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| 1 | Tumor–stromal cross-talk modulating the therapeutic response in pancreatic cancer显示文摘Background: Pancreatic ductal adenocarcinoma(PDAC) is a highly malignant solid tumor with a dismal prognosis. The stroma component makes up to 90% of the tumor mass and is thought to be one of the main reasons for the tumor's high chemoresistance. Cancer associated fibroblasts(CAFs) have previously been identified to be the key stromal players. This is the first time we provide detailed in vitro experiments investigating tumor–stromal interactions when exposed to three well-known chemotherapeutic agents. Methods: Monocultures, indirect and direct co-cultures of two PDAC cell lines(AsPC and Panc-1) and six primary patients derived CAFs were treated with gemcitabine, nab-paclitaxel and the γ-secretaseinhibitor(GSI) DAPT. The cell viability of each component was measured with XTT. Finally, IL-6 concentrations of the supernatants were analyzed. Results: On the contrary to PDAC cell lines, CAF monocultures hardly responded to any treatment which suggested that stroma(CAFs) itself is more resistant to standard chemo-treatments than the epithelial cancer cells. Moreover, only a weak chemotherapeutic response was observed in direct co-cultures of cancer cells with CAFs. A change in the morphology of direct co-cultures was accompanied with the chemoresistance. CAFs were observed to build cage-like structures around agglomerates of tumor cells. High levels of IL-6 were also associated with a reduced response to therapy. Indirect co-cultures make the tumor–stromal interaction more complex. Conclusions: CAFs are highly chemoresistant. Direct cell–cell contact and high levels of IL-6 correlate with a high chemoresistance. | Christopher C.M.Neumann Ellen von Horschelmann Anja Reutzel-Selke Elisabeth Seidel Igor Maximilian Sauer Johann Pratschke Marcus Bahra Rosa Bianca Schmuck | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，5： | 2 |
| 2 | A bibliometric analysis of climate engineering research显示文摘 | Christopher W. Belter Dian J. Seidel | 2013 | WIREs Clim Change2013，，5： | 1 |
| 3 | Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis显示文摘眼的裂缝() 在将近所有网膜的祖先房间区别发生了以前,是关门的发展中的脊椎动物眼睛的腹的方面上的短暂开始。关上 OF 的失败导致 coloboma,是童年盲目的一个主要原因的先天的疾病。尽管人的基因研究和动物模型连接了很多基因到 coloboma,驾驶 OF 的闭合的细胞、分子的机制大部分仍然是不清楚的。在这研究,我们使用了 Cre-LoxP-mediated 成纤维细胞生长的有条件的移动因素(FGF ) 受体, Fgfr1 和 Fgfr2,从发展,眼的杯(OC ) 调整关门 OF 显示出发信号的那 FGF。我们的分子,细胞并且 Fgfr1 和 Fgfr2 的 transcriptome 分析加倍有条件的猛烈 OC 建议发信号的 FGF 通过网膜的祖先房间增长,命运说明和词法变化的调整控制 OF 闭合。而且, Fgfr1 和 Fgfr2 加倍房间没能开始网膜的中心房间(RGC ) 的有条件的变异的网膜的祖先开始。一起拿,我们基因研究揭示的鼠标发信号的那 FGF 是必要的为形态发生和 RGC 开发。 | Shuyi Chen Hua Li Karin Gaudenz Ariel Paulson Fengli Guo Rhonda Trimble Allison Peak Christopher Seidel Chuxia Deng Yasuhide Furuta Ting Xie | 2013 | Cell Research2013，23，2： | 1 |
| 4 | Influence of the cross-linking agent on the gel structure of starch derivatives 显示文摘 | Christian Seidel Werner-Michael Kulicke Christoph Heβ | 2001 | Starch2001，53，7： | 1 |
| 5 | Synthesis and characterization of cross-linked carboxymethyl potato starch ether gels 显示文摘 | Christian Seidel Werner-Michael Kulicke Christoph Heβ | 2004 | Starch2004，56，5： | 1 |
| 6 | Pre-compensation of Warpage for Additive Manufacturing显示文摘 | Christoph Schmutzler Fabian Bayerlein Stephan Janson Christian Seidel Michael F. Zaeh | 2016 | Journal of Mechanics Engineering and Automation2016，6，8： | 1 |
| 7 | Harmonic imaging of the human brain: visualization of brain perfusion with ultrasound 显示文摘 | Seidel G Algermissen C Christoph A | 2000 | Stroke2000，31，1： | 1 |
| 8 | Total chromium and hexavalent chromium occurrence analysis显示文摘 | Seidel Chad J Corwin Christopher J | 2013 | Journal of American Water Works Association2013，105，6： | 1 |
| 9 | 3D-laser scanning: A non-destructive method for studying above- ground biomass and growth of juvenile trees显示文摘 | Dominik Seidel Friderike Beyer Dietrich Hertel Stefan Fleck Christoph Leuschner | 2011 | Agricultural and Forest Meteorology2011，，： | 1 |
| 10 | Factor 30 Pulse Compression by Hybrid Multipass Multiplate Spectral Broadening显示文摘As ultrafast laser technology advances towards ever higher peak and average powers,generating sub-50 fs pulses from laser architectures that exhibit best power-scaling capabilities remains a major challenge.Here,we present a very compact and highly robust method to compress 1.24 ps pulses to 39fs by means of only a single spectral broadening stage which neither requires vacuum parts nor custom-made optics.Our approach is based on the hybridization of the multiplate continuum and.the multipass cell spectral broadening techniques.Their combination leads to significantly higher spectral broadening factors in bulk material than what has been reported from either method alone.Moreover,our approach efficiently suppresses adverse features of single-pass bulk spectral broadening.We use a burst-mode Yb:YAG laser emitting pulses with 80 MW peak power that are enhanced to more than 1 GW after postcompression.With only 0.19%rms pulse-to-pulse energy fluctuations,the technique exhibits excellent stability.Furthermore,we have measured state-of-the-art spectral-spatial homogeneity and good beam quality of M^(2)=1.2 up to a spectral broadening factor of 30.Due to the method's simplicity,compactness,and scalability,it is highly attractive for turning a picosecond laser into an ultrafast light source that generates pulses of only a few tens of femtoseconds duration. | Marcus Seidel Prannay Balla Chen Li Gunnar Arisholm Lutz Winkelmann Ingmar Hartl Christoph M.Heyl | 2022 | Ultrafast Science2022，，1： | 0 |
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