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| 1 | Study on β-TCP Coated Porous Mg as a Bone Tissue Engineering Scaffold Material显示文摘Three-dimensional honeycomb-structured magnesium (Mg) scaffolds with interconnected pores of accurately controlled pore size and porosity were fabricated by laser perforation technique. Biodegradable and bioactive β-tricalcium phosphate (β-TCP) coatings were prepared on the porous Mg to further improve its biocompatibility, and the biodegradation mechanism was simply evaluated in vitro. It was found that the mechanical properties of this type of porous Mg significantly depended on its porosity. Elastic modulus and compressive strength similar to human bones could be obtained for the porous Mg with porosity of 42.6%-51%. It was observed that the human osteosarcoma cells (UMR106) were well adhered and proliferated on the surface of the β-TCP coated porous Mg, which indicates that the β-TCP coated porous Mg is promising to be a bone tissue engineering scaffold material. | Fang Geng Lili Tan Bingchun Zhang Chunfu Wu Yonglian He Jingyu Yang Ke Yang | 2009 | Journal of Materials Science & Technology2009，25，1： | 13 |
| 2 | Haploidentical hematopoietic cell transplantation for severe acquired aplastic anemia: a case-control study of post-transplant cyclophosphamide included regimen vs. anti-thymocyte globulin & colony-stimulating factor-based regimen显示文摘Dear Editor,Haploidentical allogeneic hematopoietic stem cell transplantation(haplo-HSCT),a curative therapy for severe aplastic anemia(SAA)patients,has been used clinically for decades.Two models,not involving ex vitro T-cell depletion,have been adopted for haplo-HSCT in patients with SAA.The first is referred to as the'Beijing protocol'(Xu et al.,2017),and comprises a conditioning regimen using busulfex(BU),cyclophosphamide(CY). | Lanping Xu Bin Fu Wenjing Wang Yajing Xu Depei Wu Shunqing Wang Qifa Liu Linghui Xia Sujun Gao Ming Jiang Jianmin Wang Xi Zhang Hai Bai Huiren Chen Chunfu Li Xiaojun Huang | 2020 | Science China(Life Sciences)2020，63，6： | 3 |
| 3 | Preparation and Evaluation of Insulin-loaded Nanoparticles based on Hydroxypropyl-β-cyclodextrin Modified Carboxymethyl Chitosan for Oral Delivery显示文摘Novel insulin-loaded nanoparticles based on hydroxypropyl-β-cyclodextrin modified carboxymethyl chitosan(CMC-HP-β-CD) were prepared to improve the oral bioavailability of insulin. The CMC-HP-β-CD was characterized by FT-IR spectroscopy and 1H-NMR spectra. The insulin-loaded nanoparticles were prepared through crosslinking with calcium ions, and the morphology and size of the prepared nanoparticles were characterized by transmission electron microscopy(TEM) and dynamic light scattering(DLS). Cumulative release in vitro study was performed respectively in simulated gastric medium fluid(SGF, p H=1.2), simulated intestinal fluid(SIF, p H=6.8) and simulated colonic fluid(SCF, p H=7.4). The encapsulation efficiency of insulin was up to 87.14 ± 4.32% through high-performance liquid chromatography(HPLC). Statistics indicated that only 15% of the encapsulated insulin was released from the CMC-HP-β-CD nanoparticles in 36 h in SGF, and about 50% of the insulin could be released from the nanoparticles in SIF, whereas more than 80% was released in SCF. In addition, the solution containing insulin nanoparticles could effectively reduce the blood glucose level of diabetic mice. The cytotoxicity test showed that the samples had no cytotoxicity. CMC-HP-β-CD nanoparticles are promising candidates as potential carriers in oral insulin delivery systems. | 宋豪源 马晓玲 XIONG Fuliang HONG Hui LI Chunfu LI Lianghong WU Shanshan ZHANG Xueqiong 张娟 胡建华 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，6： | 3 |
| 4 | A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps显示文摘Background and Aims:Gallbladder polyp(GBP)assessment aims to identify the early stages of gallbladder carcinoma.Many studies have analyzed the risk factors for malignant GBPs.In this retrospective study,we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs.Methods:We devel-oped a nomogram-based model in a training cohort of 233 GBP patients.Clinical information,ultrasonographic find-ings,and blood test findings were analyzed.Mann-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram model.An internal validation was conducted in 225 consecutive patients.Performance and clinical bene-fit of the model were evaluated using receiver operating characteristic curves and decision curve analysis(DCA),re-spectively.Results:Age,cholelithiasis,carcinoembryonic antigen,polyp size,and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training group.Compared with five other proposed predic-tion methods,the established nomogram model presented better discrimination of neoplastic GBPs in the training co-hort(area under the curve[AUC]:0.846)and the validation cohort(AUC:0.835).DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five methods.Conclusions:Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decision-making. | Xudong Zhang Jincheng Wang Baoqiang Wu Tao Li Lei Jin Yong Wu Peng Gao Zhen Zhang Xihu Qin Chunfu Zhu | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 3 |
| 5 | Evolution of shoals and vegetation of Jiuduansha in the Changjiang River Estuary of China in the last 30 years显示文摘The evolution of the shoals and vegetation plays an important role in maintaining the stability of the river regime and the estuarine ecosystem. However, the interaction between the evolution of shoals and vegetation dynamic has rarely been reported. In this study, we determined the interaction between the shoal and vegetation evolution of Jiuduansha in the Changjiang River Estuary in the last 30 years. We did this through the collection and summarization of the existing data of the regional hydrological processes, wading engineering, and vegetation,and combined it with the analysis of nautical charts and remote sensing images. During the past 30 years, the expansion of the shoals within the 0 m isobath in Jiuduansha was obvious, with an increase of 176.5%, while the expansion of the shoals within the 5 m isobath was relatively slow. The regional hydrological characteristics in the Jiuduansha area changed dramatically, especially the sediment discharges. The area of vegetation in Jiuduansha increased from 9.1 km^2 in 1990 to 65.68 km^2 in 2015, while the variations in the different vegetation types were different. The best combination of environmental factors with a significant correlation on the shoals within the 0 m isobath is the area of Spartina alterniflora and Phragmites australis. The evolution of Jiuduansha shoals was significantly affected by the variations in hydrological characteristics. Meanwhile, on a long-term scale, the expansion of the shoals could promote the regional vegetation expansions due to the suitable elevation and environmental conditions it provides. The interaction between the shoal and vegetation evolution varied in the different vegetation types and different elevations. In the future, long-term monitoring and detailed data are needed to the systematical analysis of the interaction between the hydrological processes and the evolution of the shoal and vegetation. | Fengrun Wu Chunfu Tong Mitch Torkelson Yan Wang | 2020 | Acta Oceanologica Sinica2020，39，8： | 2 |
| 6 | Effect of shikonin on human breast cancer cells proliferation and apoptosis in vitro显示文摘 | Yue hou Tao guo Chunfu wu | 2006 | Pharmaceutical Society of Japan2006，126，12： | 1 |
| 7 | Effect of shikonin on human breast cancer cells proliferation and apoptosis in vitro显示文摘 | Yue HOU Tao GUO Chunfu WU | 2006 | Pharmaceuti-cal Society of Japan2006，126，12： | 1 |
| 8 | Crystalline and amorphous Mn0_(2)cathodes with open framework enable high-performance aqueous zinc-ion batteries显示文摘Currently,δ-Mn0_(2)is one of the popularly studied cathode materials for aqueous zinc-ion batteries(ZIBs)but impeded by the sluggish kinetics of Zn^(2+)and the Mn cathode dissolution.Here,we report our discovery in the study of crystalline/amorphous Mn0_(2)(disordered Mn0_(2)),prepared by a simple redox reaction in the order/disorder engineering.This disordered Mn0_(2)cathode material,having open framework with more active sites and more stable structure,shows improved electrochemical performance in 2 mol L^(-1)ZnSO_(4)/0.1 mol L^(-1)MnS0_(4)aqueous electrolyte.It delivers an ultrahigh discharge specific capacity of 636 mA·h·g^(-1)at 0.1 A·g^(-1)and remains a large discharge capacity of 216 mA·h·g^(-1)even at a high current density of 1 A·g^(-1)after 400 cycles.Hence disordered Mn0_(2)could be a promising cathode material for aqueous ZIBs.The storage mechanism of the disordered Mn0_(2)electrode is also systematically investigated by structural and morphological examinations of ex situ,ultimately proving that the mechanism is the same as that of the δ-Mn0_(2)electrode.This work may pave the way for the possibility of using the order/disorder engineering to introduce novel properties in electrode materials for high-performance aqueous ZIBs. | Chunfu HUANG Cong WU Zilu ZHANG Yunyun XIE Yang LI Caihong YANG Hai WANG | 2021 | Frontiers of Materials Science2021，15，2： | 0 |
| 9 | The protective effects of Gastrodia elata Bl.decoction and Gastrodin on Acrylamide-induced DNA damage in mice显示文摘Acrylamide(AA)is ubiquitous in packaging materials,paints,cosmetics,food and drinking water.However,AA has obvious neurotoxicity,reproductive toxicity and carcinogenicity,which seriously endangers human health.As one of precious traditional Chinese medicines,Gastrodia elata Bl.has been mainly used to lower blood pressure and resist myocardial ischemia.However,the antioxidant activity of Gastrodia elata Bl.on AA-induced DNA damage has not been reported.We found that AA(25,30 and 50 mg/kg)could cause DNA damage and the damage was time/dose dependent.After AA administration,Tail moment,micronuclei formation rate,8-OHdG and MDA level were significantly increased and SOD activity was decreased.Gastrodia elata Bl.decoction,gastrodin and vitamin C could reduce AA-induced DNA damage by decreasing AA-induced increment of tail moment and micronuclei formation rate.What’s more,Gastrodia elata Bl.decoction,gastrodin and vitamin C could lower 8-OHdG and MDA level and improve SOD activity.In conclusion,our research showed that Gastrodia elata Bl.decoction and gastrodin had protective effects on AA-induced DNA damage,and the potential protective mechanism might be related to anti-oxidative stress. | Fan Wang Kuo Zhang Xiaoya Du Jingyu Yang Chunfu Wu | 2020 | Asian Journal of Traditional Medicines2020，15，6： | 0 |
| 10 | 坏死激酶RIP1/RIP3通过特异性结合HSV-1的ICP6蛋白从而启动细胞坏死来抑制病毒在小鼠中的繁殖显示文摘2007年3月,细胞出版社正式推出《细胞-宿主与微生物》(月刊)。本刊出版的研究论文和综述文章重点关注对微生物与其宿主关系的理解。通过与作者、审稿人和科学编委的紧密合作,本刊的编辑人员以保持细胞出版社期刊一贯的高标准为使命,对该领域的研究结果予以及时报道。该杂志2015年公布的影响因子为12.328。 | Zhe Huang Su-Qin Wu 梁耀极 Xiaojuan Zhou Wanze Chen Lisheng Li Jianfeng Wu Qiuyu Zhuang Chang'an Chen Jingxian Li Chuan-Qi Zhong Weixiang Xia Rongbin Zhou Chunfu Zheng 韩家淮 | 2016 | 科学新闻2016，0，1： | 0 |
| 11 | A review:anticancer activity of grape seed proanthocyanidins显示文摘For years,a great deal of work has been carried out on proanthocyanidins extracted from various kinds of plants,of which grape seed proanthocyanidins(GSPs)attract most attention due to their benefi cial roles in human health.Indeed,GSPs have demonstrated substantial health benefi ts for a variety of disorders such as cancer,atherosclerosis,and cardiovascular diseases,to just name a few.In particular,GSPs inhibit cell proliferation,migration and invasion,and induce apoptosis and cell cycle arrest in various human cancers,including head and neck carcinoma,gastrointestinal tumors,lung cancer,skin tumors,and reproductive tumors,which points them to be promising chemo-preventive and/or chemotherapeutic agents.In this setting,we summarized the eff ects of GSPs against various types of cancer with a focus on the detailed molecular mechanisms involving various signaling pathways of tumor cells,which may serve as a basis for development of improved chemo-preventive or therapeutic strategies for cancer. | Fengjiao Zhang Tingting Zhang Jingyu Yang Chunfu Wu | 2020 | Journal of Polyphenols2020，2，1： | 0 |
| 12 | Amorphous nickel-cobalt bimetal-organic framework nanosheets with crystalline motifs enable efficient oxygen evolution reaction: Ligands hybridization engineering显示文摘Development of high-efficiency and low-cost electrocatalyst for oxygen evolution reaction(OER) is very important for use at alkaline water electrolysis.Metal-organic frameworks(MOF) provide a rich platform for designing multi-functional materials due to their controllable composition and ultra-high surface area.Herein,we report our findings in the development of amorphous nickel-cobalt bimetal-organic framework nanosheets with crystalline motifs via a simple 'ligands hybridization engineering' strategy.These complexes' ligands contain inorganic ligands(H_2 O and NO_3) and organic ones,hexamethylenetetramine(HMT).Further,we investigated a series of mixed-metal with multi-ligands materials as OER catalysts to explore their possible advantages and features.It is found that the Ni doping is an effective approach for optimizing the electronic configuration,changing lattice ordering degree,and thus enhancing activities of HMT-based electrocatalysts.Also,the crystalline-amorphous boundaries of various HMTbased electrocatalyst can be easily controlled by simply changing amounts of Ni-precursor added.As a result,the optimized ultrathin(Co,0.3 Ni)-HMT nanosheets can reach a current density of 10 mA cm^(-2)at low overpotential of 330 mV with a small Tafel slope of 66 mV dec^(-1).Our findings show that the electronic structure changes induced by Ni doping,2 D nanosheet structure,and MOF frameworks with multiligands compositions play critical roles in the enhancement of the kinetically sluggish electrocatalytic OER.The present study emphasizes the importance of ligands and active metals via hybridization for exploring novel efficient electrocatalysts. | Yang Li Zhonggui Gao Huiming Bao Binghui Zhang Cong Wu Chunfu Huang Zilu Zhang Yunyun Xie Hai Wanga | 2021 | Journal of Energy Chemistry2021，30，2： | 0 |
| 13 | Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats显示文摘Cognitive impairment caused by chronic cerebral hypoperfusion(CCH)is associated with white matter injury(WMI),possibly through the alteration of autophagy.Here,the autophagy—lysosomal pathway(ALP)dysfunction in white matter(WM)and its relationship with cognitive impairment were investigated in rats subjected to two vessel occlusion(2VO).The results showed that cognitive impairment occurred by the 28th day after 2VO.Injury and autophagy activation of mature oligodendrocytes and neuronal axons sequentially occurred in WM by the 3rd day.By the 14th day,abnormal accumulation of autophagy substrate,lysosomal dysfunction,and the activation of mechanistic target of rapamycin(MTOR)pathway were observed in WM,paralleled with mature oligodendrocyte death.This indicates autophagy activation was followed by ALP dysfunction caused by autophagy inhibition or lysosomal dysfunction.To target the ALP dysfunction,enhanced autophagy by systemic rapamycin treatment or overexpression of Beclin1(BECN1)in oligodendrocytes reduced mature oligodendrocyte death,and subsequently alleviated the WMI and cognitive impairment after CCH.These results reveal that early autophagy activation was followed by ALP dysfunction in WM after 2VO,which was associated with the aggravation of WMI and cognitive impairment.This study highlights that alleviating ALP dysfunction by enhancing oligodendrocyte autophagy has benefits for cognitive recovery after CCH. | Huiyang Wang Yueyang Liu Zhenkun Guo Minghui Cui Peng Pang Jingyu Yang Chunfu Wu | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
| 14 | N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats显示文摘Lead exposure induces decreased hippocampal N-methyl-D-aspartic acid(NMDA) receptor gene and protein expressions,which influences the molecular mechanisms of learning and memory.However,lead poisoning-induced differences in NMDA subunit expression,and the correlation of lead poisoning with learning and memory,remain poorly understood.The present study measured differences in expression of NMDA receptor subunits NR1,NR2A,and NR2B in memory-related brain regions of rats who underwent different doses of lead exposure.Results demonstrated decreased NR1,NR2A,and NR2B subunit expressions in some memory-related brain areas.The inhibitory effect of 4.8 mmol/L lead exposure on hippocampal NR2B was most significant,although NR2A expression also significantly decreased following 14.4 mmol/L lead exposure.There was no difference in NR1 expression following exposure to < 4.8 mmol/L lead,although the inhibitory effect of 19.6 mmol/L lead exposure was strongest for NR1 expression in the hippocampus.Inhibitory avoidance test results revealed that greater concentrations of lead exposure resulted in decreased learning and memory.Therefore,lead toxicity was dependent on NMDA receptor subunit composition,and NR1,NR2A,and NR2B expressions were associated with time and concentration of lead exposure. | Qiwen Zhu Weijian Hou Jianwen Zhao Yu Yang Qi Zhang Li Guo Lihong Shang YinglinCao Chunfu Wu | 2010 | Neural Regeneration Research2010，5，23： | 0 |
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