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| 1 | Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs显示文摘Background: Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most of the world. In China, pigs were raised with alfalfa-containing diets to seek for good quality pork.However, the influence of dietary alfalfa involving high level of insoluble dietary fiber(IDF) on pig intestinal luminal microbiota composition remains unclear. The objective of this study was to investigate the effects of alfalfa on luminal microbiota and short chain fatty acids(SCFA) production, and gene expressions involved in SCFA sensing, transporting and absorbing in pig caecal mucosa.Results: Twenty-four growing pigs were randomly allotted to four diets containing 0%, 5%, 10% and 15% alfalfa meal for a 28-d experiment. Ingestion of alfalfa meal-contained diets significantly increased the ratio of body weight gain to feed consumption. Illumina MiS eq sequencing of the V3 region of the 16 S r RNA genes showed that alfalfa-containing diet significantly decreased the relative abundance of genera Turicibacter, Acidiphilium, Paracoccus, Propionibacterium,Corynebacterium, Pseudomonas, Acinetobacter, and Staphylococcus, and increased the relative abundance of genera Lachnospira, Marvinbryantia, and Desulfovibrio in the caecal digesta. Butyrate concentration was significantly increased in the hindgut by the supplementation of alfalfa meal in diets. The m RNA gene expressions of FFAR3, SMCT1, MCT1,PYY, and GCG were significantly increased in the caecal mucosa of pigs fed alfalfa meal.Conclusions: Our results suggested that alfalfa-containing diet has exerted significant impacts on caecal microbiota composition, butyrate concentration and significantly upregulated m RNA expression of host caecal mucosal genes involved in SCFA sensing and absorption as well as regulation of satiety. | Jiawei Wang Chunfu Qin Ting He Kai Qiu Wenjuan Sun Xin Zhang Ning Jiao Weiyun Zhu Jingdong Yin | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 12 |
| 2 | A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps显示文摘Background and Aims:Gallbladder polyp(GBP)assessment aims to identify the early stages of gallbladder carcinoma.Many studies have analyzed the risk factors for malignant GBPs.In this retrospective study,we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs.Methods:We devel-oped a nomogram-based model in a training cohort of 233 GBP patients.Clinical information,ultrasonographic find-ings,and blood test findings were analyzed.Mann-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram model.An internal validation was conducted in 225 consecutive patients.Performance and clinical bene-fit of the model were evaluated using receiver operating characteristic curves and decision curve analysis(DCA),re-spectively.Results:Age,cholelithiasis,carcinoembryonic antigen,polyp size,and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training group.Compared with five other proposed predic-tion methods,the established nomogram model presented better discrimination of neoplastic GBPs in the training co-hort(area under the curve[AUC]:0.846)and the validation cohort(AUC:0.835).DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five methods.Conclusions:Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decision-making. | Xudong Zhang Jincheng Wang Baoqiang Wu Tao Li Lei Jin Yong Wu Peng Gao Zhen Zhang Xihu Qin Chunfu Zhu | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 3 |
| 3 | Interfacial Voids Trigger Carbon-Based, All-Inorganic Cs Pb IBr2 Perovskite Solar Cells with Photovoltage Exceeding 1.33 V显示文摘A novel interface design is proposed for carbon-based,all-inorganic CsPbIBr2 perovskite solar cells(PSCs)by introducing interfacial voids between TiO2 electron transport layer and CsPbIBr2 absorber.Compared with the general interfacial engineering strategies,this design exempts any extra modification layer in final PSC.More importantly,the interfacial voids produced by thermal decomposition of 2-phenylethylammonium iodide trigger three beneficial e ects.First,they promote the light scattering in CsPbIBr2 film and thereby boost absorption ability of the resulting CsPbIBr2 PSCs.Second,they suppress recombination of charge carriers and thus reduce dark saturation current density(J0)of the PSCs.Third,interfacial voids enlarge built-in potential(Vbi)of the PSCs,awarding increased driving force for dissociating photo-generated charge carriers.Consequently,the PSC yields the optimized e ciency of 10.20%coupled with an open-circuit voltage(Voc)of 1.338 V.The Voc achieved herein represents the best value among CsPbIBr2 PSCs reported earlier.Meanwhile,the non-encapsulated PSCs exhibit an excellent stability against light,thermal,and humidity stresses,since it remains^97%or^94%of its initial e ciency after being heated at 85℃for 12 h or stored in ambient atmosphere with relative humidity of 30–40%for 60 days,respectively. | Weidong Zhu Zeyang Zhang Dandan Chen Wenming Chai Dazheng Chen Jincheng Zhang Chunfu Zhang Yue Hao | 2020 | Nano-Micro Letters2020，12，7： | 3 |
| 4 | Ecosystem service values and restoration in the urban Sanyang wetland of Wenzhou, China显示文摘 | Chunfu Tong Rusty A. Feagin Jianjian Lu Xiufeng Zhang Xiaojun Zhu Wei Wang Wenshan He | 2006 | Ecological Engineering2006，，： | 1 |
| 5 | Extended depth of field with the optimal ‘0, π’ binary phase pupil mask显示文摘 | Qinghua Lv Xiao Zhu Zhongbao Xu Zhongsheng Zhai Chunfu Cheng Shuang Zou | 2013 | Journal of Modern Optics2013，，7： | 1 |
| 6 | The linear and nonlinear optical effects of white light显示文摘An overview of our research group’s experimental and theoretical developments is provided on the linear and nonlinear optical effects of white light since 2003. Their work includes the experimental researches on the white light one-dimensional photovoltaic dark spatial solitons and the waveguides and directional couplers induced by them, the circular and elliptic white-light dark spatial solitons and the white-light photorefractive phase masks, two-dimensional white-light photonic lattices and the applications of the white-light dark spatial solitons in the digital image transmission field, the interaction between the two-dimensional white-light dark spatial solitons to enhance or to improve the correlated degree of the white light through the interaction between the white-light beam and coherent dark spatial solitons, the interaction between the one- or two-dimensional white-light dark spatial solitons and the two-dimensional white-light photonic lattices, respectively. We also numerically simulate the interaction between two or more partially incoherent bright spatial solitons and the white bright spatial soliton pairs in the saturated logarithmic nonlinear medium. We have observed experimentally for the first time, the modulation instability of the coherent light and white light, respectively, in self-defocusing medium and so on. | QI XinYuan LIU SiMin GUO Ru LU Yi GAO YuanMei LIU ZhaoHong HUANG ChunFu ZHANG XiaoHua ZHU Nan XU JingJun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 0 |
| 7 | Ultrahigh fill-factor all-inorganic CsPbBr_(3)perovskite solar cells processed from two-step solution method and solvent additive strategy显示文摘All-inorganic CsPbBr_(3)perovskite solar cells(PSCs)have attracted more attentions due to the excellent environmental stability,however,the wide bandgap and relatively poor crystallinity of CsPbBr_(3)have been the main obstacle to improve their power conversion efficiency(PCE).Herein,we proposed an efficient and simple strategy of precursor additive in the two-step aqueous-solution method,the resulted CsPbBr_(3)film has achieved more uniform grain size,almost pure perovskite phase,smoother surface,less defects,enhanced light absorption and longer carrier lifetime.This is due to the rapid evaporation of additive(IPA and CH_(3)OH)in the CsBr/H_(2)O precursor leads to a relatively higher local CsBr concentration on the surface of PbBr_(2),which can provide more nucleation sites and accelerate the crystallization of perovskite.Further,when utilizing the optimal additive of 5%(in volume)IPA,the HTM-free carbonbased CsPbBr_(3)PSCs obtained a PCE improvement from 9.09%to 10.29%,and an ultrahigh fill factor(FF)of 85.21%.What is more,by adding 0.1 mol/L PbCl_(2)into the PbBr_(2)solution in the first step,the open circuit voltage of device has increased from 1.36 V to 1.48 V,the champion PCE reached 10.37%(steady output PCE of 10.17%),and the non-encapsulated device could maintain 85%of its initial efficiency after 50 d in the air.This work provides a cost-effective approach to grow CsPbBr_(3)film and boosts the efficiency benchmark of the CsPbBr_(3)PSCs to more than 10%,it is desirable that the highly efficient and stable CsPbBr_(3)PSCs can be developed in future. | Dazheng Chen Yibing He Gang Fan Zeyang Zhang Weidong Zhu He Xi Long Zhou Chunfu Zhang Jincheng Zhang Yue Hao | 2023 | Journal of Materiomics2023，9，4： | 0 |
| 8 | N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats显示文摘Lead exposure induces decreased hippocampal N-methyl-D-aspartic acid(NMDA) receptor gene and protein expressions,which influences the molecular mechanisms of learning and memory.However,lead poisoning-induced differences in NMDA subunit expression,and the correlation of lead poisoning with learning and memory,remain poorly understood.The present study measured differences in expression of NMDA receptor subunits NR1,NR2A,and NR2B in memory-related brain regions of rats who underwent different doses of lead exposure.Results demonstrated decreased NR1,NR2A,and NR2B subunit expressions in some memory-related brain areas.The inhibitory effect of 4.8 mmol/L lead exposure on hippocampal NR2B was most significant,although NR2A expression also significantly decreased following 14.4 mmol/L lead exposure.There was no difference in NR1 expression following exposure to < 4.8 mmol/L lead,although the inhibitory effect of 19.6 mmol/L lead exposure was strongest for NR1 expression in the hippocampus.Inhibitory avoidance test results revealed that greater concentrations of lead exposure resulted in decreased learning and memory.Therefore,lead toxicity was dependent on NMDA receptor subunit composition,and NR1,NR2A,and NR2B expressions were associated with time and concentration of lead exposure. | Qiwen Zhu Weijian Hou Jianwen Zhao Yu Yang Qi Zhang Li Guo Lihong Shang YinglinCao Chunfu Wu | 2010 | Neural Regeneration Research2010，5，23： | 0 |
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