed to herbicides. This study was conducted to investigate the potential impact of the herbicides trifluralin and 2-methyl-4-chlorophenoxyacetic acid sodium salt (MCPA-Na) on the susceptibility of the nocturnal moth Spodoptera litura to the insecticides X-cyhalothrin, phoxim and bifenthrin. We found that larvae exposed to trifluralin or MCPA-Na became significantly less susceptible to both insecticides than nonexposed control larvae. Herbicide-treated larvae did not show altered growth under the used test conditions. However, heads of herbicide-treated larvae showed increased expression of the acetylcholinesterase genes SI Ace I and SI Ace 2. Moreover, the fat body and midgut of herbicide-treated larvae displayed elevated expression of detoxification genes (the carboxylesterase gene SI CarE;the glutathione S-transferase genes SlGSTe2 and SlGSTe3\ the cytochrome P450 monooxygenase genes CYP6B48, CYP9A40 and CYP321B1). The CYP6B48 gene exhibited highest inducibility. In conclusion, the data of this study suggest that exposure of S. litura larvae to herbicides may stimulate detoxification mechanisms that compromise the efficacy of insecticides. | Shi-Wei Liu Mohammed Esmail Abdalla Elzaki Christian Staehelin Zhi-Hui Ma Zhong Qin Rui-Long Wang | 2019 | Insect Science2019，26，4： | 2 |
| 6 | Prognostic values of NTpro BNP/BNP ratio in comparison with NTpro BNP or BNP alone in elderly patients with chronic heart failure in a 2-year follow up显示文摘 | Juliana Jensen Li-Ping Ma Christian Bjurman Ola Hammarsten Michael L.X. Fu | 2011 | International Journal of Cardiology2011，，1： | 1 |
| 7 | T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication显示文摘 | Hongxiang Liu Hongtao Ye Agnes Ruskone-Fourmestraux Daphne De Jong Stefano Pileri Christian Thiede Anne Lavergne Henk Boot Giancarlo Caletti Thomas Wündisch Thierry Molina Babs G. Taal Sabattini Elena Togliani Thomas Pier Luigi Zinzani Andreas Neubauer Ma | 2002 | Gastroenterology2002，，5： | 1 |
| 8 | Measurement of heterogeneous uptake of NO2 on inorganic particles, sea water and urban grime显示文摘Heterogeneous reactions of NO2 on different surfaces play an important role in atmospheric NOxremoval and HONO formation,having profound impacts on photochemistry in polluted urban areas.Previous studies have suggested that the NO2 uptake on the ground or aerosol surfaces could be a dominant source for elevated HONO during the daytime.However,the uptake behavior of NO2 varies with different surfaces,and different uptake coefficients were used or derived in different studies.To obtain a more holistic picture of heterogeneous NO2 uptake on different surfaces,a series of laboratory experiments using different flow tube reactors was conducted,and the NO2 uptake coefficients(γ)were determined on inorganic particles,sea water and urban grime.The results showed that heterogeneous reactions on those surfaces were generally weak in dark conditions,with the measuredγvaried from<10-8 to 3.2×10-7 under different humidity.A photo-enhanced uptake of NO2 on urban grime was observed,with the obvious formation of HONO and NO from the heterogeneous reaction.The photo-enhancedγwas measured to be 1.9×10-6 at 5%relative humidity(RH)and 5.8×10-6 at 70%RH on urban grime,showing a positive RH dependence for both NO2 uptake and HONO formation.The results demonstrate an important role of urban grime in the daytime NO2-to-HONO conversion,and could be helpful to explain the unknown daytime HONO source in the polluted urban area. | Chuan Yu Zhe Wang Qingxin Ma Likun Xue Christian George Tao Wang | 2021 | Journal of Environmental Sciences2021，33，8： | 1 |
| 9 | Peptide deformylase as an antibacterial drug target:target validation and resistance development显示文摘 | Christian MA Locher H Keck W | 2001 | Antimicrob Agents chemother2001，45，4： | 1 |
| 10 | Uremic pruritus- new perspectives and insights from recent trials显示文摘 | Thomas M Christiane PM and Dominik MA | 2002 | Nephrol Dial Transplant2002，17，： | 1 |
| 11 | An automated, 0.5 Hz nano-foil target positioning system for intense laser plasma experiments显示文摘We report on a target system supporting automated positioning of nano-targets with a precision resolution of 4 μm in three dimensions. It relies on a confocal distance sensor and a microscope. The system has been commissioned to position nanometer targets with 1 Hz repetition rate. Integrating our prototype into the table-top ATLAS 300 TW-laser system at the Laboratory for Extreme Photonics in Garching, we demonstrate the operation of a 0.5 Hz laser-driven proton source with a shot-to-shot variation of the maximum energy about 27% for a level of confidence of 0.95. The reason of laser shooting experiments operated at 0.5 Hz rather than 1 Hz is because the synchronization between the nano-foil target positioning system and the laser trigger needs to improve. | Ying Gao Jianhui Bin Daniel Haffa Christian Kreuzer Jens Hartmann Martin Speicher Florian H.Lindner Tobias M.Ostermayr Peter Hilz Thomas F.Rsch Sebastian Lehrack Franz Englbrecht Sebastian Seuferling Max Gilljohann Hao Ding Wenjun Ma Katia Parodi Jorg Schreiber | 2017 | High Power Laser Science and Engineering2017，5，2： | 1 |
| 12 | Budesonide versus Prednisone with Azathioprine for the Treatment of Autoimmune Hepatitis in Children and Adolescents显示文摘 | Marek Woynarowski Antal Nemeth Yaacov Baruch Sibylle Koletzko Michael Melter Burkhard Rodeck Christian P. Strassburg Markus Pr?ls Ma?gorzata Wo?niak Michael P. Manns | 2013 | The Journal of Pediatrics2013，，5： | 1 |
| 13 | Handwashing andrespiratory illness among young adults in military training显示文摘 | Ryan MA Christian RS Wohlrabe J | 2001 | Am J Prev Med2001，21，2： | 1 |
| 14 | Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases显示文摘 | Xia Z P Christian K Ma J | 2009 | Bioorg Med Chem Lett2009，52，1： | 1 |
| 15 | A novel plant protein disulfide isomerase involved in the oxid active folding of cystine knot defense proteins 显示文摘 | Christian W G Ma? a ? ema? ar Richard J C | 2007 | J B C2007，22，14： | 1 |
| 16 | Prognostic values of NTpro BNP/BNP ratio in comparison with NTpro BNP or BNP alone in elderly patients with chronic heart failure in a 2 - year follow up 显示文摘 | Juliana Jensen Li - Ping Ma Christian Bjurman | 2012 | International Journal of Cardiology2012，155，1： | 1 |
| 17 | T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication显示文摘 | Hongxiang Liu Hongtao Ye Agnes Ruskone-Fourmestraux Daphne De Jong Stefano Pileri Christian Thiede Anne Lavergne Henk Boot Giancarlo Caletti Thomas Wündisch Thierry Molina Babs G. Taal Sabattini Elena Togliani Thomas Pier Luigi Zinzani Andreas Neubauer Ma | 2002 | Gastroenterology2002，，： | 1 |
| 18 | Protein disulfide isomerase: the structure of oxidative folding显示文摘 | Christian W. Gruber Ma?a ?ema?ar Bego?a Heras Jennifer L. Martin David J. Craik | 2006 | Trends in Biochemical Sciences2006，，8： | 1 |
| 19 | Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation显示文摘 | Christophe Camus Sylvain Lavoué Arnaud Gacouin Yves Tulzo Richard Lorho Karim Boudjéma Christian Jacquelinet Rémi Thomas | 2006 | Intensive Care Medicine2006，，11： | 1 |
| 20 | TNF-α release by monocytic THP-1 cells through cross-linking of the extended Vregion of the oral streptococcal protein Ⅰ/Ⅱ显示文摘 | Christian CR Innocient Y Sciooti MA | 2000 | Leukoc Biolo2000，67，： | 1 |
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