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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 3 | 循证医学 误用漏斗图的案例分析显示文摘本文要点应该使用严格的标准对循证医学中使用的方法进行评价用于检验发表偏倚的漏斗图在系统性文献综述中应用广泛漏斗图的不对称性,无论是直观上看到的或统计学检验发现的。 | Joseph Lau John P A Ioannidis Norma Terrin Christopher H Schmid Ingram Olkin 谢朝晖 | 2007 | 英国医学杂志中文版2007，10，3： | 1 |
| 4 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 5 | Knowl edge network characteristics and entrepreneurial orienta tion of multinational corporations, research policy显示文摘 | CHRISTOPHER W SOO H L RESOURCE A | 2009 | Re search Policy2009，38，8： | 1 |
| 6 | Analysis of the anticoccidial drug,halofuginone,in chicken feed using gas-liquid chromatography and high-performance liquid chromatography显示文摘 | Anderson A Christopher D H Woodhouse R N | 1979 | Journal of Chromatography1979，168，： | 1 |
| 7 | Increasing rates of cardiac device infections among medicare beneficiaries: 1990–1999显示文摘 | Christopher H Cabell Paul A Heidenreich Vivian H Chu Christopher M Moore Martin E Stryjewski G.Ralph Corey Vance G Fowler | 2004 | American Heart Journal2004，，4： | 1 |
| 8 | Shielding effectiveness measurements of materials using nested reverberation chambers 显示文摘 | Christopher L H David A H | 2003 | IEEE Transactions on Electromagnetic Compatibility2003，45，2： | 1 |
| 9 | 查看详情显示文摘 | Christopher A S Rasmus H Arfa R.M Warwick B D Gillian M S Royston G Alan J D | | 0，，01： | 1 |
| 10 | Effects of a modified-live virus vaccine against porcine reproductive and respiratory syndrome in boars显示文摘 | Christopher H J Nelson E A Nelson J K | 1997 | Am J Vet Res1997，58，1： | 1 |
| 11 | Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning 显示文摘 | Gremer H Lange R Christoph A | 1994 | Nature1994，367，6462： | 1 |
| 12 | Service architecture and modularity 显示文摘 | Christopher A Voss Juliana H Mikkola | 2009 | Decision Sciences2009，40，3： | 1 |
| 13 | U-shaped slope gully systems and sediment waves on the passive margin of Gabon (West Africa) 显示文摘 | LIDIA L NUR H J CHRISTOPHER A L | 2013 | Marine Geology2013，，337： | 1 |
| 14 | Gdt2 regulates the transition of Dictyostelium cells from growth to differentiation显示文摘 | Margarita V C Christophe A Robert H I | 2004 | BMC Dev Biol2004，4，1： | 1 |
| 15 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 16 | Magnetic mitoxantrone nanoparticles detection by histology, X-ray and MRI after magnetic tumor targeting显示文摘 | Christoph A Wolfgang A Peter H | 2001 | J Magnetism & Magnetic Materials2001，225，： | 1 |
| 17 | The nature of π-π interactions显示文摘 | Christopher A H Jeremy K M S | 1990 | J Am Chem Soc1990，112，14： | 1 |
| 18 | Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas显示文摘 | Christopher R H Keith A C Carol L K S | 2001 | Molecular Carcinogenesis2001，30，： | 1 |
| 19 | Potential mechanisms for achieving agricultural benefits from bioehar application to temperate soils: a review显示文摘 | Christopher J A Jean D F Nell A H | 2010 | Plant and Soil2010，337，： | 1 |
| 20 | Historical review of air-bearing spacecraft simulators 显示文摘 | Jana L S Mason A P Christopher D H | 2003 | Journal of Guidance Control and Dynamics2003，26，4： | 1 |
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